• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1413-1418
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• 2012

Background: Previous studies generally indicate that synchronous bilateral breast cancers (SBBC) have an equivalent or moderately poorer survival compared with unilateral cases. The prognostic characteristics of SBBC would be relevant when planning adjuvant therapies and follow-up medical surveillance. The frequency of SBBC among early breast cancers in clinical settings in Australia and New Zealand was investigated, plus their prognostic significance, using the Breast Cancer Audit Database of the Society of Breast Surgeons of Australia and New Zealand, which covered an estimated 60% of early invasive lesions in those countries. Design: Rate ratios (95% confidence limits) of SBBC were investigated among 35,370 female breast cancer cases by age of woman, histology type, grade, tumour diameter, nodal status, lymphatic/vascular invasion and oestrogen receptor status. Univariate and multivariable disease-specific survival analyses were undertaken. Results: 2.3% of cases were found to be SBBC (i.e., diagnoses occurring within 3 months). The figure increased from 1.4% in women less than 40 years to 4.1% in those aged 80 years or more. Disease-specific survivals did not vary by SBBC status (p=0.206). After adjusting for age, histology type, diameter, grade, nodal status, lymphatic/vascular invasion, and oestrogen receptor status, the relative risk of breast cancer death for SBBC was 1.17 (95% CL: 0.91, 1.51). After adjusting for favourable prognostic factors more common in SBBC cases (i.e., histology type, grade, lymphatic/vascular invasion, and oestrogen receptor status), the relative risk of breast cancer death for SBBC was 1.42 (95% CL: 1.10, 1.82). After adjusting for unfavourable prognostic factors more common in SBBC cases (i.e., older age and large tumour diameter), the relative risk of breast cancer death for SBBC was 0.98 (95% CL: 0.76, 1.26). Conclusions: Results confirm previous findings of an equivalent or moderately poorer survival for SBBC but indicate that SBBC status is likely to be an important prognostic indicator for some cases.

• Parasites, Hosts and Diseases
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• 제35권4호
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• pp.245-250
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• 1997

마우스에 있어서 쥐와포자충 감염에 대한 면역기전을 해명하기 위하여 이 원충을 최초 및 도전 감염시켜 위점막 비만세포수의 동태를 관찰하였다. ICR계 SPF3주령 마우스에. 그리고 감염 내과 후 분변 내의 오오시스트 음전 후에 두 번에 걸쳐 각각 $2{\;}{\times}{\;}10^6$의 쥐와포자충 (MCR주) 오오시스트를 경구투여하였다 최초 감염 후 5일 및 도전 감염 후 10일 간격으로 희생시켜 위를 적출하여 pH 2.0으로 조정된 Camoy's solution에 5-6시간 고정한 다음 pH 0.3으로 조정된 l% alcian blue에서 2시간. pH 1.0의 0.5% sihnin에서 5분간 염색하여 위점막 비만세포수를 계수하였다. 위점막 비만세포수는 최초 감염 후 15일에서 25일까지 최고치에 이른 다음 30일에 감소하여 그 이후에는 정상으로 복귀하였으며. 도전 감염 후 20-30일에도 역시 증가하였다 최초 감염 후 이 세포의 증가 후에는 분변에 배설되는 오오시스트의 수도 감소하였으며. 도전 감염 후에는 분변에서 오오시스트를 거의 검출할 수 없었다 이러한 사실로 미루어 보아 이 세포는 최초 감염 흡충체 배출. 그리고 도전 감염의 방어기전과 관련이 있다고 생각한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3279-3283
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• 2015

Background: Colorectal cancer (CRC) is the most common gastrointestinal cancer and the incidence is increasing. CRC is more common with increasing age, but a proportion occurs in young adults, termed young CRC. This study assessed the incidence and the demographic of young CRC in Brunei Darussalam. Materials and Methods: All histologically proven CRC between 1986 and 2014 registered with the Department of Pathology cancer registry were reviewed and data extracted for analyses. Young CRC was defined as cancer in patients aged less than 45 years. The various population groups were categorized into locals (Malays, Chinese and Indigenous) and expatriates. Results: Over the study period, there were 1,126 histologically proven CRC (mean age $59.1{\pm}14.7$ years, Male 58.0%, Locals 91.8% and 8.2% expatriates). Young CRC accounted for 15.1% with the proportion declining over the years, from 29% (1986-1990) to 13.2% (2011-2014). The proportion of young CRC was highest among the indigenous (30.8%), followed by the expatriates (29.3%), Malays (14.3%) and lowest among the Chinese (10.8%). The mean age of young CRC was $35.9{\pm}6.2$; lowest among the indigenous ($33.5{\pm}6.7$), expatriate ($34.9{\pm}6.0$) groupd and the Malays ($35.6{\pm}6.5$) compared to the Chinese ($38.6{\pm}4.6$), a similar trend being observed in the non-young CRC groups. There were no difference between the genders and tumor locations (rectum or colon) between the young and the non-young CRC cases. Female young CRC was significantly younger than male (p<0.05) without any significant variation between the various population groups (p>0.05). Conclusions: Our study showed that the young CRC accounted for 15.1% of all CRC with declining trend observed over recent years. Young CRC was more common among indigenous, expatriates and Malays and least common among the Chinese. There were no differences in the gender and tumor locations.

