• Title/Summary/Keyword: IkB

Search Result 841, Processing Time 0.033 seconds

Effects of Addition Gases(Hydrogen and Nitrogen Gas) of Diamond-like Carbon Films Deposited by RF PECVD) (RF PECVD로 증착된 다이아몬드상 탄소막의 보조가스 첨가의 영향)

  • Choi, Woon;Kim, Hyoung-June;Nam, Seoung-Eui
    • Korean Journal of Materials Research
    • /
    • v.7 no.1
    • /
    • pp.8-14
    • /
    • 1997
  • DLC막은 여러가지 기술적인 응용에 매우 기대된느 재료이다. 탄화수소 가스의 플라즈마 분해에 의해 증착되는 DLC 막은 높은 경도, 화학적 안정성, 높은 전기 저항성, 적외선 영역의 투과성 등의 여러가지 우수한 성질을 지니고 있다. 그러나 이들막은 높은 내부응력으로 인하여 실제 응용에 상당한 제약을 받고 있다. 본 연구에서는 rf PECVD 법에 의해 합성된 다이아몬드상 탄소막을 보조가스 첨가에 따른 영향에 대하여 조사하였다. 수소가스를 첨가하여 합성된 DLC막의 잔류응력 거동은 낮은 이온 에너지 (V$_{b}$ $P^{1}$2/-20Volt/m Torr)에서 최대 잔류응력이 발생되지만, 질소 가스를 첨가시키면 높은 이온(V$_{b}$ P$_{1}$2/->70Volt/m Torr)에너지 영역에서 잔류응력의 감소가 나타났다. 수소 량이 증가하면 ion bombardment와 식각 작용을 하고, 질소의 경우 막의 표면 스퍼터링 현상이 발생되었다. 보조가스 첨가에 따라 S$P^{3}$net work구조의 생성과 소멸의 결합 구조를 형성하여, 보조가스 첨가는 DLC막의 잔류응력 거동에 영향을 미치는 것을 알 수 있었다. 이온 에너지에 따른막의 비저항은 막 합성 공정 조건에 관계없이 $10^{6}$-$10^{7}$ Ωm 의 범위에서 분포하고 있는 것으로 조사되었다. 이는 메탄가스(rf PECVD)로 합성된 DLC막의 비저항과 거의 일치하는 것으로 나타났다.

  • PDF

Expression of Chemokine and Tumor Necrosis Factor Alpha Genes in Murine Peritoneal Macrophages Infected with Orientia tsutsugamushi

  • Koh, Young-Sang
    • Journal of Microbiology
    • /
    • v.39 no.3
    • /
    • pp.186-194
    • /
    • 2001
  • Scrub typhus, caused by Orientia tsutsugamushi infection, is clinically and histopathologically characterized by local as well as systemic inflammatory reactions, indicating that orientiae induce mechanisms that amplify the inflammatory response. To reveal underlying mechanisms of chemoattraction and activation of responding leukocytes, expression of chemokine and tumor necrosis factor alpha (TNF-$\alpha$) genes in murine peritoneal macrophages after infection with the obligate intracellular bacterium Ο.tsutsugamushi was investigated. The genes that were unregulated included macrophage inflammatory proteins l$\alpha$/$\beta$(MIP-l$\alpha$/$\beta$), MIP-2, monocyte chemoattractant protein 1(MCP-1), RANTES (regulated upon activation, normal T-cell expressed and secreted), gamma-interferon-inducible protein 10(IP-10) and TNF-$\alpha$. Peak expression of these chemokines and TNF-$\alpha$ was observed between 1 and 3 h after infection. These responses returned to or approached baseline preinfection levels 6 h after challenge. Semiquantitative reverse transcription (RT)-PCR analysis revealed dramatic Increases during infection in the steady-state levels of mRNA ceding for the inhibitory subunit of NF-kB (IkB$\alpha$), whose transcription is enhanced by binding of NF-kB within the IkB$\alpha$promoter region. Thus, Ο. tsutsugamushi appears to be a stung inducer of chemokines and TNF-$\alpha$ which may significantly contribute to inflammation and tissue damage observed in scrub typhus by attracting and activating phagocytic leukocytes.

