• 한국식품영양과학회지
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• 제36권2호
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• pp.186-193
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• 2007

The prevalence of diabetes has increased to 8% of population. Unlike type 2 diabetes in the western countries, Korean diabetic patients are nonobese and have low serum insulin levels. As the increased prevalence of diabetes and the peculiar characteristics may be related to dietary fat contents, we determined their effects on insulin resistance, insulin secretion and pancreatic $\beta-cell$ mass in 90% pancreatectomized (Px) diabetic rats in the present study. The rats were provided with low fat diet (LF, 10 energy% fat), moderate fat diet (MF, 25 energy% fat) and high fat diet (HF, 40 energy% fat) for 6 months. HF increased body weight and epidydimal fat pads parallel with increased food intake compared to LF and MF. Fasting serum glucose and insulin levels and homeostasis model assessment of insulin resistance were higher in HF, compared to LF and MF, indicating that HF increased insulin resistance. Rats fed LF and MF diets reduced insulin resistance, but only rats fed MF improved pancreatic $\beta-cell$ mass and insulin secretion capacity, measured by hyperglycemic clamp and in situ pancreatic perfusion. LF had low insulin secretion capacity and pancreatic $\beta-cell$ mass, indicating the increased possibility of diabetic prevalence and progression. MF increased $\beta-cell$ mass by stimulating $\beta-cell$ proliferation and neogenesis and reducing $\beta-cell$ apoptosis. In conclusion, MF is effective for the prevention of prevalence and progression of diabetes.

• 대한세포병리학회지
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• 제14권2호
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• pp.43-52
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• 2003

The incidence of cervical cancer has been gradually decreased since 1990, now it ranks the fourth most common carcinoma among Korean women in 2001. If squamous cell carcinomas in situ are included, the cervical cancer is still the most frequent tumor in Korean women. However, cervical cancer mortality in Korea has been decreased over the last 10 years in large part attributable to the introduction of the Papanicolaou test (Pap. test). The guidelines for the early detection of cervical cancer recommend women aged 30 and more to lake biennial screening with Pap. lest. According to the screening data of National Health Insurance Corporation (NHIC), 4,425 women (0.94%) showed an abnormal Pap among 473,395 cases tested in 2001; dysplasia was in 3,953 (0.84%) women, in situ carcinoma in 357 (0.075%) women, and invasive carcinoma in 115 (0.024%) women. The detection rates of abnormal Pap. were 4.21% in Korean Society for Cytopathology(KSC-2001), 1.37% (ASCUS : 0.26%, AGUS : 0.03%, LSIL : 0.45%, HSIL : 0.55%, Carcinoma 0.09%) in health check-up and 5.41% (ASCUS : 1.89%, AGUS . : 0.69%, LSIL : 1.39%, HSIL : 0.84%, Carcinoma : 0.64%) of patients in out-patient clinic without having history of cervical neoplasia at Hanyang University Hospital in 2002 Low rate of cervical cancer screening (34%) in Korea is mainly due to the lack of information for the Row income people regarding national cancer screening program. More adenuate budget by government and more man-power for precise screening, new guideline and system for management of the cervical cancer patients are required.

• Ocean and Polar Research
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• 제42권2호
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• pp.97-113
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• 2020

In-situ observations were carried out in April 2015 to investigate the occurrence of water temperature inversion in a region west of Jeju Island. Analysis of in-situ in the western part of Jeju island showed that cold water moved to the southeast from the surface to the middle layer and warm water moved from the middle to the lower layer of the northwest direction. The water temperature inversion occurred at 84 stations (63.1%) out of 133 stations. At the boundary of the water temperature inversion layer, it was formed in the middle layer and disappeared. In the strongly appearing, it started from the middle layer to the lower layer. The shape of the water temperature inversion layer was different. As a result of horizontal water temperature slope analysis of the water temperature inversion zone, maximum 0.23℃/km was obtained and the mean was 0.06℃/km. The role of water temperature inversion as an indicator to determine the formation of water front. As a result of the water mass analysis, Jeju Warm Current Water and Tsushima Warm Current Water of high temperature and high salt intruded from the middle to the bottom. In the middle layer occurred as the Yellow Sea Cold Water of low water temperature and low salinity expanded.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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• pp.429-429
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• 2012

