• Journal of Microbiology
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• v.33 no.3
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• pp.191-195
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• 1995

IciA protein has been shown as an inhibitor for the initiation of E. coli chromosomal DNA replication at oriC. IciA protein binds the AT-rich region in oriC and then blocks the initiation of chromosomal DNA replication. Two binding sites for IciA protein were identified in dnaA gene, encoding the initiator for the E. coli chromosomal replication, promoter region by gel-shift assay and DNase I footprinting, One, named as IciA site I, is located upstream of the dnaA promoter 1P. The other, named as IciA site II, is located downstream of the dnaA promoter 2P. The sequence comparison of the regions protected from the DNase I cleavage did not result in a clear consensus sequence for the binding of IciA protein, suggesting that IciA protein may be a member of multimeric complex dsDNA binding proteins. This study provided information about the binding mode of IciA protein. Even though the IciA site II and IciA binding site in oriC seem to be composed of two IciA binding units, one binding unit is likely enough to cause the binding of IciA protein to the IciA site I. The binding of IciA protein to the dna4 promoter implies that IciA protein may involve not only the control of the initiation of chromosomal DNA replication but also the control of the dna4 gene expression.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.3 s.94
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• pp.319-326
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• 2005

In the multi-carrier OFDM communication system for the high data rate transmission, the ICI caused by phase noise of transceiver local oscillator may degrade the system performance seriously. In this paper, a new ICI self-cancellation scheme using data-conjugate method is proposed to reduce the ICI caused by phase noise effectively. Then, the CPE, ICI and CIR are derived by the phase noise linear approximation method. Besides, to analyze the efficiency of system performance improvement, the proposed method is compared with the original OFDM and the conventional ICI self-cancellation scheme using data-conversion method. As results, the performance degradation caused by ICI can be mitigated effectively in the OFDM system with ICI self-cancellation scheme, and more performance improvement can be achieved by the proposed ICI self-cancellation scheme using data-conjugate method than the conventional ICI self-cancellation scheme using data-conversion method when phase noise exists.

• Applied Microscopy
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• v.43 no.3
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• pp.103-109
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• 2013

ICI 182,780 (ICI) is known as an estrogen receptor antagonist, whereas propyl pyrazole triol (PPT) is an estrogen receptor agonist. In this study, ICI or ICI added with PPT was injected into adult male mice. Body and reproductive organ weights were reduced in the ICI added with PPT group compared to the control group. Further, the ICI and ICI added with PPT groups both showed increases in luminal areas of the seminiferous tubules of the testis, whereas cell heights of efferent ductules and the initial segment of the epididymis were reduced. Sperm count in the caudal epididymis was reduced in the ICI and ICI added with PPT groups. These results show that reproductive tissues were more deeply affected in the ICI added with PPT group. We also demonstrated that treatment with ICI resulted in histological changes in the testis, efferent ductule, and epididymis. Further, alternate treatment with ICI and PPT induced abnormalities in reproductive organs. These results indicate that a high concentration of PPT together with ICI may cause histological abnormalities instead of histological restoration in reproductive organs.

• Korean Journal of Radiology
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• v.22 no.4
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• pp.584-595
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• 2021

Objective: Immune checkpoint inhibitor (ICI) therapy has shown activity against melanoma brain metastases. Recently, promising results have also been reported for ICI combination therapy and ICI combined with radiotherapy. We aimed to evaluate radiologic response and adverse event rates of these therapeutic options by a systematic review and meta-analysis. Materials and Methods: A systematic literature search of Ovid-MEDLINE and EMBASE was performed up to October 12, 2019 and included studies evaluating the intracranial objective response rates (ORRs) and/or disease control rates (DCRs) of ICI with or without radiotherapy for treating melanoma brain metastases. We also evaluated safety-associated outcomes. Results: Eleven studies with 14 cohorts (3 with ICI combination therapy; 5 with ICI combined with radiotherapy; 6 with ICI monotherapy) were included. ICI combination therapy {pooled ORR, 53% (95% confidence interval [CI], 44-61%); DCR, 57% (95% CI, 49-66%)} and ICI combined with radiotherapy (pooled ORR, 42% [95% CI, 31-54%]; DCR, 85% [95% CI, 63-95%]) showed higher local efficacy compared to ICI monotherapy (pooled ORR, 15% [95% CI, 11-20%]; DCR, 26% [95% CI, 21-32%]). The grade 3 or 4 adverse event rate was significantly higher with ICI combination therapy (60%; 95% CI, 52-67%) compared to ICI monotherapy (11%; 95% CI, 8-17%) and ICI combined with radiotherapy (4%; 95% CI, 1-19%). Grade 3 or 4 central nervous system (CNS)-related adverse event rates were not different (9% in ICI combination therapy; 8% in ICI combined with radiotherapy; 5% in ICI monotherapy). Conclusion: ICI combination therapy or ICI combined with radiotherapy showed better local efficacy than ICI monotherapy for treating melanoma brain metastasis. The grade 3 or 4 adverse event rate was highest with ICI combination therapy, and the CNS-related grade 3 or 4 event rate was similar. Prospective trials will be necessary to compare the efficacy of ICI combination therapy and ICI combined with radiotherapy.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.14 no.11
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• pp.1191-1197
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• 2003

