• Tuberculosis and Respiratory Diseases
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• v.74 no.1
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• pp.1-6
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• 2013

The concept on idiopathic pulmonary fibrosis (IPF) pathogenesis has progressed from chronic inflammation to aberrant wounding healing and even more to the current paradigms of a multifactorial and heterogeneous disease process. Despite the growth of clinical trials for IPF, most of the results, including N-acetylcysteine combination, warfarin, and bosentan, were disappointing. On the other hand, there have been a number of important developments; the foremost is the licensing of pirfenidone in Europe and Asia. In this article, we briefly review the recent knowledge of pathogenesis of IPF. We also summarize the recent clinical trials regarding the management of IPF.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.01a
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• pp.313-316
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• 2021

사물 인터넷 시스템에서 서버와 클라이언트의 신뢰성 확보는 매우 중요하다. 대부분의 IoT 시스템에서 신뢰성 확보를 위해 인증서 기법이 사용되고 있다. 인증서 기법을 사용하는 IoT 시스템은 데이터(인증서,공개키) 탈취 및 분실 취약점이 있다. 이러한 취약점을 강화하기 위해 서버와 클라이언트는 서로 주고받는 데이터의 무결성과 신뢰성을 보장할 수 있는 환경이 구축되어야 한다. 본 논문에서는 이러한 취약점을 보완하기 위하여 IPFS와 블록체인을 결합한 인증 강화 기법을 제시한다. 제시한 기법의 기본 개념은 IPFS를 이용하여 CA와 서버의 인증서와 공개키를 분산 저장하고, IPFS에 저장한 인증서와 공개키의 Content-Address를 블록체인에 보관한다. 마지막으로 제시한 기법의 타당성을 검토하기 위하여 Mobius, nCube, Ethereum, IPFS를 결합한 IoT 시스템을 구축하고 SSL을 사용한 인증 과정을 실험한다.

• Tuberculosis and Respiratory Diseases
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• v.74 no.6
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• pp.264-268
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• 2013

Background: Idiopathic pulmonary fibrosis (IPF) is a lethal pulmonary fibrotic disease. In general, the exaggerated activation of the coagulation cascade has been observed during initiation or maintenance of the fibrotic disease. In our recent study, immunohistochemical expression of protease-activated receptor-2 (PAR-2), which plays a key role in coagulation cascade, was observed in surgical specimen of IPF patients, and associated with poor clinical outcome. The aim of this study was to evaluate the overexpression of PAR-2 in inflammatory cells from peripheral blood and bronchoalveolar lavage fluid in IPF patients. Methods: From May 2011 to March 2012, IPF patients and controls were enrolled in Seoul National University Hospital. Peripheral blood and bronchoalveolar lavage fluid were collected for analysis of PAR-2 expression. Flow cytometry and reverse transcription polymerase chain reaction were used for PAR-2 receptor and mRNA assessment. Results: Twelve IPF patients and 14 controls were included in this study. Among them, flow cytometry analysis was conducted from 26 peripheral blood (patient group, 11; control group, 13) and 7 bronchoalveolar lavage fluid (patient group, 5; control group, 2). The expression of PAR-2 receptor was not different between patient and control groups (p=0.074). Among all 24 population, PAR-2 mRNA assessment was performed in 19 persons (patient group, 10; control group, 9). The mRNA expression of PAR-2 was not significant different (p=0.633). Conclusion: In IPF patients, PAR-2 receptor and mRNA expression were not different from control group.

• Molecules and Cells
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• v.41 no.3
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• pp.224-233
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• 2018

