• Molecules and Cells
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• v.42 no.7
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• pp.530-545
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• 2019

Tumor cells can vary epigenetically during ionizing irradiation (IR) treatment. These epigenetic variegations can influence IR response and shape tumor aggressiveness. However, epigenetic disturbance of histones after IR, implicating in IR responsiveness, has been elusive. Here, we investigate whether altered histone modification after IR can influence radiation responsiveness. The oncogenic CXCL12 mRNA and protein were more highly expressed in residual cancer cells from a hepatoma heterotopic murine tumor microenvironment and coculture of human hepatoma Huh7 and normal IMR90 cells after radiation. H3K4 methylation was also enriched and H3K9 methylation was decreased at its promoter region. Accordingly, invasiveness and the subpopulation of aggressive $CD133^+/CD24^-$ cells increased after IR. Histone demethylase inhibitor IOX1 attenuated CXCL12 expression and the malignant subpopulation, suggesting that responses to IR can be partially mediated via histone modifications. Taken together, radiation-induced histone alterations at the CXCL12 promoter in hepatoma cells are linked to CXCL12 upregulation and increased aggressiveness in the tumor microenvironment.

• Current Optics and Photonics
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• v.2 no.3
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• pp.241-249
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• 2018

We report a midinfrared dual-field-of-view (FOV) optical system design for an airborne electro-optical targeting system. To achieve miniaturization and weight reduction of the system, it has a common aperture and fore-optics for three different spectral wavelength bands: an electro-optic (EO) band ($0.6{\sim}0.9{\mu}m$), a midinfrared (IR) band ($3.6{\sim}4.9{\mu}m$), and a designation laser wavelength ($1.064{\mu}m$). It is free to steer the line of sight by rotating the pitch and roll axes. Our design co-aligns the roll axis, and the line of sight therefore has a fixed entrance pupil position for all optical paths, unlike previously reported dual-FOV designs, which dispenses with image coregistration that is otherwise required. The fore-optics is essentially an achromatized, collimated beam reducer for all bands. Following the fore-optics, the bands are split into the dual-FOV IR path and the EO/laser path by a beam splitter. The subsequent dual-FOV IR path design consists of a zoom lens group and a relay lens group. The IR path with the fore-optics provides two stepwise FOVs ($1.50^{\circ}{\times}1.20^{\circ}$ to $5.40^{\circ}{\times}4.32^{\circ}$), due to the insertion of two Si lenses into the zoom lens group. The IR optical system is designed in such a way that the location and f-number (f/5.3) of the cold stop internally provided by the IR detector are maintained when changing the zoom. The design also satisfies several important performance requirements, including an on-axis modulation transfer function (MTF) that exceeds 10% at the Nyquist frequency of the IR detector pitch, with distortion of less than 2%.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.12 s.354
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• pp.9-15
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• 2006

In this paper, signal processing techniques for noncoherent impulse-radio-based UWB (IR-UWB) communication system are proposed to provide system implementation of low power consumption and low complexity. The proposed system adopts a simple modulation technique of OOK (on-oft-keying) and noncoherent signal detection based on signal amplitude. In particular, a technique of a novel high speed digital sampler using a stable, lower reference clock is developed to detect nano-second pulses and recover digital signals from the pulses. Also, a 32 bits Turyn code for data frame synchronization and a convolution code as FEC are applied, respectively. To verify the proposed signal processing techniques for low power, low complexity noncoherent IR-UWB system, the proposed signal processing technique is implemented in FPGA and then a short-range communication system for wireless transmission of high quality MP3 data is designed and tested.

• The Korean Journal of Nuclear Medicine Technology
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• v.16 no.1
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• pp.12-16
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• 2012

Purpose : In conventional PET image reconstruction, iterative reconstruction methods such as OSEM (Ordered Subsets Expectation Maximization) have now generally replaced traditional analytic methods such as filtered back-projection. This includes improvements in components of the system model geometry, fully 3D scatter and low noise randoms estimates. SharpIR algorithm is to improve PET image contrast to noise by incorporating information about the PET detector response into the 3D iterative reconstruction algorithm. The aim of this study is evaluation of SharpIR reconstruction method in PET/CT. Materials and Methods: For the measurement of detector response for the spatial resolution, a capillary tube was filled with FDG and scanned at varying distances from the iso-center (5, 10, 15, 20 cm). To measure image quality for contrast recovery, the NEMA IEC body phantom (Data Spectrum Corporation, Hillsborough, NC) with diameters of 1, 13, 17 and 22 for simulating hot and 28 and 37 mm for simulating cold lesions. A solution of 5.4 kBq/mL of $^{18}F$-FDG in water was used as a radioactive background obtaining a lesion of background ratio of 4.0. Images were reconstructed with VUE point HD and VUE point HD using SharpIR reconstruction algorithm. For the clinical evaluation, a whole body FDG scan acquired and to demonstrate contrast recovery, ROIs were drawn on a metabolic hot spot and also on a uniform region of the liver. Images were reconstructed with function of varying iteration number (1~10). Results: The result of increases axial distance from iso-center, full width at half maximum (FWHM) is also increasing in VUE point HD reconstruction image. Even showed an increasing distances constant FWHM. VUE point HD with SharpIR than VUE point HD showed improves contrast recovery in phantom and clinical study. Conclusion: By incorporating more information about the detector system response, the SharpIR algorithm improves the accuracy of underlying model used in VUE point HD. SharpIR algorithm improve spatial resolution for a line source in air, and improves contrast recovery at equivalent noise levels in phantoms and clinical studies. Therefore, SharpIR algorithm can be applied as through a longitudinal study will be useful in clinical.

