• The Journal of Korean Physical Therapy
• /
• 제20권2호
• /
• pp.19-24
• /
• 2008

Purpose: The purpose of this study was to examine how norepinephrine affects immunity in patients over age 65. Methods: We enrolled 25 male and female subjects age 65 or older. A low frequency electroacupuncture (EA) device was used to stimulate acupoint Hogu (L14). The 2 Hz frequency EA was applied to the acupoint for 20 minutes. Leukocyte subtypes-including neutrophils, lymphocytes, monocytes, eosinophils, and basophil-were then measured. The immunoglobulins IgG and IgM were also quantified. The data were finally analyzed using Wilcoxon singed-rank test and regression test as part of the SPSS WIN v. 10.1 program. Results: As norepinephrine levels decreased after EA stimulation, neutrophil, lymphocyte, and monocyte levels increased, and eosinophil and neutrophils levels decreased. Neutrophil and monocyte levels did not change to a statistically significant degree, but eosinophil levels showed a statistically significant decrease (p<0.05). Immunoglobulin IgG showed a statistically significant increase (p<0.05). Conclusion: This study showed that norepinephrine does affect immunity in persons over the age of 65. This indicates that there is an interaction between the nervous system and the immune system, and interaction that plays a crucial roles in the body's immune resistance and homeostasis.

• Pediatric Infection and Vaccine
• /
• 제2권2호
• /
• pp.194-199
• /
• 1995

Most boys afflicted with panhypogammaglobulinemia, also known as X-linked agammaglobulinemia, remain healthy during the first 6 to 12 months of life because of protection by maternally transmitted IgG antibodies. Thereafter, they repeatedly acquire infections with high-grade pathogens, such as pneumococci, streptococci, and hemophilus unless given antibiotics or immunoglobulin replacement therapy. We experienced a case of panhypogammaglobulinemia in a 4 years old boy. He had been suffered from recurrent upper respiratory tract infection, otitis media and pneumonia since late infancy. He was admitted due to right pleural effusion with pneumonia, and streptococcus pneumoniae was isolated from pleural fluid and blood cultures. His immune status revealed panhypogammaglobulinemia and deficiency in mature B lymphocyte. He was treated with appropriate antibiotics therapy, but showed poor responses. He was transferred to department of thoracic surgery, and received minithoracotomy (decortication) operation. He was successfully treated with operation, antibiotics, and IV gammaglobulin infusions. Now he is being followed with periodic IV gammaglobulin replacement therapy.

• Archives of Plastic Surgery
• /
• 제33권1호
• /
• pp.116-119
• /
• 2006

Management of chronic wound has been a great problem to many surgeons because the wound is usually associated with an underlying disease of the patient. Without accurate diagnosis and treatment of the disease, the wound can not be healed. Systemic vasculitis is a rare systemic disease which causes inflammation and obstruction of the vessels. This autoimmune disease involves multiple organs and may inflict skin wound spontaneously without traumas. It would improve or aggravate the wound in proportion to the activities of the disease. Our experience is a case of 28-year-old female who has had chronic ulcers on her right foot, especially on the great toe for 1 year. Although she had several operations of sympathectomy, debridement and artificial dermal graft, her wound was not improved. She has been diagnosed as systemic vasculitis during the evaluation for histopathology and cause of fever and pancytopenia. After medical treatments, she had the operation of adipofascial turnover flap coverage and skin graft, and the wound was improved without any complication or relapse. The diagnosis and treatment of the underlying disease should be ahead of the management of chronic wound.

• 대한수의학회지
• /
• 제30권4호
• /
• pp.511-513
• /
• 1990

$11{\alpha}$-hydroxyprogesterone hemisuccinate-BSA를 항원으로 하여 항원량을 $50{\mu}g/head$ 및 $100{\mu}g/head$의 2 group(세마리씩)으로 나누어 BALB/c mouse에 면역첩종한 결과 후자에서 항체가의 상송이 확인되었다. 이와 동시에 항원($20{\mu}g$)과 adjuvant의 비율을 1:9로 하여 장기 접종한 결과는 $100{\mu}g$투여시 보다 항체가가 낮았다. 항체가가 확인된 clone의 culture에 의해 progesterone 단일크론 hybridoma를 생산해 이의 supernatant에 대한 분석을 실시한 결과 immunoglobulin class는 IgM이었다. progesterone 이외의 다른 steroids와의 교차반응은 매우 낮았다.