Primary cilia are solitary, non-motile, axonemal microtubule-based antenna-like organelles that project from the plasma membrane of most mammalian cells and are implicated in transducing hedgehog signals during development. It was recently proposed that aberrant SHH signaling may be implicated in the progression of idiopathic pulmonary fibrosis (IPF). However, the distribution and role of primary cilia in IPF remains unclear. Here, we clearly observed the primary cilia in alveolar epithelial cells, fibroblasts, and endothelial cells of human normal lung tissue. Then, we investigated the distribution of primary cilia in human IPF tissue samples using immunofluorescence. Tissues from six IPF cases showed an increase in the number of primary cilia in alveolar cells and fibroblasts. In addition, we observed an increase in ciliogenesis related genes such as IFT20 and IFT88 in IPF. Since major components of the SHH signaling pathway are known to be localized in primary cilia, we quantified the mRNA expression of the SHH signaling components using qRT-PCR in both IPF and control lung. mRNA levels of SHH, the coreceptor SMO, and the transcription factors GLI1 and GLI2 were upregulated in IPF compared with control. Furthermore, the nuclear localization of GLI1 was observed mainly in alveolar epithelia and fibroblasts. In addition, we showed that defective KIF3A-mediated ciliary loss in human type II alveolar epithelial cell lines leads to disruption of SHH signaling. These results indicate that a significant increase in the number of primary cilia in IPF contributes to the upregulation of SHH signals.

• Tuberculosis and Respiratory Diseases
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• v.66 no.2
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• pp.141-151
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• 2009

Background: There is limited data on the epidemiology and relative frequency of idiopathic interstitial pneumonia (IIP) worldwide. This survey was performed to assess the epidemiology and relative frequency of IIP in Korea. Methods: The patients with IIP and who were confirmed by lung biopsy, except those patients with idiopathic pulmonary fibrosis, (IPF) over a 5 year period (from Jan. $1^{st}$, 2003 to Dec. $31^{st}$, 2007) were registered by a web-base questionnaire. Results: A total of 3,156 cases were registered, but 970 cases were excluded due to duplicative registration, inadequate data and the unmet ATS/ERS diagnostic criteria. A total of 2,186 cases were analyzed. The male to female ratio was about 2 : 1 and their mean age was 65 (range: 11-94). The most frequent disease was IPF (77.1%), followed in decreasing order by nonspecific interstitial pneumonia (NSIP) (11.9%), cryptogenic organizing pneumonia (COP) (8.5%), acute interstitial pneumonia (AIP) (1.1%), desquamative interstitial pneumonia (DIP) (0.9%), respiratory bronchiolitis-interstitial lung disease (RB-ILD) (0.4%) and lymphocytic interstitial pneumonia (LIP) (0.1%). The mean age of the patients with IPF, NSIP and COP was 67.8, 57.1 and 57.7 years old, respectively. The most frequent symptom was dyspnea on exertion (69%) followed by coughing (61%) and sputum (33%) for the whole population. The three year survival rate was 62% for the patients with IPF and the five year survival rate was 85% in both the NSIP and COP patients. Conclusion: This survey provides helpful information for the management of IIP and to produce management guidelines for this illness in Korea.

• The Korean journal of internal medicine
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• v.39 no.2
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• pp.295-305
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• 2024

Background/Aims: The prognosis of patients with idiopathic pulmonary fibrosis (IPF) and respiratory failure requiring mechanical ventilation is poor. Therefore, mechanical ventilation is not recommended. Recently, outcomes of mechanical ventilation, including those for patients with IPF, have improved. The aim of this study was to investigate changes in the use of mechanical ventilation in patients with IPF and their outcomes over time. Methods: This retrospective, observational cohort study used data from the National Health Insurance Service database. Patients diagnosed with IPF between January 2011 and December 2019 who were placed on mechanical ventilation were included. We analyzed changes in the use of mechanical ventilation in patients with IPF and their mortality using the Cochran-Armitage trend test. Results: Between 2011 and 2019, 1,227 patients with IPF were placed on mechanical ventilation. The annual number of patients with IPF with and without mechanical ventilation increased over time. However, the ratio was relatively stable at approximately 3.5%. The overall hospital mortality rate was 69.4%. There was no improvement in annual hospital mortality rate. The overall 30-day mortality rate was 68.7%, which did not change significantly. The overall 90-day mortality rate was 85.3%. The annual 90-day mortality rate was decreased from 90.9% in 2011 to 83.1% in 2019 (p = 0.028). Conclusions: Despite improvements in intensive care and ventilator management, the prognosis of patients with IPF receiving mechanical ventilation has not improved significantly.

