• Title/Summary/Keyword: I3C

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Roles of sugar chains in immunostimulatory activity of the polysaccharide isolated from Angelica gigas (참당귀에서 분리한 다당의 면역활성에 대한 당쇄의 역할)

  • Shin, Kwang-Soon
    • Korean Journal of Food Science and Technology
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    • v.51 no.4
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    • pp.336-342
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    • 2019
  • To elucidate structure-function relationship of polysaccharide from Angelica gigas, the AGE-2c-I was purified by two successive chromatography steps. AGE-2c-I showed a potent anti-complementary activity in a dose-dependent manner. AGE-2c-I with a molecular weight of 140 kDa comprised four monosaccharides and 13 glycosyl linkages, and strongly reacted with ${\beta}$-glucosyl Yariv reagent. For the fine structure analysis of AGE-2c-I, it was sequentially digested by exo-arabinofuranosidase and endo-galactanase. The results indicated that AGE-2c-I was a typical RG-I polysaccharide with side chains such as highly branched ${\alpha}$-arabinan, ${\beta}$-($1{\rightarrow}4$)-galactan and arabino-${\beta}$-3,6-galactan. To characterize the active moiety of AGE-2c-I, the anti-complementary activities of AGE-2c-I and its subfractions were assayed. It was observed that the anti-complementary activity of AGE-2c-I was due to the entire structure that resembled RG-I. In addition, arabino-${\beta}$-3,6-galactan side chain (GN-I) in AGE-2c-I probably plays a crucial role in the anti-complementary activity, whereas ${\alpha}$-arabinan side chain (AFN-I) consisting of 5-linked Araf and 3,5-branched Araf partially contributes to the activity.

The Complex Formation of Gallium Bromide with i-Butyl Bromide in Nitrobenzene) (니트로벤젠용액내에서의 브롬화갈륨과 i-브롬화부틸과의 착물형성에 관한 연구)

  • Gwon, O Cheon;NamGung, Jin Hui;Choe, Gi Jun
    • Journal of the Korean Chemical Society
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    • v.38 no.3
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    • pp.208-213
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    • 1994
  • The solubility of i-butyl bromide in nitrobenzene have been measured at 19, 25 and $40^{\circ}C$ in the presence and absence of gallium bromide. In the presence of gallium bromide, 1 : 1 complex, $i-C_4H_9Br{\cdot}GaBr_3$ is formed in the solution. The instability constant K of the complex formation was evaluated from the following equilibrium equation. $i-C_4H_9Br{\cdot}GaBr_3{\rightleftharpoons}C_4H_9Br + 1/2Ga_2Br_6.$ From these result, it seems that the stabilities of the complex formation, gallium bromide with alkyl bromide, are directly related with those of the carbonium ions of alkyl bromide.

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Pre-initiation treatment of indole-3-carbinol(I3C) inhibits 7,12-Dimethylbenz[α] anthracene(DMBA)-induced rat mammary carcinogenesis (Indole-3-carbinol(I3C) 투여에 의한 7,12-Dimethylbenz[α] anthracene(DMBA) 유발 랫드 유선발암 억제)

  • Kang, Jin Seok;Ahn, Byeongwoo;Nam, Ki Taek;Choi, Mina;Kim, Ji Young;Kim, Dae Joong;Jang, Dong Deuk;Yang, Ki-Hwa
    • Korean Journal of Veterinary Research
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    • v.41 no.4
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    • pp.549-555
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    • 2001
  • Indole-3-carbinol (I3C), one component of cruciferous vegetables (the Fammily of Cruciferae), has been shown to exert its chemopreventive effect in liver, colon and mammary tissue before or concurrent exposure of carcinogen, but there have been several evidences that consumption of I3C induced tumor promotion in some tissues. Our studies were investigated to examine the modifying effects of I3C in the 7,12-dimethylbenz[$\alpha$]anthracene (DMBA) induced rat mammary gland tumor model. Fifty-two female Sprague-Dawley rats were randomly divided into five groups. Animals of the group 1 were given the diet containing 100ppm I3C and animals of the groups 2 and 4 were given the diet containing 300ppm I3C from 6 weeks of age. At 7 weeks of age, the animals of the groups 1, 2 and 3 were intubated with DMBA. All amimals were killed at 20 weeks after carcinogen treatment. There were significant increases of food consumption in I3C feeding groups compared with those of basal diet feeding groups. The incidences of the mammary tumors in the group 1, 2 and 3 were 75.0% (9/12), 56.3% (9/16) and 93.8% (15/16), respectively and the average number of tumors of group 1 (DMBA+I3C 100ppm: $2.08{\pm}0.61$) and 2 (DMBA+I3C 300ppm: $1.19{\pm}0.32$) were significantly lower than that of group 3 (DMBA alone: $4.63{\pm}0.72$) at the value of P<0.05 and P<0.001, respectively. In the pathological examination of appearing tumors, most of them were adenocarcinoma. Many epithelial cells of tumors showed strong estrogen receptor (ER) $\alpha$ expression but there were slight difference of ER $\alpha$ expression among the type of tumors. We suggest that pre-initiation treatment of I3C has an inhibitory effects on mammary carcinogenesis induced by DMBA.

