• Korean Journal of Acupuncture
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• 제23권1호
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• pp.1-14
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• 2006

Objectives : This research was performed to investigate the effect of invasive low level laser acupuncture therapy(LLLAT) at Yolgyol+yogu(LU7+LR5) on weight gain, food intake, food efficiency, lipid metabolism and liver function in hyperlipemia rats. Methods : Experimental groups were divided into high fat diet cup(Control group), high fat diet and 15 mW/5 min LLLAT at LU7+LR5(15 mW/5 min group), 15 mW/10 min LLLAT at LU7+LR5(15 mW/10 min group), 30 mW/5 min LLLAT at LU7+LRS(30 mW/5 min group), 30 mW/10 min LLLAT at LU7+LR5(30 mW/10 min group). LLLAT was treated at the 15,30mW-5,10min once a 2day during 5 weeks. Results : Body weight was decreased significantly in 30 mW/s min group and 30 mW/10 min group compared with control group. Food intake was decreased significantly in 15 mW/5 min group and 15 mW/10 min group compared with control group. Food efficiency was decreased significantly in 30 mW/10 min group compared with control group. In the lipid metabolism, total cholesterol, HDL-cholesterol and free fatty acid were increased significantly in 15 mW/5 min group and 30 mW/10 min group compared with control group. LDL-cholesterol was increased in 30 mW/10 min group and phospholipids was decreased significantly in all experimental group compared with control group. triglyceride was not showed significant result in all experimental group. In the liver function, AST was not showed significant result in all experimental group, ALT and ALP were increased significantly in 30 mW/10 min group, ALP was decreased in 30 mW/5 min group compared with control group. Conclusions : LLLAT at LU7 and LR5 can manage hyperlipemia by controlling body weight, food intake, food efficiency ratio and lipid metabolism.

• 생명과학회지
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• 제17권10호
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• pp.1387-1393
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• 2007

함박잎새버섯은 잎새버섯의 한 품종으로 농업과학기술원의 야생균주로부터 개량된 새로운 품종이다. 인공재배에 의하여 대량생산이 이루어지고 있다. Streptozotocin와 고지방식이에 의해 유도된 실험쥐 당뇨에 있어서 고혈당 및 고지질 혈에 대한 함박잎새버섯분말의 효능과 부분적인 기전을 6 주간의 사육기간을 통한 결과는 다음과 같다. 1. 함박잎새버섯분말 투여에 의한 체중증가량은 당뇨를 가진 실험쥐의 2 배로 분말이 당뇨에 의해 유도된 체중감소의 병폐현상을 막아주는 주는 역할을 하는 것으로 추정된다. 2. 함박잎새버섯분말 투여는 혈당을 약 200 mg/dl 정도 감소한 당뇨를 가진 실험쥐 혈당의 약 50% 수준이었다. 3. 당뇨 유발에 의해 증가된 Triglyceride, 총콜레스테롤, LDL-cholesterol의 함량은 함박잎새버섯분말 투여에 의해 용량-의존성 경향을 보이면서 감소되었다. 그러나 당뇨 유발에 의해 감소된 HDL-cholesterol 함량은 함박잎새버섯분말 투여에 의해 증가되었다. 4. 함박잎새버섯분말 투여에 의한 당뇨-유도성 췌장 손상정도가 감소하였으며 이러한 효능이 당뇨 유발 실험쥐에 있어서 고혈당과 고혈지질을 조절하는 부분적인 기전으로 이해된다.

• 한국산학기술학회논문지
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• 제15권2호
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• pp.923-933
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• 2014

일부 건강검진 수진자들의 4대질환(고혈압, 당뇨병, 간질환, 고지혈증)에 대한 경계군과 유질환군 및 건강행태의 변화를 분석하고자 2009년과 2011년 2회에 걸쳐 일개 건강검진센터에서 정기 건강검진을 받았던 13,828명을 조사대상으로 하였다. 조사내용은 대상자의 일반적 특성으로 음주와 흡연습관을 조사하였고, 건강검진 항목으로는 SBP, DBP, AST, ALT, GGT, Glucose, T-Cholesterol, Triglyceride 이었으며 주요 결과는 다음과 같다. 연구시작년도에 비하여 종료년도 음주율 및 흡연율은 1.6%, 1.4% 각각 감소하였고. 검진항목별 경계군은 조사시작년도에 비하여 종료년도 고혈압은 62.0%에서 59.8%로 2.2%, 식전혈당은 17.1%, 고지혈증은 6.6%, 간기능은 2.0% 감소하였고, 유질환군은 고혈압은 6.7%에서 6.1%로 0.6%, 식전혈당은 1.9%, 고지혈증은 4.2%, 간기능은 1.3% 감소하였다. 이상의 결과에서 4대질환 모든 항목에서 경계군이 유질환군에 비해 유소견율이 더 많이 감소하는 경향을 보여 향후 유질환군이 감소할 것으로 예측할 수 있으나, 지속적인 관리 및 추적관찰을 통하여 미래의 변화에 대해 연구해야 할 필요성이 있겠다.