• Journal of Gastric Cancer
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• 제17권2호
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• pp.132-144
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• 2017

Purpose: To identify baseline prognostic factors for survival in patients with disease progression, during or after chemotherapy for the treatment of advanced gastric or gastroesophageal junction (GEJ) cancer. Materials and Methods: We pooled data from patients randomized between 2009 and 2012 in 2 phase III, global double-blind studies of ramucirumab for the treatment of advanced gastric or GEJ adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing therapy (REGARD and RAINBOW). Forty-one key baseline clinical and laboratory factors common in both studies were examined. Model building started with covariate screening using univariate Cox models (significance level=0.05). A stepwise multivariable Cox model identified the final prognostic factors (entry+exit significance level=0.01). Cox models were stratified by treatment and geographic region. The process was repeated to identify baseline prognostic quality of life (QoL) parameters. Results: Of 1,020 randomized patients, 953 (93%) patients without any missing covariates were included in the analysis. We identified 12 independent prognostic factors of poor survival: 1) peritoneal metastases; 2) Eastern Cooperative Oncology Group (ECOG) performance score 1; 3) the presence of a primary tumor; 4) time to progression since prior therapy <6 months; 5) poor/unknown tumor differentiation; abnormally low blood levels of 6) albumin, 7) sodium, and/or 8) lymphocytes; and abnormally high blood levels of 9) neutrophils, 10) aspartate aminotransferase (AST), 11) alkaline phosphatase (ALP), and/or 12) lactate dehydrogenase (LDH). Factors were used to devise a 4-tier prognostic index (median overall survival [OS] by risk [months]: high=3.4, moderate=6.4, medium=9.9, and low=14.5; Harrell's C-index=0.66; 95% confidence interval [CI], 0.64-0.68). Addition of QoL to the model identified patient-reported appetite loss as an independent prognostic factor. Conclusions: The identified prognostic factors and the reported prognostic index may help clinical decision-making, patient stratification, and planning of future clinical studies.

• Journal of Oral Medicine and Pain
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• 제36권3호
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• pp.199-205
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• 2011

근관치료 중 수동 또는 엔진구동파일을 사용하다 과도한 기구 조작을 하게 되면, 근관충전제, 드레싱제 그리고 근관세척제가 근관에서 나와 하악관으로 확산될 수 있다. 이 때 환자는 통증, 지각과민, 지각감퇴, 무감각, 이상감각 등을 호소하게 될 것이다. 이런 문제들은 근관충전제에 포함되어 있으면서 생체적합성이 떨어지는 물질들에 의한 비가역적인 손상을 피하기 위해 가능한 빨리 해결되어야 한다. 비록 근관치료와 관련하여 발생한 하치조신경의 손상을 치료하는 진료지침이 비교연구 되어 있는 것이 없으나, 이 합병증에 대한 통상의 치료는 통증과 염증을 조절하는 것이고, 가능하다면 수술적인 치료로 근원을 처치하는 것이다. 그러나, 비수술적인 치료로 통증을 완전히 개선하거나 감소시키고 또는 감각이상을 치료하는 것이 보고되어왔다. 가바펜틴(gabapentin) 또는 프리가발린(pregabalin) 같은 항간질제는 신경병증 통증의 치료에 이용되어 왔다. 이번 논문에서는 하악 우측 제 2대구치의 근관치료 후의 하치조신경의 손상과 이에 대해 프레드니솔론과 가바펜틴으로 비외과적 치료를 시행한 것과 임상적으로 신경감각검사와 신경전류인지역치검사(Neurometer)를 통해 경과관찰을 시행하였다.

