• Journal of Preventive Medicine and Public Health
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• 제29권2호
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• pp.199-214
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• 1996

노인들의 인지기능과 우울에 관련이 있는 요인을 알아보기 위해 대전시 및 대전시의 인근지역의 노인들 729명을 대상으로 MMSE 및 GDS를 이용한 면접조사를 실시하고 자료를 분석한 결과는 다음과 같다. 1. 조사대상군의 인지기능은 정상이 56.8%, 치매가 의심되는 경도장애가 24.1%, 치매가 거의 확실 한 중증의 장애가 19.1%로 나타났으며, 인지기능에 장애가 심할수록 우울의 정도가 증가하였다. 2. 연령이 증가함에 따라 인지기능은 감소하였으며, 남자보다는 여자에서 인지기능 및 우울증상의 정도가 높게 나타났다. 3. 연령의 효과를 보정한 후 인지기능 장애여부에 관련이 있는 요인은 성, 배우자 유무, 교육정도, 과거직업, 도구적 일상생활능력, 규칙적 운동, 외출빈도와 신체적 증상 중 흉부통중, 시력 및 청력장애, 어지러움증이었다. 4. 연령효과를 보정한 후에 유의한 관련성이 있는 변수를 이용한 회귀모형에서 도구적 일상생활 능력, 연령, 시력장애, 성, 집밖 외출의 요인이 통계적 유의성을 보였다. 5. 단계적 회귀분석을 통해 우울점수에 유의한 관련성을 보인 변수는 교육수준, 집밖 외출과 직업 활동 및 집안일의 참여, 규칙적 운동, 도구적 일상생활능력, 주관적으로 평가한 본인의 건강과 영양상태, 신체적 증상으로 어지러움증, 시력장애 및 흥부통증이었다. 이상의 결과를 볼 때 조사대상 노인들에 있어서 인지 기능과 우울에 관련성이 높은 주된 특성은 신체적 활동 능력과 주관적으로 평가된 건강상태라고 볼 수 있다.

• 치위생과학회지
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• 제19권4호
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• pp.245-253
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• 2019

Background: This study aimed to analyze correlations between depression, cognitive function, oral health state, ability to perform activities of daily living, oral dryness symptoms, and oral health-related quality of life, and determine factors influencing the latter. Methods: This was a cross-sectional study based on questionnaires completed by 260 participants with suspected dementia, residing in South Korea. Psychiatrists, psychiatric nurses, and dental hygienists visited clinics in the participating regions for examination and questionnaire administration. General characteristics, the geriatric depression scale, ability to perform activities of daily living, cognitive function, oral health state, and oral health-related quality of life were analyzed. Independent t-tests, one-way analysis of variance (ANOVA), correlation analysis and multiple regression analysis were conducted, identifying factors affecting oral health-related quality of life. Data analysis was performed using SPSS ver. 20.0 (IBM Corp., USA), and the significance was set at p<0.05. Results: Approximately 65.0% of participants were female, 63.5% were in their 70s, and 90.0% had health insurance. About 21.5%, 42.0%, and 36.5% were normal, slightly impaired, and had dementia, respectively. High cognitive impairment was associated with poor oral health. Sex, education levels, marital status, and living arrangements influenced oral health-related quality of life. According to the regression analysis, geriatric depression and oral dryness affected the Geriatric Oral Health Assessment Index scores. Conclusion: In conclusion, oral dryness and depression levels among elders influenced oral health-related quality of life. The results showed that to enhance elders' oral health-related quality of life, it is essential to not only improve their oral health state, but also relieve oral health problems, especially oral dryness, and take into consideration their psychological aspects.

• Toxicological Research
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• 제17권
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• pp.47-57
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• 2001