• 대한지역사회영양학회:학술대회논문집
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• 대한지역사회영양학회 2004년도 추계학술대회
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• pp.87-87
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• 2004

• 대한본초학회지
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• 제22권3호
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• pp.109-116
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• 2007

Objective : In order to elucidate hyperlipidemic effects of the fruits of Poncirus trifoliata and Citrus aurantium, our experimental study was performed on hyperlipidemia rats induced by Triton WR-1339. Method : The hyperlipidemia rats induced by intraperitonial injection of triton WR-1339 were treated with the fruits of P. trifoliata (rare and preparata) and C. aurantium 50 and 200mg/kg. The amount of triglyceride. total cholesterol. HDL-cholesterol, LDL-cholesterol, AST. and ALT levels were measured. Results: The levels of triglyceride. total cholesterol and LDL-cholesterol were significantly reduced in fruits of P. trifoliata (rare and preparata) and C. aurantiu. Simvastatine treated group compared with those of control but the level of HDL-cholesterol was incresed. The level of AST and ALT were not significantly reduced by the treatment to the fruits of P. trifoliata (rare and preparata) and C. aurantium. Conclusion : In the hyperlipidemia rats induced by triton WR-1339. the fruits of P. trifoliata (rare and preparata) and C. aurantium showed a hyperlipidemic effect.

• KSBB Journal
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• 제26권2호
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• pp.126-130
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• 2011

To investigate the antihyperglycemic and antihyperlipemic effect of 80% ethanol extract of Schizandra Chinensis fruit, we induced diabetes in the rats with streptozotocin (STZ) and administered schizandra extract or Acarbose to diabetic rats for 21 days by oral administration. Consequently, the groups treated using schizandra extract decreased blood glucose levels more 39% than no treatment group and the case of Acarbose group was decreased it about 21%. The concentration of cholesterol, triglyceride and LDL-C in blood was also decreased while treating schizandra extract, on the other hand, HDL-C concentration was significantly increased it about 26%. Those results induced that anti-atherogenic index (AAI) in blood was improved more than 82% level like normal condition, especially in treatment of schizandra extract 100 mg. The lipid profiled in feces was likewise showed apparent tendency to decrease and food efficiency ratio of diabetic rats was became higher for treatment with schizandra extract, but Acarbose group had low efficiency in compared with the result of glucose level and lipid profile in blood. As a result, schizandra extract is regard a good medicine for diabetes due to improve physical constitution, blood glucose and lipid level caused hyperglycemia and suggest that schizandra extract has real effects on the diabetes complication as atherosclerosis, coronary heart disease, high blood pressure.

• Journal of Pharmaceutical Investigation
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• 제19권3호
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• pp.137-143
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• 1989

This study was attempted to investigate the effect of Tricholoma matsutake on experimentally induced hyperlipemia in rats. The levels of cholesterol, triglyceride and phospholipid were measured. Diagnostic attention has been paid to the cholesterol concentration associated with high density lipoprotein (HDL), which appears to be inversely related to the incidence of coronary artery disease. For these reasons, determination of HDL-cholesterol has significant meaning. Total cholesterol was determined by Abell-Kindall method, and to measure HDL-cholesterol, serum low density lipoproteins (LDL) were first selectively precipitated by HDL-precipitating reagent. The results obtained were as follows : 1) The level of total cholesterol in serum of hyperlipemic rats was decreased by oral administration of Tricholoma matsutake extract. 2) The level of HDL-cholesterol was increased by the mushroom extract. 3) The level of triglyceride was significantly decreased by the mushroom extract. 4) The level of phospholipid was slightly decreased by the mushroom extract.