To investigate the gettering effect of B-doped n-type monocrystalline silicon wafer, we made the p-n junction by diffusing boron into n-type monocrystalline Si substrate and then oxidized the boron doped n-type monocrystalline silicon wafer by in-situ wet and dry oxidation. After oxidation, the minority carrier lifetime was measured by using microwave photoconductance and the sheet resistance by 4-point probe, respectively. The junction depth was analyzed by Secondary Ion Mass Spectrometry (SIMS). Boron diffusion reduced the metal impurities in the bulk of silicon wafer and increased the minority carrier lifetime. In the case of wet oxidation, the sheet resistance value of ${\sim}46{\Omega}/{\Box}$ was obtained at $900^{\circ}C$, depostion time 50 min, and drive-in time 10 min. Uniformity was ~7% at $925^{\circ}C$, deposition time 30 min, and drive-in time 10 min. Finally, the minority carrier lifetime was shown to be increased from $3.3{\mu}s$ for bare wafer to $21.6{\mu}s$ for $900^{\circ}C$, deposition 40 min, and drive-in 10 min condition. In the case of dry oxidation, for the condition of 50 min deposition, 10 min drive-in, and O2 flow of 2000 SCCM, the minority carrier lifetime of 16.3us, the sheet resistance of ${\sim}48{\Omega}/{\Box}$, and uniformity of 2% were measured.

• JSTS:Journal of Semiconductor Technology and Science
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• 제13권4호
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• pp.395-401
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• 2013

In-situ optical emission spectroscopy (OES) is employed for leak detection in plasma etching system. A misprocessing is reported for significantly reduced silicon etch rate with chlorine gas, and OES is used as a supplementary sensor to analyze the gas phase species that reside in the process chamber. Potential cause of misprocessing reaches to chamber O-ring wear out, MFC leaks, and/or leak at gas delivery line, and experiments are performed to funnel down the potential of the cause. While monitoring the plasma chemistry of the process chamber using OES, the emission trace for nitrogen species is observed at the chlorine gas supply. No trace of nitrogen species is found in other than chlorine gas supply, and we found that the amount of chlorine gas is slightly fluctuating. We successfully found the root cause of the reported misprocessing which may jeopardize the quality of thin film processing. Based on a quantitative analysis of the amount of nitrogen observed in the chamber, we conclude that the source of the leak is the fitting of the chlorine mass flow controller with the amount of around 2-5 sccm.

• Journal of Chest Surgery
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• 제23권4호
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• pp.825-830
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• 1990

Esophageal cancer is relatively uncommon except in isolated endemic areas, but it generally devastating to the patient. Usually, by the time the disease becomes clinically evident, it is incurable. The aim of treatment is then relegated to attempting to palliate the symptoms in the best possible manner with the least morbidity and mortality. Squamous cell carcinoma in by far the commonest type of malignancy involving the body of the esophagus, accounting for more than 95 percent of all esophageal malignancies. Because the tumor’s microscopic spread is much greater than its macroscopic extent, it is necessary to resect a sufficiently long segment of the esophagus. And second tumors may occur either in the esophagus as a manifestation of a field change or in other organs. Recently we had experienced a case with in situ carcinoma away from the invasive squamous cell carcinoma of the esophagus. A 58 year-old male was admitted with the chief complaint of swallowing difficulty for a month prior to admission. While we studied the esophagogram and chest CT, we found that the mass was protruded to the lumen of esophagus at the level of the 7th-9th thoracic vertebral columns. We performed esophagectomy with lymph node dissection and esophagogastrostomy by thoracic and abdominal approaches. The pathologic result showed separation of another in situ carcinoma away from the invasive squamous cell carcinoma of esophagus at the level of esophagogastric junctions. Postoperative course was uneventful. Now he is taking the postoperative irradiation at out patient department.

• Nuclear Engineering and Technology
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• 제43권6호
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• pp.573-582
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• 2011

The in-cabinet response spectrum is used to define the input motion in the seismic qualification of instruments and devices mounted inside an electrical cabinet. This paper presents a procedure for generating the in-cabinet response spectrum for electrical equipment based on in-situ testing by an impact hammer. The proposed procedure includes an algorithm to build the relationship between the impact forces and the measured acceleration responses of cabinet structures by estimating the state-space model. This model is used to predict seismic responses to the equivalent earthquake forces. Three types of structural model are analyzed for numerical verification of the proposed method. A comparison of predicted and simulated response spectra shows good convergence, demonstrating the potential of the proposed method to predict the response spectra for real cabinet structures using vibration tests. The presented procedure eliminates the uncertainty associated with constructing an analytical model of the electrical cabinet, which has complex mass distribution and stiffness.

