• Title/Summary/Keyword: In-line Valve

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Consecutive automated production of carbon-11 labeled radiopharmaceuticals by sharing 11C-methylation reagent from one 11C-synthetic module

  • Park, Hyun Sik;Lee, Hong Jin;An, Hyun Ho;Moon, Byung Seok;Lee, Byung Chul;Kim, Sang Eun
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.2 no.2
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    • pp.123-131
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    • 2016
  • Increasing clinical demand for carbon-11 labeled radiopharmaceuticals has triggered technological advances in fields of radiochemistry and automated modules. Even though carbon-11 has a short half-life ($t_{1/2}=20.4min$), the consecutive second production of carbon-11 labeled radiopharmaceutical in one $^{11}C$-synthetic module should be delayed at least over 4 h to avoid the high radiation exposure. We herein aimed to produce two different carbon-11 labeled radiopharmaceuticals ([$^{11}C$]PIB and [$^{11}C$]methionine) by sharing of [$^{11}C$]methylation source in one $^{11}C$-synthetic module. The synthesis of $^{11}C$-labeling reagents ($[^{11}C]CH_3I$ or $[^{11}C]CH_3OTf$) is fully automated using the commercial TRACERlab $FX_{C-pro}$ module and is readily adaptable to $^{11}C$-labeling reactor for [$^{11}C$]PIB as well as another $^{11}C$-labeling apparatus for [$^{11}C$]methionine via the three-way valve. After completing the [$^{11}C$]PIB production, the re-synthesized $[^{11}C]CH_3I$ was passed through the three-way valve connected the polyetheretherketone (PEEK) line and loaded into the C18 Sep-Pak cartridge including the methionine precursor. The labeled product [^${11}C$]methionine was purified by a simple cartridge separation and reformulated into saline. The radiochemical yield of [$^{11}C$]PIB and [$^{11}C$]methionine were $5.3{\pm}0.6%$ and $18.7{\pm}0.8%$ (n.d.c.), respectively, with over 97% of radiochemical purity. The specific activity of [$^{11}C$]PIB was over $110GBq/{\mu}mol$. Total production time of two radiopharmaceuticals needs about 2 h from $1^{st}$ beam irradiation including quality control tests. Final [$^{11}C$]PIB and [$^{11}C$]methionine were satisfied all quality control test standards.

Operational Characteristics of the High-speed Interrupter for Reliability Enhancement of Power Supply and Demand (전력수급의 신뢰도 확보를 위한 고속 인터럽터 동작 특성)

  • Choi, Hye-Won;Choi, Hyo-Sang;Jung, Byung-Ik
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.62 no.1
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    • pp.143-148
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    • 2013
  • When the fault occurs in power system, the fault-current exceeds breaking capacity of the circuit breaker. So, reliablity of the power system is decreased sharply. Superconducting fault-current limiter (SFCL) is operated without impedance in normal state. The fault-current is limited by its impedance during the fault condition. However, the SFCL has several weak points such as huge size, high-price, liquid-nitrogen operation for the real power system. In this paper, We suggested the high-speed interrupter to limit the fault-current in case of the single line-to-ground fault. In addition, we compared the high-speed interrupter with the SFCL to ensure the operation reliability. The proposed interrupter detected the fault-current through the CT, and the power was supplied by operation of the SCR control system. In this experiment, the power of high-speed interrupter was applied after the 4.8[msec] from fault instant. The on-off operation of the interrupter was started after half-cycle from the fault. The fault-current was flowed into the impedance element by the switching operation of the high-speed interrupter. So, the fault current was limited within one cycle, and then it didnt exceed the capacity of a circuit breaker. We confirmed that there was slight difference between the SFCL with high-speed interrupter in terms of limiting-time of the fault-current and switching speed of the SCR. The high-speed interrupter was considered to be more efficient than the SFCL in size, cost or reliability.

Fuel Spiking Test for the Surge Margin Measurement in a Gas Turbine Engine (연료 돌출 시험에 의한 가스터빈엔진의 서지마진 측정)

  • Lee, Jin-Kun;Lee, Kyung-Jae;Ha, Man-Ho;Kim, Chun-Taek;Yang, Soo-Seok;Lee, Dae-Sung
    • Journal of the Korean Society of Propulsion Engineers
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    • v.8 no.2
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    • pp.18-24
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    • 2004
  • A fuel spiking test was performed to measure the surge margin of the compressor in a gas turbine engine. During the test, fuel spiking signal is superposed on the engine controller demand signals and the combined signals are used to control a fuel control valve. For the superposition, a subsystem composed of a fuel controller and a function generator is used. The real engine test was performed at the Altitude Engine Test Facility (AETF) in Korea Aerospace Research Institute (KARI). In the preliminary test, the fuel spiking signals are in good agreement with the dynamic pressure at the fuel line and at the compressor discharge point. After the preliminary test, a fuel spiking test to measure the surge point at a specific engine speed was performed. The test results show that the fuel spiking test is very effective in the measurement of surge.