In the multi-carrier OFDM communication system, the inter-carrier-interference(ICI) produced by phase noise in the transceiver local oscillator makes a severe influence on the system performance. In this paper, a new ICI self-cancellation scheme in the data-conversion type is proposed to reduce effectively the ICI. Also, the common phase error(CPE), ICI and carrier to interference power ratio(CIR) are found by the linear approximation of the phase noise. Then, the proposed method is compared with the conventional OFDM to analyze the efficiency of system performance improvement. When the number of subcarriers is 64, there are respectively the SNR gain of 0.6 ㏈ in the phase noise variance of 0.3 with QPSK and 1.5 ㏈ in the phase noise variance of 0.1 with 16 QAM at BER=10$\^$-3/. As a result, the performance degradation by ICI can be effectively lowered in the proposed system with ICI self. cancellation scheme, compared with the conventional OFDM system.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.6
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• pp.1150-1155
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• 2007

Orthogonal Frequency Division Multiplexing (OFDM) is an emerging multi-carrier modulation scheme, which has been adopted for several wireless standards such as IEEE 802.11a and HiperLAN2. A well-known problem of OFDM is its sensitivity to frequency offset between the transmitted and received carrier frequencies. This frequency offset introduces inter-carrier interference (ICI) in the OFDM symbol. This paper investigates three methods for combating the effects of ICI: ICI self-cancellation (SC), maximum likelihood (ML) estimation, and extended Kalman filter (EKF) method. These three methods are compared in terms of bit error rate performance.

• Korean Journal of Crystallography
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• v.5 no.1
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• pp.20-23
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• 1994

Specific binding to the oric region of E, coli chromsome by IciA protein inhibits initiation of chrorrnsomal replication in vitro by blocking the opening of this region effected by the initiator DnaA protein. The IciA protein has been suggested play a critical role in a key stage of the cell cycle. In order to study the structure-function relationship of IciA protein, we are determining the three-dimensional structure of IciA Votein by X-ray crystallography, As a first step toward its structure detumination E. coli IciA protein has been crystallized using sodium formate as a precipitant.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.10A
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• pp.950-957
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• 2007

In this paper, a recursive intercarrier interference (ICI) cancellation technique for cooperative space-time block coded orthogonal frequency division multiplexing (STBC-OFDM) with different carrier frequency offsets (CFOs) is proposed. Also, different CFOs existing in a cooperative STBC-OFDM system is shown to produce phase difference in the received signal, causing noise enhancement effect in the STBC decoding process. The performance degradation caused by the noise enhancement effect can be effectively reduced by a proposed ML-based recursive ICI cancellation technique. It is shown by computer simulation that the proposed recursive ICI cancellation technique is effective in reducing ICI, especially for STBC-OFDM systems with a large FFT size and large CFOs.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.9C
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• pp.896-905
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• 2009

In this paper, we propose an enhanced iterative ICI (Inter Carrier Interference) cancellation method for cooperative STBC-OFDM (Space Time Block Coded-Orthogonal Frequency Division Multiplexing) system. In cooperative STBC-OFDM system, ICI cancellation is necessary because ICI due to the independent local oscillators always exits. The conventional iterative ICI cancellation method has severe performance degradation due to the initial estimation error. Also the performance degradation increases as CFOs (Carrier Frequency Offsets) and modulation order increases. Therefore, in this paper, we propose an enhanced iterative ICI cancellation method which can reduce the initial estimation error by giving a priority to initial estimation and cancellation process. Through the complexity and performance comparisons, we verwey that the proposed method has better performance with approximately same complexity compared with the conventional method.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.2A
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• pp.155-163
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• 2009

OFDM System is a promising transmission technique due to its spectral efficiency But, a major disadvantage of the OFDM system is its sensitivity to frequency offset and phase noise that makes intercarrier interference (ICI), which degrades the system performance severely The ICI self-cancellation method has a good performance with frequency offset or phase noise. This paper proposed the N/2 spacing data-conjugate method that works well in large frequency offset and phase noise (normalized frequency offset=0.2-0.4, phase noise standard deviation=about lodes). Also, an efficiency ICI cancellation method using pilot was proposed. Simulation results confirm that performance of the proposed scheme is better than conventional schemes.