• Genomics & Informatics
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• 제19권2호
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• pp.14.1-14.6
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• 2021

Coronavirus disease 2019 (COVID-19) is an on-going pandemic disease infecting millions of people across the globe. Recent reports of reduction in antibody levels and the re-emergence of the disease in recovered patients necessitated the understanding of the pandemic at the core level. The cases of multiple organ failures emphasized the consideration of different organ systems while managing the disease. The present study employed RNA sequencing data to determine the disease associated differentially regulated genes and their related protein interactions in several organ systems. It signified the importance of early diagnosis and treatment of the disease. A map of protein interactions of multiple organ systems was built and uncovered CAV1 and CTNNB1 as the top degree nodes. A core interactions sub-network was analyzed to identify different modules of functional significance. AR, CTNNB1, CAV1, and PIK3R1 proteins were unfolded as bridging nodes interconnecting different modules for the information flow across several pathways. The present study also highlighted some of the druggable targets to analyze in drug re-purposing strategies against the COVID-19 pandemic. Therefore, the protein interactions map and the modular interactions of the differentially regulated genes in the multiple organ systems would incline the scientists and researchers to investigate in novel therapeutics for the COVID-19 pandemic expeditiously.

• 로봇학회논문지
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• 제17권4호
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• pp.438-446
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• 2022

In this paper, we propose an intelligent three-legged landing system that can maintain stability and level even on rough terrain than conventional four-legged landing systems. Conventional landing gear has the limitation that it requires flat terrain for landing. The 3-leg landing system proposed in this paper extends the usable range of the legs and reduces the weight, allowing the quadcopter to operate in various environments. To do this, kinematics determine the joint angles and coordinates of the legs of the two-link structure. Based on the angle value of the quadcopter detected via the IMU sensor, the leg control method that corrects the posture is determined. A force sensor attached to the end of the leg is used to detect contact with the ground. At the moment of contact with the ground, landing control starts according to the value of the IMU sensor. The proposed system verifies its reliability in various environments through an indoor landing test stand. Finally, in an outdoor environment, the quadcopter lands on a 20 degree incline and 20 cm rough terrain after flight. This demonstrates the stability and effectiveness of the 3-leg landing system even on rough terrain compared to the 4-leg landing system.

• 한국환경복원기술학회지
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• 제7권3호
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• pp.78-85
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• 2004

The non-planned development of the rural area surrounding the Metropolitan area has become a social problem. The land development program until now has an aspect of not combining the spacial plan and the environmental plan. The land use and city development system based on development should change into a form that combines developing the area and conserving the environment. Therefore, this research attempts to compare the results of the overlay analysis and the gravity matrix which are ways to evaluate the value land that has a high environmental conservation value. The research area is the town of Seonggeo-eup, Cheonan City, and the reason for selecting this area is because it is expected to be densely populated as a connected area to the Metropolitan and the development pressure, such as expanding the industrial area, is high due to convenient transportation. The environmental factors used in the research are the relative altitude, incline, age-class, natural degree of the ecology, classification of the land covering and the NDVI, and the research methods used are the overlay analysis of the GIS and the statistical method. The overlay analysis results showed level 1 13.2%, level 2 30.7%, level 3 47.4%, level 4 1.0%, level 5 2.4%, level 6 5.4% and so on. The gravity matrix was classified as level 1 27.0%, level 2 9.3%, level 3 58.2%, level 4 2.4%, level 5 2.3%, level 6 0.9% and so on. These results are more appropriate than current methods for plans that value the environment because the analyzed results of the gravity matrix have a tendency to highly condense the environmentally valuable area. Consequently, if the spacial and environmental plans combine and therefore expand the efficient use of the land in the current state where the nation's concern in environment is getting higher, it is thought that it will contribute highly on the development of the nation's life quality.

