• Title/Summary/Keyword: IL4R

Search Result 1,526, Processing Time 0.032 seconds

Optical follow-up observation of three long GRBs with SomangNet facilities

  • Paek, Gregory S.H.;Im, MyungShin;Kim, Joonho;Lim, Gu;Jeong, Mankeun;Kang, Wonseok;Kim, Taewoo;Burkhonov, Otabek;Mirazaqulov, Davron;Ehgamberdiev, Shyhrat A.;Seo, Jinguk;Lee, Chung-Uk;Kim, Seung-Lee;Sung, Hyung-Il
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.46 no.1
    • /
    • pp.49.5-50
    • /
    • 2021
  • We report the optical follow-up observations of three long γ-ray burst events, GRB 201020A, GRB 201103B and GRB 210104A by the network of telescopes in the SomangNet project. We show light curves, color evolution and SED evolution, and fit them to a single power law function to derive decay index and compare their properties with other long GRBs samples. Also, we show a good observational example that 0.4-1m class telescopes in SomangNet have potential to catch dim light from high red shift object (R>22 mag) by deep imaging. In conclusion, we found that three GRBs have optical afterglow properties of long GRB and our results are consistent with the reports of high energy analysis.

  • PDF

Effects of Atorvastatin on the Pharmacokinetics of Nicardipine after Oral and Intravenous Administration in Rats

  • Choi, Jun-Shik;Ha, Sung-Il;Choi, Dong-Hyun
    • Biomolecules & Therapeutics
    • /
    • v.18 no.2
    • /
    • pp.226-232
    • /
    • 2010
  • The aim of this study was to investigate the effect of atrovasatatin on the pharmacokinetics of nicardipine after oral and intravenous administration of nicardipine to rats. Nicardipine was administered orally (12 mg/kg) or intravenously (i.v., 4 mg/kg) without or with oral administration of atrovasatatin (0.3 or 1.0 mg/kg) to rats. The effect of atorvastatin on the P-glycoprotein (P-gp) as well as CYP3A4 activity was also evaluated. Atorvastatin inhibited CYP3A4 enzyme activity in a concentration-dependent manner with 50% inhibition concentration ($IC_{50}$) of 48 ${\mu}M$. Compared to the controls (nicardipine alone), the area under the plasma concentration-time curve (AUC) of nicardipine was significantly (1.0 mg/kg, p<0.05) greater by 16.8-45.4%, and the peak plasma concentration ($C_{max}$) was significantly (1.0 mg/kg, p<0.05) higher by 28.0% after oral administration of nicardipine with atorvastatin, respectively. Consequently, the relative bioavailability (R.B.) of nicardipine was increased by 1.17- to 1.45-fold and the absolute bioavailability (A.B.) of nicardipine with atrovasatatin was significantly greater by 16.7-20.9% compared to that of the controls (14.3%). Compared to the i.v. control, atrovasatatin did not significantly change pharmacokinetic parameters of i.v. administration nicardipine. The enhanced oral bioavailability of nicardipine by atorvastatin suggests that CYP3A subfamily-mediated metabolism were inhibited in the intestine and/or in the liver rather than P-gp-mediated efflux of nicardipine. Based on these results, modification of nicardipine of dosage regimen is required in the patients. Human studies are required to prove the above hypothesis.

Yield Response of Soybean [Glycine max (L.) Merrill] to High Temperature Condition in a Temperature Gradient Chamber

