• 대한한방내과학회지
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• 제37권6호
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• pp.990-997
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• 2016

Objectives: This study observed changes in gait pattern according to the motor grade of the paretic lower limb in patients with basal ganglia stroke who are in the subacute phase. Methods: We used the Manual Muscle Test (MMT) to evaluate the motor grade of the paretic lower limb of 21 patients with subacute basal ganglia stroke and then divided them into two groups based on the MMT results. Stroke patients with a motor grade above Gr. III were put in group I (15 people) and those with a grade less than Gr. III in group II (6 people). We also estimated spatiotemporal factors using treadmill gait analysis equipment. The values were gait velocity, step length, step time, double support phase, and cadence. The first measure was conducted during the early period of admission and the second was between four and five weeks after admission. Results: In Group I, the gait velocity and step length of both legs significantly increased. In Group II, the step length and step time of the paretic side and the gait velocity tended to decrease, but not significantly. The step length of the paretic side in Group II was significantly longer than that in Group I at the first measure. The step time of the paretic side in Group I was significantly shorter than that in Group II and gait velocity and cadence in Group I were significantly higher than in Group II at the second measure. Conclusions: The gait parameters of all stroke patients improved in terms of time. In addition, the changes in gait pattern were different depending on the motor grade of the paretic lower limb.

• Journal of Genetic Medicine
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• 제20권2호
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• pp.60-69
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• 2023

Purpose: Despite enzyme replacement therapy (ERT) and/or allogeneic hematopoietic stem cell transplantation, individuals with mucopolysaccharidosis (MPS) I or II often experience significant growth deficiencies. This study aimed to assess the safety and efficacy of recombinant human growth hormone (hGH) treatment in children diagnosed with MPS I or II. Materials and Methods: A total of nine pediatric patients-four with MPS I and five with MPS II-underwent treatment with ERT and hGH at Samsung Medical Center. Results: The mean hGH dose administered was 0.26±0.03 mg/kg/week. In the MPS I group, three patients showed an increase in height Z-score from -4.09±0.83 to -3.68±0.43 after 1 year of hGH treatment, and to -3.10±0.72 by the end of the hGH regimen. In the MPS II group, while the height Z-score of four patients decreased according to standard growth charts, it improved from 1.61±1.79 to 2.71±1.68 based on the disease-specific growth chart through hGH treatment. Two patients discontinued hGH treatment due to lack of efficacy after 22 and 6 months each of treatment, respectively. No new-onset neurological symptoms or necessity for prosthetic or orthopedic surgery were reported during hGH treatment. Conclusion: This study provides insights into the impact of hGH on MPS patients, demonstrating its potential to reverse growth deceleration in some cases. Further research is needed to explore the long-term effects of hGH on changes in body composition, muscle strength, and bone health in this population.

• Archives of Plastic Surgery
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• 제35권5호
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• pp.581-588
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• 2008

Purpose: It is generally accepted that anatomical structures of the soft tissue in Asian faces are quite different from those in Caucasian. It is presumed that these differences are due to collagen rich thick dermis and durable superficial musculo-apponeurotic system (SMAS) in Asian. We classified the aging lower eyelids and reviewed the operative procedures according to the types of aging lower eyelids in Asian. Methods: We compared preoperative and postoperative photos of 117 patients over 30 years of age, who underwent lower blepharoplasty at the Kyunghee Medical Center from January 2001 to April 2006. We classified the patients based on the degree of skin laxity, presence of nasojugal groove and malar bag, the extent of aging process. We also reviewed the operative procedures according to each type of classification. Results: We classified our patients into four types as following. Type I patients showed minimal skin-muscle excess confined to lower eyelids regardless of the facial line. For these patients, we performed only transcutaneous or transconjunctival blepharoplasty. In type II patients, nasojugal grooves were shown and skin- muscle laxity was limited to the medial side of imaginary vertical line at lateral margin of pupil. In these cases, we performed free fat graft or fat repositioning on nasojugal groove or fat removal and septal duplication confined to medial side. Type III patients displayed more advanced medial bulging and remarkable laxity over the lateral side, the same operation methods as those of type II were applied at the lateral side of the line. Type IV patients demonstrated extensive midfacial aging changes including malar bags and underwent superficial subciliary cheek lift. Conclusion: The lower eyelid aging of Asian is different from those of Caucasian. We think that our classification is useful in selection of appropriate operative procedure to address specific problems for Asian patients.