Numerical Analysis for Evaluation of Ejection Capacity Relationship of Safety Valves in Pressure Regulating Station(I) - Flow Analysis and Mass Flow Rate Verification of Pressure Regulator - (정압기지내의 안전밸브 분출용량 관계식 검증을 위한 유동해석(I) - 정압기 유동 해석 및 질량 유량 검증 -)

  • Gwon, Hyuk-Rok;Roh, Kyung-Chul;Kim, Young-Seop;Lee, Seong-Hyuk
    • Journal of the Korean Institute of Gas
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    • v.12 no.2
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    • pp.99-104
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    • 2008
  • Gas pressure regulators in pressure regulating station reduce high-pressure gas in a process line to a lower. Gas pressure regulators are not flow control devices, they are used to control delivery pressure only. For the safety of pressure regulating station, it is essential to study flow regime and characteristics of a safety valves that is connected to a pressure regulator. For this, it is necessary to understand flow characteristics and the flow rate of upstream component part such as gas pressure regulators in regulating station. In the present study, numerical analysis of flow characteristics and the mass flow rate of a pressure regulator is conducted under the several inlet, outlet conditions and open rates. Then, the numerical result of the mass flow rate is verified with experimental equation from manufacture of pressure regulator. Consequently, the numerical result is comparatively good agreement with values from experimental equation.

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Development of an Active Tire Pressure Control System Using a Tire Simulator (타이어 시뮬레이터를 이용한 능동형 타이어 공기압 제어 시스템 개발)

  • Lee, Kyu-Cheol;Ryu, Kwan-Hee;Rhee, Joong-Yong;Hong, Ji-Hyang;Kim, Hyeok-Joo;Yu, Ji-Hoon
    • Journal of Biosystems Engineering
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    • v.35 no.1
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    • pp.21-30
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    • 2010
  • This study was performed to develop an active tire pressure control system that can adjust tire pressure to the optimum level according to traveling and working condition of agricultural tractor. For the development of active tire pressure control system, pneumatic supplier, solenoid valve block including pneumatic supply line, infinite rotation type pneumatic supplier with rotary joint unit, tire pressure transceiver module and control algorithm were developed. Also, tire simulator was developed. Using this tire simulator, the feasibility of each part constructing actual system was tested by checking the performance. The average communication success ratio was 98.3% between tire pressure transmitter and receiver module according to the various tire rotational speed and data receipt position of receiver module. The communication performance of the developed transmitter and receiver module was very stable in any condition. The tire pressure control system was accomplished by using the proportional control algorithm in this study. Also tire pressure control performance of developed control system was analyzed by using the tire simulator. As a result of control performance analysis to the developed system, the developed control system took 307 seconds to inflate agricultural tractor's tire from 50 kPa to 180 kPa. In opposite case, it took 210 seconds. Also it was able to control the tire pressure accurately under ${\pm}0.9%$ (FS) in any condition.

Development of the HPM System to Improve Efficiency of the Hydraulic Excavator (유압식 굴삭기 효율 향상을 위한 HPM 시스템 개발)

  • Kwon, Yong Cheol;Lee, Kyung Sub;Kim, Sung Hun;Koo, Byoung Kook
    • Journal of Drive and Control
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    • v.16 no.4
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    • pp.1-8
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    • 2019
  • The HPM (High-speed Power Matching) system is an electro-hydraulic control system. It directly controls the swash plate of the pump by selecting four-loop logic based on joystick signals, pump flow, and pressure signal to improve the efficiency and controllability of construction machines. In the NFC (Negative Flow Control) system, a typical pump control system using conventional open center type MCV, the loss is continuously generated by flow through the center bypass line even when the excavator is not in operation. Also, due to the slow response of the pump that indirectly controls the flow rate using the pressure regulator, peak pressure occurs at the start or stop of the operation. Conversely, the HPM system uses an MCV without center-by-pass flow path and the swash plate of a pump for the HPM is controlled by a high-speed proportional flow control valve. As a result, the HPM system minimizes energy loss in standby state of the excavator and enables peak pressure control through rapid electro-hydraulic control of a pump. In this paper, the concept of the HPM system algorithm is introduced and the hydraulic system efficiency is compared with the NFC system using the excavator SAT (System Analysis Tool).

Characterization Tests on the SIT Injection Capability of the ATLAS for an APR1400 Simulation (APR1400 모의를 위한 ATLAS 안전주입탱크의 주입 성능에 관한 특성 시험)

  • Park, Hyun-Sik;Choi, Nam-Hyun;Park, Choon-Kyung;Kim, Yeon-Sik
    • Journal of Energy Engineering
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    • v.17 no.2
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    • pp.67-76
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    • 2008
  • A thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation), has been constructed at KAERI (Korea Atomic Energy Research Institute). Recently several integral effect tests for the reflood period of a LBLOCA (Large Break LOss of Coolant Accident) of the APR1400 have been performed with the ATLAS. In the APR1400 a high flow condition is changed to a low flow condition due to an fluidic device during an operation of the SIT. As the self-controlled fluidic device was not installed in the ATLAS, a set of characterization tests was performed to simulate its injection capability from the SIT for the APR1400 simulation. In the ATLAS the required SIT flow rate in the high flow condition was acquired by installing orifices with an optimized flow area to throttle the SIT discharge line and the low flow condition was achieved by changing the opening of the flow control valve in the SIT injection line. The test results showed that the safety injection systems of the ATLAS could simulate the required high and low flow rates of the SIT for the APR1400 simulation efficiently.

