• Journal of Chest Surgery
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• v.35 no.7
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• pp.548-552
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• 2002

Korean artificial heart(AnyHeart) is a single-pieced and implantable hi-ventricular pulsaile pump adapting a moving actuator mechanism. The authors report a case of clinical application of AnyHeart as a life-saving device for the patients with end-stage heart disease combined with biventricular failure.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.5
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• pp.858-865
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• 2008

In this paper, Capacitive Telemetry RF Sensor System using Recursive Least Square (RLS) algorithm was proposed. General Telemetry RF Sensor System means that it should be "wireless", "implantable" and "batterless". Conventional Telemetry RF Sensor System adopts Integrated Circuit type, but there are many defects like complexity of structure and the limitation of large power consumption in some cases. In order to overcome these disadvantages, Telemetry RF Sensor System based on inductive coupling principle was proposed in this paper. Proposed Telemetry RF Sensor System is very simple because it consists of R, L and C and measures the changes of environment like pressure and humidity in the type of capacitive value. This system adopted RLS algorithm for estimation of this capacitive parameter. For the purpose of applying RLS algorithm, proposed system was mathematically modelled with phasor method and was quasi-linearized. As two parameters such as phase and amplitude of output voltage for estimation were needed, Phase Difference Detector and Amplitude Detector were proposed respectively which were implemented using TMS320C2812 made by Texas Instrument. Finally, It is verified that the capacitance of proposed telemetry RF Sensor System using RLS algorithm can be estimated efficiently under noisy environment.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.126-130
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• 1997

In the development of the totally implantable artificial heart (TAH), the information of the preload condition is important to ind appropriate condition or the automatic control of the heart. Our TAH configuration consists of two artificial ventricles, and brushless DC motor within actuator. The pressure between ventricles could indicate the preload condition during the TAH operation. If we can measure accurately inspite of the noise induced from TAH and environmental condition. We suggested integrating a feedback loop to remove an unexpected DC drift. NPI 19-series Nova sensor was used which could measure pressure in gas and liquid. This method and sensor enabled us to develop the pressure transducer compact so (that) the systems can be implanted with TAH into patient. This system has been verified in vitro and in vivo test. This results showed that the output waveform of this system was stable irrespective of animal condition.

• Proceedings of the KOSOMBE Conference
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• v.1992 no.11
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• pp.117-122
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• 1992

In systems in which inductive coupling between a pancake-shaped coil on the surface of the body and a similar coil within the body is utilized for the transfort of electromagnetic energy, the minimization of temperature rise in the tissue is intimately related to the achievement of minimum losses in the region of the implanted coil. The new class of amplifiers, named "class E", for inverter is defined and is illustrated by a detailed description and a set of desist equations for one simple member of the class. For TET circuit the authors measured 65 to 76 percent efficiency at 1985kHz at 30 to 50 W output from IRF250 MOSFET transistor.

• Journal of Biomedical Engineering Research
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• v.16 no.4
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• pp.447-456
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• 1995

As a part of electro-mechanical totally implantable artificial heart (TIAH) program, a transcut- aneous energy transmission system has been developed. By mutual magnetic induction between the first coil on the skin and the subcutaneously implanted second coil, the system transfers elctrical power through the skin. This research aimed at minimizing the size of the implanted part as well as maximizing the transfer efficiency. Using class I amplifier, we achieved above 75% power transfer efficiency at average 40W power transfer level which is required for normal TIAH operation. In vivo performance of the developed system and bio-compatibility of the material used in Implanted parts were evaluated through animal experiments.

• The Korean Journal of Pain
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• v.25 no.1
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• pp.47-51
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• 2012

Intrathecal drug administration system (ITDAS) can reduce the side effects while increasing the effectiveness of opioids compared to systemic opioid administration. Therefore, the use of ITDAS has increased in the management of cancer pain and chronic intractable pain. Catheter obstruction is a serious complication of ITDAS. Here, we present a case of catheter obstruction by a mass formed at the side hole and in the lumen. A 37-year-old man suffering from failed back surgery syndrome received an ITDAS implantation, and the ITDAS was refilled with morphine every 3 months. When the patient visited the hospital 18 months after ITDAS implantation for a refill, the amount of delivered morphine sulfate was much less than expected. Movement of the pump rotor was examined with fluoroscopy; however, it was normal. CSF aspiration through the catheter access port was impossible. When the intrathecal catheter was removed, we observed that the side hole and lumen of the catheter was plugged.