• Journal of Advanced Navigation Technology
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• v.13 no.4
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• pp.515-522
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• 2009

In this paper, we have investigated the technology of location-aware applicable for ubiquitous environment and considered IEEE 802.15.4a IR UWB of location-aware WPAN specification which is capable of both communication of 1Mbps and wireless localization. We analyzed both system structure and the characteristic of transmission pulse as comprising of the transmitter for wireless localization of IR UWB.

• Journal of the Korean Ceramic Society
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• v.33 no.8
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• pp.863-870
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• 1996

Fabricated modified PZT system for pyroelectric IR sensor were analyzed and characterized for dielectric piezoelectric and pyroelectric properties. Particle size and distribution of source powders were controlled by attrition milling process. 0.05PSS+yPT+(0.95-y)PZ+0.4 wt%MnO2 system was fabricated and investigated sintering density crystal structure and micro-structure through sintering conditions sintering temperature and sintering atmosphere. The poled sintered system of y=0.11 showed the lowest dielectric constant. The dielectric constants were increased with increasing y-mole ratio. The pyroelectric properties of modified PZT systems which were assembled to TO-5 package were measured by IR measurement system average out-voltage of 0.05PSS+0.1PT+0.84PZ+ wt%MnO2 was 3V.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.7
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• pp.652-659
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• 2011

A computational system to predict flowfield and infrared signature in aircraft exhaust system is developed. As the first step, a virtual mission profile is considered and an engine is selected through a performance analysis. Then a nozzle that meets the requirement of each mission is designed. The internal flow in the exhaustion nozzle at the maximum thrust is analyzed using a state-of-the-art CFD code. In addition, a system to combine information of the skin temperature distribution of the nozzle and after-body surface with an infrared prediction code is developed. Finally, qualitative results for the infrared signature reduction design are obtained by investigating the infrared signature level under various conditions.

• The Journal of the Convergence on Culture Technology
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• v.5 no.1
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• pp.395-399
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• 2019

In order to support various parallel computing systems, it is necessary to extend LLVM IR to more efficiently support vector / matrix and to design LLVM IR to machine code as a new algorithm. As shown in the IR example, RISC instruction generation is naturally generated because the RISC instruction is basically composed of the RISC instruction, and the vector instruction is also not supported. There is a need for new IR structures, command generation algorithms and related extensions to support vector / matrix more robustly. To do this, it is important to map each instruction in the LLVM IR to the appropriate instruction in the target architecture (vector / matrix) (instruction selection algorithm). It is necessary to understand the meaning of LLVM IR command, to compare the meaning of each instruction of the target architecture with syntax, and to select the instruction that matches the pattern to make mapping efficient.

• The Transactions of the Korea Information Processing Society
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• v.6 no.11S
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• pp.3410-3419
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• 1999

Autonomous Intrusion Analysis Agent(AIAA) is Incident Response Team staff's tool that scans, analyses, reports and alerts the traces of intrusion based on system logs and intruder's backdoors inside compromised system by IR staff after security incident is reported to the IR team. AIAA is intelligent to recognize to check out who is intruder from all the user accounts and to report the suspected candidates to the master control system in IR team. IR staff who controls AIAA with master system can pick up an intruder from the candidates reported by AIAA agent and review all related summary reports and details including source host's mane, finger information, all illegal behavior and so on. AIAA is moved to compromised system by the staff to investigate the signature of intrusion along the trace of victim hosts and it is also operated in secret mode to detect the further intrusion. AIAA is alive in all victim systems until the incident is closed and IR staff can control AIAA operation and dialogue with AIAA agent in Web interface.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.226-226
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• 2016

PHOLED devices which have the structure of ITO/HAT-CN(5nm)/NPB(50nm)/EML(30nm)/TPBi(10nm)/Alq3(20nm)/LiF(0.8nm)/Al(100nm) are fabricated to investigate the green emission profile in EML by using a gasket doping method. CBP and Ir(ppy)3 (2% wt) are co-deposited homogeneously as a background material of EML for green PHOLED, then a 5nm thickness of additionally doped layer by Ir(btp)2 (8% wt) is formed as a profiler of the green emission. The total thickness of the EML is maintained at 30nm while the distance of the profiler from the HTL/EML interface side (x) is changed in 5nm steps from 0nm to 25nm. As shown in Fig. 1, the green (513nm) peak from Ir(ppy)3 is not observed when Ir(btp)2 is also doped homogeneously because Ir(ppy)3 works as an gasket dopant of the Ir(btp)2 :CBP system. Therefore, in this experment, Ir(btp)2 can be used as a profiler of the green emission in CBP:Ir(ppy)3 system. The emission spectra from the PHOLED devices with different x are shown in Fig. 2. In this gasket doping system, stronger red peak means more energy transfer from green to red dopant or higher exciton density by green dopant. To find the green emission profile, the external quantum efficiency (EQE) at 3mA/cm2 for red peaks are calculated. More green light emission at near EML/HBL interface than that of HTL/EML is observed (insert of Fig. 2). This means that the higher exciton density at near EML/HBL interface in homogeneously doped CBP with Ir(ppy)3. As shown in Fig. 3, excitons can be quenched easily to HTL(NPB) because the T1 level of HTL(2.5eV) is relatively lower than that of EML(2.6eV). On the other hand, the T1 level of HBL(2.7eV) is higher than that of EML.