• Journal of the Korea Institute of Military Science and Technology
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• v.13 no.2
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• pp.304-312
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• 2010

The function of IRCM(Infrared Countermeasures) jamming is to cause the missile to miss its intended target by disturbing the seeker tracking process. This paper analyzes the jamming effect of IRCM jamming for a stationary reticle seeker. The phase error containing the azimuth angle information of target is analyzed for the intensity, frequency and duty ratio variation of the jammer pulse signal. We confirmed that the more the jammer frequency is similar to the spinning frequency of the stationary seeker, the more jamming effect is high.

• IMMUNE NETWORK
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• v.20 no.5
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• pp.36.1-36.13
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• 2020

Hippo signaling pathways are evolutionarily conserved signal transduction mechanisms mainly involved in organ size control, tissue regeneration, and tumor suppression. However, in mammals, the primary role of Hippo signaling seems to be regulation of immunity. As such, humans with null mutations in STK4 (mammalian homologue of Drosophila Hippo; also known as MST1) suffer from recurrent infections and autoimmune symptoms. Although dysregulated T cell homeostasis and functions have been identified in MST1-deficient human patients and mouse models, detailed cellular and molecular bases of the immune dysfunction remain to be elucidated. Although the canonical Hippo signaling pathway involves transcriptional co-activator Yes-associated protein (YAP) or transcriptional coactivator with PDZ motif (TAZ), the major Hippo downstream signaling pathways in T cells are YAP/TAZ-independent and they widely differ between T cell subsets. Here we will review Hippo signaling mechanisms in T cell immunity and describe their implications for immune defects found in MST1-deficient patients and animals. Further, we propose that mutual inhibition of Mst and Akt kinases and their opposing roles on the stability and function of forkhead box O and β-catenin may explain various immune defects discovered in mutant mice lacking Hippo signaling components. Understanding these diverse Hippo signaling pathways and their interplay with other evolutionarily-conserved signaling components in T cells may uncover molecular targets relevant to vaccination, autoimmune diseases, and cancer immunotherapies.

• IMMUNE NETWORK
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• v.14 no.6
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• pp.265-276
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• 2014

The interactions between B7 molecules and CD28-family receptors are crucial in the regulation of adaptive cellular immunity. In cancer, the aberrant expression of co-inhibitory B7 molecules has been attributed to reduced anti-tumor immunity and cancer immune evasion, prompting the development of cancer therapeutics that can restore T cell function. Murine tumor models have provided significant support for the targeting of multiple immune checkpoints involving CTLA-4, PD-1, ICOS, B7-H3 and B7-H4 during tumor growth, and clinical studies investigating the therapeutic effects of CTLA-4 and PD-1 blockade have shown exceptionally promising results in patients with advanced melanoma and other cancers. The expression pattern of co-inhibitory B7 ligands in the tumor microenvironment has also been largely correlated with poor patient prognosis, and recent evidence suggests that the presence of several B7 molecules may predict the responsiveness of immunotherapies that rely on pre-existing tumor-associated immune responses. While monotherapies blocking T cell co-inhibition have beneficial effects in reducing tumor burden, combinatorial immunotherapy targeting multiple immune checkpoints involved in various stages of the anti-tumor response has led to the most substantial impact on tumor reduction. In this review, we will examine the contributions of B7- and CD28-family members in the context of cancer development, and discuss the implications of current human findings in cancer immunotherapy.

• Management & Information Systems Review
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• v.36 no.2
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• pp.187-206
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• 2017

This study empirically investigated the direct and indirect effects of inter-organizational relationships control mechanisms (IRCM; prudent partner selection and complex contract) on the decrease of inter-organizational risks (i.e., relational risk and performance risk). The empirical results showed that prudent partner selection has a positive impact on the degrees of inter-organizational cooperation and the levels of inter-organizational information flow. The effects of complex contract on the inter-organizational cooperation and information flow were not significant. In the results of the decrease of inter-organizational risks, it was observed that inter-organizational cooperation has significant positive effects on the decrease of both relational risk and performance risk. It was found that partner selection only influences the decrease of performance risk. The impact of inter-organizational information flow on the decrease of inter-organizational risks was not statistically significant. The indirect effects of IRCM on the decrease of performance risk through inter-organizational cooperation were also empirically demonstrated. The significant impact of inter-organizational cooperation on the decrease of risks implies that high levels of collaborations among employees decrease the risk of opportunistic behavior as well as the possibility of low degrees of performance through cooperative efforts. According to the results of the effects of risks on supply-chain performance, only the impact of performance risk was negatively significant. This result points out that the low levels of performance cause delays in delivery and product launch, deterred production and delayed market response, and these deteriorated managerial activities necessarily decrease the degrees of supply-chain performance.

