• Title/Summary/Keyword: Hyunsook

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How Chromosome Mis-Segregation Leads to Cancer: Lessons from BubR1 Mouse Models

  • Lee, Hyunsook
    • Molecules and Cells
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    • v.37 no.10
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    • pp.713-718
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    • 2014
  • Alteration in chromosome numbers and structures instigate and foster massive genetic instability. As Boveri has seen a hundred years ago (Boveri, 1914; 2008), aneuploidy is hall-mark of many cancers. However, whether aneuploidy is the cause or the result of cancer is still at debate. The molecular mechanism behind aneuploidy includes the chromosome mis-segregation in mitosis by the compromise of spindle assembly checkpoint (SAC). SAC is an elaborate network of proteins, which monitor that all chromosomes are bipolarly attached with the spindles. Therefore, the weakening of the SAC is the major reason for chromosome number instability, while complete compromise of SAC results in detrimental death, exemplified in natural abortion in embryonic stage. Here, I will review on the recent progress on the understanding of chromosome missegregation and cancer, based on the comparison of different mouse models of BubR1, the core component of SAC.

The phonetics and phonology of flapping in Yonbyon dialects (연변어 탄설음화 현상의 음성, 음운론적 분석)

  • Kang Hyunsook
    • MALSORI
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    • no.37
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    • pp.1-12
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    • 1999
  • In this paper, we examine the allophones of an underlying segment /l/ in Korean dialects. In particular, we examine how an underlying /l/ sound surfaces in the Korean dialect spoken at Yonbyon, China. To do so, we employ the following processes: First, we perform the phonetic studies on the allophones of an underlying /l/ in the Yonbyon dialect. Secondly, we compare the phonological environments of the allophones of an underlying /l/ in the Yonbyon dialect with the South Korean dialect. Finally, we discuss the phonological implications of the allophones of the underlying /l/ in terms of Feature Geometry and Syllable Contact Law. Based on the phonetic study, we will argue that the distinctive feature [sonorant] should be placed outside the root node and that the flap, an allophone of an underlying /l/, should be understood as an obstruent, not a sonorant.

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IPM(Integrated Pest Management) Method at National Museum of Korea (국립중앙박물관에서의 IPM(Integrated Pest Management) 방안)

  • Lee, Sungeun;Roh, Hyunsook
    • Conservation Science in Museum
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    • v.8
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    • pp.25-30
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    • 2007
  • One of the most important reasons why the method of IPM(Integrated pest management) was introduced to the museum is to prevent the damages by insects in the more efficient, economic and safer way. First, through monitoring the insects, the distribution, kinds, condition and inflow path of the insects should be confirmed, and then the safe and rational methods of prevention and elimination should be found in order to take more appropriate measures against them.

A SEMI-LAGRANGIAN METHOD BASED ON WENO INTERPOLATION

  • Yi, Dokkyun;Kim, Hyunsook
    • Journal of the Chungcheong Mathematical Society
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    • v.28 no.4
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    • pp.623-633
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    • 2015
  • In this paper, a general Weighted Essentially Non-Oscillatory (WENO) interpolation is proposed and applied to a semi-Lagrangian method. The proposed method is based on the conservation law, and characteristic curves are used to complete the semi-Lagrangian method. Therefore, the proposed method satisfies conservation of mass and is free of the CFL condition which is a necessary condition for convergence. Using a several standard examples, the proposed method is compared with the third order Strong Stability Preserving (SSP) Runge-Kutta method to verify the high-order accuracy.