• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.12
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• pp.1-8
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• 2003

Scheduling technology is one of the most important elements required to support the Quality of service (QoS) in the Internet and a lot of scheduling algorithms have been developed. However, most of these algorithms ire not flexible to distribute the excess bandwidth. In order to provide flexibility for distributing the excess bandwidth, we proposed excess bandwidth fair queueing (EBFQ) algorithm with relatively low complexity. In this paper, we propose the new extension to this EBFQ algorithm for the hierarchical fair queueing system. This extension can be naturally applied to the existing hierarchical algorithm and simultaneously provide the same level of fairness. Through the simulation and analysis, we verify it.

• BMB Reports
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• v.48 no.8
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• pp.445-453
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• 2015

Endoplasmic Reticulum (ER) is an organelle where most secretory and membrane proteins are synthesized, folded, and undergo further maturation. As numerous conditions can perturb such ER function, eukaryotic cells are equipped with responsive signaling pathways, widely referred to as the Unfolded Protein Response (UPR). Chronic conditions of ER stress that cannot be fully resolved by UPR, or conditions that impair UPR signaling itself, are associated with many metabolic and degenerative diseases. In recent years, Drosophila has been actively employed to study such connections between UPR and disease. Notably, the UPR pathways are largely conserved between Drosophila and humans, and the mediating genes are essential for development in both organisms, indicating their requirement to resolve inherent stress. By now, many Drosophila mutations are known to impose stress in the ER, and a number of these appear similar to those that underlie human diseases. In addition, studies have employed the strategy of overexpressing human mutations in Drosophila tissues to perform genetic modifier screens. The fact that the basic UPR pathways are conserved, together with the availability of many human disease models in this organism, makes Drosophila a powerful tool for studying human disease mechanisms. [BMB Reports 2015; 48(8): 445-453]

• Biomedical Science Letters
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• v.16 no.4
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• pp.359-363
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• 2010

The miniature pig is a very suitable donor species in xenotransplantation of human organs. Intestine ischemia/reperfusion (I/R) is associated with high morbidity and mortality. Endoplasmic reticulum (ER) stress and apoptosis has been associated with the onset of diverse diseases. Thus, we examined the effect of intestine I/R on the expression of ER stress and apotptosis related molecules. In the present study, I/R induced phosphorylation of protein kinase-like endoplasmic reticulum kinase (PERK), IRE, and ATF-4. I/R also increased the expression of the proapoptotic transcription factor CAAT/enhancer-binding protein homologous protein (CHOP). In addition, I/R decreased the expression of Bcl-2, but increased the expression of Bax, cleaved PARP, and cleaved caspase-3. Moreover, I/R increased splicing form of XBP-1 mRNA and the expression of caspase-6 and caspase-3 mRNA. In conclusion, intestine I/R induced ER stress and apoptosis in miniature pig.

• Nuclear Engineering and Technology
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• v.20 no.1
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• pp.54-64
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• 1988

This paper assesses the models in the SCDAP code using the results of the FLHT-2 test. Calculations show that the SCDAP correctly predicts Ire temperatures, oxidation front movement, overall hydrogen generation and peak generation rate, internal fuel rod pressure, and cladding rupture due to ballooning. A comparison of the calculated results with measured data shows that two phase level is underpredicted, and that radiation heat transfer and auto-catalytic reaction temperature of zircaloy are overpredicted. These models are recommended to be modified. The analysis also shows that the simulation of the gap in a fuel rod improves the code prediction on core damage progression.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.27 no.2
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• pp.99-106
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• 1982

Highly positive correlations were obtained between the growth duration of the 1978 IReTN entries in Chuncheon, Korea and all the experimental sites in 7 other countries. Among the entries the photoperiod responsive varieties had very long growth duration in Chuncheon although relatively early in flowering in the other low latitude sites. Selection under Korean conditions would eliminate the short growth duration varieties caused by photoperiod sensitivity in tropics or sub tropics. Except for photoperiod sensitive rices, selection of varieties or lines for optimum growth duration before further evaluation in other low temperature areas would be most effective in Chuncheon, Korea.

• SUVANNABHUMI
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• v.12 no.1
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• pp.157-175
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• 2020

This paper presents the work of Southeast Asian scholar Ramon Guillermo. Using sophisticated computer-aided methods, Guillermo approaches a range of topics in the wide fields of social sciences and the humanities. A creative writer as well as an activist, Guillermo grounds his studies in nationalism and Marxism. Particularly interested in Indonesian and Philippine society and culture, Guillermo engages with the writings of labor leaders Tan Malaka and Lope K. Santos, translations of Marx's Capital into Bahasa and Filipino, and studies as well the discursive and historical connections between the Communist Parties of both countries. The paper aims to introduce the innovations of Guillermo's studies, particularly in the fields of cultural studies and translation studies. The type of cultural studies Guillermo practices is empirical, taking inspiration from innovations done in the digital humanities. Guillermo is most opposed to trendy, fashion-seeking approaches that are not grounded on history. He reserves particular ire for "hip" postcolonialism, and instead praises studies that are founded on politics and materialism. In translation studies, Guillermo goes beyond the mere cataloguing of mistakes. For him, it is the mistakes and "perversities" of a translation that is interesting and illuminating. Guillermo himself is a translator, and the paper ends with a brief discussion of his production in this field.

