• Toxicological Research
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• v.24 no.1
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• pp.51-58
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• 2008

The present study was designed to explore the immunotoxic effects of orally administered aluminum (AI) on pregnant rats (n = 60) and their growing fetuses and consequently on the animal wealth. The animals were randomly allocated into three equal groups of 20 rats each. The first group has no treatment and kept as a control (G1). The second and third groups of pregnant rats were treated orally with aluminum chloride at 345 mg/Kg b.wt. The second group (G2) received the tested compound from the $6^{th}$ day of gestation to the end of weaning, whereas the third group (G3) received the tested compound from the $15^{th}$h day of gestation to the end of weaning. Control and treated animals (dams and offspring) were immunized ip with (0.5 ml) 20% sheep red blood cell (SRBC) suspension seven days before the end of experiments. At the end of exposure, ten dams and ten offspring from each group were used for assessment of cell-mediated immunity and a similar number of animals were sacrificed for evaluating the humoral immune response and serum protein profile. Aluminum chloride exposure of dams ($G_2&G_3$) caused significant suppression of both cell mediated and humoral immune responses in the obtained offsprings compared to the control group ($G_1$) without any significant effect on the immune responses of these dams. Moreover, the serum total globulins, albumin/ globulin (A/G) ratio and gamma globulin fraction were significantly decreased in the treated dam's offsprings compared to the corresponding controls while the serum total protein and all serum protein fractions showed non significant difference between the control and treated dams and between the two treated dam groups themselves. There were no histopathological changes observed in thymus, spleen and liver of the control and treated dams. Thymus of treated dam's offsprings (G2) showed lymphoid depletion in both cortex and medulla. Their spleens showed lymphoid depletion in the white pulps and congestion with hemosiderosis in the red pulps. Liver of treated dam's offsprings showed dilation and congestion of its central vein with degenerative changes in the hepatocytes. These histopathological changes were more severe in G2 than in G3 offsprings. It can be concluded that gestational and/ or lactation exposure of pregnant dams to AI chloride caused suppression of both cellular and humoral immune responses of their offsprings.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.3
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• pp.598-607
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• 1992

The environment degradation of structural steel under high temperature is one of the key phenomena governing the availability and life of plant. This degradation resulted from the microstructural changes due to the long exposure at high temperature affect the mechanical properties such as creep strength and toughness. For instance, boiler tube materials usually tend to degrade, after long term operation, by precipitates, spherodizing, coarsening, and change in chemical composition of carbides. In this study, the material degradation under high temperature exposure was investigated by evaluating the carbide precipitation. The electrochemical polarization method was facilitated to investigate the precipitation and coarsening of carbides. It was shown by the modified electrochemical potentiokinetic reactivation (EPR) tests that the passivation of Mo-rich carbides did not occur even in the anodic peak current (Ip) which indicates the precipitation of Mo$_{6}$C was also observed. And it was assured that special electrolytic cell assembled in this research can be used for the detection of Mo$_{6}$C precipitation in the field.eld.

• Journal of IKEEE
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• v.23 no.4
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• pp.1461-1464
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• 2019

In this paper, we propose the development of embedded board for integrated radiation exposure protection fireman's life-saving alarm capable of location tracking and radiation measurement. The proposed techniques consist of signal processing unit, communication unit, power unit, main control unit. Signal processing units apply shielding design, noise reduction technology and electromagnetic wave subtraction technology. The communication unit is designed to communicate using the wifi method. In the main control unit, power consumption is reduced to a minimum, and a high performance system is formed through small, high density and low heat generation. The proposed techniques are equipment operated by exposure to poor conditions, such as disaster and fire sites, so they are designed and manufactured for external appearance considering waterproof and thermal endurance. The proposed techniques were tested by an authorized testing agency to determine the effectiveness of embedded board. The waterproof grade has achieved the IP67 rating, which can maintain stable performance even when flooded with water at the disaster site due to the nature of the fireman's equipment. The operating temperature was measured in the range of -10℃ to 50℃ to cope with a wide range of environmental changes at the disaster site. The battery life was measured to be available 144 hours after a single charge to cope with emergency disasters such as a collapse accident. The maximum communication distance, including the PCB, was measured to operate at 54.2 meters, a range wider than the existing 50 meters, at a straight line with the command-and-control vehicle in the event of a disaster. Therefore, the effectiveness of embedded board for embedded board for integrated radiation exposure protection fireman's life-saving alarm has been demonstrated.

