• BMB Reports
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• v.36 no.6
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• pp.533-537
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• 2003

The nonsyndromic cleft lip and palate (NSCL/P) is a congenital deformity of multifactorial origin with a relatively high incidence in the oriental population. Various etiologic candidate genes have been reported with conflicting results, according to race and analysis methods. Recently, the ablation of the TGF-${\beta}3$ gene function induced cleft palates in experimental animals. Also, polymorphisms in the TGF-${\beta}3$ gene have been studied in different races; however, they have not been studied in Koreans. A novel A $\rightarrow$ G single nucleotide polymorphism (defined by the endonuclease SfaN1) was identified in intron 5 of TGF-${\beta}3$ (IVS5+104 A > G). It resulted in different genotypes, AA, AG, and GG. The objective of this study was to investigate the relationship between the SfaN1 polymorphism in TGF-${\beta}3$ and the risk of NSCL/P in the Korean population. The population of this study consisted of 28 NSCL/P patients and 41 healthy controls. The distribution of the SfaN1 genotypes was different between the cases and controls. The frequency of the G allele was significantly associated with the increased risk of NSCL/P [odds ratio (OR) = 15.92, 95% confidence interval (CI) = 6.3-41.0]. The risk for the disease increased as the G allele numbers increased (GA genotype: OR = 2.11, 95% CI = 0.38-11.68; GG genotype: OR = 110.2, 95% CI = 10.67 - 2783.29) in NSCL/P. A stratified study in patients revealed that the SfaN1 site IVS5+104A > G substitution was strongly associated with an increased risk of NSCL/P in males (p < 0.001), but not in females. In conclusion, the polymorphism of the SfaN1 site in TGF-${\beta}3$ was significantly different between the NSCL/P patients and the control. This may be a good screening marker for NSCL/P patients among Koreans.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.2
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• pp.280-287
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• 2001

These studies aimed to determine how lighting might be used to improve feed intake and reduce aggressive behavior in newly weaned pigs. To examine whether this objective could be achieved an experiment was conducted to compare performance, behavior and body condition of weaners over 17-45 days, provided similar lighting quality (i.e. color temperature, color rendering index and lighting distribution) after weaning that piglets experienced prior to weaning. Triphosphor (TP) lighting to simulate daylight was provided during the day while at night, Pascal red (PR) lighting was provided to simulate the night-light piglets previously had received from infrared heating lamps. This treatment was compared to weaners provided conventional cool-white fluorescent light during the day only. Weaners on treatment lighting from 17-45 days of age showed no improvement in body weight or feed conversion at 24, 31, 38 and 45 days compared to the controls. There was, however, a significant improvement (p<0.05) in feed intake in the first week of weaning for weaners provided TP/PR lighting. Over the first 3 days of weaning, pigs on TP/PR lighting showed an increase (p<0.05) in the incidence of ear chewing but reduced (p<0.05) levels of nosing the abdomen of other pigs and reduced (p<0.05) occurrences of being stood on by other pigs. Females exhibited more (p<0.05) mounting and nosing behaviors and rubbing the heads of other pigs than males. On the other hand, males engaged in more (p<0.05) fighting, nipping, ear chewing and standing on other pigs compared to females. Pigs provided PR lighting on the first night of weaning engaged in higher (p<0.05) incidences of nosing and tail sucking behaviors, more (p<0.05) head thrusting, fighting and ear chewing compared to control pigs. The body condition of weaners provided the TP/PR lighting treatment was significantly poorer (p<0.05) compared to weaners on control lighting. In conclusion there was no improvement in production performance of weaners provided new technology lighting apart from the improvement in feed intake in the first week weaners were exposed to the TP/PR lighting.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3527-3531
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• 2015

Background: Serbia is one of the countries with highest incidence and mortality rates for cervical cancer in Central and South Eastern Europe. Introducing a risk index could provide a powerful means for targeting groups at high likelihood of having an abnormal cervical smear and increase efficiency of screening. The aim of the present study was to create and assess validity ofa index for prediction of an abnormal Pap test result. Materials and Methods: The study population was drawn from patients attending Departments for Women's Health in two primary health care centers in Serbia. Out of 525 respondents 350 were randomly selected and data obtained from them were used as the index creation dataset. Data obtained from the remaining 175 were used as an index validation data set. Results: Age at first intercourse under 18, more than 4 sexual partners, history of STD and multiparity were attributed statistical weights 16, 15, 14 and 13, respectively. The distribution of index scores in index-creation data set showed that most respondents had a score 0 (54.9%). In the index-creation dataset mean index score was 10.3 (SD-13.8), and in the validation dataset the mean was 9.1 (SD=13.2). Conclusions: The advantage of such scoring system is that it is simple, consisting of only four elements, so it could be applied to identify women with high risk for cervical cancer that would be referred for further examination.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3307-3312
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• 2015