• BMB Reports
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• v.52 no.11
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• pp.665-670
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• 2019

Nucleotide-binding oligomerization domain protein 2 (NOD2), an intracellular pattern recognition receptor, plays important roles in inflammation and cell death. Previously, we have shown that NOD2 is expressed in vascular smooth muscle cells (VSMCs) and that NOD2 deficiency promotes VSMC proliferation, migration, and neointimal formation after vascular injury. However, its role in endoplasmic reticulum (ER) stress-induced cell death in VSMCs remains unclear. Thus, the objective of this study was to evaluate ER stress-induced viability of mouse primary VSMCs. NOD2 deficiency increased ER stress-induced cell death and expression levels of apoptosis mediators (cleaved caspase-3, Bax, and Bak) in VSMCs in the presence of tunicamycin (TM), an ER stress inducer. In contrast, ER stress-induced cell death and expression levels of apoptosis mediators (cleaved caspase-3, Bax, and Bak) were decreased in NOD2-overexpressed VSMCs. We found that the $IRE-1{\alpha}-XBP1$ pathway, one of unfolded protein response branches, was decreased in NOD2-deficient VSMCs and reversed in NOD2-overexpressed VSMCs in the presence of TM. Furthermore, NOD2 deficiency reduced the expression of XBP1 target genes such as GRP78, PDI-1, and Herpud1, thus improving cell survival. Taken together, these data suggest that the induction of ER stress through NOD2 expression can protect against TM-induced cell death in VSMCs. These results may contribute to a new paradigm in vascular homeostasis.

• Biomolecules & Therapeutics
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• v.30 no.3
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• pp.265-273
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• 2022

Resistance to chemotherapeutic drugs is a significant problem in the treatment of colorectal cancer, resulting in low response rates and decreased survival. Recent studies have shown that shikonin, a naphthoquinone derivative, promotes apoptosis in colon cancer cells and cisplatin-resistant ovarian cells, raising the possibility that this compound may be effective in drug-resistant colorectal cancer. The aim of this study was to characterize the molecular mechanisms underpinning shikonin-induced apoptosis, with a focus on endoplasmic reticulum (ER) stress, in a 5-fluorouracil-resistant colorectal cancer cell line, SNU-C5/5-FUR. Our results showed that shikonin significantly increased the proportion of sub-G₁ cells and DNA fragmentation and that shikonin-induced apoptosis is mediated by mitochondrial Ca²⁺ accumulation. Shikonin treatment also increased the expression of ER-related proteins, such as glucose regulatory protein 78 (GRP78), phospho-protein kinase RNA-like ER kinase (PERK), phospho-eukaryotic initiation factor 2 (eIF2α), phospho-phosphoinositol-requiring protein-1 (IRE1), spliced X-box-binding protein-1 (XBP-1), cleaved caspase-12, and C/EBP-homologous protein (CHOP). In addition, siRNA-mediated knockdown of CHOP attenuated shikonin-induced apoptosis, as did the ER stress inhibitor TUDCA. These data suggest that ER stress is a key factor mediating the cytotoxic effect of shikonin in SNU-C5/5-FUR cells. Our findings provide an evidence for a mechanism in which ER stress leads to apoptosis in shikonin-treated SNU-C5/5-FUR cells. Our study provides evidence to support further investigations on shikonin as a therapeutic option for 5-fluorouracil-resistant colorectal cancer.

• Korean Journal of Applied Biomechanics
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• v.18 no.4
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• pp.191-199
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• 2008

The purpose of this study was to analyze movement of inline skate players at inline roller skate T300m start so that we can find effective starting movement, and provide basic and scientific materials in improving performance of inline roller skaters for T300m inline roller skating. In doing so, five Korean national representative inline skaters who elected in 2008 Korean National Inline Roller Skating Cup were taped during the cup and analyzed through 3D viewing in terms of their starting movement Conclusions of the analysis were as follows: First, the better the record of starting phase is the shorter average of contact time on track. Second, to improve starting speed, players raised their body just like running instead of lowering them when gliding. players could shorten their strike and moved faster in order to accelerate, and it was more effective to speed up when they quickly switched from running to gliding. Third, the five country-representative players speeded up by bending their knees to a greater degree in order to improve stability. And then the most effective way was believed to minimize track connection of skating at starting in each phase.

• Journal of Korean society of Dental Hygiene
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• v.13 no.1
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• pp.146-157
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• 2013

Objectives : The purpose of this paper is to analyze the effects of short-term oral health care on children at community care centers, in order to allow them to maintain good oral health. Methods : The SPSS (Statistical Package for Social Science), Window Version 18.0 was used to analyze the data for the children's present conditions of oral health; their ability to maintain good oral health; their general knowledge about oral health; changes in their oral health awareness; habit formations concerning oral health; and the satisfaction level of oral health education. Results : 1. While the average number of teeth before the program is 19.84(6.19), that of teeth after the program is 21.33(6.10). 2. Average test scores on oral health information of post-program are improved more than those of pre-program. 3. The 8th measurement of O'Leary plaque index is 3.27, which shows significant changes. 4. Satisfaction level with the program is 4.75(0.45), which shows that children are satisfied with the program. Conclusions : The paper shows that in order to maintain the oral health of children at community care centers, their habit formation and practice for the oral health is important. It also shows that cooperation among communities and public health centers is important to develop various oral health education programs like the program.