• Journal of Biomedical Engineering Research
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• v.17 no.3
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• pp.297-304
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• 1996

Although collagen is still considered to be a poor immunogen, animals can produce antibodies to a number of different sites in the collagen molecule. In type I collagen, three classes of antigenic determinants have been described those are recogrlized as different degrees in different species. These are essentially composed of helical, conformation-dependent antigenic determinants and terminal, nonhelical antigenic determinants, and finally central antigenic determinants exposed only after denaturation of the collagen molecule. To utilize collagen as implantable biomateriall human e61bryonic collagen, ten immunological to body, was purified from human umbilical cords and found to contain [$\alpha$1(I)]$_2$. [$\alpha$2(I). Each step of purification were observed by polarized light microscope and analyzed through SDS-PAGE. The conclusious are follows; 1 . The purified collagen revealed gradual fiber indenties on each step of purification by polarized microscope. 2. The structual changes of extracted collagen as removed telopeptide were confirmed by SDS-PAGE.

• Proceedings of the KOSOMBE Conference
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• v.1993 no.05
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• pp.129-131
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• 1993

A transcutaneoos information transmission system using transmitted infrared light for an implantable total artificial heart(TAH) an developed and the performance of the system was tested. In an in vitro test, transmittance of the developed system was measured through various thicknesses of pig shins. In an in vivo test, a loopback test using a personal computer was performed to determine the error rate and an experiment using a mock system was taken. In this experiment, within acceptable lateral and vertical displacements, the error rate of at least 3.8E-6 was guaranteed. Monitoring signals from the internal controller(Intel 87C196) of the mock system were successfully transmitted to the external controller(IBM PC) and the operating commands from the external controller were successfully conducted by the mock system. Communication was done in half duplex mode according to RS-232 protocol at the speed of 4800 bps.

• Journal of Biomedical Engineering Research
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• v.30 no.3
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• pp.199-204
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• 2009

Iridium oxide films (IROFs) have been extensively studied as a material for electrical stimulation of neurons, as iridium oxide has higher charge storage capacity than other metal films. More recently, sputtered iridium oxide film (SIROF) has been studied, because it can be made more conveniently than activated iridium oxide film (AIROF). Typically, the SIROFs are grown at temperatures from 400 to 600 $^{\circ}C$. However, such high temperatures cannot be used when the iridium oxide (IrOx) film is to be deposited on a flexible polymer material, such as polyimide. In this paper, we show that we can still obtain excellent characteristics in SIROFs grown without heating (cold SIROF), by optimizing the growth conditions. We show that the oxygen flow rate is a critical parameter for controlling the surface properties of a cold SIROF. At an oxygen flow rate of 12 seem, the cold SIROF exhibited a charge storage capacity (CSC) of 60 mC/cm$^2$, which is comparable to or better than other published values for iridium oxide films including heated SIROFs. The film produced under these conditions also had the minimum impedance value of all cold SIROFs deposited for this study. A stability test and biocompatibility test also demonstrated the superiority of the optimized cold SIROF.

• Journal of Biomedical Engineering Research
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• v.34 no.1
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• pp.34-39
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• 2013

For the biocompatibility test of implantable devices or for the sensitivity evaluation of biomedical sensors, it is required to understand the mechanism of the protein adsorption and the interaction between the adsorbed proteins and cells. In this study, the adsorption of proteins in a cell culture medium with fetal bovine serum onto an indium tin-oxide electrode was characterized by using linear sweep voltammetry and impedance spectroscopy. We immersed the fabricated ITO electrodes in the culture medium for 30, 60, or 90 min, and then measured the electrochemical properties of electrodes with 10 mM $Fe(CN){_6}^{3-/4-}$ and 0.1 M KCl electrolyte. With an increase of contacting time, the anodic peak current was decreased and the charge transfer resistance was increased. However, both parameters were recovered to the values before contact with the medium after the treatment of Trypsin/Ethylenediaminetetraacetic acid hydrolyzing proteins.