• Title/Summary/Keyword: IV-PCA

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The analgesic efficacy of a single injection of ultrasound-guided retrolaminar paravertebral block for breast surgery: a prospective, randomized, double-blinded study

  • Hwang, Boo-Young;Kim, Eunsoo;Kwon, Jae-young;Lee, Ji-youn;Lee, Dowon;Park, Eun Ji;Kang, Taewoo
    • The Korean Journal of Pain
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    • v.33 no.4
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    • pp.378-385
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    • 2020
  • Background: The thoracic paravertebral block is an effective analgesic technique for postoperative pain management after breast surgery. The ultrasound-guided retrolaminar block (RLB) is a safer alternative to conventional paravertebral block. Thus, we assessed the analgesic efficacy of ultrasound-guided RLB for postoperative pain management after breast surgery. Methods: Patients requiring breast surgery were randomly allocated to group C (retrolaminar injection with saline) and group R (RLB with local anesthetic mixture). The RLB was performed at the level of T3 with local anesthetic mixture (0.75% ropivacaine 20 mL + 2% lidocaine 10 mL) under general anesthesia before the skin incision. The primary outcome was cumulative morphine consumption using intravenous patient-controlled analgesia (IV-PCA) at 24 hour postoperatively. The secondary outcomes were the visual analogue scale (VAS) scores at 1, 6, 24, and 48 hour postoperatively and the occurrence of adverse events and patient satisfaction after the surgery. Results: Forty-six patients were included, 24 in group C and 22 in group R. The cumulative morphine consumption using IV-PCA did not differ between the two groups (P = 0.631). The intraoperative use of remifentanil was higher in group C than in group R (P = 0.025). The resting and coughing VAS scores at 1 hour postoperatively were higher in group R than in group C (P = 0.011, P = 0.004). The incidence of adverse events and patient satisfaction was not significantly different between the two groups. Conclusions: A single injection of ultrasound-guided RLB did not reduce postoperative analgesic requirements following breast surgery.

Multivariate Analysis of Agronomic Characteristics of Wheat (Triticum spp.) Germplasm

  • Pilmo Sung;Mesfin Haile Kebede;Seung-Bum Lee;Eunae Yoo;Gyu-Taek Cho;Nayoung Ro
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2022.10a
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    • pp.303-303
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    • 2022
  • The purpose of this study was to evaluate agronomic characteristics and identify the useful traits to utilize the wheat genetic resources for breeding programs by understanding the phenotypic variation among germplasm through multivariate analysis. In this study, a total of 394 wheat accessions were characterized for 15 agronomic traits using the National Agrobiodiversity Center (NAC) descriptor list, of which 31 accessions from 6 species and 363 unidentified accession (Triticum spp.) available at the NAC, Rural Development Administration (RDA), Korea. Growth characteristics such as leaf width, culm length, spike length, spikelet length, solid stemmed, days to heading, days to maturity, grain-filing period, and also seed characteristics such as width, height, area, perimeter, circle, solidity, and germination percent were studied. Among the 15 agronomic characteristics, the germination percent showed the smallest variation between resources (CV = 0.4%), and the spikelet length (CV = 66.5%) showed the highest variation. A strong positive correlation was found between seed traits such as seed height and seed area (r = 0.90), seed height and seed perimeter (r = 0.87) and seed length and width (r = 0.80). Principal component analysis (PCA) was conducted and the first five principal components comprised 76.7% of the total variance. Among the first five PCs, PCI accounted for 28.5% and PC2 for 20.0%. Wheat resources (394) were classified into four clusters based on cluster analysis, consisting of 215 resources(I), 117 resources(II), 48 resources(III), and 14 resources(IV). Among the clusters, the resources belonging to Cluster III showed the lowest seed width, height, area, and perimeter characteristics compared to other clusters. The wheat resources belonging to cluster IV had small seed width and low germination percent, but took longer to form heads and mature than resources in other clusters. These results will serve as the basis for further genetic diversity studies, and important agronomic characteristics will be used for improving wheat, including developing high-yielding and resistant varieties to biotic and abiotic stresses via breeding programs.