• Steel and Composite Structures
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• 제11권5호
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• pp.423-434
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• 2011

Tongwamen Bridge is a critical link between Dongmen Island and the land in Shipu town, Zhejiang province, China. It is a 238 m span, half-through, concrete-filled steel tubular (CFST) X-type arch bridge. The width of the deck is only 10 m, yielding a width-to-span ratio of 1/23.8. The plane truss type section rib was adopted, which made of two CFST chords and web member system. The lateral stability is the key issue to this bridge. However, the existing researches on Tongwamen Bridge's lateral stability are all the deterministic structural analysis. In this paper, a new strategy for positioning sampling points of the response surface method (RSM), based on the composite method combining RSM with geometric method for structural reliability analysis, is employed to obtain the reliability index of lateral stability. In addition the correlated parameters were discussed in detail to find the major factors. According to the analysis results, increasing the stiff of lateral braces between the arch ribs and setting the proper inward-incline degree of the arch rib can enhance obviously the reliability of lateral stability. Moreover, the deck action of non-orienting force is less than the two factors above. The calculated results indicate that the arch ribs are safe enough to keep excellent stability, and it provides the foundation that the plane truss rib would be a competitive solution for a long-span, narrow, CFST arch bridge.

• 한국잠사곤충학회지
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• 제51권2호
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• pp.123-129
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• 2013

The purpose of this study is to investigate the effects of supplementation of mulberry powder, mulberry extract and silkworm powder during the 8 weeks of resistance exercise on muscle increase of rats. Fifty males, Sprague-Dawley rat, were randomly divided into 5 groups: CON(control group, n = 10), REG(resistance exercise group, n = 10), MP REG(mulberry powder intake and resistance exercise group, n = 10), ME REG(mulberry extract intake and resistance exercise group, n = 10) and SP REG(silkworm powder intake and resistance exercise group, n = 10). After climbing the ladder without weights during the 1 week of adaptation period, the rats in the resistance exercise group were trained to climb a 0.98-m vertical(80 degree incline) ladder with weights in their tail during 7 weeks(10 times each day, 2 days per week). After exercise, the skeletal muscle was extracted from the flexor hallucis longus. The absolute weight of skeletal muscle was measured by the electronic balance and the relative weight of skeletal muscle about the weight was calculated. The strength and density of legs muscle were analyzed by the computed tomography scan. After 8 weeks of resistance exercise, the absolute weight of skeletal muscle wasn't significant, but it increased in MP REG 8%, ME REG 8% and SP REG 10% compared to REG. The relative weight of skeletal muscle increased significantly in SP REG compared to REG (p < 0.05). Additionally, there was a significant increase of density and strength of the forelegs in SP REG compared to CON (p < 0.05). However, there was no significant increase of density and strength of the hind legs. In conclusion, regular resistance exercise made rats muscle increase and there was more muscle increase effected by providing silkworm.

• 한국치위생학회지
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• 제9권2호
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• pp.45-56
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• 2009

The purposes of this study were to investigate the relationships between the degree of physical pain and the knowledge and preventive actions of musculoskeletal diseases among dental hygiene students with a potential risk of contracting those diseases and thus to help them prevent them. A survey was taken among 207 sophomores and juniors specializing in dental hygiene at S1 and S2, Gyeonggi Province in the area of physical pain, knowledge of musculoskeletal diseases, and preventive actions against them. The findings were as follows: 1. The mean scores of the sophomore in the knowledge of musculoskeletal diseases were $6.20{\pm}2.21$, and those of the juniors were $6.72{\pm}2.29$. The mean scores of the sophomores and juniors in the preventive actions against musculoskeletal diseases were $22.50{\pm}2.37$ and $22.29{\pm}3.01$, respectively. 2. The subjects displayed severe physical pain in the lower back, shoulder, and neck in the descending order and medium physical pain in the neck, shoulder, and lower back in the descending order. 3. The higher level knowledge of musculoskeletal diseases they had, the less physical pain they felt. And there were significant differences among the shoulder, lower back, hip, ankle, and foot. 4. There were relationships between physical pain and the preventive actions against musculoskeletal diseases in "placing the hands at the height of the elbows during treatment", "reducing such positions as bending and extending during treatment", "narrowing the distance with the patient", "taking regular breaks during treatment for recovery", "trying not to incline the neck, back, arm, and wrist as much as possible", and "trying to keep the torso in the neutral position." 5. As for the education about musculoskeletal diseases, 74 sophomores(88.10%) and 102 juniors(89.74%) answered they received no such education. The results suggest that there should be some instructions to help dental hygiene students practice the preventive actions against musculoskeletal diseases and further prevention programs against those diseases.