• 대한물리의학회지
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• 제13권1호
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• pp.107-119
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• 2018

PURPOSE: This research was intended to investigate the influence to function recovery at the early stage after surgery, by conducting Multipath Electrical Simulation and isometric exercise treatment as early stage medical treatment method for Total knee arthroplasty patients. METHODS: The subject of 30 patients having Unilateral Total knee arthroplasty over age 65, Multipath Electrical Simulation and isometric exercise (experiment group I), Conventional Electrical Simulation and isometric exercise (experiment group II) and isometric exercise (control group). The intervention was performed in 5 times per a week and 60 minutes per a day during 4 weeks. We performed research by conducting Neuromuscular Electrical Stimulation and isometric exercise together and measured pain, range of motion, muscle strength and gait ability before and after intervention. RESULTS: The result showed therapeutic improvement in experiment group I, experiment group II and control group, but Multipath Electrical Simulation and isometric exercise showed significant improvement in function recovery of early stage compared to Conventional Electrical Simulation and isometric exercise, only isometric exercise. CONCLUSION: Based on research result, in order for early state function recovery of Total knee arthroplasty patients, when conducting neuromuscular electrical stimulation and isometric exercise together, especially when applying Multipath Electrical Stimulation, we could know that it showed more significant improvement to function recovery after surgery. Also, we suggest that Multipath Electrical Simulation may become a useful tool as a method for intervention and performing in various diseases for weakening of Quadriceps muscle.

• 한국동물학회지
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• 제34권2호
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• pp.131-141
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• 1991

TPA나 PDGF를 처리로 인한 Protein Kinase C의 신호전달은 힌산화에 의해 일어난다. 그렇지만, PKC에 의해 인산화 되어지는 targeting protein은 TAP나 PDGF 처리시에는 분자량이 서로 다른 단백질들이 인산화가 되어졌다. TPA처리한 myoblast에서 분자량 20,000의 단백질이 인산화되었다. PDGF처리한 세포에서는 분자량 40,000의 단백질이 인산화된 반면에 TPA처리로 인산화 되었던 분자량 20,000의 단백질은 탈인산화 되었다. 이러한 결과들은 TPA와 PDGF가 신호전달계의 활성에 있어서 다를 뿐만 아니라 그들은 장시간의 처리동안 PKC의 down regulation에 관계되어 짐을 암시한다. 그러나 PDGF는 TPA의 경우에서 보다 빠른 down regulation을 유도하였다. 면역세포 화학적인 연구에서 PKC의 동위효소인 PKC II는 세포질에, PKC III는 세포질과 인에 각각 분포하고 있었다. Myoblast에 있어서 PCK두가지 형태의 동위효소의 발현은 이들 동위효소들이 signal transduction이나 down regulation의 각기 다른 경로에 개입되어 진다는 것을 암시한다.

• 대한임상전기생리학회지
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• 제11권1호
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• pp.31-38
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• 2013

Purpose : This study was to identify the effect of cognitive reaction following inactive electrode placement when applying anodal transcranial direct current stimulation over the primary motor cortex. Methods : For this study a total of 28 stroke patients participated. Before applying transcranial direct current stimulation, cognitive reaction was measured (P300 of event related potential, cognitive reaction time), and subjects were randomly assigned to two group. Transcranial direct current stimulation was applied to the scalp with an intensity of $0.04mA/cm^2$ for 15 minutes. All subjects were given an anode transcranial direct current stimulation over the primary motor area and inactive electrodes over the deltoid muscle (group I) and supra-orbital area (group II). Cognitive reactions were measured after applying transcranial direct current stimulation. Results : For this study a total of 28 stroke patients participated. Before applying transcranial direct current stimulation, cognitive reaction was measured (P300 of event related potential, cognitive reaction time), and subjects were randomly assigned to two group. Transcranial direct current stimulation was applied to the scalp with an intensity of $0.04mA/cm^2$ for 15 minutes. All subjects were given an anode transcranial direct current stimulation over the primary motor area and inactive electrodes over the deltoid muscle (group I) and supra-orbital area (group II). Cognitive reactions were measured after applying transcranial direct current stimulation. Conclusion : Thus transcranial direct current stimulation on the primary motor area may help cognitive reaction regardless of inactive electrode placement.