• 한국재료학회지
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• 제9권6호
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• pp.635-653
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• 1999

The present work considers work considers research strategies to address global warming. Specifically, this work considers the development of technologies of importance for the reduction of greenhouse gas emission and, especially, the materials that are critical to these technologies. It is argued that novel materials that are essential for the production of environmentally friendly energy may be developed through a special kind of engineering: interface engineering, rather than through classical bulk chemistry. Progress on the interface engineering requires to increase the present state of understanding on the local properties of materials interfaces and interfaces processes. This, consequently, requires coordinated international efforts in order to establish a strong background in the science of materials interfaces. This paper considers the impact of interfaces, such as surfaces and grain boundaries, on the functional properties of materials. This work provides evidence that interfaces exhibit outstanding properties that are not displayed by the bulk phase. It is shown that the local interface chemistry and structure and entirely different than those of the bulk phase. In consequence the transport of both charge and matter along and across interfaces, that is so important for energy conversion, is different than that in the bulk. Despite that the thickness of interfaces is of an order to a nanometer, their impact on materials properties is substantial and, in many cases, controlling. This leads to the conclusion that the development of novel materials with desired properties for specific industrial applications will be possible through controlled interface chemistry. Specifically, this will concern materials of importance for energy conversion and environmental monitoring. Therefore, there is a need to increase the present state of understanding of the local properties of materials interfaces and the relationship between interfaces and the functional properties of materials. In order to accomplish this task coordinated international efforts of specialized research centres are required. These efforts are specifically urgent regarding the development of materials of importance for the reduction of greenhouse gases. Success of research in this area depends critically on financial support that can be provided for projects on materials of importance for a sustainable environment, and these must be considered priorities for all of the global economies. The authors of the present work represent an international research group economies. The authors of the present work represent an international research group that has entered into a collaboration on the development of the materials that are critical for the reduction of greenhouse gas emissions.

• 지구물리
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• 제9권3호
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• pp.189-197
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• 2006

The Korea Plateau is a continental fragment rifted and partially segmented from the Korean Peninsulaat the initial stage of the opening of the East Sea (Japan Sea). We interpreted marine seismic profiles from the South Korea Plateau in conjunction with swath bathymetric to investigate processes of con-tjnental rifting and separation of the southwestern Japan Arc. The SouU-i Korea Plateau preserves funda-mental elements of rift architecture comprising a seaward succession of a rift basin and an uplifted rift flank passing into the slope, typical of a passive continental margin. Two distinguished rift basins (Onnuri and Bandal Basins) in the South Korea Plateau are bounded by major synthetic and smaller antithetic faults, creating wide and symmetric profiles. The large-offset border fault zones of these basins have convex dip slopes and demonstrate a zig-zag arrangement along strike. Rifting was primarily controlled by normal faulting resulting from extension orthogonal to the inferred line of breakup along the base ofthe slope rather U-ian strike-slip deformation. Two extension direcdons for rifdng are recog-nized; U-ie Onnuri Basin was rifted in U-ie EW direction; U-ie Bandal Basin in U-ie EW and NW-SE directions, suggesting two rift stages. We interpret that the E-W direction represents initial rifting at the inner margin; while the Japan Basin widened, rifting propagated repeatedly from the Japan Basin to the southeast toward the Korean margin but could not penetrate the strong continental lithosphere of the Korean Shield and changed direction to the south, resulting in E-W extension to create the rift basins at the Korean margin. The Hupo Basin to the south of the Korea Plateau is estimated to have formed in this process. The NW-SE direction probably represents the direction of rifting orthogonal to the inferred line of breakup along the base of the slope of the South Korea Plateau; after breakup the southwestern Japan Arc separated in the SE direction, indicating a response to tensional tectonics associated with the subduction of the Pacific Plate in the NE direction. We suggest that structural evolution of the eastern Korean margin can be explained by the processes occurring at the passive continental margin.

• Journal of Ecology and Environment
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• 제45권3호
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• pp.143-151
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• 2021

Background: Plants are able to optimize defense responses induced by various herbivores, which have different feeding strategies. Local and systemic responses within a plant after herbivory are essential to modulate herbivore-specific plant responses. For instance, leaf-chewing herbivores elicit jasmonic acid signaling, which result in the inductions of toxic chemicals in the attacked leaf (tissue-specific responses) and also in the other unattacked parts of the plant (systemic responses). Root herbivory induces toxic metabolites in the attacked root and alters the levels of transcripts and metabolites in the unattacked shoot. However, we have little knowledge of the local and systemic responses against stem-boring herbivores. In this study, we examined the systemic changes in metabolites in the wild tobacco Nicotiana attenuata, when the stem-boring herbivore Trichobaris mucorea attacks. Results: To investigate the systemic responses of T. mucorea attacks, we measured the levels of jasmonic acid (JA), JA-dependent secondary metabolites, soluble sugars, and free amino acids in 7 distinct tissues of N. attenuata: leaf lamina with epidermis (LLE), leaf midrib (LM), stem epidermis (SE), stem pith (SP), stem vascular bundle (SV), root cortex with epidermis (RCE), and root vascular bundle (RV). The levels of JA were increased in all root tissues and in LM by T. mucorea attacks. The levels of chlorogenic acids (CGAs) and nicotine were increased in all stem tissues by T. mucorea. However, CGA was systematically induced in LM, and nicotine was systematically induced in LM and RCE. We further tested the resource allocation by measuring soluble sugars and free amino acids in plant tissues. T. mucorea attacks increased the level of free amino acids in all tissues except in LLE. The levels of soluble sugars were significantly decreased in SE and SP, but increased in RV. Conclusions: The results reveal that plants have local- and systemic-specific responses in response to attack from a stem-boring herbivore. Interestingly, the level of induced secondary metabolites was not consistent with the systemic inductions of JA. Spatiotemporal resolution of plant defense responses against stem herbivory will be required to understand how a plant copes with attack from herbivores from different feeding guilds.

