• Nutrition Research and Practice
• /
• 제7권5호
• /
• pp.393-399
• /
• 2013

Asian populations are thought to receive significant health benefits from traditional diets rich in soybeans due to high isoflavone contents. However, available epidemiologic data only weakly support this hypothesis. The present study was carried out to assess the pharmacokinetics of isoflavones in South Korean women after ingestion of soy-based foods. Twenty-six healthy female volunteers (20-30 y old) consumed three different soy products (i.e., isogen, soymilk, and fermented soybeans) with different aglycone/glucoside ratios. Plasma and urine isoflavone concentrations were measured by high-performance liquid chromatography (HPLC) after ingestion of one of the soy products. Pharmacokinetic parameters were determined using the WinNonlin program. The area under the curve (AUC) for plasma daidzein levels of the soymilk group ($2,101{\pm}352ng{\cdot}h/mL$) was significantly smaller than those of the isogen ($2,628{\pm}573ng{\cdot}h/mL$) and fermented soybean ($2,593{\pm}465ng{\cdot}h/mL$) groups. The maximum plasma concentration ($C_{max}$) of daidzein for the soymilk group ($231{\pm}44$ ng/mL) was significantly higher than those of the isogen ($160{\pm}32$ ng/mL) and fermented soybean ($195{\pm}35$ ng/mL) groups. The half-lives of daidzein and genistein in the soymilk group (5.9 and 5.6 h, respectively) were significantly shorter than those in the individuals given isogen (9.6 and 8.5 h, respectively) or fermented soybean (9.5 and 8.2 h, respectively). The urinary recovery rates of daidzein and genistein were 42% and 17% for the isogen group, 46% and 23% for the fermented soybean group, and 33% and 22% for the soymilk group. In conclusion, our data indicated that soy products containing high levels of isoflavone aglycone are more effective for maintaining plasma isoflavone concentrations. Additional dose-response, durational, and interventional studies are required to evaluate the ability of soy-based foods to increase the bioavailability of isoflavones that positively affect human health.

• 한국전산구조공학회논문집
• /
• 제34권1호
• /
• pp.19-24
• /
• 2021

본 논문에서는 배관의 ISO 도면 교환파일을 이용하여 AR/VR모델을 실시간으로 생성하는 방법을 소개한다. 도면 교환 파일 중에서 산업 표준으로 활용되는 IDF 파일을 분석했으며, 속성 정보의 추출과 함께 형상을 파라메트릭한 방법으로 정의하는 방법을 사용하였다. 이 방법을 통해서 파일 크기가 작은 도면 교환 파일을 사용함으로써 원거리 데이터 교환이 용이하면서도 형상과 속성을 모두 전달할 수 있는 효과를 가질 수가 있다. 이 과정에서 본 논문에서는 배관과 컴포넌트의 형상을 템플릿 형태로 정의해 놓았으며, 이를 통해 배관의 도면 교환 파일로부터 실시간으로 배관 형상을 생성함과 동시에 설계 정보와 함께 AR/VR모델로 가시화가 됨을 검증하였다.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
• /
• pp.246.2-247
• /
• 2003

Lately, soybeans have received considerable public attention for their potential roles in the prevention of the chronic diseases. Epidemiologic study showed that Asian countries have significant health benefits because of the high contents of the isoflavones in their traditional diets(soybean-rich diet). This study was carried out to determine pharmacokinetic parameters of isoflavone in Korean woman. Pharmacokinetic study of three soy products(isogen, soymilk, and fermented soybean) with different ration of aglycone/glucoside in 26 healthy female volunteers(20-30 years of age) was performed. (omitted)