• 제목/요약/키워드: Hyunsook

검색결과 192건 처리시간 0.032초

How Chromosome Mis-Segregation Leads to Cancer: Lessons from BubR1 Mouse Models

  • Lee, Hyunsook
    • Molecules and Cells
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    • 제37권10호
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    • pp.713-718
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    • 2014
  • Alteration in chromosome numbers and structures instigate and foster massive genetic instability. As Boveri has seen a hundred years ago (Boveri, 1914; 2008), aneuploidy is hall-mark of many cancers. However, whether aneuploidy is the cause or the result of cancer is still at debate. The molecular mechanism behind aneuploidy includes the chromosome mis-segregation in mitosis by the compromise of spindle assembly checkpoint (SAC). SAC is an elaborate network of proteins, which monitor that all chromosomes are bipolarly attached with the spindles. Therefore, the weakening of the SAC is the major reason for chromosome number instability, while complete compromise of SAC results in detrimental death, exemplified in natural abortion in embryonic stage. Here, I will review on the recent progress on the understanding of chromosome missegregation and cancer, based on the comparison of different mouse models of BubR1, the core component of SAC.

연변어 탄설음화 현상의 음성, 음운론적 분석 (The phonetics and phonology of flapping in Yonbyon dialects)

  • 강현숙
    • 대한음성학회지:말소리
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    • 제37호
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    • pp.1-12
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    • 1999
  • In this paper, we examine the allophones of an underlying segment /l/ in Korean dialects. In particular, we examine how an underlying /l/ sound surfaces in the Korean dialect spoken at Yonbyon, China. To do so, we employ the following processes: First, we perform the phonetic studies on the allophones of an underlying /l/ in the Yonbyon dialect. Secondly, we compare the phonological environments of the allophones of an underlying /l/ in the Yonbyon dialect with the South Korean dialect. Finally, we discuss the phonological implications of the allophones of the underlying /l/ in terms of Feature Geometry and Syllable Contact Law. Based on the phonetic study, we will argue that the distinctive feature [sonorant] should be placed outside the root node and that the flap, an allophone of an underlying /l/, should be understood as an obstruent, not a sonorant.

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국립중앙박물관에서의 IPM(Integrated Pest Management) 방안 (IPM(Integrated Pest Management) Method at National Museum of Korea)

  • 이승은;노현숙
    • 박물관보존과학
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    • 제8권
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    • pp.25-30
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    • 2007
  • 국립중앙박물관에 IPM(Integrated pest management) 방법을 도입하게 된 가장 중요한 이유는 보다 효율적이면서 경제적이고 안전한 해충 피해 방지를 위해서이다. 먼저 곤충 모니터링을 통해 현재 박물관의 해충분포 및 종류, 상태, 유입경로 등을 확인한 후 적합한 대책을 세워 보다 안전하면서도 합리적인 방제방법을 찾도록 하였다.

A SEMI-LAGRANGIAN METHOD BASED ON WENO INTERPOLATION

  • Yi, Dokkyun;Kim, Hyunsook
    • 충청수학회지
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    • 제28권4호
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    • pp.623-633
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    • 2015
  • In this paper, a general Weighted Essentially Non-Oscillatory (WENO) interpolation is proposed and applied to a semi-Lagrangian method. The proposed method is based on the conservation law, and characteristic curves are used to complete the semi-Lagrangian method. Therefore, the proposed method satisfies conservation of mass and is free of the CFL condition which is a necessary condition for convergence. Using a several standard examples, the proposed method is compared with the third order Strong Stability Preserving (SSP) Runge-Kutta method to verify the high-order accuracy.