  • PDF

Astaxanthin Ameliorates Atopic Dermatitis by Inhibiting the Expression of Signal Molecule NF-kB and Inflammatory Genes in Mice

  • Donghwan, Kim;Yong-Suk, Kim;Ho Sueb, Song
    • Journal of Acupuncture Research
    • /
    • v.39 no.4
    • /
    • pp.304-309
    • /
    • 2022
  • Background: This study was conducted to determine the anti-inflammatory effect of astaxanthin, on atopic dermatitis. Methods: Changes in mouse body weight, lymph node weight, and the degree of improvement in symptoms were measured to determine the inflammatory response. Real-time reverse transcription-polymerase chain reaction tests were performed to determine the degree of expression of inflammation-related cytokines (IL-31 and IL-33 and chemokines such as CCL17 and CCL22), and western blot analysis was performed to evaluate the expression of inflammation-related factors (iNOS, COX-2, and NF-kB signaling molecules p-IkBα, p50, p-65 and pSTAT3). Results: The degree of symptoms significantly improved in the PA+AX group. Lymph node weight in the PA+AX group was lower than the PA group. Inflammatory cytokines (IL-31, IL-33, and inflammatory chemokines such as CCL17 and CCL22) were significantly reduced in the PA+AX group compared with the PA group. The expression of inflammatory genes (iNOS, COX-2, NF-kB and signaling molecules (p-IkBα, p50, p65, and p-STAT 3) was lower in the PA+AX group compared with the PA group. Conclusion: Astaxanthin may modulate the inflammatory response in a mouse model of atopic dermatitis and has an anti-inflammatory effect.

Finite element modeling of human cervical spine (인체 경추부의 유한요소 모델링)

  • Choi, H.Y.;Eom, H.W.;Lee, T.H.;Kang, S.B.;Hwang, M.C.
    • Proceedings of the KOSOMBE Conference
    • /
    • v.1997 no.11
    • /
    • pp.280-283
    • /
    • 1997
  • Human cervical spine has to protect the neural components and vascular structures. Also, it must have the flexibility afforded by an extensive range of motion to integrate the head with the body and environment. Because of these two-sided features, human cervical spine has very complicated shapes and their injury mechanisms are not fully understood yet. We have developed analytical model of human CS by using the finite element method. The model has been verified with in vivo and in vitro experimental results. From the qualitative analysis of simulation results, we were able to explain some of the fundamental mechanisms of neck pain. Further more, this FE model of human CS can be used as an analytical tool or biomechanical design of the clinical device and safety restraints.

  • PDF

2×2 Ti:LiNbO3 Waveguide Digital Optical Switches

  • Kim Seung-Jae;Jung, Hong-Sik;Lee, Han-Young
    • Journal of the Optical Society of Korea
    • /
    • v.7 no.4
    • /
    • pp.253-257
    • /
    • 2003
  • We propose and demonstrate a novel polarization- and wavelength-independent digital electrooptic switch in $Ti:LiNbO_3$ with switching voltage of ${\pm}$32V at $1.55{\mu}m$ wavelength. This $2{\times}2$ integrated optic switch is characterized by a step-like response to the applied voltage. Switching is achieved through adiabatic mode evolution in an asymmetric waveguide junction. An average insertion loss of ∼4.5dB and polarization independent switching with average crosstalk of -12dB are achieved.

