• 천문학회보
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• 제41권2호
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• pp.56.1-56.1
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• 2016

A low-mass star-forming region, L1251B, is an excellent example of a small and nearby group of protostellar objects. L1251B has been mapped spectroscopically with the Infrared Spectrograph (IRS) onboard the Spitzer Space Telescope. IRS has provided mid-IR emission lines (e.g., [Fe II], [Ne II], and ro-vibrational H2) and absorption features of CO2 and H2O ice in studying the physical state of the ionized gas and the material residing in the circumstellar environments. We will present the distribution of outflows and ice components in L1251B.

• 천문학회지
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• 제38권2호
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• pp.249-252
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• 2005

We present results of the velocity-resolved spectroscopy of the [Fe II] $\lambda$1.644${\mu}m$ emission toward outflow sources with the Subaru Telescope at the angular resolution of 0.apos;16 ${\~}$ 0.apos;5 arcseconds. The observed sources are L1551 IRS 5, DG Tau, HL Tau and RW Aur, which are located in the Taurus-Aurigae Molecular Cloud, one of the closest star forming regions (0.apos;1 = 14 AU). We were able to resolve outflow structure in the vicinity of the sources at a scale of a few tens of AU. The position-velocity diagram of each object shows two velocity components: the high velocity component (HVC: 200 - 400 km $s^{-l}$) and the low velocity component (LVC: 50 - 150 km $s^{-l}$), which are clearly distinct in space and velocity. The HVC may be a highly collimated jet presumed from its narrow velocity width and high velocity. The LVC, on the other hand, may be a widely opened disk wind inferred from its broad velocity width and low velocity. The spectrum taken perpendicular to the L1551 IRS 5 outflow at its base shows that the LVC has a spatially wide subcomponent, supporting the above interpretation. We demonstrated that the [Fe II] 1.644 $\mu$ spectroscopy is a very powerful tool for the studies of fast jets and winds that directly emanate from star-disk systems.

• 대한한의학회지
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• 제36권1호
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• pp.75-85
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• 2015

Objectives: Type 2 diabetes mellitus is a metabolic disease characterized by insulin resistance and high blood glucose level from progressive insulin secretory defect. The rhizome of Atractylodes japonica Koidz. (AJ) has been used for treatment of retention of water in oriental medicine. The aim of this study is to examine the effects of AJ on type 2 diabetes rats. Methods: Type 2 diabetes was induced by 60% high fat diet and low dose streptozotocin. Rats were divided into 4 groups (n = 6); Nor (normal control group), Con (diabetic group treated with vehicle), Met (diabetic group treated with 200 mg/kg metformin) and AJ (diabetic group treated with 100 mg/kg AJ). The body weights and food intakes were measured during the treatment period. After 4 weeks treatment, blood glucose level, HOMA-IR, and protein expressions of IRS-1, p-IRS-1, PPAR-${\gamma}$, and GLUT4 were measured, and histopathological examination of beta cell was performed. Results: Compared with the control group, blood glucose level and HOMA-IR were reduced in rats treated with AJ. Impaired beta cells in pancreas of rats were recovered and phosphorylation of IRS-1 was increased in rats treated with AJ. And also, protein expressions of PPAR-${\gamma}$ and GLUT4 were increased by treatment of AJ. Conclusions: The results suggest that Atractylodes japonica Koidz. may have anti-diabetic effect on type 2 diabetic rats through regulation of blood glucose level and insulin resistance. Therefore Atractylodes japonica Koidz. may have positive effects on patients with type 2 diabetes.

• 한국식품영양과학회지
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• 제32권3호
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• pp.437-443
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• 2003

선행연구에서 라이코펜이 HT-29세포의 증식을 억제하는 것을 관찰하였기 때문에 본 연구는 그 기전을 연구하기 위하여 수행되 었다. 라이코펜이 HT-29 세포의 사멸을 유도하는지 조사하기 위해서 여러 농도의 라이코펜이 포함된 배지에서 세포를 4일 동안 배양하였다. 라이코펜 농도의 증가에 따라 사멸되는 세포에서 나타나는 특징의 하나인 DNA fragmentation이 증가하는 것을 관찰하였다. Western blot을 수행하여 얻은 결과에 의하면 라이코펜이 IGF-IR, IRS-1, PI3K, Akt와 같은 IGF-IR pathway에 속하는 단백질의 수준을 감소시켰다. IGF-IR의 인산화를 유도하기 위해서 라이코펜이 포함된 배지에서 세포를 배양하고 IGF-I을 첨가하여 0, 5, 10, 60분간 배양한 다음 IGF-IR antibody를 이용하여 immunoprecipitation을 수행하였다. 라이코펜은 IGF-I에 의한 IGF-IR, IRS-1의 인산화와 IGF-IR와 PI3K의 결합을 감소하고 인산화된 Akt를 감소시켰다. 이와 같은 IGF-IR signaling의 억제는 이 대장암세포에 존재하는 IGF-II의 autocrine loop을 억제하는 원인이 될 수 있어, 라이코펜의 암세포증식을 억제하는 기전 중의 하나가 될 수 있다. 라이코펜은 토마토와 그 가공품에 많이 존재하는 물질로 자연적인 식사를 통해 많이 섭취할 수 있는 물질이다. 라이코펜의 항암 기전을 밝혀냄으로써 미래 암예방과 치료를 위한 중요한 기능성 영양소를 생산할 수 있는 기초를 마련해줄 수 있을 것으로 기대된다.