The papillary patterned lesion of thyroid may be challenging with many diagnostic pitfalls. Tumor stroma plays an important part in the determination of the tumor phenotype. CD34 is thought to be involved in the modulation of cell adhesion and signal transduction as CD34(+) fibrocytes are potent antigen-presenting cells. Smooth muscle actin (SMA) positivity could be diagnostic for fibroblast activation during tumorigenesis. We aimed to examine the expression of CD34 and alphaSMA in the stroma of papillary thyroid hyperplasia, papillary thyroid carcinoma and papillary tumors of uncertain malignant potential in order to elucidate their possible differential distribution and roles. A total number of 54 cases with papillary thyroid lesions were studied by routine H&E staining, CD34 and ASMA immunostaining. ASMA was not expressed in benign papillary hyperplastic lesions while it was expressed in papillary carcinoma, indicating that tumors have modulated stroma. Although the stroma was not well developed in papillary lesions with equivocal features of uncertain potentiality, CD34 was notable in such cases with higher incidence in malignant cases. So ASMA as well as CD34 could predict neoplastic behavior, pointing to the importance of the stromal role. Differences between groups suggest that the presence of CD34 + stromal cells is an early event in carcinogensis and is associated with neoplasia, however ASMA+ cells are more likely to be associated with malignant behavior and metastatic potential adding additional tools to the light microscopic picture helping in diagnosis of problematic cases with H&E.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1767-1770
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• 2012

Background: The Asia Pacific consensus for colorectal cancer (CRC) recommends that screening programs should begin by the age of 50. However, there have been reports about increasing incidence of CRC at a younger age (i.e. early-onset CRC). Little is known about the features of early-onset CRC in the Vietnamese population. Aim: To describe the clinical, endoscopic and pathological characteristics of early-onset CRC in Vietnamese. Method: A prospective, cross-sectional study was conducted at the University Medical Center from March 2009 to March 2011. All patients with definite pathological diagnosis of CRC were recruited. The early-onset CRC group were analyzed in comparison with the late-onset (i.e. ${\geq}$ 50-year-old) CRC group. Results: The rate of early-onset CRC was 28% (112/400) with a male-to-female ratio of 1.3. Some 22.3% (25/112) of the patients only experienced abdominal pain and/or change in bowel habit without alarming symptoms, 42.9% (48/112) considering their symptoms intermittent. The rate of familial history of CRC in early-onset group was significantly higher that of the late-onset group (21.4% versus 7.6%, p<0.001). The distribution of CRC lesions in rectum, distal and proximal colon were 51.8% (58/112), 26.8% (30/112) and 21.4% (24/112), respectively; which was not different from that in the late-onset group (${\chi}2$, p = 0.29). The rates for poorly differentiated tumors were also not significantly different between the two groups: 12.4% (14/112) versus 8.3% (24/288) (${\chi}2$, p = 0.25). Conclusion: A high proportion of CRC in Viet Nam appear at an earlier age than that recommended for screening by the Asia Pacific consensus. Family history was a risk factor of early-onset CRC. Diagnosis of early-onset CRC needs more attention because of the lack of alarming symptoms and their intermittent patterns as described by the patients.

• Clinical and Experimental Pediatrics
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• v.56 no.11
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• pp.477-481
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• 2013

Purpose: Ureaplasma colonization is related with perinatal complications in preterm infants. Little is known about the difference in virulence among various Ureaplasma urealyticum serovars. The aim of this study was to determine U. urealyticum serovars of preterm infants in order to assess whether any of the serovars were associated with bronchopulmonary dysplasia (BPD). Methods: Three hundred forty-four preterm infants with a gestational age less than 34 weeks admitted to Gangnam Severance Hospital neonatal intensive care unit from July 2011 to December 2012 were included in this study. Tracheal and gastric aspirations were conducted on infants to confirm Ureaplasma colonization. Ureaplasma colonization was confirmed in 9% of infants, of these, serovars were determined by real-time polymerase chain reaction. Results: A total of 31 infants (gestational age, $29.3{\pm}3.1$ weeks; birth weight, $1,170{\pm}790g$) were U. urealyticum positive. The Ureaplasma positive group treated for more days with oxygen and ventilation than the negative group (P<0.05). Histologic chorioamnionitis and moderate to severe BPD were more frequent in the Ureaplasma positive group than in the negative group (P<0.05). U. urealyticum isolates were either found to be a mixture of multiple serovars (32%), serovar 9 alone or combined with other serovars (39%), serovar 11 (26%), 2 (13%), 8 (10%), 10 (13%), and 13 (25%). No individual serovars were significantly associated with moderate to severe BPD and chorioamnionitis. Conclusion: This is the first study to describe the distribution of U. urealyticum serovars from Korean preterm infants. Ureaplasma -colonized infants showed higher incidence of BPD and chorioamnionitis.