• Journal of the Korea Society for Simulation
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• v.28 no.2
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• pp.139-147
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• 2019

A MANPADS(Man Portable Air Defense System), which tracks infrared energy, is light enough for individuals to carry and can against to a variety of aircraft, making it widely deployed around the world, posing a major threat to aircraft. A flare has been developed as an IRCM(Infrared Countermeasures) that protects the life of friendly aircraft and combatants by deceiving such guided missiles. However, DIRCM, which can overcome the problems of existing IRCM, is being developed mainly in some developed countries, and the need for it has been increasing gradually. This paper modeled first generation IR seeker of AM modulation method, the second generation IR seeker of FM modulation method, and the third generation IR seeker of pulse modulation method among various MANPADS, and modeled the scattering light phenomenon in the seeker when laser beams are investigated in DIRCM. Using this, jamming simulations were performed in various engagement environments of the MANPADS and aircraft equipped with DIRCM, and the miss distance of the guided missiles and aircraft were analyzed. Simulation results show that DIRCM, which irradiates a modulated laser beam with one jamming code, deceives both first, second and third generation MANPADS at 1km and 2km of engagement distance. In particular, the survival rate of aircraft equipped with DIRCM increased when the distance of engagement increased from 1km to 2km, and the survival rate was at least 99% at 2km of engagement distance.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.7
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• pp.1031-1039
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• 2015

Present guided missiles are equipped with infrared seeker to find the infrared sources radiating from target plane and then chase, which results in an improvement of the hitting success rate when in striking target objects. To interrupt the chases from the guided missile, the target plane spreads the flare, avoiding the missile attracts. Our research is to develop a 2-color infrared identification technique to discern the flare and real thermal source from target plane. Considering flare radiation properties and EM atmosphere transmission rates, two channels were selected, in which main channel (MC) was in a range of 3.7 μm∼4.8 μm and auxiliary channel (AC) in 1.7 μm∼2.3 μm. A 2500K heat source was used for an artificial flare source, while a 570K heat source was utilized for airplane infrared source in experimental testing. Two infrared sensors detectable only at each chanel were employed in order to measure the voltage ratio from two channels, identifying the flare and real target plane via comparison the voltage ratio. Several experimental conditions were imported in order to prove that our proposed 2-color infrared identification technique is very efficient way to discern heat sources from aircraft and flare, demonstrating that our proposed technique is very promising means for our force’s InfraRed Counter Counter Measure (IRCCM) in order to countermeasure opposite force’s InfraRed Counter Measures (IRCM).

• Molecules and Cells
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• v.38 no.3
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• pp.195-201
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• 2015

Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs. A subset of T cells termed T follicular helper cells (Tfh) play a central role in instructing B cells to form a repertoire of antibody producing cells that provide life-long supply of high affinity, pathogenspecific antibodies. Therefore, understanding how Tfh cells arise and how they facilitate B cell selection and differentiation during germinal center reaction is critical to improve vaccines and better treat autoimmune diseases. In this review, I will summarise recent findings on molecular and cellular mechanisms underlying Tfh generation and function with an emphasis on T cell costimulation.

• Proceedings of the KSRS Conference
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• 2008.10a
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• pp.247-250
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• 2008

The paper presents the advanced radiometric calibration method, called the lRCM (Iterative Radiometric Calibration Method), in order to avoid an operational constraint (solar source) for calibration. The IRCM assumes that an optical instrument is equipped with a filter assembly which consists of same band filters with different transmission ratios. Given all the noise sources (including the artificial one caused by the filters) of an image sensor, the noncentral ${\chi}^2$ distribution of the output result is induced by the approach of a noise PDF (Power Density Function). Finally, the radiometric calibration problem is transformed into equating two independent relations for the image sensor gains through the specified distribution.