• Journal of KIISE:Databases
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• v.30 no.6
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• pp.593-605
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• 2003

Since spatial join processing consumes much time, several algorithms have been proposed to improve spatial join performance. The M-way R-tree join (MRJ) is a join algorithm which synchronously traverses M R-trees in the M-way spatial join. In this paper, we introduce indirect predicates which do not directly come from the multi-way join conditions but are indirectly derived from them. By applying the concept of indirect predicates to MRJ, we improve the performance of MRJ. We call such a multi-way R-tree join algorithm using indirect predicates indirect predicate filtering (IPF). Through experiments using synthetic data and real data, we show that IPF significantly

• Journal of Communications and Networks
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• v.7 no.3
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• pp.367-376
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• 2005

The smooth handoff supported by the route optimization extension to the mobile IP standard protocol should support a packet buffering mechanism at the base station (BS), in order to reduce the degradation in TCP performance caused by packet losses within mobile network environments. The purpose of packet buffering at the BS is to recover the packets dropped during intersubnetwork handoff by forwarding the packets buffered at the previous BS to the new BS. However, when the mobile host moves to a congested BS within a new foreign subnetwork, the buffered packets forwarded by the previous BS are likely to be dropped. This subsequently causes global synchronization to occur, resulting in the degradation of the wireless link in the congested BS, due to the increased congestion caused by the forwarded burst packets. Thus, in this paper, we propose an implicit priority forwarding (IPF) packet buffering scheme as a solution to this problem within mobile IP based networks. In the proposed IPF method, the previous BS implicitly marks the priority packets being used for inter-subnetwork handoff. Moreover, the proposed modified random early detection (M-RED) buffer at the new congested BS guarantees some degree of reliability to the priority packets. The simulation results show that the proposed IPF packet buffering scheme increases the wireless link utilization and, thus, it enhances the TCP throughput performance in the context of various intersubnetwork handoff cases.

• Molecules and Cells
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• v.37 no.2
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• pp.133-139
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• 2014

Idiopathic pulmonary fibrosis (IPF) is the most common and severe type of idiopathic interstitial pneumonias (IIP), and which is currently no method was developed to restore normal structure and function. There are several reports on therapeutic effects of adult stem cell transplantations in animal models of pulmonary fibrosis. However, little is known about how mesenchymal stem cell (MSC) can repair the IPF. In this study, we try to provide the evidence to show that transplanted mesenchymal stem cells directly replace fibrosis with normal lung cells using IPF model mice. As results, transplanted MSC successfully integrated and differentiated into type II lung cell which express surfactant protein. In the other hand, we examine the therapeutic effects of microvesicle treatment, which were released from mesenchymal stem cells. Though the therapeutic effects of MV treatment is less than that of MSC treatment, MV treat-ment meaningfully reduced the symptom of IPF, such as collagen deposition and inflammation. These data suggest that stem cell transplantation may be an effective strategy for the treatment of pulmonary fibrosis via replacement and cytoprotective effect of microvesicle released from MSCs.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.16 no.11
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• pp.1028-1034
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• 2004

Recently, the ice storage system using ice slurry has been used increasingly since it has been introduced where the rapid cooling load change is required. Because it overcomes a decrease of the melting performance and an increase of the thermal resistance on the ice layer in static ice thermal storage system. This study is performed to understand the effects of transporting ice slurry through horizontal, vertical and inclined tubes ($30^{\circ},\;45^{\circ}$). It used propylene glycol-water solution and ice particles (diameter of about 2 mm) in this experiment. The experiments were carried out under various conditions, with concentration of water solution ranging from 0 to $20wt\%$, and velocity of water solution at the entry ranging from 1.5 to 2.5 m/s. The results were as follows: Regarding the angle of inclined tube, the highest pressure loss was measured for vertical tube and the pressure loss for $45^{\circ},\;30^{\circ}$, horizontal straight tubes were lower successively. The lowest pressure loss in these tubes was measured at velocity of $2.0{\sim}2.5m/s$ and concentration of $10wt\%$. The outlet IPF was likewise stable in these ranges.