• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.6
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• pp.123-154
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• 2002

Im Mittelpunkt der vorliegenden Arbeit steht die Untersuchung der Dynamik im System des deutschen Passivs mit dem $R\"{u}ckblick$ auf das Genuanische. Dabei steht es vorrangig im Zusammenhang mit der Grammatikalisierung der $Verbalf\"{u}gungen$ 'werden + PP' und 'sein + PP'. Und im heutigen deutschen Passivsystem ist zwar die $F\"{u}gung$ 'werden + PP' unmarkiert, aber im Genuanischen $\"{u}berwiegt\;die\;F\"{u}gung$ 'sein + PP'. Das Partizip der Kombination 'werden/sein + PP' wird im Gotischen $ausschlie{\ss}lich$ und im Althochdeutschen noch stellenweise flektiert. Hieraus darf geschlossen werden, dass im $Fr\"{u}hdeutschen$ das Verb finita und das Partizip als relativ $unabh\"{a}ngige$ Glieder einander $gegen\"{u}ber$ stehen und in einer Konstruktion verkettet werden, die einfach den Status der neuhochdeutschen periphrastischen Konstruktion aufweist. Die aspektuelle Bedeutung der $Passivf\"{u}gungen\;l\"{a}sst$ sich da als $bin\"{a}re$ Opposition von kategoriellen Merkmalen 'mutativ' (= Zustandswechel) und 'statal' (= Zustand), verteilt auf die F\"{u}gungen$ 'werden + PP' und 'sein + pp', beschreiben. Diese Merkmale kommt jeweils aus dem inchoativen bzw. durativen Verbalaspekt der Verba 'werden' bzw. 'sein' heraus. Diese Opposition unterscheidet sich von der neuhochdeutschen $Gegen\"{u}berstellung$ vom Vorgangspassiv und Zustandspassiv. Die Eigenbedeutung der Verben 'werden' und 'sein' $l\"{o}st$ sich nun, insbesondere im $Sp\"{a}talthochdeutschen$ in der Semantik der ganzen $F\"{u}gungen$ weitgehend auf, was seinerseits den Verlust der aspektualen Markiertheit der Passiv-Periphrasen mit den Verben finiten verursacht und ihre Entwicklung in Richtung auf die Paradigmatisierung der beiden $F\"{u}gungen\;erm\"{o}glicht$. Die weiter Entwicklung von $Passivf\"{u}gungen$ zeichnet sich durch eine zunehmende Expansion der $F\"{u}gung$ 'werden+PP' in die ursprungliche aspektuale $Sph\"{a}re$ der sein-Konstruktion aus. Dieser Prozess, der zur Auxilialisierung des Verbums finitum $f\"{u}hrt$, setzt schon im $Sp\"{a}talthochdeutschen$ ein und gelangt im Mittelhochdeutschen zur vollen $Auspr\"{a}gung$. Die Konkurrenz der beiden Passivkonstruktionen $f\"{u}hrt$ nun zur $allm\"{a}hlichen$ Verengung des aspektualen Bereichs der $F\"{u}gung$ '.sein+PP', $f\"{u}r$ die nun nur das Resultivum $\"{u}brig$ bleibt.

• The Korean Journal of Pesticide Science
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• v.6 no.1
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• pp.31-35
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• 2002

Objectives of this study were to determine if impurities in technical grade benfuracarb inhibit glutathione-S-transferase and amidase and to identify structures of impurities in technical grade benfuracarb. Technical grade benfuracarb, active ingredient, and impurity inhibited glutathione-S-transferase, and their $I_{50}$ were $9.7{\times}10^{-4}M,\;>1.0{\times}10^{-3}M,\;1.8{\times}10^{-4}M$, respectively. Such inhibition, however, was not higher than that by ethacrynic acid, a selective inhibitor to GST. Technical grade benfuracarb, active ingredient, and impurity also inhibited amidase, and their $I_{50}$ were $6.0{\times}10^{-5}M,\;4.3{\times}10^{-4}M,\;7.6{\times}10^{-5}M$, respectively. Our results show that the inhibition of both detoxifying enzymes by impurities in benfuracarb was 10-fold lower than that by active ingredient, suggesting that both active ingredient and impurities are involved in the inhibition of both detoxifying enzymes. Of four impurities (IM $1{\sim}4$) that were separated from technical grade benfuracarb, IM 2 and IM 3 inhibited GST and amidase. Based on data from IR, $^1H$-NMR, $^{13}C$-NMR and MS, it was determined that IM 2 is ethyl-N-isopropylamino propionate and IM 3 is ethyl-N-isopropyl-N(chlorosulfenyl)aminopropionate.

