• Korean Journal of Clinical Pharmacy
• /
• v.14 no.1
• /
• pp.32-35
• /
• 2004

The purpose of this study was to investigate the pharmacokinetic changes of verapamil in rabbits with hepatic disorder induced by carbon tetrachloride. The plasma concentrations of verapamil were increased significantly (p<0.05, in slight group; P<0.01, in moderate and severe group) in all groups of hepatic disorder compared to the control group. Morover, the $C_{max}\;in\;slight\;(77.9\%$ increase), moderate ($110\%$ increase), and severe ($174\%$ increase) hepatic disorder groups were significantly (p<0.05, in slight; p<0.01, in moderate and severe) higher than that in control rabbits. These resulted in significantly (p<0.05, in slight; p<0.01, in moderate and severe) greater area under the plasma concentration-time curve (AUC) in moderate ($49.8\%$ increase), moderate ($95.0\%$ increase), and severe ($144\%$ increase) hepatic disorder groups than that in control rabbits. Hence, the relative bioavailability values were 149, 195, and $244\%$ for slight, moderate, and severe hepatic disorder groups, respectively. This could be due to decrease in metabolism of verapamil in the liver because of suppressed hepatic function in the hepatic disorder groups because verapamil is mainly metabolized in the liver.

• The Bulletin of The Korean Astronomical Society
• /
• v.37 no.1
• /
• pp.88.2-88.2
• /
• 2012

We investigate solar flare occurrence rate and daily flare probability depending on McIntosh sunspot classification, its area, and its area change. For this we use the NOAA active region and GOES solar flare data for 15 years (from January 1996 to December 2010). We consider the most flare-productive 10 sunspot classification: 'Dko', 'Dai', 'Eai', 'Fai', 'Dki', 'Dkc', 'Eki', 'Ekc', 'Fki', and 'Fkc'. Sunspot area and its change can be a proxy of magnetic flux and its emergence/cancellation, respectively. we classify each sunspot group into two sub-groups: 'Large' and 'Small'. In addition, for each group, we classify it into three sub-groups according to sunspot group area change: 'Decrease', 'Steady', and 'Increase'. As a result, in the case of compact groups, their flare occurrence rates and daily flare probabilities noticeably increase with sunspot group area. We also find that the flare occurrence rates and daily flare probabilities for the 'Increase' sub-groups are noticeably higher than those for the other sub-groups. In case of the (M+X)-class flares of 'Dkc' group, the flare occurrence rate of the 'Increase' sub-group is three times higher than that of the 'Steady' sub-group. Mean flare occurrence rates and flare probabilities for all sunspot regions increase with the following order: 'Steady', 'Decrease', and 'Increase'. Our results statistically demonstrate that magnetic flux and its emergence enhance major solar flare occurrence. We are going to forecast solar flares based on these results and NOAA scale.

• Journal of Power System Engineering
• /
• v.20 no.3
• /
• pp.11-16
• /
• 2016

The effect of carbides on the tensile properties in 0.5C-17Cr-0.5Ni martensitic stainless steel was studied. With the increase of austenitizing temperature, the volume fraction of residual carbide was decreased rapidly. In tempered specimens after quenching, the volume fraction of total carbide was decreased with the increase of austenitizing temperature. In tempered specimens after quenching, strength was decrease and elongation was increased with the increase of austenitizing temperature. Tensile strength was increase and elongation was decreased with the increase of volume fraction of residual and total carbides. With the increase of austenitizing temperature, the tensile properties of mod. 0.5C-17Cr-0.5Ni martensitic stainless was affected greatly by residual carbide than tempered carbide.

• New & Renewable Energy
• /
• v.6 no.3
• /
• pp.13-21
• /
• 2010

This paper analyzes the factors of renewable energy consumption in Korea, China and Japan. We consider renewable energy consumption per capita as dependent variable, GDP per capita, $CO_2$ emissions per capita and real oil prices as independent variables. To analyze this model, this paper uses three econometric methods such as OLS, fixed effect model and panel GLS, utilizing data from 1990 to 2006 in Korea, China and Japan. According to the results by OLS for each country, an increase in GDP per capita or $CO_2$ emissions per capita or oil prices leads to an increase in renewable energy consumption. According to the results by fixed effect model, an increase in GDP per capita or $CO_2$ emissions per capita leads to an increase in renewable energy consumption. And real oil prices do not have a significant impacts on this model. According to the results by panel GLS, an increase in real GDP per capita as a proxy of income leads to an increase renewable energy consumption. And both $CO_2$ emissions per capita and real oil prices do not correlated closely with renewable energy consumption. Thus oil is not substituted to renewable energy in Northeast asian countries.

• Animal cells and systems
• /
• v.6 no.1
• /
• pp.19-22
• /
• 2002

Life table studies were conducted in the laboratory for the eulophid gregarious pupal parasitoid, Tetrastichus sp., on Hyphantria cunea Drury at a constant temperature of 28.2$\pm$2$^{\circ}C$, 50-60% RH to evaluate their impact on the host and their potential biological control. Development of immature stage took 20.1$\pm$2.7 d: adult females lived for 23.2$\pm$2.2 (range, 16-27)d and produced a mean of 53.6$\pm$26.6 adult progeny per female, with a sex ratio of 1: 9.5 (M:F). The intrinsic rate of natural increase (r$_{m}$) was 0.178/ female/day; the net reproductive rate (R$_{o}$), 46.74; the capacity for increase (r$_{c}$) 0.177; the finite rate of increase (λ) 1.19/female/day; thus each female contributed 46.74 individuals to the population in a mean generation time of 21.6 d. Biological factors in determining the life history trait variation of the parasitoid were discussed.d.d.d.