• Journal of Korea Multimedia Society
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• v.19 no.1
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• pp.51-59
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• 2016

Physical security protecting people from physical threats, such as a person or vehicle, has received a great attention. However, it has many risks of hacking and other security threats because it is highly dependent on automated management systems. In addition, a representative system of physical security, a CCTV control system has a high risk of hacking, such as video interceptions or video modulation. So physical security needs urgent security measures in accordance with these threats. In this paper, we examine the case of security threats that have occurred in the past, prevent those from threatening the physical security, and analyze the security problem with the threats. Then we study the countermeasures to prevent these security threats based on the problems found in each case. Finally we study for the method to apply these countermeasures.

• Toxicological Research
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• v.12 no.2
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• pp.231-236
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• 1996

The toxicity of the mixture of diazinon, toxaphene(TOX) and/or endrin was studied in ICR male mice(18-22 g) by oral intubation, in corn oil, daily for up to 14 days. On day 15, the exposure was discontinued and animals were monitored for an additional period of 7 days for the possible reversibility of the toxicity. The body weight gain decreased with the mixtures, as well as with the individual pesticides, during the 14-day period. TOX and TOX containing mixtures significantly increased the liver/body weight ratio. The serum glutamic pyruvic transaminase level increased at 23~374% in diazinon, TOX, and endrin or their mixture group. The cholinesterase(ChE) activity in the serum and brain was inhibited in the animals of the group of diazinon(5, 10 mg/kg) and diazinon(5 mg/kg) containing mixtures. TOX(40, 80 mg/kg) caused initial inhibitory effects on the serum ChE Day 1. but there is little effects on the brain ChE levels. endrin(5,10 mg/kg) results in significantly elevated levels of the serum ChE, with substantial decreases in the brain ChE activity. TOX and TOX containing mixtures decreased the pentobarbital(60 mg /kg, ip., in saline) induced sleep. The effects produced by this pesticides singly, as well as by their mixtures, appeared to be reversible in nature. The toxic effects exhibited by the mixtures of diazinon(5 mf/kg), TOX(40 mg/kg), and /or endrin(5 mg/kg) were found to be the resultant of the effect showed by their components individually.

• Journal of KIISE:Information Networking
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• v.34 no.1
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• pp.62-72
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• 2007

Mobile Virtual Private Network (MVPN) provides VPN services without geographical restriction to mobile workers using mobile devices. Coexistence of Mobile IP (MIP) protocol for mobility and IPsec-based VPN technology are necessary in order to provide continuous VPN service to mobile users. However, Problems like registration failure or frequent IPsec tunnel re-negotiation occur when IPsec-based VPN Gateway (GW) and MIP are used together. In order to solve these problems, IETF proposes a mechanism which uses external home agent (x-HA) located external to the corporate VPN GW. In addition, based on the IETF proposal, a mechanism that assigns x-HA dynamically in the networks where MN is currently located was also proposed with the purpose to reduce handover latency as well as end-to-end delay. However, this mechanism has problems such as exposure of a session key for dynamic Mobility Security Association (MSA) or a long latency in case of the handover between different networks. In this paper, we propose a new MVPN protocol in order to minimize handover latency, enhance the security in key exchange, and to reduce data losses cause by handover. Through a course of simulation, the performance of proposed protocol is compared with the existing mechanism.

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.1
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• pp.27-34
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• 1997

