• Title/Summary/Keyword: IL-la

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A Study on Development of Marine Tank Monitoring System (선박용 탱크 모니터링 시스템 개발에 관한 연구)

  • Weon, La-Kyoung;Rhyu, Keel-Soo;Kim, Joo-Won;Seong, Chang-Gyu;Park, Jong-Il;Kim, Tai-Jin
    • Proceedings of the Korean Society of Marine Engineers Conference
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    • 2006.06a
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    • pp.65-66
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    • 2006
  • As industrial technology recently, a field of marine engineering is demanding integration and manless system. In this study, tank monitoring system is developed, which is able to watch real-time the marine tank for measuring a level, pressure, temperature. The system will provide efficiently measuring data for operator.

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Effects of Dietary Supplementation of Cerium and Lanthanium on Growth Performance, Nutrient Digestibility, Carcass Characteristics and Meat Colors in Broilers (희토원소 세륨과 란타늄의 첨가가 육계 생산성, 영양소 소화율, 도체 성상과 육색에 미치는 영향)

  • Jo, Jong-Kwan;Yun, Ku;Kim, Young-Woo;Kim, Jin-Soo;Kim, Kwang-Hyun;Kwon, Il-Kyung;Chae, Byung-Jo
    • Korean Journal of Poultry Science
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    • v.36 no.4
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    • pp.279-286
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    • 2009
  • An experiment was conducted to investigate the effects of dietary supplementation of cerium (Ce), a rare earth, individually and in combination with lanthanium (La), a rare earth, in the basal diet on growth performance, nutrient digestibility, bone composition, breast meat composition, carcass characteristics and meat color in broiler chicks. A total of 1,600 day-old broiler chicks were randomly allotted to four dietary treatments with four replicates in a completely randomized block design. Treatments were T1) CON (control diet), T2) 100 ppm Ce, T3) 100 ppm La, T4) 100 ppm Ce+100 ppm La. There were no significant differences in feed intake among dietary treatments during the whole experimental period (0 to 5 weeks). Body weight gain for the first three weeks was greater in birds T4 than birds fed T3 diet. Feed conversion ratio (FCR) was better in birds fed T4 diet (p<0.05) than birds fed T3 diet during 0~3 weeks, and better FCR for 0~5 weeks was noticed in birds fed T4 diet than birds fed T1 diet. Nutrient digestibility was greatest in birds fed T3 diet (p<0.05) compared with other treatments. Bone composition, carcass characteristics and meat color were no statistically different among the treatments. These results suggest that Ce supplementation, alone and combination with La could improve performance of broilers.

Dexmedetomidine Modulates Histamine-induced Ca2+ Signaling and Pro-inflammatory Cytokine Expression

  • Yang, Dongki;Hong, Jeong Hee
    • The Korean Journal of Physiology and Pharmacology
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    • v.19 no.5
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    • pp.413-420
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    • 2015
  • Dexmedetomidine is a sedative and analgesic agent that exerts its effects by selectively agonizing ${\alpha}2$ adrenoceptor. Histamine is a pathophysiological amine that activates G protein-coupled receptors, to induce $Ca^{2+}$ release and subsequent mediate or progress inflammation. Dexmedetomidine has been reported to exert inhibitory effect on inflammation both in vitro and in vivo studies. However, it is unclear that dexmedetomidine modulates histamine-induced signaling and pro-inflammatory cytokine expression. This study was carried out to assess how dexmedetomidine modulates histamine-induced $Ca^{2+}$ signaling and regulates the expression of pro-inflammatory cytokine genes encoding interleukin (IL)-6 and -8. To elucidate the regulatory role of dexmedetomidine on histamine signaling, HeLa cells and human salivary gland cells which are endogenously expressed histamine 1 receptor were used. Dexmedetomidine itself did not trigger $Ca^{2+}$ peak or increase in the presence or absence of external $Ca^{2+}$. When cells were stimulated with histamine after pretreatment with various concentrations of dexmedetomidine, we observed inhibited histamine-induced $[Ca^{2+}]_i$ signal in both cell types. Histamine stimulated IL-6 mRNA expression not IL-8 mRNA within 2 hrs, however this effect was attenuated by dexmedetomidine. Collectively, these findings suggest that dexmedetomidine modulates histamine-induced $Ca^{2+}$ signaling and IL-6 expression and will be useful for understanding the antagonistic properties of dexmedetomidine on histamine-induced signaling beyond its sedative effect.

Design Methodology of Expert System for aging diagnosis of Arrester (피뢰설비 열화진단 전문가 시스템의 설계 방법론)

  • Kim, Tai-Jin;Rhyu, Keel-Soo;Kil, Gyung-Suk;Seong, Chang-Gyu;Kim, Il-Kwon;Park, Jong-Il;Weon, La-Kyoung
    • Proceedings of the Korean Society of Marine Engineers Conference
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    • 2006.06a
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    • pp.69-70
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    • 2006
  • The arrester's condition is related directly to protected equipment's safety. The most important is, therefore, arrester aging diagnosis. In this study, arrester aging diagnosis expert system is implemented to use JESS shell-engine and the leakage current detection technique.

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Effect of benzo(a)pyrene and mitomycine C on HeLa cell division cycle

  • Yu, Il-Je;Lim, Cheol-Hong;Kim, Hyo-Jung;Chung, Kyu-Hyuk;Song, Kyung-Seuk;Han, Jeong-Hee;Chung, Yong-Hyun
    • Environmental Mutagens and Carcinogens
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    • v.21 no.2
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    • pp.82-88
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    • 2001
  • Recently, there has been significant progress in understanding the control process of the cell division cycle. To investigate the influence of toxic substances on the cell cycle, the effect of benzo(a)pyrene (BAP) and mitomycine C (MMC) on synchronized HeLa cells was analyzed during the cell cycle. To synchronize the HeLa cells, 10$^{6}$ cells were grown for 1 day and then treated with 1 mM hydroxyurea for 14 h. The arrested cells were then allowed to proceed through their cell cycle by removing the hydroxyurea and resupplying a fresh medium. The arrested cells in the G1/S transition then proceeded to the S phase after 4 h, the G2/M phase after 8h, and the G1 phase after 12 h, subsequent to the resupply of a fresh medium. In the untreated HeLa cells, the p34$^{cdc2}$ kinase activity, measured using a p34$^{cdc2}$ specific peptide, peaked after 8h (G2/M) and then declined after 12 h (G1). However, treatment with 30 $\mu$M BAP delayed the peak of the p34$^{cdc2}$ kinase activity. The amount of p34$^{cdc2}$ remained unchanged in the untreated, BAP-, and MMC-treated cells throughout the cell cycle. The cyclin B level peaked after 8 h in the untreated cells, yet peaked after 10-12 h in the BAP-treated cells. There was no significant change in the cyclin B level in the MMC-treated cells.

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