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The Complex Formation of Gallium Bromide with i-Propyl Bromide in Nitrobenzene (니트로벤젠용액내에서의 브롬화갈륨과 i-브롬화프로필과의 착물형성에 관한 연구)

  • Oh Cheun Kwun;Dong Sup Lee;Young Hoon Lee
    • Journal of the Korean Chemical Society
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    • v.29 no.1
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    • pp.9-14
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    • 1985
  • The solubilities of i-propyl bromide in nitrobenzene have been measured at 10$^{\circ}$, 19$^{\circ}$ and 25$^{\circ}C$ in the presence and absence of gallium bromide. In the presence of gallium bromide, 1 : 1 complex, i-C$_3$H$_7Br{\cdot}GaBr_3$ is formed in the solution. The instability constant K of the complex formation was evaluated from the following equilibrium equation: i-C$_3$H$_7Br{\cdot}GaBr_3$ ${\rightleftharpoons}$ i-C$_3$H$_7$Br + $\frac{1}{2}$$Ga_2Br_6$. The change of enthalpy, free energy and entropy for the dissociation of the complex were also calculated. From these result, it seems that the stabilities of the complex formation, gallium bromide with alkyl bromide, are directly related with those of the carbonium ions of alkyl bromide.

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Study on Sensory Papillae of Metagonimus yokogawai Cercaria (Metagonimus yokogawai 세르카리아의 감각유두에 관한 연구)

  • 김재진;민득영소진탁
    • Parasites, Hosts and Diseases
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    • v.22 no.1
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    • pp.11-20
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    • 1984
  • A number of studies on the papillae of cercariae of trematodes reported that the papillar patterns (or chaetotaxy) of cercariae might be an excellent method to attain better understanding of the digenetic trematodes (Richard, 1971 ; Short and Cartrett, 1973; Bayssade-Dufour, 1979) . The present study was aimed to determine the number, distribution pattern and structure of the sensory papillae of Metagonimus yokogawai cercariae, and to elucidate the chaetotaxy of this digenetic trematode. M. yokogawai cercariae were pipetted from a vial in which infected snails (Semisulcospira libertina) had been kept for 3 hours. The snails were collected from an endemic area of M. yokogawai, Boseong river in west-southern part of Korea. Observations of papillae were based on light microscopy of those stained with silver nitrate, and on scanning electron microscopy The results are summarized as follows: 1, All papillae observed were uniciliated. 2. Cilia in anterior tip were shorter than the others in other portions. 3. The body papillae were arranged in essentially symmetrical patterns, Total number of the papillae was 126(63 pairs) in average; anterior tip 40(20 pairs), ventral 20(10 pairs), lateral 42(21 pairs), and caudal 8(4 pairs). 4. The chaetotany of M. yokogawai cercaria was: Ci cycle ($3+3C_{I}V,{\;}2+2C_{I}L,{\;}2+3C_{I}D),{\;}C_{II}{\;}cycle(2C_{II}V,{\;}1C_{II}L,{\;}2C_{II}D),{\;}C_{lll}{\;}cycle{\;}(1+lC_{III}V,{\;}1C_{IlI}L),{\;}C_{IV}{\;}cycle{\;}(1C_{IV}V,{\;}IC_{lV}L){\;}in{\;}cephalic{\;}region:{\;}A_I(1A_{IV}V,{\;}1+2A_{I}L,{\;}1A_{I}D),{\;}A_{II}(1A_{II}V,{\;}1+3A_{II}L,{\;}1A_{II}D),{\;}A_{III}(1A_{III}V,{\;}1+1A_{III}L,{\;}1A_{III}D){\;}and{\;}A_{IV}(1A_{IV}V,{\;}2A_{IV}L)$ in antacetabular region: $1M_{I}V{\;}and{\;}2M_{I}L$ in median: $1+1P_{I}L,{\;}1P_{II}L,{\;}1P_{II}D,{\;}1P_{III}L,{\;}1P_{IV}L{\;}and{\;}1P_{IV}D$ in postacetabular region: 2-2-2-2 in caudal region.