  • Baek, Jae-Kyeong;Sang, Wan-Gyu;Kim, Jun-Hwan;Shin, Pyong;Cho, Jung-Il;Seo, Myung-Chul
    • KOREAN JOURNAL OF CROP SCIENCE
    • /
    • v.65 no.4
    • /
    • pp.339-345
    • /
    • 2020
  • Recently, abnormal weather conditions, such as extreme high temperatures and droughts, have increased in frequency due to climate change, there has accordingly been growing concern regarding the detrimental effects on field crop, including soybean. Therefore, this study was conducted to examine the effects of increased temperatures on soybean growth and yield using a temperature gradient chamber (TGC). Two major types of soybean cultivar, a medium- seed cultivar such as Daepung-2 and a large-seed cultivar such as Daechan, were used and four temperature treatments, aT+1℃ (ambient temperature+1℃), aT+2℃ (ambient temperature+2℃), aT+3℃ (ambient temperature+3℃) and aT+4℃ (ambient temperature+4℃) were established to examine the growth response and seed yield of each cultivar. Seed yield showed a higher correlation with seed weight (r=0.713***) and an increase in temperature affected seed yield by reducing the single seed weight. In particular, the seed growth rate of the large-seed cultivar (Daechan) increased at high temperature, resulting in a reduction in the number of days for full maturity. Our results accordingly indicate that large-seed cultivar, such as Daechan, is potentially vulnerable to high temperature stress. The results of this study can be used as basic data in the development of cultivation technology to reduce the damage caused by elevated temperatures. Also, further research is required to evaluate the response of each process contributing to seed yield production under high temperatures.

Egg Production of Clonorchis sinensis in Different Strains of Inbred Mice (근교계 마우스에서 간흡충 기생기간과 산란력의 변동)

  • Kim, Jong-In;Jeong, Dong-Il;Choe, Dong-Ik
    • Parasites, Hosts and Diseases
    • /
    • v.30 no.3
    • /
    • pp.169-176
    • /
    • 1992
  • In order to compare the intraspecific variation in host-parasite relationship of Clonorchis sinensis, six strains of inbred mice, ICR, DDY, GPC, BALB/c, nude and DS, were infected orally with 20 metacercariae of C. sinensis. The biologic incubation period of C. sinensis was the shortest in DDY mice, 21.2 days in average, followed by GPC 21.4, BALB/c and DS 23.2, ICR and nude 23.4 days, respectively. The fertile period of the cuke was also the longest in the DDY strain, 164 days on average, followed by GPC 132, BALB/c 97, nude 37, DS 32 and ICR 28 days. The egg-laying capacity of the cuke in DDY and GPC was relatively high and stable compared with the other four strains of mice. It was found that there are intraspecific variations in biologic incubation period, fertile period, and fecundity of C. sinensis. The DDY mouse is likely to be the most suitable experimental animal among the six strains of the mice tested. Key words: Mouse strain, Clonorchis sinensis, egg-laying capacity.

  • PDF

Multiferroic Property and Crystal Structural Transition of BiFeO3-SrTiO3 Ceramics

  • Kim, A-Young;Han, Seung-Ho;Kim, Jeong-Seog;Cheon, Chae-Il
    • Journal of the Korean Ceramic Society
    • /
    • v.48 no.4
    • /
    • pp.307-311
    • /
    • 2011
  • Solid solutions of the (1-x)$BiFeO_3-xSrTiO_3$ ceramic system (x = 0~0.4) are explored here in attempts to obtain multiferroic properties in these systems. The polarization-electric field hysteresis, magnetization-magnetic field curves, and dielectric properties are also characterized. This solid-solution system shows a crystal structural transition from a noncentrosymmetric (R3c) structure to a centrosymmetric (Pm-3m) structure at 0.3 < x < 0.4. The solid solution ceramic shows unsaturated M-H behavior and low remanent magnetization over the composition region of 0.1 ${\leq}$ x ${\leq}$ 0.3. The $0.7BiFeO_3-0.3SrTiO_3$ system shows the largest value of $M_s$ at 0.17 emu/g and the smallest value of $H_c$ at 1.06 kOe. The P-E hysteresis curves were not saturated under an electric field as high as E = 70 kV/cm. This system is considered to have multiferroic characteristics in the composition range of 0.1 ${\leq}$ x ${\leq}$ 0.3.