• The Journal of Pediatrics of Korean Medicine
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• v.13 no.2
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• pp.125-137
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• 1999

The common cold is the most common pediatric infectious disease, and the incidence is higher in early childhood than in any other period of life. Treatment of the common cold is largely symptomatic. Thus treatment of oriental medicine for the common cold is very effective and safe. We studied 81 children suffering from common cold Oriental Medicine Hospital in Kyunghee University, and analyzed age, sex, season, clinical manifestation, complications, prescription. The results were as follows: 1. Age and sex distribution of children from 1 to 3 was 37.1%, 3 to 6 was 34.6%, over 6 was 24.7%, male to female ratio was 1.31 : 1 2. Frequency of affection per year, from 3 to 5 was 30.9%, 6 to 9 was 29.6%, over 10 was 27.2%, below 3 was 4.9% 3. Frequency of seasons giving rising to common cold, winter was 40.7%, spring and autumn were 16%, summer was 1.2%. 4. Frequency of complications, empyema and rhinitis were 38.3%, asthma was 21%, pneumonia was 16%, atopic dermatitis was 7.4%. 5. Frequency of Clinical manifestation, cough and sputum were 45.7%, high fever and sore throat were 27.2%, complex symptom was 25.9%. 6. Frequency of prescription, BoAh-Tang-gami(補兒湯加味)was 27.2% BangPungHaeDoc-Tang(防風解毒湯)was 11.1 %, GamiGinHae-Tang (加味鎭咳湯)was 11.1%.

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.439-448
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• 2009

Three inducers were designed to avoid cavitation instabilities. This was accomplished by avoiding the interaction of tip cavity with the leading edge of the next blade. The first one was designed with extremely larger leading edge sweep, the second and third ones were designed with smaller incidence angle by reducing the inlet blade angle or increasing the design flow rate, respectively. The inducer with larger design flow rate has larger outlet blade angle to obtain sufficient pressure rise. The inducer with larger sweep could suppress the cavitation instabilities in higher flow rates more than 95% of design flow coefficient, owing to weaker tip leakage vortex cavity with stronger disturbance by backflow vortices. The inducer with larger outlet blade angle could avoid the cavitation instabilities at higher flow rates, owing to the extension of the tip cavity along the suction surface of the blade. The inducer with smaller inlet blade angle could avoid the cavitation instabilities at higher flow rates, owing to the occurrence of the cavity first in the blade passage and its extension upstream. The cavity shape and suction performance were reasonably simulated by three dimensional CFD computations under the steady cavitating condition, except for the backflow vortex cavity. The difference in the growth of cavity for each inducer is explained from the difference of the pressure distribution on the suction side of the blades.

• The Plant Pathology Journal
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• v.34 no.4
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• pp.308-315
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• 2018

Root-knot nematodes 'Meloidogyne spp' are the most destructive group of plant parasitic nematodes causeing serious losses in vegetables crops and this damages worsened when crops grown under greenhouses conditions. In this sutdy, the distribution and characterization of root-knot nematode species collected from the Souss region of Morocco where vegetables crops intensively cultivated were determined by using both morphological and molecular tools. Out of the 110 samples collected from different greenhouses 91 (81.7%) were found to be infested with root-knot nematodes. Thirty-seven populations of root-knot nematodes were morphologically identified based on perineal patterns as well as molecularlly using species-specific primers. The obtained results indicated that Meloidogyne javanica and M. incognita were identified in 86.4% and 13.5% of the total populations, respectively. The lowest incidence of root-knot nematodes (64%) was found in Toussous, whereas the highest frequencies of 100% and 90% were detected in Taddart and Biogra, respectively. As the majority of the samples have been infested with Meloidogyne species; this indicates that there is an urgent need to provide farmers with a proper control strategy.

• Archives of Plastic Surgery
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• v.36 no.4
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• pp.458-461
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• 2009

Purpose: Preaxial polydactyly is the most common congenital anomaly of upper extremities. In this study, we classified 112 patients of preaxial polydactyly for investigation of recent incidences of each types. Methods: We reviewed 120 cases of preaxial polydactyly diagnosed at university hospitals of Incheon and Bucheon from 2000 to 2008. All cases were grouped using simple radiographs and all cases were classified according to the Upton modified Iowa system. Results: Among the 120 cases of preaxial polydactyly, there were 7 cases(6%) of type I, 35 cases(29%) of type II, 1 case(1%) of type III, 48 cases(40%) of type IV, 12 cases(10%) of type V, 5 cases(4%) of type VI, 12 cases(10%) of type VII polydactyly. All cases of type VII polydactyly were triphalangism. Conclusion: Comparing with Wassel's study and Upton's study, our study showed similar distribution of each types of preaxial polydactyly.