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and its pathology is characterized by the presence of numerous numbers of senile plaques and neurofibrillary tangles. Several genetic and transgenic studies have indicated that excess amount of $\beta$-amyloid protein (A$\beta$) is produced by mutations of $\beta$TEX>$\beta$-amyloid precursor protein and causes learning impairment. Moreover, $A\beta$ has a toxic effect on cultured nerve cells. To prepare AD model animals, we have examined continuous (2 weeks) infusion of $A\beta$ into the cerebral ventricle of rats. Continuous infusion of $A\beta$ induces learning impairment in water maze and passive avoidance tasks, and decreases choline acetyltransferase activity in the frontal cortex and hippocampus. Immunohistochemical analysis revealed diffuse depositions of $A\beta$ in the cerebral cortex and hippocampus around the ventricle. Furthermore, the nicotine-evoked release of acetylcholine and dopamine in the frontal cortex/hippocampus and striatum, respectively, is decreased in the $A\beta$-infused group. Perfusion of nicotine (50 $\mu\textrm{M}$) reduced the amplitude of electrically evoked population spikes in the CA1 pyramidal cells of the control group, but not in those of the $A\beta$-infused group, suggesting the impairment of nicotinic signaling in the $A\beta$-infused group. In fact, Kd, but not Bmax, values for ［$^3H$］ cytisine binding in the hippocampus significantly increased in the $A\beta$-infused rats. suggesting the decrease in affinity of nicotinic acetylcholine receptors. Long-term potentiation (LTP) induced by tetanic stimulations in CA1 pyramidal cells, which is thought to be an essential mechanism underlying learning and memory, was readily observed in the control group, whereas it was impaired in the $A\beta$-infused group. Taken together, these results suggest that $A\beta$ infusion impairs the signal transduction mechanisms via nicotinic acetylcholine receptors. This dysfunction may be responsible, at least in part, for the impairment of LTP induction and may lead to learning and memory impairment. We also found the reduction of glutathione- and Mn-superoxide dismutase-like immunoreactivity in the brains of $A\beta$-infused rats. Administration of antioxidants or nootropics alleviated learning and memory impairment induced by $A\beta$ infusion. We believe that investigation of currently available transgenic and non-transgenic animal models for AD will help to clarify the pathogenic mechanisms and allow assessment of new therapeutic strategies.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권5호
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• pp.386-395
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• 2011

Introduction: Osteoporosis is a major health problem in the elderly that involves changes in the properties of bone as well as impaired bone healing around a titanium implant in both humans and animals. This study examined effect of low intensity pulsed ultrasound (LIPUS) on the bone healing process around a titanium implant in osteoporosis-induced rats. Materials and Methods: Sixteen rats were divided into two groups. A control group with osteoporosis induced by removing both ovaries and an experimental group of rats that were applied with LIPUS after osteoporosis had been induced. A screw type titanium implant (diameter, 2.0 mm: length, 3.5 mm, Cowell-Medi, KOREA) was placed into the tibias of 16 rats. The control and experimental group contained 8 rats each. The rats were sacrificed at 1, 2, 4, and 8 weeks after implantation to examine the histopathology and immunochemistry. Results: The histopathology examination revealed earlier new bone formation in the experimental group than the control group. In particular, at 1 week after implantation, more new bone matrix and collagen were observed around the implant of the experimental group compared to the control group. Immunochemistry analysis showed that the level of OPG expression of the experimental group was higher in the early stages than in the control group. After 8 weeks, the levels of OPG expression were similar in both groups. The expression level of receptor activator of nuclear factor kB ligand (RANKL) was stronger in the experimental group than the control group. After 4 weeks, the level of RANKL expression was similar in both groups. Conclusion: These results suggest that the application of LIPUS to implantation can promote bone healing around titanium in osteoporosis animals.

• 대한임상검사과학회지
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• 제51권3호
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• pp.351-359
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• 2019

신경인지검사는 외래에서 전반적인 인지기능 정도를 평가하는 MMSE (Mini-Mental State Examination)가 가장 보편적이지만, 최근에는 SNSB II (Seoul Neuropsychological Screening Battery II)를 통해 심층적으로 진단에 활용된다. 2017년부터 2018년까지 경기도 남부지역 일개 의료원에 내원한 보건소에서 정밀검사 의뢰된 노인층 120명의 통상적인 신경인지검사 결과와 혈액검사 항목을 후향적으로 조사하였다. GDS의 하위 영역의 평가에서는 시공간 능력이 높게 나타났다. 그리고 혈액 전해질 중 Na이 GDS 수준이 증가함에 따라 통계적으로 유의한 감소를 보였다. 또한 GDS 수준에 따른 집중력, 언어 시공간능력, 기억력, 전두엽 실행 기능이 통계적으로 유의한 감소를 보였다(P<0.001). ALT와 크레아티닌이 정상군과 비정상군에서 전두엽 실행 기능 영역이 통계적으로 유의한 차이를 보였다(P<0.001). 또한 GDS와 ALT는 음의 상관성을 보였다(P<0.01). 결론적으로 본 연구를 통해 선별 및 진단에 유의한 검사 항목을 개발하는데 기초정보를 제공하고, 통상적인 혈액화학검사가 인지장애 환자의 진단 및 진행에 대한 기본 정보를 제공할 것으로 사료된다.