• Archives of Pharmacal Research
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• v.17 no.5
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• pp.381-382
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• 1994

Administration route dependency on the distribution of PEGylated recombinant human turor necrosis factor binding protein (rhTNFbp-PEG20K dimer) was observed following a subcutaneous (sc) and an intravenous (iv) administrationin rats. ehTNFbp-PEG20K dimer is composed of two rhTNGbp molecules (molecular weight 18, 278 daltons each) joined by polyethylene glycol 2000(PEG30K). The steady state distribution volume of rhTNFbp-PEG20K was 55 m/kg and 359 ml/kg following the i.v. and s.c. administrations, respectively. These results suggest that the distribution of ehTNFbp-PEG20K is limited within the cpillary space after i.v. administration, while rhTNFbp-PEG20K can distribute into a space (35.9% of body weight) which is between extracellylar space and total body water. A lymphatic absorption may paly a role in the distribution of rhTNFbp-PEF20K dimer following the sc administration. The present study suggests that the administration route of a lartge protein molecule should be determined depedning upon target sites.

• Journal of The Institute of Information and Telecommunication Facilities Engineering
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• v.8 no.3
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• pp.122-131
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• 2009

Ubiquitous-Transportation sensor network is able to realize a vehicle ad-hoc network. Since there are some problems in an existing ITS system, the new technology and traffic information strategies are requirements in this advanced system, u-TSN. The purposes of this paper is to introduce the components on u-TSN system, establish new traffic strategies for this system, and then evaluate these strategies by making a comparative study of ITS and using micro traffic simulator, AIMSUN. The strategy evaluated by AIMSUN is position-based multicast strategy which provides traffic information to vehicles using V2I (vehicle to Infrastructure) communication. This paper focuses on the providing real-time route guidance information when congestion is occurred by the incidents. This study estimates total travel time on each route by API modules. Result from simulation experiments suggests that position-based multicast strategy can achieve more optimal network performance and increased driver satisfaction since the total accumulated travel times of both the major road and the total system on position-based multicast strategy are less than those on VMS.

• Toxicological Research
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• v.14 no.3
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• pp.385-391
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• 1998

The study was carried out to evaluate the acute toxicity of enrofloxacin-colistin combination via a single oral(p.o.)and intravenous(i.v.) administration in ICR mice. All procedures of the test were performed by the established regulation of Korean National Institute of Safety Research (1994. 4.14). The maximal dose of oral and intravenous routes was 5,000mg/kg and 90mg/kg, consisting with each 6 groups including control of male and female, respectively. As the results, $LD_{50}$m}'s of the combinations showed 3,075mg/kg (f)and 2,564mg/kg(m) after oral administrations, together with 48mg/kg(f) and 40mg/kg(m) after intravenous administration. These facts indicated that acute toxicitiy of enrofloxacin-colistin combination were different depending on the administration routes and sexes in ICR mice. In conclusion, the route of enrofloxacin-colistin combination must not choose as i.v. route administration in terms of acute toxicity based on $LD_{50}$.

• Journal of Microbiology and Biotechnology
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• v.24 no.4
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• pp.556-562
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• 2014

The occurrence of human norovirus (NoV) genogroup I (GI) and genogroup II (GII) strains was investigated in Korea. Between 2007 and 2010, 265 samples were collected from 89 Korean water source locations. NoV GI was detected in 4.5% and NoV GII in 1.5%. Samples collected in winter had the highest occurrence; 9.4% for NoV GI and 6.3% for NoV GII. NoV GI detection was highest in groundwater, with the next highest in river water and the lowest in lake water (5.9%, 5.4%, and 1.6%, respectively), and NoV GII was found only in river water. When three representative Korean basin systems (Han (H)-, Geum/Seom (G/S)-, and Nakdong (N)-river basins) were compared, both NoV genogroups were high in the G/S-, but absent in the H- river basin. The most prevalent genotypes within the GI and GII groups were GI.5 and GII.4, respectively. The NoVs found in surface water were identical to those found in patients and those found in groundwater. The NoVs appeared to be transmitted from the patient to the surface water, and then to the groundwater, suggesting a fecal-oral route of transmission. This is the first nationwide surveillance of NoV in major Korean water sources.

• Archives of Pharmacal Research
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• v.24 no.3
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• pp.219-223
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• 2001

Nasal absorption of procyclidine, a synthetic anticholinergic compound, was investigated in Wistar rats and Beagle dogs. The dosing solution was prepared by dissolving$^{14}C$-procyclidme in 50% ethanolic saline. The dosing solution was administered intravenously and intranasally to rats at a dose of 0.6 mg/kg (i.e., $60{\mu}$l/kg in the form of a 1% w/v solution), and intravenously, orally and intranasally to doss at a dose of 0.3 mg/kg(i.e., $6{mu}$l/kg in the form of a 5% w/v solution). Blood samples were taken from an artery of the animals through the catheter for periods of 1200 (for rats) and 1440 min (for dogs), and the radioactivity in the samples was determined by liquid scintillation counting. The nasal bioavailability of Procyclidine in rats and dogs, based on the radioactivity was calculated to be 81.1 and 98.6% respectively. In both rats and dogs, the plasma profiles of procyclidine following nasal administration were very close to those following intravenous administration, leading to nearly superimposable profiles between the two protocols. In dogs, nasal administration resulted in significantly higher plasma concentrations during the first 30 min period compared to oral administration, suggesting the superiority of the nasal route over the oral route in terms of a prompt expression of the pharmacological effect of the drug. The results obtained in this study indicate that procyclidine is rapidly and nearly completely absorbed via the nasal route. In conclusion, nasal administration represents a viable alternative to intravenous administration in the case of procyclidine.