• Journal of Yeungnam Medical Science
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• 제39권4호
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• pp.285-293
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• 2022

Background: This study was conducted to analyze the effects of low skeletal muscle mass index (SMI) and obesity on aging-related osteoarthritis (OA) in the Korean population. Methods: A total of 16,601 participants who underwent a dual-energy X-ray absorptiometry and 3,976 subjects with knee X-rays according to the modified Kellgren-Lawrence (KL) system were enrolled. Knees of ≥KL grade 2 were classified as radiologic OA. The severity of joint space narrowing (JSN) was classified by X-rays as normal, mild-to-moderate, and severe JSN in radiologic OA. The subjects were grouped as normal SMI (SMI of ≥-1 standard deviation [SD] of the mean), low SMI class I (SMI of ≥-2 SDs and <-1 SD), and low SMI class II (SMI of <-2 SDs). Obesity was defined as a body mass index (BMI) of ≥27.5 kg/m². Results: The modified KL grade and JSN severity were negatively correlated with the SMI and positively correlated with BMI and age. The SMI was negatively correlated with age. JSN severity was significantly associated with a low SMI class compared to a normal SMI, which was more prominent in low SMI class II than class I. Obesity was significantly associated with more severe JSN, only for obesity with a low SMI class. Furthermore, patients with a low SMI class, regardless of obesity, were prone to having more severe JSN. Conclusion: This study suggested that a low SMI class was associated with aging and that an age-related low SMI was more critically related to the severity of JSN in OA.

• 대한관절경학회지
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• 제11권1호
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• pp.13-19
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• 2007

목적: 동반 손상이 없는 급성 후방십자인대 손상에 있어서 보존적 치료를 시행 후 자연 경과를 알아보고자 하였다. 대상 및 방법: 1999년 2월부터 2006년 10월까지 본원에서 급성 단독 후방십자인대 손상으로 진단되어 보존적 치료를 시행한21례의 환자를 대상으로 후향적 연구를 하였다. 초기 진찰과 추시 관찰시 이학적 검사, KT-2000TM 관절검사(arthrometer) 및 후방십자인대의 연속성 정도(두께)를 관찰하기 위한 MRI 촬영을 시행하였고, 모든 환자에서 IKDC(International Knee Documentation Committee) knee score와 대퇴 사두근 근력 정도, 수상 전 운동 능력으로의 복귀 여부 등을 조사하였다. 이후 초기 진찰시와 추시 관찰시의 결과를 비교함으로써 보존적 치료를 한 급성 단독 후방십자인대 손상의 자연 경과를 알아보고자 하였다. 본 연구의 평균 추시 기간은 22.7개월이었다. 결과: 초기 진찰시 이학적 검사에서 관찰된 후방 불안정성은 Grade I이 14례, Grade II가 6례, Grade III가 1례였으며, 추시는 Grade I이 18예, Grade II가 3예였다. KT-2000TM 관절검사는 초기 진찰시 건측과 평균 5.7 mm($3{\sim}12\;mm$)의 차이에서 추시에서는 평균 2.7 mm($0{\sim}7\;mm$)의 차이를 보였고, MRI 촬영을 통한 인대의 연속성 정도(두께)는 48.1%에서 69.7%로 증가된 소견을 보였다. 대퇴 사두근 근력은 평균Good등급이었고, 평균 IKDC knee score는 A등급에 가까운 결과를 보였다. 결론: 급성 단독 후방십자인대 손상의 치료에 있어서 급성기 초기에 적극적인 보존적 치료를 시행함으로써 임상적 및 영상의학적으로 만족할 만한 결과를 얻을 수 있었다.

• 환경위생공학
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• 제3권2호
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• pp.61-78
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• 1988