• 생명과학회지
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• 제23권1호
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• pp.116-124
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• 2013

본 연구의 목적은 저항성 운동 후 골격근에서 저항성 관련 유전자를 규명하는 것이다. 연구 목적을 달성하기 위하여 총 32두의 Sprague-Dawley계 수컷 흰쥐를 분양 받은 후 4주차 통제군(4 wks CON, n=8), 8주차 통제군(8 wks CON, n=8), 4주차 운동군(4 wks REG, n=8), 8주차 운동군(8 wks REG, n=8)으로 집단을 분류하였다. 저항성 운동군은 꼬리에 무게를 달고 동물용 사다리(1-m vertical, 85 degree incline)를 오르는 저항성 사다리 운동을 1회 10번, 주당 3일, 4주와 8주간 점증적으로 실시하였으며, 골격근 조직은 저항성 운동 후 장무지굴근(flexor hallucis longus; FHL)을 적출하여 분석에 이용하였다. 적출한 골격근에서 total RNA를 분류한 후, 대규모 유전자 발현분석을 위하여 Illumina RatRef-12 Expression BeadChip을 이용한 Beadarray를 시행하였으며, Beadarray 결과를 확인하기 위해 qPCR (real-time quantitative PCR)를 실시하였다. 유의성 검증은 Beadstudio software를 이용하여 실시하였으며, Beadarray 데이터 중 Detection p-value to <0.01, M-value {M= $log_2$ (condition)-$log_2$ (reference)} to >1.0, DiffScore to >20인 유전자만을 통계적으로 의미 있는 유전자로 선택하였다. 4주차 저항성 운동 후 통제집단에 비해 2배 이상 유의하게 발현이 증가한 유전자는 30개였으며, 6개의 유전자가 감소하였다. 8주차 저항성 운동 후에는 5개의 유전자가 발현이 증가하였으며, 12개의 유전자가 유의하게 감소하였다. 연구결과 다음의 유전자를 포함한 저항성 운동과 근비대와 관련 후보 유전자를 도출하였다; 1) 세포 성장 조절(IGFBP1, PLA2G2A, OKL38); 2) 근육발생(CSRP3); 3) 조직 재생과 근육 발달(MUSTN1, MYBPH); and 4) 비대 모델(CYR61, ATF3, NR4A3); and 5) 당대사(G6PC, PCK1). 이러한 연구결과는 차후 저항성 운동과 관련된 다양한 생리학적 변인을 연구하는데 있어서 기초 자료를 제공할 것으로 생각된다.

• 콘크리트학회논문집
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• 제24권2호
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• pp.147-156
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• 2012

최근 몇 년간 보-기둥 접합부에 영향을 줄 수 있는 경사기둥을 포함한 비정형 구조 시스템을 가진 초고층 빌딩이 증가하고 있다. 경사기둥-보 접합부에 외력이 작용 시 전단과 휨 모멘트의 분포가 정형화된 보-기둥 접합부와 상이하여 접합부의 파괴모드, 전단강도, 연성능력 및 에너지소산능력이 변화할 가능성이 크다. 이 연구에서는 6개의 철근콘크리트 경사기둥-보 접합부($90^{\circ}$, $67.5^{\circ}$, $45^{\circ}$) 실험을 수행하고 결과를 분석하였다. 실험 결과에 의하면 경사기둥-보 접합부에서 비대칭 파괴가 발생하였으며 수직기둥-보 접합부에 비해서 최대하중과 에너지소산능력이 감소하는 것으로 나타났다. 이것은 경사기둥으로 인해 발생되는 접합부의 상이한 모멘트 분포와 압축력만 받는 수직기둥과 다르게 경사기둥이 압축력뿐 아니라 인장력도 작용하기 때문이다.