• 한국직업건강간호학회지
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• 제9권1호
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• pp.39-48
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• 2000

Hyperlipemia is the most leading risk factor of cardiovascular disease which is the main cause of death in Korea. However, there is a tendency to neglect the prevention and treatment since it has no specific symptoms. It has been reported that the level of serum-lipid can be lowered by the improvement of eating habits. Therefore, it is highly likely that the development of programs on the improvement of eating habits through behavioral theory is required to the community nursing practice. The theory of planned behavior, which assumes that human behaviors are determined by one's intention to carry out the behavior, can be characterized by the point that behaviors are not only individual factors but also social behaviors relating to subjective norms. It is widely recognized that this theory has a high predictability on health behavior due to it's simplicity clearness, and measurability as well as high quality of being general. Thus, the theory of planned behavior could be useful in developing a model of a health promotion program to the change of behaviors of the risk group of cardiovascular disease. Consequently, based on the theory of planned behavior, the purpose of this study is to develop an intention promotion program of the diet, and then to testify the effects. The sample of this study consisted of 26 industrial workers who had proved hyperlipemia from a medical examination in 1996 (experimental group 13, control group 13). The intention promotion program, which includes education, monitoring, pressure, counselling on the level of individuals, families and organizations, was conducted for 10 weeks The purpose of this program was to promoting intention of the diet through changes of the prerequisite factors of intention such as behavioral belief, outcome evaluation, normative belief and control belief. When it came to data analysis, the ${\chi}^2$-test and Fisher's Exact test were used to compare the general characteristics between the experimental and the control group, an independent t-test for the other variables. ANOVA was used to the test hypothesis, and the Pearson correlation test for variable's correlation. The results of this study can be summarized as follows ; 1) There was a significant increase in the intention(F=18.51, p=.00) of diet in the experimental group. 2) Diets(F=32.51, p=.001) in the experimental group were better carried out than in the control group. 5) There was a moderate correlation between the intention of diet and performance (r=.587. p=.003). From the results, it can be concluded that the intention promotion program is very effective, leading to the change of health promotion behavior. Above all, it is really valuable that the intention promotion program in this study regards health promotion behavior as a social behavior and that intervention was done on the level of family and organization. Consequently, when performing a health promotion program, social approach elevating the intention should go hand in hand in order to make the program effective.

• 동의생리병리학회지
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• 제19권1호
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• pp.218-223
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• 2005

According to the Chinese and Korean medicinal and herbal literature, SSG(Silsosangami) is effective for the treatment of inflammation, hyperlipemia and arteriosclerosis. The pharmacological action of SSG has been limitedly studied in regard to ischemic infarction. This herbal medicine has been shown to express diverse activities such as immunomodulating, anti-infarction, anti-allergic and anti-inflammatory effects. Antisclerotic effects of SSG in experimentally induced atherosclerosis in rabbits have also been reported. However, pharmacological mechanisms of SSG on lipid metabolism and atherosclerosis formation are poorly understood. The present paper reports the effect of extracts obtained from SSG on endotoxin-induced experimental DIC in rats. Also, these were tested for their effect on endotoxin-induced blood platelet aggregation, thrombin-induced conversion of fibrinogen and fibrinolysis in vitro experiments with aspirin as a positive agent. The anti-thrombic properties of SSG were also investigated by means of analytical parameters of bood composition. The extracts of SSG and its seven herbs, except Cnidii Rhizoma and Carthami Flos, inhibited the endotoxin-induced DIC and thrombosis in rats. Also the extract inhibited the endotoxin-induced decrease in blood platelets and fibrinogen, and endotoxin-induced increase in fibrin degradation products (FDP) on disseminated intravascular coagulation in normal rats.

• 대한한방내과학회지
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• 제31권3호
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• pp.631-649
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• 2010

Objective : The object of this study was to observe the effects of aqueous extracts of Chunglijagam-tang(CLJGT), which has traditionally been used in Korean medicine for treating various diseases, on streptozotocin(STZ)-induced rat diabetes and related complications: diabetic nephropathy, hepatopathy and hyperlipemia. Methods : CLJGT extracts were orally administered once a day for 28 days at a dosage 50, 100 and 200mg/kg from 21 days after STZ treatment, and the changes on body weights, blood glucose levels, kidney and liver weights, serum BUN(blood urea nitrogen), creatinine, AST(aspartate transaminase), ALT(alanine aminotransferase), HDL(high-density lipoprotein), LDL (low-density lipoprotein), total cholesterol and triglyceride levels were observed with pancreatic malondialdehyde(MDA) and glutathione(GSH) contents. The results were compared with silymarin 100mg/kg. Results : Significant decrease of blood glucose levels, kidney and liver weights, serum BUN, creatinine, AST, ALT, LDL, total cholesterol, triglyceride levels, pancreatic malondialdehyde contents and significant increase of body weights, serum HDL levels, pancreatic glutathione contents were detected in CLJGT extracts 50, 100 and 200mg/kg administered groups as compared to the STZ control group. Conclusion : CLJGT extracts showed favorable effects on the STZ-induced diabetes and related complications mediated by their antioxidant effects as similar to silymarin. Therefore, it is expected that DBEH has potential for use in the management of diabetes and various diabetic complications.