In the present study, it was aimed to further indentify the intracellular action mechansm of cromakalim and levcromakalim in the porcine coronary artery. In intact porcine coronary arterial strips loaded with fura-2/AM, acetylcholine caused an increase in intracellular free $Ca^{2+}$ $([Ca^{2+}]_i)$ in association with a contraction in a concentration-dependent manner. Cromakalim (1 ${\mu}M$) caused a reduction in acetylcholine-induced increased $[Ca^{2+}]_i$ not only in the mormal physiological salt solution (PSS) but also in $Ca^{2+}$-free PSS (containing 1 mM EGTA). In the skinned strips prepared by exposure of tissue to 20 .${\mu}M$ B-escin, inositol 1,4,5-trisphosphate ($IP_3$) evoked an increase in $[Ca^{2+}]_i$, but it was without effect on the intact strips. The $IP_3$-induced increase in $[Ca^{2+}]_i$ was inhibited by cromakalim by 78% and levcromakalim by 59% (1 .${\mu}M$, each). Pretreatment with glibenclamide (a blocker of ATP-sensitive $K^+$ channels, 10 .${\mu}M$) and apamin (a blocker of small conductance $Ca^{2+}$-activated $K^+$ channels, 1 .${\mu}M$) strongly blocked the effect of cromakalim and levcromakalim. However, charybdotoxin (a blocker of large conductance $Ca^{2+}$-activated $K^+$ channels, 1 .${\mu}M$) was without effect. In addition, cromakalim inhibited the $GTP{\gamma}S$ (100 .${\mu}M$, non-hydrolysable analogue of GTP)-induced increase in $[Ca^{2+}]_i$. Based on these results, it is suggested that cromakalim and levcromakalim exert a potent vasorelaxation, in part, by acting on the $K^+$ channels of the intracellular sites (e.g., sarcoplasmic reticulum membrane), thereby, resulting in decrease in release of $Ca^{2+}$ from the intracellular storage site.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2565-2570
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• 2014

H19 is an imprinted oncofetal gene, and loss of imprinting at the H19 locus results in over-expression of H19 in cancers. Aflatoxin B1(AFB1) is regarded as one of the most dangerous carcinogens. Exposure to AFB1 would most easily increase susceptibility to diseases such as hepatocellular carcinoma(HCC) but any possible relationship between AFB1 and H19 is not clear. In present study, we found that AFB1 could up-regulate the expression of H19 and promote cell growth and invasion by hepatocellular carcinoma HepG2 cells. Knocking down H19 RNA co ld reverse the effects of AFB1 on cell growth and invasion. In addition, AFB1 induced the expression of E2F1 and its knock-down could down-regulate H19 expression and suppress cell growth and invasion in hepatocellular carcinoma HepG2 cells. Furthermore, E2F1 over-expression could up-regulate H19 expression and promote cell growth and invasion, with binding to the H19 promoter being demonstrated by chromatin immunoprecipitation assays (ChIP). In summary, our results suggested that aflatoxin B1could promote cell growth and invasion in hepatocellular carcinoma HepG2 cells through actions on H19 and E2F1.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.10C
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• pp.1011-1022
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• 2006

WSN(Wireless Sensor Network) performs to detect and collect environmental information for one purpose. The WSN is composed of a sink node and several sensor nodes and has a constraint in an aspect of energy consumption caused by limited battery resource. So many required mechanisms in WSN should consider the remaining energy condition. To deploy WSN, tile collected information is required to protect from an adversary over the network in many cases. The security mechanism should be provided for collecting the information over the network. we propose asynchronized key management considering energy efficiency over WSN. The proposed key management is focused on independence and difference of the keys used to deliver the information over several routes over the network, so disclosure of any key does not results in exposure of total key information over the overall WSN. Also, we use hash function to update key information for energy efficiency Periodically. We define the insecurity for requested security Properties and Proof that the security properties are guaranteed. Also, we evaluate and analyze the energy efficiency for the proposed mechanism.

• Journal of Conservation Science
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• v.37 no.3
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• pp.220-231
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• 2021

The use of digital copies of film-based analog images and the introduction of digital radiographic imaging systems using image plates gradually replace the non-destructive radiationirradiation method of Cultural Heritage. The quality of images obtained from this technique is affected by conditions such as tube voltage, tube current, and exposure time, type of image acquisition medium, distance of the artifacts from the image acquisition medium, and thickness of artifacts. In this study, we evaluated the grayscale image obtained using GE's Computed Radiograhpy (CR) imaging system, the transmission characteristics of the X-ray source for each tree type (pine, chestnut, sawtooth oak, ginkgo) used in wooden Cultural Heritage, and the signal-to-noise ratio (SNR) and contrast. The GE's CR imaging were analyzed using the Duplex wire image quality indicator, line-pair gauges.