• Journal of Ocean Engineering and Technology
• /
• v.19 no.6 s.67
• /
• pp.22-28
• /
• 2005

We investigated the characteristics of the overflow/wave overtopping, induced by the storm surge and high waves in Masan bay and Busan Coast during Typhoon 'Maemi', which landed at the southeast coast of the Korean peninsula on September, of 2003, causing a severe inundation disaster. Characteristics of the water level, increase by the overflow / wave overtopping, were discussed in two patterns. One is the increase of water level in the region, located inside of a bay, like Masan fishing port, and the waves are relatively small. The other is in the open sea, in which the waves act directly, as on the seawall in Suyong bay. In the former region, the water level increase was affected by the storm surge, as well as the long period oscillation and waves. In Masan fishing port, about $80\%$ of the water level increase on the quay wall was caused by the storm surge. In the latter one, it was greatly affected by the wave run-up. In Suyong bay, about $90\%$ of the water level increase on the seawall was caused by the wave run-up.

• Journal of the Korea Institute of Building Construction
• /
• v.5 no.2 s.16
• /
• pp.161-166
• /
• 2005

This study is to evaluate on the increased cost of construction according to the depth change of concrete slabs in apartment building. When we increased the depth of concrete slab from 150mm to 180, 210mm, the qualitative and cost of construction were calculated by the high-rise type, the unit-size type. As a result of this study, in 32 Pyong type, increment of construction cost rate appeared by $5.1\%$ in case of increase from slab 150mm to 180mm, and $10.0\%$ in case of increase from slab 150mm to 210mm. In 45 Pyong type, Increment of construction cost rate appeared by $5.7\%$ in case of increase from slab 150mm to 180mm, and $10.2\%$ in case of increase from slab 150mm to 210mm. In 55 Pyong type, Increment of construction cost rate appeared by $2.4\%$ in case of increase from slab 150mm to 180mm, and $8.9\%$ in case of increase from slab 150mm to 210mm.

• Earthquakes and Structures
• /
• v.14 no.3
• /
• pp.241-248
• /
• 2018

To study the mechanical properties of joints in ancient timber buildings in depth, the force mechanism of the through-tenon joints was analyzed, also the theoretical formulas of the moment-rotation angles of the joints with different loosening degrees were deduced. To validate the rationality of the theoretical calculation formulas, six joint models with 1/3.2 scale ratio, including one intact joint and five loosening joints, were fabricated and tested under cyclic loading. The specimens underwent the elastic stage, the plastic stage and the destructive stage, respectively. At the same time, the moment-rotation backbone curves of the tenon joints with different looseness were obtained, and the theoretical calculation results were validated when compared with the experimental results. The results show that the rotational moment and the initial rotational stiffness of the tenon joints increase gradually with the increase of the friction coefficient. The increase of the tenon section height can effectively improve the bearing capacity of the through-tenon joints. As the friction coefficient of the wood and the insertion length of the tension increase, the embedment length goes up, whereas it decreases with the increase of section height. With the increase of the looseness, the bearing capacity of the joint is reduced gradually.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.27 no.7
• /
• pp.948-955
• /
• 2003

Pressure coefficient in rotating discharge hole was measured to gain insight into the influence of rotation to the discharge characteristics of rotating discharge hole. Pressure measurements were done by the telemetry system that had been developed by the authors. The telemetry system measures static pressure using piezoresistive pressure sensors. Pressure coefficients in rotating discharge hole were measured in longitudinal direction and circumferential direction with various rotating speed and 3 pressure ratios. From the results, the pressure coefficient, and therefore the discharge coefficient, is known to decrease with the increase of Ro number owing to the increase of flow approaching angle to the discharge hole inlet. However, there exists critical Ro number where the decrease rate of discharge coefficient with the increase of Ro number changes abruptly; flow separation occurs from the discharge hole exit at this critical Ro number. Critical Ro number increases with the increase of length-to-diameter ratio, but the increase is small where the length-to-diameter ratio is higher than 3. The decrease rate of discharge coefficient with the increase of Ro number depends on the pressure recovery at the discharge hole, and the rate is different from each length-to-diameter ratio; it has tendency that the short discharge hole shows higher decrease rate of discharge coefficient.

• Journal of the Korean Society of Tobacco Science
• /
• v.27 no.2
• /
• pp.201-206
• /
• 2005

In this work, we studied the effects of the moisture contents of cut tobacco on loose end of cigarettes. The loose end of the cigarette groups decreased with the increase of moisture contents of the cut tobacco and especially the loose end of A and C groups decreased to $31\%\;and\;52\%$ with the increase of $1\%$ moisture contents. $A-13.5\%\;and\;B-14.0\%\;and\; C-14.0\%$ moisture samples showed the increase of the weight ratio of cut tobacco over 1.4mm cut length but the decrease under 1.4mm cut length. We concluded that the main reasons were regarded to reduction of small fragment tobaccos caused by increase of moisture contents and exception of air-suction transport of tobaccos to cigarette making machine. In spite of the moisture increase of cut tobaccos under fixed EPD(encapsulated pressure drop), the hardness of Band C sample groups were maintained constantly except A group. This result means that under fixed EPD, the weight of cut tobacco in cigarette rods increases to compensate the reduction of pressure drop by moisture increase of cut tobaccos.