Mapping QTL for ratooning ability in advanced backcross lines from an Oryza sativa × O. rufipogon cross

  • Ji, Shi-Dong;Luo, Xiao;Ahn, Sang-Nag
    • Korean Journal of Agricultural Science
    • /
    • v.41 no.1
    • /
    • pp.1-7
    • /
    • 2014
  • Ratooning ability is one of the major different traits from perennial to cultivated rice and annual type. We developed a set of 126 introgression lines derived from a cross between Hwayeong and W1944 (O. rufipogon) to gain an insight into the genetic factors underlying differences between common wild rice and cultivated rice. One IL, CR6 among the 126 ILs of $BC_3F_4$ showed a significant difference in rationing ability compared with Hwayeong. To further characterize the rationing ability, CR6 was selected and crossed to Hwayeong to produce three secondary populations, $BC_4F_2$, $BC_4F_3$ and $BC_5F_2$. In the Hwayeong background, the W1944 allele was associated with an increase in rationing ability. QTL analysis showed that the qRAT5 for rationing ability was linked to RM194 ($R^2$=6.6%, 19.6%, and 44.5% in the $BC_4F_2$, $BC_5F_2$, and $BC_5F_3$, respectively). The putative qRAT5 was also tightly linked to QTLs for spikelets per panicle and grain weight indicating that this region harbors a QTL cluster related to domestication. To our knowledge, this is the first report to map the major QTL for ratooning ability in rice. The SSR markers linked to qRAT5 would be useful in marker-assisted selection for breeding lines with enhanced ratooning ability.

Maturity and Spawning of Snailfish, Liparis ochotensis (Schmidt), in the East Sea

  • Yang, Jae-Hyeong;Lee, Sung-Il;Yoon, Sang-Chul;Kim, Jong-Bin;Chun, Young-Yull
    • Fisheries and Aquatic Sciences
    • /
    • v.13 no.4
    • /
    • pp.332-339
    • /
    • 2010
  • Maturity and spawning of the snailfish, Liparis ochotensis was investigated based on samples collected by gill net in the East Sea of Korea from December 2008 to December 2009. The average total length of L. ochotensis was 63.4 cm and 64.1 cm for females and males, respectively. Gonadosomatic index (GSI) began to increase in July, reaching a maximum in November, then began to decrease in December. Monthly changes in the GSI values of L. ochotensis were similar for females and males. Annual reproductive cycle of this species can be divided into five successive stages in females: early growing stage (May), late growing stage (June to July), mature stage (August to September), ripe and spent stage (September to December), and recovery and resting stage (January to April). Males show four successive stages; growing stage (May to July), mature stage (August to September), ripe and spent stage (September to December), and recovery and resting stage (January to April). Relationship between total length (TL) and fecundity (F) was F=$0.00003TL^{4.002}$ ($R^2$ = 0.703), and F increased with TL. Total length at 50% group maturity was estimated to be 55.8 cm. Our findings suggest that the spawning period takes place from September to December, with the main spawning period occurring from October to December.

Effects of Mixed Application of Wood Vinegar and Herbicides on Weed Control, Yield and Quality of Rice(Oryza sativa L.)

  • Rico, Cyren M.;Souvandouane, Souliya;Mintah, Lemuel Ohemeng;Chung, Il-Kyung;Son, Tae-Kwon;Lee, Sang-Chul
    • KOREAN JOURNAL OF CROP SCIENCE
    • /
    • v.52 no.4
    • /
    • pp.387-392
    • /
    • 2007
  • The effect of mixed treatments of wood vinegar and sulfonylurea-based herbicides on weed control, yield and yield components, and quality of rice was investigated. Two herbicides were tested namely: imazosulfuron-ethyl+thiobencarb[ethyl-1-(2-chloroimidazo[1,2-$\alpha$]pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl) urea+S-4-chlorobenzyl diethyl(thiocarbamate)], and bensulfuronmethyl+butachlor [methyl $\alpha$-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-o-toluate+N-butoxymethyl-2-chloro-2',6'-diethylacetanilide]. The experiment was carried out in a randomized complete block design with 3 replications and 5 treatments. Treatments used were recommended(RH: 100%) and half-recommended(HRH: 50%) application rates of each herbicide. Half-recommended application rates were combined with 1 mL wood vinegar $500mL\;water^{-1}$(500) and 1 mL wood vinegar $1000mL\;water^{-1}$(1000) wood vinegar. Plots for no herbicide treatments were also prepared and used as control. Results showed that wood vinegar significantly increased efficacy of HRH in bensulfuron-methyl+butachlor while high efficacy was already obtained in HRH treatment of imazosulfuron-ethyl+thiobencarb. Wood vinegar did not improve the efficacy of imazosulfuron-ethyl+thiobencarb but improved rice yield. Significantly similar rice yields were obtained in the HRH+1000 WV and RH treatments of both herbicides. There were no significant variations in the yield components among the treatments; however, differences in yield can be attributed to the variations in the spikelet number and ripening ratio. Data on rice quality analysis did not show clear trend on the effects of the treatments on grain appearance and nutritional quality.