• Transactions of Materials Processing
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• v.11 no.6
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• pp.519-528
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• 2002

The microstructural evolution during the equal channel angular pressing of Ti-6Al-4V alloy was investigated using the transmission electron microscopy (TEM). ECA pressing was carried out isothermally with route C at $600^{\circ}C$ for two types of initial microstructure, i.e., equiaxed and Widmanstatten microstructures. At an initial stage of ECA pressing, the equiaxed microstructure showed more uniform flow than the Widmanstatten microstructure. However, both microstructures were significantly refined revealing nearly equiaxed grains of 0.3$mu extrm{m}$ in diameter with high angle grain boundaries after 4 passes of ECA pressing. These ultrafine gains were found to be stable with little grain growth, when annealed up to $600^{\circ}C$ for 1hr.

• Proceedings of the KSR Conference
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• 2006.11b
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• pp.581-586
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• 2006

Selection and application recommendations of lightning arresters for DC electric traction vehicles are presented. To decide arrester specification such as continuous operating voltage(COV, $U_c$), rated voltage($U_R$), and nominal discharge current($I_n$), variations of system voltage and surge currents flowing arresters were analyzed in running-service of traction vehicles. System voltages increased up to 1,800V during anti-breaking. Surge currents recorded 3 times per running-service-route and their magnitudes were ranges of $150A{\sim}2kA$. From the field measurement and consideration of EN50163, COV, $U_c$, and $U_R$ for the $1,500V_{DC}$ traction vehicles were proposed.

• Proceedings of the KIEE Conference
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• 2002.07a
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• pp.169-171
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• 2002

The western route of KEPCO's 765kV transmission line has been tentatively operating as 345kV voltage before commercial operation. After finishing the test operation of 765kV substation in 2002. KEPCO decided to operate the 765kV line for commercial operation. During the applying of 765kV voltage to the transmission line, double circuit transmission line will be operated with two voltage grades of 765kV and 345kV. Because the earthing switch is installed on both end of transmission line, we had estimated the electrostatic induction voltage and electromagnetic induction current before the line energizing in order to confirm the ratings of earthing switch. The induced voltage and current is very important for the maintenance of parallel circuit. This paper describes the simulation study of electrical phenomena such as electrostatic induction voltage from the parallel line and electromagnetic induction current from the parallel circuit. The transmission line model was developed by EMTP (Electro-Magnetic Transient Program).

• Journal of the Korean Institute of Landscape Architecture
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• v.25 no.2
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• pp.31-42
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• 1997

Visibility has been used for Visual Impact Assessment and Buildingheight Control. The purpose of this study is to elaborate visibility analysis technique in GIS, and to design a visual information system baed on this technique for diverse application. The results of this study are as follows : 1) By classifying visibility analysis techniques into two groups, Each one's merits and demerits were investigated. Practically GIS visibility analysis by DTM model using contour map and investigating it by means of site-observation can be the most effective method. 2) A visibility analysis techniquwe for V.I.A. and B.H.C. was presented by studying GIS visibility analysis by means of DTM model using contour map. There were 5 problems. 3) Adequate analysis techniques were presented according to the landscape factor-road, ship-route, port, mountain, etc. 4) Viewing distance from road and ship-route in visual corridor, landma가 visibility and distance, the angle of incidence and invisible region's depth are helpful for land scape management or land use planning.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1998.06a
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• pp.151-154
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• 1998

The layered trivanadate, LiV$_3$O$_{8}$ has been investigated as a cathode material for secondary lithium batteries. Early in its development the preparation method of LiV$_3$O$_{8}$ strongly influenced its electrochemical properties, such as discharge capacity, rate capability and cycling efficiency. In the present experiment, a new synthesis route has been applied to obtain LiV$_3$O$_{8}$ . Instead of the conventional high temperature technique leading to the crystalline form, a solution technique producing the amorphous form has been used. This material, after dehydration, shows an electrochemical performance exeeding that of the crystalline one. The rationale for this behavior mainly lies in microscopic factors, i.e., in the possibility for the unit cell of amorphous LiV$_3$O$_{8}$ to insert up to 9 Li$^{+}$, instead of six for crystalline LiV$_3$O$_{8}$ . The ultrasonically treated products in water were characterized by XRD, TGA, DSC, and SEM. These measurements showed that the ultrasonic treatment process of crystalline LiV$_3$O$_{8}$ causes a decrease in crystallinity and considerable increases in specific surface area and interlayer spacing.g.