• 한국군사과학기술학회지
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• 제13권2호
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• pp.304-312
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• 2010

The function of IRCM(Infrared Countermeasures) jamming is to cause the missile to miss its intended target by disturbing the seeker tracking process. This paper analyzes the jamming effect of IRCM jamming for a stationary reticle seeker. The phase error containing the azimuth angle information of target is analyzed for the intensity, frequency and duty ratio variation of the jammer pulse signal. We confirmed that the more the jammer frequency is similar to the spinning frequency of the stationary seeker, the more jamming effect is high.

• IMMUNE NETWORK
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• 제20권5호
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• pp.36.1-36.13
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• 2020

Hippo signaling pathways are evolutionarily conserved signal transduction mechanisms mainly involved in organ size control, tissue regeneration, and tumor suppression. However, in mammals, the primary role of Hippo signaling seems to be regulation of immunity. As such, humans with null mutations in STK4 (mammalian homologue of Drosophila Hippo; also known as MST1) suffer from recurrent infections and autoimmune symptoms. Although dysregulated T cell homeostasis and functions have been identified in MST1-deficient human patients and mouse models, detailed cellular and molecular bases of the immune dysfunction remain to be elucidated. Although the canonical Hippo signaling pathway involves transcriptional co-activator Yes-associated protein (YAP) or transcriptional coactivator with PDZ motif (TAZ), the major Hippo downstream signaling pathways in T cells are YAP/TAZ-independent and they widely differ between T cell subsets. Here we will review Hippo signaling mechanisms in T cell immunity and describe their implications for immune defects found in MST1-deficient patients and animals. Further, we propose that mutual inhibition of Mst and Akt kinases and their opposing roles on the stability and function of forkhead box O and β-catenin may explain various immune defects discovered in mutant mice lacking Hippo signaling components. Understanding these diverse Hippo signaling pathways and their interplay with other evolutionarily-conserved signaling components in T cells may uncover molecular targets relevant to vaccination, autoimmune diseases, and cancer immunotherapies.

• IMMUNE NETWORK
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• 제14권6호
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• pp.265-276
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• 2014

The interactions between B7 molecules and CD28-family receptors are crucial in the regulation of adaptive cellular immunity. In cancer, the aberrant expression of co-inhibitory B7 molecules has been attributed to reduced anti-tumor immunity and cancer immune evasion, prompting the development of cancer therapeutics that can restore T cell function. Murine tumor models have provided significant support for the targeting of multiple immune checkpoints involving CTLA-4, PD-1, ICOS, B7-H3 and B7-H4 during tumor growth, and clinical studies investigating the therapeutic effects of CTLA-4 and PD-1 blockade have shown exceptionally promising results in patients with advanced melanoma and other cancers. The expression pattern of co-inhibitory B7 ligands in the tumor microenvironment has also been largely correlated with poor patient prognosis, and recent evidence suggests that the presence of several B7 molecules may predict the responsiveness of immunotherapies that rely on pre-existing tumor-associated immune responses. While monotherapies blocking T cell co-inhibition have beneficial effects in reducing tumor burden, combinatorial immunotherapy targeting multiple immune checkpoints involved in various stages of the anti-tumor response has led to the most substantial impact on tumor reduction. In this review, we will examine the contributions of B7- and CD28-family members in the context of cancer development, and discuss the implications of current human findings in cancer immunotherapy.

• 경영과정보연구
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• 제36권2호
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• pp.187-206
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• 2017

본 연구는 관계 통제방안인 신중한 파트너 선택과 상세한 계약 체결이 실행 과정에서 조직간 위험을 어떻게 감소시키는지를 실증적으로 규명하였다. 실증분석 결과, 신중한 파트너 선택이 조직간 협력과 조직간 정보교류에 유의한 양의 영향을 미치는 것으로 나타났다. 그러나 상세한 계약 체결은 영향을 미치지 않는 것으로 밝혀졌다. 관계 및 성과 위험에 대한 신중한 파트너 선택, 상세한 계약 체결, 조직간 협력과 정보교류가 미치는 영향 분석에서는 조직간 협력이 두 가지 위험 모두에 음의 영향을 미치며, 신중한 파트너 선택은 성과 위험에만 유의적인 음의 영향을 미치는 것으로 나타났다. 신중한 파트너 선택의 성과 위험에 대한 음의 영향은 다음과 같은 의미를 시사한다. 신중한 파트너 선택은 실행 과정에서 지적 자산을 갖춘 능력 있는 공급 기업을 선정하게 되며, 이러한 공급기업의 능력 자체가 성과 달성에 도움을 준다. 그리고 능력 있는 공급 기업과의 인적 접촉과 상호작용 등은 지식 공유와 학습을 상호간에 유발하며, 이를 통해 목표달성을 위한 다양한 방안들이나 책략이 고안, 개발되어 성과 획득에 도움을 줄 수도 있다. 상세한 계약 체결의 조직간 협력을 통한 성과 위험에 대한 간접 영향은 다음을 의미한다. 계약에 명시됨으로써 달성할 목표가 명확해지고 이는 관련 기업들 간의 공동 달성 노력, 즉, 협력을 촉진하게 된다. 그리고 이러한 공동 달성 노력이 상대방 기업의 성과 미달성 가능성을 낮추어준다는 것이다. 공급망 성과에 대한 조직간 위험의 영향 분석에서는 성과 위험이 유의한 음의 영향을 미치는 것으로 나타났다. 관계 위험의 음의 영향은 유의적이지 않았다.