• 대한수의학회지
• /
• 제47권1호
• /
• pp.1-6
• /
• 2007

The importance of milk for the growth and health of a newborn offspring is well known. Milkcontains immunoglobulin G (Ig G), Ig A, lactoperoxidase, lactoferin, cytokines, and growth factors.Osteopontin, one of the multifunctional proteins, is secreted by macrophages, T cel, and epithelial cells.bovine milk have not been clarified. The aim of this study was to observe the expression of osteopontin,in bovine milk during the lactation period or bovine mamary glands..Western blot analysis detected thatosteopontin was expressed in bovine milk whey and mamary glands. The expression level of osteopontinin colostrum whey was higher than those in early milk and mature milk whey. Immunohistochemistryshowed that osteopontin was detected in the glandular epithelium and epithelial cels of intralobular ductof mamary glands. These findings suggest that osteopontin transiently shows high expression in colostrumand plays a potential role in the immunological development of breast-fed calves.

• Pediatric Infection and Vaccine
• /
• 제3권2호
• /
• pp.194-199
• /
• 1996

Cryptococcosis is a rare in normal child and the majority of cases usually occur in patients with defective cell-mediated immunity. Infection is acquired by inhalation of organisms from the environment and disseminated via the blood stream to any organ of the body. We experienced a 7 year old girl who presented with fever, both cervical lymphadenopathy, hepatomegaly under the impression of lymphoma. However lymph node biopsy revealed cryptococcal budding and culture of lymph nodes yielded cryptococcus neoformans. The radiologic finding showed huge, multiple cervical lymph node enlargement spreading to mediastinum and abdomen. The immune fuction in term of T cell, B cell, serum immunoglobulin, complement and neutrophil function tests was normal. The patient was treated with amphotericin B and flucytosine for 6 weeks and responded to the treatment well. We report this case with brief review of the related literatures.

• Pediatric Infection and Vaccine
• /
• 제19권2호
• /
• pp.79-83
• /
• 2012

라이 증후군은 간부전을 동반하며 급속히 진행하는 뇌증으로, 인플루엔자와 수두 바이러스 등에 감염된 어린이에게 발병한다. 아스피린이 주된 원인 인자로 알려진 이후 소아에서 아스피린의 사용을 줄이면서 현재는 매우 드물게 보고 되고 있다. 저자들은 가와사키병 치료를 위해 정맥내 면역글로불린을 투여받고 아스피린을 복용하던 중 보챔, 강직, 활동량 저하, 식욕 저하, 처짐, 구토, 간수치 상승, 혈액 응고 장애와 고암모니아혈증으로 치료받은 5개월 여아를 보고하는 바이다.

• Pediatric Infection and Vaccine
• /
• 제16권2호
• /
• pp.205-209
• /
• 2009

독성 쇼크 증후군은 황색 포도알균 등에서 생성하는 독소에 의한 고열, 발진 및 쇼크에 병발하는 다발성 장기 부전이 발생하는 증후군이다. 저자들은 화상 후 속발한 독성 쇼크 증후군으로 진단한 환아를 vancomycin, 신선 냉동 혈장, 정맥내면역 글로불린 투여로 치료하고, 화상 부위에서 동정된 CAMRSA의 분자 생물학 및 유전적 특징을 분석하여 이를 보고하는 바이다.

• Childhood Kidney Diseases
• /
• 제7권1호
• /
• pp.73-76
• /
• 2003

전형적 HSP 증상이후 혈뇨, 단백뇨를 보여 신조직검사를 받은 생후 21개월 여아에서 전형적인 HSP 신염에서 볼 수 있는 소견과는 다르게 광학현미경에서 사구체 세포간질의 증식 소견이 관찰되었고, 면역형광현미경에서 세포간질과 혈관을 따라 IgG와 C3가 침착되었으나 IgA 침착은 관찰되지 않았다. 전자현미경에서는 전형적인 HSP 신염에서 보이는 세포간질에의 electron dense한 deposits가 관찰되지 않았으며 주로 APSGN에서 볼 수 있는 상피하 electron dense deposits가 관찰되었다. 본 증례처럼 HSP 신염으로 보이는 환아의 신조직검사가 APSGN에서와 유사한 소견을 보이는 경우를 보고하면서 저자들은 HSP의 원인으로 GAS와의 연관성을 제시하는 바이다.

• Natural Product Sciences
• /
• 제12권4호
• /
• pp.232-236
• /
• 2006

In this study, we investigated the effect of Phellinus baumii (PB) on immediate-type allergic reaction and inflammatory cytokine secretion. PB inhibited compound 48/80-induced systemic reactions in mice. PB inhibited compound 48/80-induced plasma histamine release. In addition, PB also inhibited the immunoglobulin (Ig) E-mediated local allergic reaction. Furthermore, PB decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis $factor-\alpha$ and interleukin-6 secretion in human mast cells. These results indicate that PB may be beneficial in the treatment of immediate-type allergic reactions.