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Short and long-term immune effects of Poly (I:C) in kidney of Olive flounder (Paralichthys olivaceus) (넙치(Paralichthys olivaceus) 신장에서 Poly (I:C)의 단기 및 장기적인 면역 효과)

  • Minjae Seong;Youngjin Park
    • Journal of fish pathology
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    • v.37 no.1
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    • pp.123-132
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    • 2024
  • Viral diseases cause enormous economic losses to the olive flounder (Paralichthys olivaceus) aquaculture industry in Korea. This study aimed to identify immune-related genes expressed in the kidney of olive flounder injected with Polyinosinic-polycytidylic acid (Poly (I:C)). Thirty fish were divided into two groups by intraperitoneal injection of 100µl of diethylpyrocarbonate-treated water or poly I:C per fish. Kidney tissues at day 3 and 30 after the injection were used for RNA-seq analysis to identify differentially expressed genes (DEGs). Poly I:C group upregulated il8, cfh, tnfaip2b, c3b.2, ly6d and cd38 genes at 3 days post-injection. Additionally, cd22, ccl34a.3, c9, cxcl19, ccl27a, ccl7, and cfh genes were upregulated at 30 days post-injection. Differential expression gene analysis showed that poly I:C has both short and long-term immune effects in olive flounder. This study provides a theoretical basis for understanding the molecular mechanism of the short and long-term immune effects of poly I:C.

SOME RESULTS ON 1-ABSORBING PRIMARY AND WEAKLY 1-ABSORBING PRIMARY IDEALS OF COMMUTATIVE RINGS

  • Nikandish, Reza;Nikmehr, Mohammad Javad;Yassine, Ali
    • Bulletin of the Korean Mathematical Society
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    • v.58 no.5
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    • pp.1069-1078
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    • 2021
  • Let R be a commutative ring with identity. A proper ideal I of R is called 1-absorbing primary ([4]) if for all nonunit a, b, c ∈ R such that abc ∈ I, then either ab ∈ I or c ∈ ${\sqrt{1}}$. The concept of 1-absorbing primary ideals in a polynomial ring, in a PID and in idealization of a module is studied. Moreover, we introduce weakly 1-absorbing primary ideals which are generalization of weakly prime ideals and 1-absorbing primary ideals. A proper ideal I of R is called weakly 1-absorbing primary if for all nonunit a, b, c ∈ R such that 0 ≠ abc ∈ I, then either ab ∈ I or c ∈ ${\sqrt{1}}$. Some properties of weakly 1-absorbing primary ideals are investigated. For instance, weakly 1-absorbing primary ideals in decomposable rings are characterized. Among other things, it is proved that if I is a weakly 1-absorbing primary ideal of a ring R and 0 ≠ I1I2I3 ⊆ I for some ideals I1, I2, I3 of R such that I is free triple-zero with respect to I1I2I3, then I1I2 ⊆ I or I3 ⊆ I.

Fabrication of Barium Oxide Ferrite Magnet-II (바리움 훼라이트 자석의 시작 - II)

  • 백용현
    • 전기의세계
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    • v.21 no.6
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    • pp.17-20
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    • 1972
  • The magnetic properties of Ba-Ferrite ( $M^{+2}$O.nF $e_{2}$ $O_{3}$ is highly improved under the condition of composition ratio n=4.4 when B $i_{2}$ $O_{3}$ is added to Ferrite, the adding amount and sintering temperature which affect the magnetic properties were investigated and the following results; were obtained; 1. Magnetic properties are varied with B $i_{2}$ $O_{3}$ content and singering temperature, and coercive force and residual induction can be improved with B $i_{2}$ $O_{3}$. 2. The optimal content of B $i_{2}$ $O_{3}$ amount is about 4 mol %, 3. Without the addition of B $i_{2}$ $O_{3}$, the optimal sintering temperature is about 1300.deg. C, but when 4 mol % of B $i_{2}$ $O_{3}$ is added, the optimal sintering temperature falls to the range of 900.deg. C to 1100.deg. C and it also improves magnetic properties. 4. Residual induction increases as the singering temperature is raised to 1100.deg. C. Coercive force also increased as the sintering temperature is raised to 1000.deg. C, but it rapidly decreases when sintering temperature goes beyond 1000.deg. C. 5. Only a negligible change may be noticed in the decrease of Curie temperature by the addition of about 4 mol % of B $i_{2}$ $O_{3}$.

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$C^3$I 추계학적 제어(Stochastic Contorl)의 응용

  • Lee, Man-Hyeong
    • Journal of the Korean Society for Precision Engineering
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    • v.1 no.3
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    • pp.26-40
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    • 1984
  • 전자공업은 방위산업발달에 획기적인 역할을 담당하고 있으며, 특히 전략적 $C^{3}$/I( Command, Control, Communication, and Intelligence) 개념을 도입하여, 국가방위를 위한연구가 미국의 여러 대학들과 방위성 산하 연구기관에서 활발히 진행되고 있다. 이 글에서는 $C^{3}$/I에 대한 개략적인 개념을 소개하고, 추계학적(Stochastic) 관점에서 $C^{3}$/I가 실전을 위해 어떻게 응용되고 있는가를 고찰하기 위하여 최근에 발표되고 있는 비 선형필터링(Nonlinear Filtering), 적응필터링(Adaptive Filtering) 최적제어 문제들을 소개하고자 한다.

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