• Journal of the Korean Electrochemical Society
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• v.11 no.3
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• pp.176-183
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• 2008

Redox complexes to transport electrodes from bioreactors to electrodes are very important part in electrochemical biosensor industry. A novel osmium redox complexes were synthesized by the coordinating pyridine group having different functional group at 4-position with osmium metal. Newly synthesized osmium complexes are described as ${[Os(dme-bpy)}_2{(ap-im)Cl]}^{+/2+}$, ${[Os(dme-bpy)}_2{(ap-im)Cl]}^{+/2+}$, ${[Os(dmo-bpy)}_2{(ap-im)Cl]}^{+/2+}$, ${[Os(dcl-bpy)}_2{(ap-im)Cl]}^{+/2+}$. We have been studied the electrochemical characteristics of these osmium complex with electrochemical techniques such as cyclic voltammetry and chronoamperommetry. Osmium redox complexes were immobilized on the screen printed carbon electrode(SPE) with deposited gold nanoparticles. The electrical signal converts the osmium redox films into an electrocatalyst for glucose oxidation. Each catalytic currents were related with the potentials of osmium complexes.

• The Korean Journal of Food And Nutrition
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• v.17 no.2
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• pp.171-176
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• 2004

The purpose of this study was to examine physical properties of the bread flour added two different commercial sour dough powder. Addition of sour dough powder didn't show different water absorption, but reduce stability and increase breakdown on farinogram. Initial pasting temperatures of bread flour were increased by 0.7-1.3$^{\circ}C$ when sour dough powder was added. Peak viscosity were increased by 3-6 RVA with addition of Phil IM 1, but addition of Phil XN 290 didn't show much difference with unadded bread flour Hardness of bread added Phil XN 290 and Phil IM 1 were lower than control after 2 days of making bread, but after 4 days they showed rapid increment. Sensory test showed that addition of Phil XN 290 2％ and Phil IM 1％ had better general evaluation than the others.

• Journal of Korean Foot and Ankle Society
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• v.12 no.1
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• pp.80-85
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• 2008

Purpose: To evaluate and compare the outcome between interlocking IM nailing and LCP fixation in the treatment of distal metaphyseal tibial fracture. Materials and Methods: From January 2000 to December 2007, 17 patient were treated by interlocking IM nail and 13 patient were treated by LCP fixation for distal metaphyseal tibial fracture. Results: According to AO classification, there were 2 type A1 fracture (12%), 6 type A2 fracture (36%), 3 type A3 fracture (18%), 4 type B1 fracture (24%), 1 type B3 fracture (6%), 1 type C1 fracture (6%) in interlocking IM nailing group and 1 type A2 fracture (7.7%), 2 type A3 fracture (15.4%), 3 type B1 fracture (23%), 3 type B2 fracture (23%), 3 type C1 fracture (23%), 1 type C2 fracture (7.7%) in LCP fixation group. The clinical functional outcome (according to AOFAS score) is 75.6 point in IM nailing group and 81.5 point in LCP fixation group. In IM nailing group, 65% of patient showed satisfactory result and In LCP fixation group, 77% of patient showed satisfactory result. Conclusion: There is no difference on clinical results between IM nailing and MIPPO (minimal invasive percutaneous plate osteosynthesis) group in the treatment of distal tibia fracture. But MIPPO group have higher subjective satisfactory score and less complication rate. The weakness of our study is a small case number and limited follow-up and we believe a better designed prospective study will be needed.

• Journal of Society of Preventive Korean Medicine
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• v.16 no.1
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• pp.1-13
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• 2012

