• 대한생식의학회:학술대회논문집
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• 1997.11a
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• pp.65-66
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• 1997

• 대한생식의학회:학술대회논문집
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• 2007.11a
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• pp.140.1-140.1
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• 2007

• 대한생식의학회:학술대회논문집
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• 2006.11a
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• pp.159-160
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• 2006

• 대한생식의학회:학술대회논문집
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• 2002.11a
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• pp.72-72
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• 2002

• 대한생식의학회:학술대회논문집
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• 2006.06a
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• pp.164.1-164.1
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• 2006

• Clinical and Experimental Reproductive Medicine
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• v.42 no.4
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• pp.175-180
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• 2015

Objective: Embryo loading (EL) is a major step in embryo transfer (ET) and affect on the success of in vitro fertilization (IVF). This study aimed to compare the effect of two different EL techniques on the rates of pregnancy and delivery in IVF/ET cycles. Methods: 207 fresh ET and 194 Frozen-thawed ET (FET) cycles were included in this retrospective study. Two groups (A and B) were defined based on the EL technique used. In group A, the entire catheter was flushed with Ham's F-10 medium. The embryos were then drawn into the catheter using one air bracket. In group B, $70{\mu}L$ of air was aspirated into the syringe and the catheter was flushed using Ham's F10 medium. The medium, air, embryos, air, and finally another layer of medium were then sequentially drawn into the catheter. The main outcome measures were the pregnancy and delivery rates. Results: The groups did not differ with respect to the etiology of infertility, the source of spermatozoa, the quality of the embryos, the type of EL catheter, and the ease of transfer. The pregnancy rate was similar between two groups. In fresh ET cycles, a higher delivery rate was observed in group B than it group A (78.1% vs. 60%, p=0.1). In FET cycles, the rate of delivery was significantly higher in group B than in group A to a nonsignificant extent (88.9% vs. 58.8%, p=0.06). Conclusion: EL techniques did not have a significant impact on the delivery rate in either fresh or FET cycles.

• Clinical and Experimental Reproductive Medicine
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• v.23 no.3
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• pp.277-282
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• 1996

Serum inhibin concentrations, determimed by radioimmunoassay, were measured in women undergoing pituitary suppression with Decapeptyl and subsequently ovarian stimulation with Highly Purified-Metrodin(HP-FSH) to appraise follicular development. Early follicular basal serum inhibin level correlated with the number of oocytes retrieved(r=0.89, n=8, p<0.05). The number of oocytes retrieved showed a significant correlation with serum inhibin level on the day of hCG administration(r=0.73, n=8, p<0.05). The number of mature oocytes showed a significant correlation with serum inhibin level on the day of hCG administration(r=0.73, n=8, p<0.05). These data suggest that: (1) In the early follicular phase, basal serum inhibin may be a valid index to predict ensuing follicular growth : (2) In the preovulatory phase, maximum serum inhibin may be one of the indexes of follicular development during hyperstimulation cycles.

• Clinical and Experimental Reproductive Medicine
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• v.43 no.4
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• pp.247-252
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• 2016

Objective: Heparin can modulate proteins, and influence processes involved in implantation and trophoblastic development. This study aimed to assess the improvement of clinical pregnancy and implantation rates after local intrauterine injection of low-molecular-weight heparin (LMWH) in patients undergoing intracytoplasmic sperm injection (ICSI). Methods: A randomised case/control design was followed in women scheduled for ICSI. The study arm was injected with intrauterine LMWH during mock embryo transfer immediately following the ovum pickup procedure, while the control arm was given an intrauterine injection with a similar volume of tissue culture media. Side effects, the clinical pregnancy rate, and the implantation rate were recorded. Results: The pregnancy rate was acceptable (33.9%) in the LMWH arm with no significant reported side effects, confirming the safety of the intervention. No statistically significant differences were found in the clinical pregnancy and implantation rates between both groups (p= 0.182 and p= 0.096, respectively). The odds ratio of being pregnant after intrauterine injection with LMWH compared to the control group was 0.572 (95% confidence interval [CI], 0.27-1.22), while the risk ratio was 0.717 (95% CI, 0.46-1.13; p= 0.146). No statistical significance was found between the two groups in other factors affecting implantation, such as day of transfer (p= 0.726), number of embryos transferred (p= 0.362), or embryo quality. Conclusion: Intrauterine injection of LMWH is a safe intervention, but the dose used in this study failed to improve the outcome of ICSI. Based on its safety, further research involving modification of the dosage and/or the timing of administration could result in improved ICSI success rates.

• Clinical and Experimental Reproductive Medicine
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• v.38 no.1
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• pp.53-60
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• 2011

Objective: This study was carried out to compare the clinical outcome of elective single cleavage-embryo transfer (eSCET) to that of elective single blastocyst-embryo transfer (eSBET) in human IVF-ET. Methods: This study was a retrospective study which analyzed for 614 women who visited the Daegu Maria Clinic from August 2008 to December 2009. All were under 37 years old and had more than 8 mm of endometrial thickness on the day of hCG administration and at least one good quality embryo on day 3. The eSCETs were performed on day 3 (n=450) and the eSBETs were conducted on day 5 (n=164). Results: The numbers of retrieved oocytes, fertilized oocytes, and day 3 good quality embryos were significantly lower in the eSCET group (12.1${\pm}$6.0, 8.2${\pm}$4.6, and 4.2${\pm}$3.1, respectively) compared to the eSBET group (16.7${\pm}$7.2, 12.1${\pm}$5.0, and 8.5${\pm}$4.5, respectively; p<0.001). However, the clinical pregnancy, implantation, on-going pregnancy, and live birth rates of the eSCET group (46.7, 46.9, 40.0, and 36.7%, respectively) were not statistically different from those of the eSBET group (51.2, 51.8, 45.1, and 43.9%, respectively; p=0.318, 0.278, 0.254, and 0.103, respectively). Conclusion: These results suggested that elective single embryo transfer should be performed regardless of the developmental stage to women less than 37 years old who had more than 8 mm of endometrial thickness on the hCG administration day and at least one good quality embryo on day 3 in order to reduce the twin pregnancy rate without reducing the whole pregnancy rate.

• The Journal of Korean Obstetrics and Gynecology
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• v.37 no.3
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• pp.63-84
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• 2024

Objectives: This study aims to understand the stress patterns and coping behaviors of women with infertility and to improve existing infertility stress assessment tools to develop a tool suited for Korean society. Methods: The study involved 10 women diagnosed with primary or secondary infertility. Data were collected through surveys and in-depth interviews. Participants were recruited voluntarily, and snowball sampling was used for additional recruitment. Data collection occurred from September 2023 to April 2024. Data analysis included Spearman's rank correlation, Mann-Whitney U test, and Kruskal-Wallis test. Interview results were analyzed using text mining and network analysis with Python 3.12. Results: There was a significant correlation between IVF/ICSI treatment and resilience scores, with non-IVF/ICSI groups showing higher resilience scores. Existing infertility stress assessment tools were generally useful but had limitations, such as discomfort with religious expressions and fixed gender roles, as well as issues with the number of items and response scales. Text mining of interview responses revealed key stress-related keywords including worry, depression, burden, pregnancy outcome, and health. Main stressors included uncertainty about pregnancy outcomes, physical discomfort during treatments, economic burdens, and emotional reactions from family and social relationships. Conclusions: This study identified the stress patterns of women with infertility through interviews. It showed the need for a new assessment tool to evaluate and support the complex stressors experienced by these women. Developing a comprehensive tool is essential for better understanding and managing the various stress factors faced by infertile women.