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Morphological Characteristics and Classification of 25 Selected Clones of Aralia elata Seem (두릅나무 25개 선발 클론의 형태적 특성과 유연관계)

  • Kim, Sea Hyn;Kim, Moon Sup;Han, Jingyu;Kim, Hyeusoo;Moon, Heung Kyu
    • Korean Journal of Plant Resources
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    • v.26 no.1
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    • pp.36-43
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    • 2013
  • Aralia elata Seem. have a typical traditional significance among the wild herbs traditionally. Edible shoots of A. elata will augment consumer's interest due to its high value functional value, eco-friendly and pesticide-free produce. A. elata's root, fruit and bark are used as material of hypoglycemic agent and medicine for diabetes, kidney trouble, acute hepatitis, rheumation arthritis, stomach cancer and gastroenteric trouble. Flavonoid glycoside compound which is separated from A. elata's shoot shows high antioxidative activity. Also, root's identified active materials of antimicrobial was reported to be produced as food preservative and handy antimicrobial. Therefore, this research investigated quantitative morphological characteristics of leaves, spine and bud in naturally dominated and introducted A. elata in south Korea and then considered its principal compound analysis(PCA) and classification analysis(CA) among the 6 improved cultivars and 19 clones. PCA results showed that it show 76% accumulated explanation from four PC. The A. elata clones were classified into five groups; the first group of 15 clones including Yeongok, the second group of 5 clones including Yeoju, the third group of Bonghwa, Ulleung, the fourth group of Yongmunsa, Boseong and the fifth group of Singu. The object of this study will give us invaluable information about breeding by selection of A. elata in south Korea.

A COMPARATIVE STUDY ON POST-OPERATIVE ANALGESIC EFFECT FOR PATIENT-CONTROLLED AND INTRAMUSCULAR ANALGESIA IN MANDIBULAR FRACTURE PATIENTS (하악골 골절환자에서 술후 자가통증조절장치와 근주용 진통제의 효과에 관한 비교)

  • Lee, Seok-Jae;Kim, Kyung-Wook;Kim, Chul-Hwan
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.28 no.1
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    • pp.42-48
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    • 2006
  • Open reduction and rigid internal fixation is the most popular treatment method for maxillofacial fracture patients, and it is unevitable that postoperative pain can be developed. Many surgeons including oral & maxillofacial surgeons have made constant efforts to decrease postoperative pain. This study is a comparison of postoperative analgesia and intramuscular analgesia in patients with mandibular fractures. In this study, twenty-one patients (Experimental group) were randomly selected and they were injected with IV patient-controlled analgesia (PCA; Walkmed$^{(R)}$, USA). For control group another twenty-one patients were injected with intramusclar non-steroid anti-inflammatory drugs (Rheoma$^{(R)}$, Samsung Pharm. Co.). And then, we measured visual analogue scale (VAS) scores from first postoperative day to second day at regular time interval. The following results were uptained; 1. In patient group who with open reduction and rigid internal fixation, there was significant difference of postoperative analgesic effect during the first postoperative day(p<0.05). 2. In patient group with over 90 minutes surgery time, there was significant difference of postoperative analgesic effect during the first and second postoperative day when compared between experimental group and control group(p<0.05). 3. In patient group with less than 90 minutes surgery time, there was no significant difference of postoperative analgesic effect during the first and second postoperative day when compared between experimental group and control group(p>0.05). 4. In patient group with surgery of open reduction using rigid internal fixation at single fractured site, there was no significant difference of postoperative analgesic effect during the first and second postoperative day when compared between experimental group and control group(p>0.05). 5. In patient group with surgery at two fractured sites, there was significant difference of postoperative analgesic effect during the first postoperative day when compared between experimental group and control group(p<0.05). As mentioned above, it suggest that patient-controlled analgesia is more effective for postoperative pain relief than intramuscular injection in patients with rigid internal fixation by open reduction after mandibular fracture occurred. Especially, it is considered that in patient with more than 90 minutes surgery time or in cases with multiple fractured sites had more effective results with PCA therapy than conventional intramuscular analgesics.

