• 대한한방소아과학회지
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• 제25권2호
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• pp.111-120
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• 2011

Objectives: The purpose of this study is to estimate genetic and environmental factors, which can affect Idiopathic true Precocious puberty, and to evaluate the clinical and endocrinologic characteristics. Methods: Retrospective and Comparative analysis of 76 children (72 girls and 4 boys) has been diagnosed with idiopathic true precocious puberty, and treated with GnRHa from December 2008 to July 2011. Results: 1. The Average chronological age (CA. yr) of children diagnosed with idiopathic true precocious puberty was $8.40{\pm}0.81$ (girls), $9.93{\pm}0.12$ (boys). 2. The Average height & weight percentile (%ile) of the girls diagnosed with idiopathic true precocious puberty was $67.38{\pm}22.04$, $67.69{\pm}23.20$. 3. The girls' mothers have diagnosed with idiopathic true precocious puberty, and they were shorter than the average. This shows that mother's small height and idiopathic true precocious puberty are closely related to each other. 4. BMI percentile (%ile) of girls diagnosed with idiopathic true precocious puberty was $63.26{\pm}24.86$. 23.6% of children were diagnosed with overweight or obesity. This result shows that obesity and idiopathic true precocious puberty are proportionally related. 5. Birth weights (kg) of the children diagnosed with idiopathic true precocious puberty were $3.16{\pm}0.43$ (girls), $3.15{\pm}0.38$ (boys). 8.3% of children were diagnosed with Intrauterine growth retardation. 6. The Average bone ages (BA. yr) of the children diagnosed with idiopathic true precocious puberty were $10.51{\pm}0.99$ (girls), $12.10{\pm}0.97$ (boys). The Average BA-CA was $2.11{\pm}0.81$ (girls), $2.00{\pm}0.87$ (boys). 7. The Average predicted adults' height (PAH. cm) of the children diagnosed with idiopathic true precocious puberty was $151.61{\pm}4.00$ (girls), $163.50{\pm}2.15$ (boys). The Average MPH-PAH was $6.84{\pm}4.91$ (girls), $6.00{\pm}5.35$ (boys). 8. 23.6% of the children treated with GnRHa were co-treated with Growth Hormone. Conclusions: Estimated factors which cause Idiopathic true precocious puberty are mother's small height, obesity, and Intrauterine growth retardation. However, the studies of Oriental Medicine for Idiopathic true precocious puberty were lacking. Further clinical and experimental researches are needed.

• 디지털융복합연구
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• 제12권9호
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• pp.283-290
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• 2014

본 연구는 조기 2차 성징을 주호소로 내원하여 특발성 성조숙증으로 진단받은 여아의 진단 유형에 따른 신체발육, 성호르몬 분비의 특성을 파악하고자 시도하었다. 2차 조기성숙을 주호소로 내원한 여아 중 기질적 원인으로 인한 경우를 제외한 성조숙증 여아들을 진성 성조숙증과 가성 성조숙증으로 분류하여, 내원 당시 연령, 출생 시 체중, 2차 성징 발현 나이, 부모 및 조부모 키, 키, 체중, 골연령, 체질량지수 등을 조사하였다. 또한 성호르몬 분비정도를 비교분석하였다. 수집된 자료는 SPSS 20.0 통계프로그램을 이용하여, 평균과 표준편차 그리고 Student t-test로 분석하였다. 본 연구결과 진성 성조숙증이 47명(38.9%), 가성 성조숙증이 66(61.1%)였다. 진성 성조숙증집단에서는 신장 및 체중 표준편차점수가 유의한 수준으로 증가되어 있었으며(p<.05), 성호르몬 검사 상 황체형성호르몬(LH), 난포자극호르몬(FSH) 그리고 에스트라디올(Estradiol)의 기저치가 가성 성조숙증에 비해 유의하게 높았다(p<.05).