Successful Ultrasound-Guided Gastrografin Enema for Very Low Birth Weight Infants with Meconium-Related Ileus

  • Shin, Jaeho;Jeon, Ga Won
    • Neonatal Medicine
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    • v.25 no.1
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    • pp.37-43
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    • 2018
  • Purpose: Meconium-related ileus is common in preterm infants. Without proper management, it can cause necrotizing enterocolitis and perforation requiring emergent operation. This study was conducted to describe the efficacy and safety of ultrasound-guided Gastrografin enema at bedside for preterm infants with meconium-related ileus. Methods: Between March 2013 and December 2014, this study enrolled preterm infants with birth weight <1,500 g, who were diagnosed with meconium-related ileus requiring ultrasound-guided Gastrografin enema refractory to glycerin or warm saline enemas. Gastrografin was infused until it passed the ileocecal valve with ultrasound guidance at bedside. Results: A total of 13 preterm infants were enrolled. Gestational age and birth weight were 28.6 weeks (range, 23.9-34.3 weeks) and 893 g (range, 610-1,440 g), respectively. Gastrografin enema was performed around postnatal day 8 (range, day 3-11). The success rate was 84.6% (11 of 13 cases). Three of these 11 infants received a second procedure, which was successful. Among 2 unsuccessful cases, one failed to pass meconium while the other required surgery due to perforation. The time required to pass meconium was $2.8{\pm}1.5hours$ (range, 1-6 hours). The time until radiographic improvement was $2.8{\pm}3.4days$ (range, 1-14 days) after the procedure. Conclusion: Ultrasound-guided Gastrografin enema at bedside as a first-line treatment to relieve meconium-related ileus was effective and safe for very low birth weight infants. We could avoid unnecessary emergent operation in preterm infants who have high postoperative morbidity and mortality. This could also avoid transporting small preterm infants to fluoroscopy suite.

Performance Characteristics of Flooded Type Evaporator for Seawater Cooling System with Heat Source Temperature of Mid-year (중간기 열원수 온도에 따른 만액식 해수냉각시스템의 성능 특성)

  • Yoon, Jung-In;Son, Chang-Hyo;Lee, Jeong-Mok;Kang, In-Ho
    • Journal of Power System Engineering
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    • v.21 no.2
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    • pp.64-69
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    • 2017
  • The purpose of this study is to investigate the performance characteristics of seawater cooling system for a fishing vessel. The circulation amount of refrigerant, condensation capacity, evaporation capacity, compression work and coefficient of performance(COP) were analyzed as the heat source temperature changed. The experimental setup consisted of an open-type compressor, a shell&tube type condenser, an evaporator and an expansion valve. The heat source was controlled by a constant temperature chamber. The main results of this study are summarized as follows. The condensation capacity increased with increasing heat source temperature, and it was confirmed that the effect of circulating amount of refrigerant was dominant. The amount of heat for vaporization was almost constant even though the temperature of the heat source increased. On the other hand, the compression power was increased. This is because the compression ratio increases as the condensation pressure, the enthalpy difference between inlet and outlet, the amount of circulating refrigerant increases. The performance coefficient of this system showed a tendency decreasing with increasing heat source temperature. Therefore, the basic data of the seawater cooling system for the maintenance of the catch line of the shore fishing boats was acquired through this study, and it is considered that it will be sufficient for the actual design.

Simulation Study for the Performance Improvement of the Injector Module for Heavy-duty CNG Engines (대형 CNG 엔진용 인젝터 모듈의 성능 개선을 위한 연구)

  • Kim, Yong-Rae;Park, Won-A;Kim, Chang-Gi;Lee, Jang-Hee
    • Journal of the Korean Institute of Gas
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    • v.20 no.4
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    • pp.1-6
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    • 2016
  • A fuel supply system of heavy-duty CNG engine is composed as a module structure which is integrated by about 6 injectors. There are only one input and output passage for gas fuel supply in this injector module. The response performance for transient operation of an CNG engine is very poor because only one output fuel supply line is connected to the intake pipe after a throttle valve. In this study, a new guideline and internal flow design for the CNG injector module is suggested for the improvement of response performance by fluid dynamic simulations. As a result, the response performance of gas fuel supply can be improved by decreasing the total volume of internal flow passages and a same distance design from each injector to the exit of module shows good response performance and acquirement of linearity of fuel supply. But the injection order has little influence to injection performances.