• 천문학회지
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• 제56권2호
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• pp.169-185
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• 2023

The GMT-Consortium Large Earth Finder (G-CLEF) is the first instrument for the Giant Magellan Telescope (GMT). G-CLEF is a fiber feed, optical band echelle spectrograph that is capable of extremely precise radial velocity measurement. G-CLEF Flexure Control Camera (FCC) is included as a part in G-CLEF Front End Assembly (GCFEA), which monitors the field images focused on a fiber mirror to control the flexure and the focus errors within GCFEA. FCC consists of an optical bench on which five optical components are installed. The order of the optical train is: a collimator, neutral density filters, a focus analyzer, a reimager and a detector (Andor iKon-L 936 CCD camera). The collimator consists of a triplet lens and receives the beam reflected by a fiber mirror. The neutral density filters make it possible a broad range star brightness as a target or a guide. The focus analyzer is used to measure a focus offset. The reimager focuses the beam from the collimator onto the CCD detector focal plane. The detector module includes a linear translator and a field de-rotator. We performed thermoelastic stress analysis for lenses and their mounts to confirm the physical safety of the lens materials. We also conducted the global structure analysis for various gravitational orientations to verify the image stability requirement during the operation of the telescope and the instrument. In this article, we present the opto-mechanical detailed design of G-CLEF FCC and describe the consequence of the numerical finite element analyses for the design.

• 한국산학기술학회논문지
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• 제18권6호
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• pp.269-276
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• 2017

본 연구는 MTS와 스피루리나 함유 화장품이 40~50대 중년여성의 피부 톤, 피부보습 및 색소침착, 미세주름 개선 등 피부에 미치는 영향을 알아보고 효과적인 피부 관리 방법을 제시하고자 실험을 진행하였다. 실험 방법은 MTS, 스피루리나 불 포함 세럼과 크림 팩을 사용한 8명의 대조군과 MTS, 스피루리나 함유 세럼과 크림 팩을 사용한 8명의 실험군으로 분류하였으며, 실험은 주 1회, 총 6회, 1회 관리 시간은 30분으로 시행하였다. 실험 전 0주, 실험 6주 후, 실험 종료 2주 후로 총 3회에 걸쳐 피부 변화를 측정하였다. 측정 결과, 스피루리나 함유 화장품을 사용한 실험군은 피부톤, 수분이 통계적으로 유의하게 증가하였고(p<0.05), 대 소 색소 침착수, 눈꼬리 주름 면적, 멜라닌, 홍반은 통계적으로 유의하게 감소하였다(p<0.05). 실험 종료 2주 후, 실험 6회 후와 비교하여 관리의 지속성을 본 결과 실험군은 눈꼬리 주름 면적, 멜라닌이 통계적으로 유의하게 감소하였고(p<0.05), 피부 톤에서 피부 밝기, 수분은 통계적으로 유의하게 증가하였다(p<0.05). 실험이 종료된 후에도 지속적으로 피부 밝기, 미세주름, 멜라닌, 수분이 개선된 것을 관찰할 수 있었다. 피부 톤에서 색조 밝기, 채도 밝기, 대 소 색소 침착수, 홍반에서도 두 군 모두 실험 6회 후와 비교하여 실험이 종료된 2주 후에도 효과가 유지됨을 알 수 있었다. 결론적으로 MTS와 스피루리나 불 포함 화장품을 이용한 관리보다 MTS와 스피루리나 함유 화장품을 이용한 관리가 피부 톤, 피부보습 및 색소침착, 미세주름 개선에 변화량의 차이가 큰 것으로 나타났다. 관리 후 피부 상태를 묻는 질문에도 모두 만족한다고 응답하여 MTS와 스피루리나 함유 화장품을 이용한 관리가 중년여성의 노화 피부 개선을 위한 효율적인 피부 관리 프로그램 방법으로 적용이 가능할 것으로 사료된다.