A Theoretical and Experimental Study for the Design of Solar Air Heaters Using Porous Material (다공성 물질을 이용한 공기용 태양열 집열기의 설계를 위한 이론 및 실험적 연구)

  • Hwang, Yong-Ha;Park, Seung-Ho
    • Transactions of the Korean Society of Mechanical Engineers B
    • /
    • v.20 no.1
    • /
    • pp.336-345
    • /
    • 1996
  • A theoretical and experimental study was conducted in order to design highly efficient solar air heaters using porous material. Radiative characteristics of glass windows and porous absorbing media were correlated through spectral transmittances measured by the UV-Visible and the FT-IR spectrometers. Using those characteristics the efficiencies of collectors were numerically calculated with the use of the two-flux radiation model. Based on the theoretical results, an experimental solar collector was designed and constructed. Experimental results under various conditions show that the daily efficiencies are over 60% in general and agree well with the theoretically calculated ones.

The Magnetic Properties and Microstrostrures for FeMX(M=Mo, Ta, X=N, C) Films. (FeMX(M=Mo, Ta, X=N, C) 박막의 자기 특성 및 미세구조 변화)

  • Shin, D.H.;Choi, W.;Kim, H.J.;Nam, S.Y.;Ahn, D.H.
    • Journal of the Korean Magnetics Society
    • /
    • v.5 no.5
    • /
    • pp.874-879
    • /
    • 1995
  • Magnetic properties of FeMoN, FeMoTaN, FeTaN and FeTaC films deposited by DC magnetron reactive sputter were investigated, and correlated with their microstructure. FeMoN films were not showen the soft magnetic prop¬erties, because of generated $Fe_{2}Mo$, $Fe_{3-2}N$ and $Fe_{4}N$ phases. Ta added films, however, effectivly retarded the $\alpha$-Fe grain growth and suppressed the generation of Fe nitrides or carbides during heat treatement. The soft magnetic properties of $B_{s}:15\;kG,\;H_{e}:0.25\;Oe,\;\mu':4000(at\;5\;MHz),\;and\;B_s:14.5\;kG,\;He:0.25\;Oe,\;\mu':2700(5MHz)$ were observed in $Fe_{78.8} Ta_{8.5}N_{12.7}\;and\;Fe{75.6}Ta_{8.1}C_{16.3}$ films, respectively.

  • PDF

Enhancement of the efficiency in green organic light-emitting devices utilizing multiple heterostructures acting as a hole transport layer

  • Choo, D.C.;Lee, D.U.;Yoon, Y.B.;Kim, T.W.;Kim, J.H.;Seo, J.H.;Kim, Y.K.
    • 한국정보디스플레이학회:학술대회논문집
    • /
    • 2006.08a
    • /
    • pp.1024-1027
    • /
    • 2006
  • The electrical and the optical properties of organic light-emitting devices (OLEDs), with and without various kinds of multiple heterostructures were investigated. The efficiency in green OLEDs were significantly enhanced by the structure of the multiple heterostructures acting as a hole transport layer (HTL) rather than by the number of periods. These results indicate that highly efficient green OLEDs utilizing multiple heterostructures acting as a HTL can be fabricated.

  • PDF

Synthesis of (N-docosyl pyridinium)-TCNQ (1:1) Complex and Negative Resistance Phenomena in Langmuir-Blodgett Ultra Thin Films ((N-docosyl pyridinium)-TCNQ(1:1) 착체의 합성과 Langmuir-Blodgett 초박막에서 부성저항현상)

  • Seo, T.S.;Choi, M.K.;Lee, W.J.;Shon, B.C.;Kwon, Y.S.;Kang, D.Y.
    • Proceedings of the KIEE Conference
    • /
    • 1989.11a
    • /
    • pp.105-108
    • /
    • 1989
  • For the purpose of fabricating of LB Ultra Thin Films. (N-docosyl pyridinium)-TCNQ(l: 1) Complex is synthesized. This specimen is verified by U.V. I.R and elemental analyzer. In fabricated LB films with this, as a measurements of electrical conduction characteristics in perpendicular direction, this films have characteristics of insulator(about $10^{-14}S/cm$). And negative resistance phenomena are observed in I-V characteristics of this films.

  • PDF