식이조성에 따른 카드뮴의 장관내 흡수에 미치는 영향을 규명할 목적으로 1988년 4월부터 5월까지 30일간 생쥐 90마리를 사육한 후 에테르 마취로 도살한 뒤 장기를 적출하여 무게를 측정한 후 습식 분해하여 원자흡광분광 광도계로 분석하였다. 다만 카드뮴은 고농도 1회 투여군 ($100{\mu}g$ 경구투여 )과 저농도 자유섭취군 (50ppm 함유음용수 자유섭취)으로 구분하여 각각 카세인, 칼슘 및 우지식이군별로 시험하였다. 생존율은 대조군 (기본사료+증류수)이 $100\%$이었고, IV군 (기본사료+Cd+Ca)의 고농도 1회 및 저농도 자유섭취군과 V군 (기본사료 + Cd + 우지)의 저농도 자유섭취군이 각각 $66.7\%$로 가장 낮았다. 최종 체중증가비는 모두 대조군의 $42.3\%$보다 낮았으며 고농도 1회 투여군에서는 V군이 $26.0\%$로 제일 낮았고 IV군이 $42.3\%$로 가장 높았으며 저농도 자유섭취군에서는 II군(기본사료+카드뮴)이 $11.6\%$로 가장 낮았고 IV군이 $24.0\%$로 제일 높았다. 고농도 1회 투여후 5일까지는 거의 체중증가가 없었으나 그 이후 회복되었고 저농도 자유섭취군은 만성적인 누적으로 체중이 증가하는 미진한 경향이었다. 장기별 무게비는 간장은 고농도 1회투여군과 저농도 자유섭취군 모두 II군이 가장 낮았으며 신장과 비장은 고농도 1회 투여군의 II군이 가장 높았고 저농도 자유섭취군의 II군이 가장 낮았다. 대변으로의 카드뮴 배설은 카드뮴 $100{\mu}g$ 1회 경구투여후 1내지 1내지 2일 사이에 거의 대부분 이루어졌다. 조직에 축적된 카드뮴 함량은 대조군보다 모두 유익하게 높게 나타났으며 간장, 신장 및 근육조직에서 식이별로는 고농도 1회 투여군과 저농도 자유섭취군 모두 II군이 가장 높게 저농도 자유섭취군 모두 II군이 가장 높게 나타났고 피부와 체모를 합한것에서는 고농도 1회 투여군의 II군과 저농도 자유섭취군의 V군이 가장 높은 함량을 보였다. 그리고 저농도 자유섭취군의 각 장기 및 조직의 카드뮴 함량이 고농도 1회 투여군보다 월등히 높게 나타났다. 이상의 결과로 보아 카세인, 칼슘 및 우지첨가식이가 카드뮴의 장관내 흡수를 저지하는 효과가 다소 있음을 알 수 있으며 이중 칼슘식이가 가장 효과가 큰 것으로 나타났다.

• 대한치과교정학회지
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• 제22권2호
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• pp.389-412
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• 1992

Along with form and function relationship of craniofacial growth comes a concern for the masticatory muscles with postnormal occlusion. It is the aim of this study to grope the certain differences upon the electromyographic activities of the masticatory muscles between normal occlusion and class II malocclusion during the varieties of oral functions. 26 persons of normal occlusion whose mean age were 18.9-25.6 years and another 26 persons of class II malocclusion whose mean age were 19.0-28.9 years served for this study. The electromyographic recordings processed by $Medelec^{\circledR}$ MS 25 EMG apparatus were taken from the anterior and posterior temporal, and anterior and posterior masseter muscles of both sides, and suprahyoid muscles as well. Analyses of the data toward such specific activities as mandibular rest, maximal biting, chewing gums and swallowing peanuts turned out the following summary and conclusions. 1. The maximal mean amplitude of the posterior temporalis showed significant augmentation in class II malocclusion, however the anterior temporalis, posterior masseter, and suprahyoid muscles manifested meaningful diminutions. 2. Stronger posterior temporalis and weaker anterior masseter and suprahyoid muscles were arranged in maximal biting with parameters of maximal mean amplitude. 3. The anterior temporalis of working side expressed smaller maximal mean amplitude in class II malocclusion. Significant swelling in duration were shown at anterior and posterior temporalis of working side, and posterior temporalis of balancing side in class II malocclusion, and marked reduction at anterior masseter of balancing side and posterior masseter of working side as well. The lessened latency were expressed at anterior masseter of working side, and anterior and posterior masseter of balancing side. Class II malocclusion group had significant prolongation of silent period duration. Mean silent period duration of 10.75 msec in normal occlusion and 24.37 msec in class II malocclusion were calculated. 4. Significant augmentations of maximal mean amplitude while swallowing peanuts were yielded at right anterior temporalis and posterior temporalis of both sides, however left anterior masseter and right posterior masseter showed diminution. No significant differences in duration showed at every muscle examined in class II malocclusion group.5. Weaker masseter and stronger temporalis were suggested as characteristics of class II malocclusion.