Chemometric Studies on Brain-uptake of PET Agents via VolSurf Analysis

  • Lee, Hyo-Seon;Kim, Mi-Kyoung;Lee, Chae-Woon;Kim, Jin-Young;Choo, Il-Han;Woo, Jong-Inn;Chong, You-Hoon
    • Bulletin of the Korean Chemical Society
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    • v.29 no.1
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    • pp.61-68
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    • 2008
  • High initial (2 minutes after iv injection) brain-uptake of PET agents is required to deliver the agent to binding sites in brain tissue but, for quantification of the specific binding, relatively rapid washout of free and non-specifically bound PET agents from the brain (30 minutes after injection) also is required. In order to compare the physicochemical properties of the PET agents which are responsible for early brain-uptake and rapid washout, respectively, chemometric analysis on brain-uptake of PET agents was performed via a classical VolSurf approach. According to the PCA and PLS results, high 2-30 min brain-uptake ratio seems to be related to the large hydrophobic regions in the PET agents which are not confined to a particular surface.

Effect of Structured Information on Immediate Preoperative Anxiety and Uncertainty for Women Undergoing Laparoscopic Hysterectomy (수술 전 구조화된 정보제공이 복강경하 자궁절제술 여성의 수술대기 중 불안과 불확실성에 미치는 효과)

  • Cho, Youn Hee;Chun, Nami
    • Women's Health Nursing
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    • v.21 no.4
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    • pp.321-331
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    • 2015
  • Purpose: Purpose of this study was to identify the effect of structured information on immediate preoperative anxiety and uncertainty for women undergoing total laparoscopic hysterectomy. Methods: Sixty women who were admitted for total laparoscopic hysterectomy were recruited at a university hospital in Gyeonggi-do from June to October 2014. Thirty women were assigned to either the experimental or the control group. Women in the experimental group were provided structured information, which consisted of visual and auditory materials about surgical preparation and process, practical experience on devices such as IV-PCA pump and Inspiro-meter and actual experience on route to go to the operating room. State-anxiety, uncertainty, and blood pressure and pulse rate as biological indicators were measured before and after the intervention to examine the effect. Results: Significant group differences were found on state anxiety, uncertainty, including ambiguity, inconsistency, and unpredictability at the holding area. There was a significant difference on pulse rate in the operating room between the two groups. Conclusion: Findings demonstrated that the structured information provided for women undergoing laparoscopic hysterectomy preoperatively was effective on immediate preoperative anxiety and uncertainty. Nurses may contribute to decreasing patients' anxiety and uncertainty by utilizing this structured information preoperatively.

Postoperative Pain Control by Ultrasound-Guided Sciatic Nerve Catheterization - A Technical Note - (초음파 유도 좌골 신경 도관 삽입에 의한 수술 후 통증 조절 - 술기 보고 -)

  • Kang, Chan;Hwang, Deuk-Soo;Kim, Young-Mo;Hwang, Jung-Mo;Lee, Seung-Hyun
    • Journal of Korean Foot and Ankle Society
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    • v.15 no.2
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    • pp.97-101
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    • 2011
  • Intravenous Patient Controlled Analgesia (IV PCA0 after general or spinal anesthesia may be a method of postoperative pain control, but side effects such as nausea, vomiting, and sedation occurs in most patients. The following research is based on the ultrasound guided femorosciatic nerve block held on parts below the knee joint operation. Because this anesthesia is held locally on the sciatic nerve with continuous anesthesia performed through perineural catheterization, the complications of nausea, vomiting, and sedation may be reduced while postoperative pain caused by the sciatic nerve is controlled. The following report is held on this experience.