The objective of this study is to discuss the role of integrative medicine (IM) in contemporary health care settings, and how and which factors affect and facilitate the success of IM in terms of the integration of complementary and alternative medicine (CAM) and conventional medicine in primary health care (PHC). IM is meant to provide the best possible health care, for both patient and physician. The way of IM use in the developed countries presents various ways that IM can be provided, and it appears that strategies have been successfully developed to facilitate integration. Although few of the barriers to the integration of CAM and conventional medicine have been resolved, concerns over the legitimacy of CAM in health care (e.g., safety, biomedical evidence, and efficacy) are being overcome by the use of evidence-based practice in IM delivery. There are dominant models of IM that have been developed. The model types signify different levels of equity between CAM and conventional medicine in regard to the power, autonomy, and control held by each. However, the factors common to all IM models, whether describing CAM as supplementary or complementary to conventional medicine, is the concept of a health care model that aspires to be client-centred and holistic, with focus on health rather than disease as well as mutual respect among peer practitioners. Finally, this study concluded that the growth and viability of traditional Korean medicine(TKM) depend on evidence-based practices and identifying the successful influences on the integration of TKM and conventional medicine for recognition of its inherent value in PHC. Some recommendations for the integration of TKM and conventional medicine were suggested.

• Journal of the Korean Society of Radiology
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• v.7 no.5
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• pp.359-364
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• 2013

Femur is the largest bone in the human body which supports the weight of body. A long pipeline shape of femur has little cancellous bone, so that regeneration is difficult when fracture happens. The fracture caused by an accident most frequently occurs at diaphysis. IM Nailing is the surgical method that implants an IM Nail into a medullary cavity for the fixation of fracture parts. However, a secondary fracture may happen if an IM Nail does not penetrate at the center of femur. In this study, a patient-specific femur was manufactured by a 3D printer using the computed tomography images scanned before surgery, which was used for the simulation of IM Nailing. It is expected that this result may prevent the secondary damage, reduce surgical operation time, and increase the precision.

• Composites Research
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• v.25 no.5
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• pp.136-140
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• 2012

This paper describes the bone healing process of fractured long bones such as a tibia applied by composite IM rods using finite element analysis. To simulated tissue differentiation process mechano-regulation theory with a deviatoric strain was implemented and a user's subroutine programmed by a Python code for an iterative calculation was used. To broadly find the appropriate rod modulus for healing bone fractures, composite IM rods were analyzed considering the stacking sequence. To compare mechanical stimulation at fracture gap, two kinds of initial loading conditions were applied. As a result, it was found that the initial loading condition was the most sensitive factor for the healing performance. In case a composite IM rod made of a plain weave carbon fiber/epoxy (WSN3k) had a stacking sequence of $[{\pm}45]_{nT}$, the healing efficiency was the most effective under a initial load of 10%BW.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1863-1869
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• 2014

The amplification of telomerase component (TERC) gene could play an important role in generation and treatment of haematological malignancies. This present study was aimed to investigate copy number amplification status of TERC gene in chronic myeloid leukaemia (CML) patients who were being treated with imatinib mesylate (IM). Genomic DNA was extracted from peripheral blood of CML-IM Resistant (n=63), CML-IM Respond (n=63) and healthy individuals (n=30). TERC gene copy number predicted (CNP) and copy number calculated (CNC) were determined based on $Taqman^{(R)}$ Copy Number Assay. Fluorescence in situ hybridization (FISH) analysis was performed to confirm the normal signal pattern in C4 (calibrator) for TERC gene. Nine of CML patients showed TERC gene amplification (CNP=3), others had 2 CNP. A total of 17 CML patients expressed CNC>2.31 and the rest had 2.31>CNC>1.5. TERC gene CNP value in healthy individuals was 2 and their CNC value showed in range 1.59-2.31. The average CNC TERC gene copy number was 2.07, 1.99 and 1.94 in CML-IM Resistant patients, CML-IM Respond and healthy groups, respectively. No significant difference of TERC gene amplification observed between CML-IM Resistant and CML-IM Respond patients. Low levels of TERC gene amplification might not have a huge impact in haematological disorders especially in terms of resistance towards IM treatment.

• Journal of the Korean Chemical Society
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• v.32 no.5
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• pp.458-463
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• 1988

The solubility parameter theory for retention behaviors of phenols in a reversed phase liquid chromatography can be applied to limited ranges of the aqueous solvent system. The many examples of the exception to this theory were found to show no agreement with the retention behavior of phenols. Therefore, a new solute-solvent interaction parameter, ${\delta}_{im}$ is added to the Schoenmakers equation of the solubility parameter theory in LC to approach the equation to the real one. The new solute-solvent interaction pararneter, ${\delta}_{im}$ depends on the kinds of solvent, the solvent composition and the structure of solutes. The parameter, ${\delta}_{im}$ has the linear relationship with the solubility parameter of mobile phase, ${\delta}_{im}$. The prediction of retention behavior by this modified equation turns out to be greater than the previous one.