Sterilization of Gochujang Sauce with Continuous Ohmic Hea (연속 옴가열 장치를 이용한 고추장 소스의 살균)

  • Choi, Jun-Bong;Cho, Won-Il;Jung, Jung-Yoon;Chung, Myong-Soo
    • Korean Journal of Food Science and Technology
    • /
    • v.47 no.4
    • /
    • pp.474-479
    • /
    • 2015
  • In this study, five different Gochujang (a traditional Korean sauce prepared using fermented red pepper paste) sauces were heated at $100^{\circ}C$ for 5 min using a continuous ohmic heating system. Ohmic heating yielded greater reduction in microbial counts (90-95% reduction) than did conventional heating (65-75% reduction). The sterilization effect of the continuous ohmic heater increased with increasing sample flow rate and decreasing Reynolds number inside the pipe. Low-viscosity samples had higher electrical conductivity and were better suited for ohmic heating than were high-viscosity samples. The color and texture were also satisfactorily maintained after ohmic heating. Compared with conventional heating, ohmic heating provided rapid and uniform heating, which is more suitable for aseptic thermal processing of viscous foods.

A Study on Characteristics of Acid-Base Balance in Goats (염소의 산·염기 균형 특성에 관한 연구)

  • Yang, Il-suk;Sung, Ho-kyng
    • Korean Journal of Veterinary Research
    • /
    • v.25 no.2
    • /
    • pp.133-144
    • /
    • 1985
  • The changes of acid-base status in vitro of the venous blood for 24 hours in ten Korean native goat were investigated. The acid-base parameters were measured within ten minutes after collection of the blood, and every hour during the first six hours and finally after twenty four hours of storage. Blood samples were stored at two different temperatures ($0-4^{\circ}C$ and $21-24^{\circ}C$). Twelve goats were induced acute acid-base disturbances by intravenous infusion of either hydrochloric acid or sodium bicarbonate and inhalated with $CO_2$ gas mixture (20% $CO_2$, 80% $O_2$) or hyperventilation were performed by means of respirator. The results were as follows; 1. Blood samples could be stored during the first two hours in ice water ($0-4^{\circ}C$) and one hour at room temperature without significant changes in pH. The magnitudes of changes were similar to those of cow, and lower than those of men and dogs. 2. The mean values of acid-base parameters in normal goat were arterial pH, 7.40; $P_{CO_2}$, 35.4mmHg; $HCO_3{^-}$, 21.8mEq/L. 3. Both the base excess and the bicarbonate showed high correlation (r=0.99) during the metabolic disturbance and were represented as $B.E.=1.38\;HCO^-{_3}-29.7$. 4. The slope of blood buffer curve obtained from the in vivo experiment was 16.3mEq/L/pH. 5. The magnitudes of changes in hydrogen ion concentration per unit change of $P_{CO_2}$ were 0.8nM/mmHg in hypercapnia and 1.0nM/mmHg in hypocapnia. 6. The ranges of acid-base parameters in normal goat urine were pH, 6.0-8.1; $P_{CO_2}$, 42-61mmHg; $HCO_3{^-}$, 2-110mEq/L. The concentration of potassium was higher (60-200mEq/L), and that of sodium was lower (8-70mEq/L) than those of human urine.

  • PDF