• 한국양식학회지
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• 제18권3호
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• pp.207-214
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• 2005

We report on the diagnosis, pathology, and taxonomy of Perkinsus sp. infection in Manila clams (Ruditapes philippinarum) from Korean waters. Amplimers were designed from internal portions of the non-transcribed spacer (NTS) of P. atlanticus for molecular diagnosis of Perkinsus infection. PCR-based identification methods and an in situ hybridization assay were developed for detection of Perkinsus sp. in live tissues as well as in histological preparations. Hybridization signals were observed around the nucleus of trophozoites. Positive results from PCR and in situ hybridization indicated that Korean Perkinsus sp. is genetically identical with P. atlanticus reported in Europe, which is currently synonymous with P. olseni reported from Australia. Microscopic morphological features of different lift stages of Perkinsus sp. appeared very similar to those of P. atlanticus. Severely infected clams often exhibited white nodules on their mantles and gills as a consequence of inflammation. In lightly to moderately infected clams, Perkinsus sp. was mainly found in gill tissues, whereas the protozoan parasites were found in digestive tracts, gonadal tissues, and foot tissues of heavily infected clams. It is likely that the gills are the portal of the infection and that P. olseni spreads to other tissues as the infection advances. In conclusion, by considering the taxonomic priority of P. olseni, Korean Perkinsus sp. is accepted as P. olseni. P. olseni appears to be common on tidal flats on the western and southern Korean coasts and is considered to be a pathogen capable of causing mass mortality of clams.

• 터널과지하공간
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• 제18권2호
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• pp.134-148
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• 2008

암반의 초기응력 상태는 방사성 폐기물 지층 처분장의 적합성을 판단하는데 중요한 요소이다. 본 연구에서는 3차원 개별요소법을 이용하여 스웨덴 방사성 폐기물 처분장 후보지 중 하나인 오스카샴 지역에서 대규모 변형대가 초기응력에 미치는 영향을 살펴보았다. 수치해석에서는 부지조사 과정에서 확인된 변형대를 모델에 포함시켰으며 원거리 지각응력을 경계조건으로 사용하였다. 현지 암반에서 관찰되는 초기응력값의 변화 양상이 수치해석에서도 재현이 됨으로써 수치해석이 암반의 초기응력상태를 이해하는데 유용하게 쓰일 수 있음을 확인하였다. 수치해석을 통한 예측값과 초기응력 측정값과의 차이는 측정된 자료의 양호한 정도, 지질모델 및 변형대의 물성치의 불확실성 등에 기인하는 것으로 생각된다.

• 한국지반공학회지:지반
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• 제13권4호
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• pp.109-120
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• 1997

공용하중 상태에서 지반이 경험하는 변형률 크기는 0.1~1% 미만임이 밝혀지고 있다. 변형특성을 보다 엄밀히 평가하기 위하여는 미소변형률 영역에서의 신뢰성 있는 변형측정이 가능한 현장시험기기의 개발이 필요하다. 본 연구의 목적은 공내째하시험기(PMT)를 사용하여 지반의 미소변형률 전단탄성계수를 측정하는 것이다. 공내재하시험에서 시추공 설치에 따른 주위 지반의 교란효과를 제거하기 위하여 초기 하중재하단계가 아닌 역재하-재재하 단계에서 PMT 주위지 반의 응력상태 및 변형률 크기를 고려하여 미소변형률 잔단탄성계수를 결정하였다. 실내 토조에서 성형한 모래시료와 화강풍화토 현장지반에서 시험을 수행하였으며,시험결과로부터 본 연구 에서 사용한 PMT시험은 변형률 크기 10-2%~0.5% 범위에서 신뢰성 있는 전단탄성계수 측정이 가능하였다. 또한 변형률 크기를 고려하여 다른 실내외시험에서 결정된 전단탄성계수와 비교 하면 서로 잘일치하는 결과를 얻을 수 있었다.