• 천문학회보
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• 제35권1호
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• pp.58.2-58.2
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• 2010

L1251B, which was revealed as a small group of protostars by the Spitzer Space Telescope (SST), presents a great site of studying chemical evolution in gas and ice as well as various dynamical processes associated with star formation (infall, rotation, and outflow). We have mapped L1251B with the Infrared Spectrograph (IRS) aboard the SST to study the chemical distribution in the phases of gas and ice and the dynamical feature related to shock in the region. Various atomic lines and the $H_2$ pure rotational lines, which trace different shock velocities, were detected. In addition, the distribution of the water and $CO_2$ ices hints variety of the ice desorption mechanism in L1251B.

• 천문학회보
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• 제43권1호
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• pp.44.3-45
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• 2018

Magnetic fields affect star formation in a broad range of scales from parsec to hundreds au. In particular, interferometric observations and ideal magneto-hydrodynamic (MHD) simulations have reported that formation of a rotation-supported disk at the earliest young stellar objects (YSOs) is largely suppressed by magnetic fields aligned to the rotational axis of YSOs: magnetic braking. Our recent ALMA observations toward L1448 IRS 2, which has a rotation detected and its magnetic fields aligned to the rotation axis (poloidal fields) in ~500 au scales, show that the fields switch to toroidal at the center in ~100 au scales. This result suggests that magnetic braking may not be so catastrophic for early disk formation even in YSOs with magnetic fields aligned to the rotational axis.

• 천문학회보
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• 제36권1호
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• pp.83.2-83.2
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• 2011

I present results from the Spitzer/IRS study to identify massive young stellar objects (YSOs) in the Galactic Center (GC). Our sample of 107 YSO candidates was selected based on Spitzer/IRAC colors in the central 300 pc region of the Milky Way Galaxy. We obtained IRS spectra over $5{\mu}m$ to $35{\mu}m$, and identified massive YSOs by the presence of a $15.4{\mu}m$ shoulder on the absorption profile of $15{\mu}m$ $CO_2$ ice, suggestive of high $CH_3OH$ abundance on $CO_2$ ice grains. This $15.4{\mu}m$ shoulder is clearly observed in 16 sources and possibly observed in an additional 19 sources. We further show that 9 massive YSOs reveal molecular gas-phase absorption from $CO_2$, $C_2H_2$, and/or HCN, which traces warm and dense gas in YSOs. Our results provide the first spectroscopic census of the massive YSO population in the GC.

• Natural Product Sciences
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• 제19권4호
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• pp.316-323
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• 2013

Adipose tissue-derived chronic inflammation contributes to development of insulin resistance in obesity, leading to type 2 diabetes and cardiovascular disease. Baicalin, a flavonoid, has antioxidant, anti-inflammatory, antihyperglycemic, anti-adipogenic, and antiobesity effects. However, whether baicalin attenuates adipose tissue-derived development of insulin resistance remains still unclear. This study was to investigate effect of baicalin on the inflammatory changes involved in the development of insulin resistance in adipose tissue. RAW 264.7 cells and differentiated 3T3-L1 adipocytes were pretreated with various concentrations of baicalin in complete media for 1 h and then cultured in the presence or absence of LPS or TNF-${\alpha}$. Our results demonstrated that baicalin remarkably inhibited LPS-induced production of TNF-${\alpha}$, IL-6, and NO by RAW 264.7 cells in a dose-dependent manner. Baicalin also inhibited TNF-${\alpha}$-induced production of IL-6 and $PGE_2$ in differentiated 3T3-L1 cells in a dose-dependent manner, while upregulated TNF-${\alpha}$-suppressed expression of adiponectin and PPAR-${\gamma}$ mRNA and IRS-1 protein. These findings suggest that baicalin may prevent the adipose tissue-derived development of insulin resistance in obesity.

• 천문학논총
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• 제27권4호
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• pp.177-179
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• 2012

We present Spitzer IRS spectroscopy of $CO_2$ ice toward 19 young stellar objects (YSOs) with luminosity lower than $1L_{\odot}$. Pure $CO_2$ ice forms only at elevated temperatures, T > 20 K, and thus at higher luminosities. Current internal luminosities of YSOs with L < $1L_{\odot}$ do not provide such conditions out to radii of typical envelopes. Significant amounts of pure $CO_2$ ice would signify a higher past luminosity. We analyze $15.2{\mu}m$ $CO_2$ ice bending mode absorption lines in comparison to the laboratory data. We decompose pure $CO_2$ ice from 12 out of 19 young low luminosity sources. The presence of the pure $CO_2$ ice component indicates high dust temperature and hence high luminosity in the past. The sum of all the ice components (total $CO_2$ ice amount) can be explained by a long period of low luminosity stage between episodic accretion bursts as predicted in an episodic accretion scenario. Chemical modeling shows that the episodic accretion scenario explains the observed total $CO_2$ ice amount best.

• 천문학회보
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• 제42권2호
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• pp.81.1-81.1
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• 2017

L1251B is an excellent example of a small group of pre- and protostellar objects in low-mass star-forming region. Previous interferometer data with a high angular resolution resolved the outflows associated with L1251B into a few components. To understand the physical conditions of the protostellar outflows in L1251B, we mapped this region spectroscopically with Spitzer/IRS and obtained spectral line data from Herschel/PACS. Spitzer/IRS provides the S(0)-S(7) pure rotational lines of H2 as well as fine-structure emissions produced in shocks such as S, [Si II], and [Fe II] and it is a powerful tool for studying shocked interstellar gas. In addition, [O I] lines observed with Herschel/PACS are described well by J-type shock models expected in the outflows from protostars. We will present an analysis of the L1251B protostellar outflow in the H2 pure rotational lines and fine-structure emissions.