Analysis of Characteristics and Test of Combining Ability in Leaf Mustard Allies (갓의 국내 수집종 및 도입종의 형질분석 및 $F_{1}$ 조합능 검정)

  • Park, Han-Ju;Lee, In-Ho;Park, Jong-In;Yang, Seung-Yul;Nou, Ill-Sup
    • Korean Journal of Plant Resources
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    • v.20 no.4
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    • pp.298-303
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    • 2007
  • To examine taxonomic relationships among 24 leaf mustard allies (Brassica juncea) derived from domestic collections and introduced species, principal component analysis (PCA) and cluster analysis on 16 morphological characters were carried out. Of 16 characters, total fresh weight, total dry weight, shoot fresh weight and leaf length were useful characters for the understanding of taxonomic relationships among them. Cluster analysis using scores of the principal components indicated that 24 leaf mustards could be grouped into domestic collections and introduced species at 1.0 of average distance in UPGMA. Moreover, in experiment of $F_{1}$ recombination test, heterosis appeared greatly in Sanchiohbachirimen takana A ${\times}$ Akaohba takana, Goheung namyang ${\times}$ Sanchiohbachirimen takana B, and Goheung namyang ${\times}$ Akaohba takana cross combinations. Sanchiohbachirimen takana A and Akaohba takana have a high parent combining ability for breeding cultivars using cytoplasmic male sterility.

Leaf Morphological Characteristics and Variation of Sorbus alnifolia (Sieb. et Zucc.) K. Koch in 11 Natural Habitats (국내자생 팥배나무 11개 천연집단의 잎 형태적 특성과 변이)

  • Kim, Young Ki;Kim, Sea Hyun;Kim, Moon Sup;Yun, A Young;Park, In Hyeop;Go, Young Seok
    • Korean Journal of Plant Resources
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    • v.32 no.1
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    • pp.29-37
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    • 2019
  • This study was conducted to provide a basic data such as leaf morphological characteristics, total 110 individual trees selected from 11 wild population, for selective breeding. As a result of investigation of the twenty morphological characteristics of the leaf, there were statistically significant differences in all leaf characteristics among the populations. Especially, Mt. Mani population had larger leaf length (LL), width (LW) and area (LAR) than other populations. On the other hand, Mt. Beakwoon and Mt. Duryun had smaller leaf size (LL, LW and LAR) among the populations. Its principal component analysis (PCA) results showed that it represented 72.9% accumulated explanation from three principal component. The characteristics such as leaf area, leaf length and leaf width were highly contributed for classification among populations. According to the cluster analysis, the natural S. alnifolia populations were classified into five groups and Mt. Mani population was different from the other population.

Distributional characteristics of phytoplankton and nutrient limitation during spring season in Jinhae Bay (춘계 진해만에서 식물플랑크톤 증식과 제한영양염 분포특성)

  • Son, Moonho;Kim, Dongseon;Baek, Seung Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.5
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    • pp.3345-3350
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    • 2014
  • We investigated to assess the relationships between the major nutrients and phytoplankton dynamics during the spring season in 2010 and 2011 at 23 stations in Jinhae Bay, Korea. The bay is divided into four different zones based on pollutant sources and geographical characteristics. Nutrient limitation (>80%) was significant in Zone II, which is located in central bay and is influenced by the water well mixed from outer bay. The limited nutrient was followed in Zone III and IV that was occupying between 17% and 83%. However, the low levels are being kept below 35% in Zone I, which is characterized by the semi-enclosed eutrophic area of Masan and Haegam bays. Based on the PCA (principle component analysis) analysis, the nitrogen (N) sources in 2010 were particularly dominant and it may be due to the water mixing and wastewater formed from bottom layers and sewage. In 2011, major nutrients including nitrogen, silicon and phosphorus were dominant in the bay and are supplied by the river discharge after rainfalls with low salinity conditions. In particular, the N nutrients being supplied in 2010 are correlated with pennate diatoms Pseudo-nitzchia spp. and is not related to the phytoplankton population densities in 2011. The present study suggests that N sources play an important role in the proliferation of diatom, and the rapid nutrient uptakes by them are potential nutrient limitation factors in the bay.