• 한국시뮬레이션학회논문지
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• 제28권2호
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• pp.139-147
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• 2019

적외선 에너지를 추적하는 휴대용대공유도탄(MANPADS: Man Portable Air Defense System)은 개인이 휴대할 수 있을 정도로 가벼우며 다양한 항공기에 대응할 수 있어, 전 세계적으로 널리 배치되어 항공기의 큰 위협이 되고 있다. 이러한 유도탄을 기만하여 아군 항공기와 전투원의 생명을 보호하는 적외선대응책(IRCM: Infrared Countermeasure)으로 섬광탄이 개발되었다. 그러나 기존 적외선대응책의 문제점을 보완할 수 있는 지향성적외선방해장비(DIRCM: Directional Infrared Countermeasure)가 최근 일부 선진국을 중심으로 개발되고 있으며, 그 필요성이 점차 증가하고 있다. 본 논문에서는 다양한 MANPADS 중 AM 변조 방식의 1세대 적외선탐색기, FM 변조 방식의 2세대 적외선탐색기, 펄스변조 방식의 3세대 적외선탐색기와 DIRCM에서 레이저빔이 조사될 때 탐색기에서 발생하는 산란광 현상을 모델링하였다. 이를 이용하여 MANPADS와 DIRCM을 장착한 항공기의 다양한 교전환경에서 기만 시뮬레이션을 수행하였고, 유도탄과 항공기의 최소거리인 Miss Distance를 분석하였다. 시뮬레이션 결과, 하나의 기만코드로 변조된 레이저빔을 조사하는 DIRCM이 교전거리 1km와 2km에서 1, 2, 3세대 MANPADS를 모두 기만하는 것을 시뮬레이션을 통하여 확인하였다. 특히 교전거리가 1km에서 2km로 늘어날 때 DIRCM을 장착한 항공기의 생존율도 증가하였고, 교전거리 2km에서는 생존율이 최소 99% 이상으로 분석되었다.

• 전기학회논문지
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• 제64권7호
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• pp.1031-1039
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• 2015

Present guided missiles are equipped with infrared seeker to find the infrared sources radiating from target plane and then chase, which results in an improvement of the hitting success rate when in striking target objects. To interrupt the chases from the guided missile, the target plane spreads the flare, avoiding the missile attracts. Our research is to develop a 2-color infrared identification technique to discern the flare and real thermal source from target plane. Considering flare radiation properties and EM atmosphere transmission rates, two channels were selected, in which main channel (MC) was in a range of 3.7 μm∼4.8 μm and auxiliary channel (AC) in 1.7 μm∼2.3 μm. A 2500K heat source was used for an artificial flare source, while a 570K heat source was utilized for airplane infrared source in experimental testing. Two infrared sensors detectable only at each chanel were employed in order to measure the voltage ratio from two channels, identifying the flare and real target plane via comparison the voltage ratio. Several experimental conditions were imported in order to prove that our proposed 2-color infrared identification technique is very efficient way to discern heat sources from aircraft and flare, demonstrating that our proposed technique is very promising means for our force’s InfraRed Counter Counter Measure (IRCCM) in order to countermeasure opposite force’s InfraRed Counter Measures (IRCM).

• Molecules and Cells
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• 제38권3호
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• pp.195-201
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• 2015

Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs. A subset of T cells termed T follicular helper cells (Tfh) play a central role in instructing B cells to form a repertoire of antibody producing cells that provide life-long supply of high affinity, pathogenspecific antibodies. Therefore, understanding how Tfh cells arise and how they facilitate B cell selection and differentiation during germinal center reaction is critical to improve vaccines and better treat autoimmune diseases. In this review, I will summarise recent findings on molecular and cellular mechanisms underlying Tfh generation and function with an emphasis on T cell costimulation.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2008년도 International Symposium on Remote Sensing
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• pp.247-250
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• 2008

The paper presents the advanced radiometric calibration method, called the lRCM (Iterative Radiometric Calibration Method), in order to avoid an operational constraint (solar source) for calibration. The IRCM assumes that an optical instrument is equipped with a filter assembly which consists of same band filters with different transmission ratios. Given all the noise sources (including the artificial one caused by the filters) of an image sensor, the noncentral ${\chi}^2$ distribution of the output result is induced by the approach of a noise PDF (Power Density Function). Finally, the radiometric calibration problem is transformed into equating two independent relations for the image sensor gains through the specified distribution.