• 한국잠사곤충학회지
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• 제51권2호
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• pp.99-106
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• 2013

본 연구는 8주간의 사다리를 이용한 점진적 저항성 운동과 더불어 오디분말, 오디추출물, 누에분말의 섭취가 흰쥐의 골격근에서 androgen receptor(AR) mRNA와 myogenic regulatory factors(MRFs)의 발현에 효과가 있는지 확인하고자 하였다. 6주령의 Rat 50두를 분양받아 일주일간 순화기간을 거친 후 군간 체중을 고르게 분리하고 시료 투여 및 저항성 운동 여부에 따라 대조군, 운동군, 오디분말 운동군, 오디추출물 운동군, 누에분말 운동군으로 설정하였다. 시료 투여집단은 고형사료에 각각의 시료가 배합된 사료를 자유롭게 섭취하도록 하였다. 저항성 운동 방법은 1주일간 주당 3일, 1일 5회씩 부하 없이 맨몸 사다리 운동을 거친 후 7주간 주당 2일, 1일 10회씩 점진적인 과부하 하에서 실시하였다. 8주간 저항성 운동이 끝난 후 오른쪽 뒷다리에서 장무지굴근을 적출한 후 RNA 추출 및 cDNA를 합성하여 $-20^{\circ}C$에 보관 후 실험에 사용하였다. AR mRNA와 MRFs를 특이적으로 검출하도록 디자인된 시발체와 탐색자를 구입하여 housekeeping 유전자인 18s rRNA와 함께 Real Time PCR을 이용하여 증폭하였다. 18s rRNA를 이용하여 흰쥐의 장무지굴근에서 AR mRNA와 MRFs를 $2^{-{\Delta}{\Delta}Ct}$법을 통해 상대정량하여 골격근 내 발현 정도를 배수변화로 비교하였다. 실험 결과 사다리 운동과 시료 섭취는 흰쥐 골격근에서 AR mRNA의 발현을 유의하게 증가시키는 것으로 나타났다. 대조군과 비교하여 모든 저항성 운동 집단에서 통계적으로 유의한 차이를 보였으며 운동군에서 $4.04{\pm}1.12$, 오디분말 운동군에서 $5.23{\pm}0.56$, 오디추출물 운동군에서 $6.24{\pm}1.85$, 누에분말 운동군에서 $9.68{\pm}0.82$배를 나타내었다. 운동군과 비교하여 오디추출물 운동군과 누에분말 운동군에서 유의한 차이를 나타냈으며 오디분말 운동군의 경우 운동군과 비교하여 유의한 차이를 나타내지 않았지만 대조군과 비교하여 유의한 차이를 나타내었다. MyoD mRNA의 경우 대조군과 비교하여 운동군에서 $2.19{\pm}0.27$, 오디분말 운동군에서 $6.04{\pm}0.48$, 오디추출물 운동군에서 $4.32{\pm}1.59$, 누에분말 운동군에서 $8.11{\pm}0.57$배를 나타내었다. 운동군과 비교하여 모든 시료 섭취 집단에서 유의한 차이를 나타내었다. Myogenin mRNA의 경우 대조군과 비교하여 운동군에서 $2.70{\pm}0.57$, 오디분말 운동군에서 $4.11{\pm}0.42$, 오디추출물 운동군에서 $4.13{\pm}0.45$, 누에분말 운동군에서 $6.50{\pm}0.61$배를 나타내었다. 대조군과 비교하여 모든 저항성 운동군에서 유의한 차이를 나타냈으며 운동군과 비교하여 모든 시료 섭취 집단에서 유의한 차이를 나타내었다. 본 실험을 통해 오디와 누에의 섭취는 저항성 운동에 따른 수컷 흰쥐의 골격근에서 근육 관련 유전자인 AR mRNA와 MRFs의 발현에 긍정적인 영향을 미치며 추후 근육 증가를 목적으로 한 운동보조제 개발을 위한 기초 자료가 될 수 있을 것으로 판단된다.