• 제목/요약/키워드: Hydroxylamine-O-sulfonic acid

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유기 붕소 화합물의 아민화 반응을 이용한 Aminophosphonic Acid의 새로운 합성방법 (New Synthetic Method of Aminophosphonic Acid via Amination of Organoboranes)

  • 김상범;조경연;홍석인
    • 대한화학회지
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    • 제38권9호
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    • pp.682-686
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    • 1994
  • 인을 포함한 유기 붕소 화합물의 아민화 반응을 이용하여 aminophosphonic acids를 합성하는 새로운 방법이 연구되었다. Diethyl 2-methyl-2-propenyl-phosphonate, diethyl 3-butenylphosphonate를 보란으로 수소화 붕소화시킨 뒤 이들을 hydroxylamine-O-sulfonic acid로 아민화시켜 각각 diethyl 3-aminopropylphosphonate, diethyl 3-amino-2-methyl-2-propylphosphonate 및 diethyl 4-aminobutylphosphonate를 합성하였으며, 이를 가수분해하여 해당하는 aminophosphonic acid들을 얻었다.

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Synthesis and Antimicrobial Activity of Some New 1-Alkyl-2-alkylthio-1,2,4-triazolobenzimidazole Derivatives

  • Mohamed, Bahaa Gamal;Hussein, Mostafa Ahmed;Abdel-Alim, Abdel-Alim Mohamed;Hashem, Mohammed
    • Archives of Pharmacal Research
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    • 제29권1호
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    • pp.26-33
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    • 2006
  • Some new derivatives of 1,2,4-triazolo[2,3-a]benzimidazoles were synthesized through the reaction of 1,2-diaminobenzimidazole with carbon disulfide. The resulting 1,2,4-triazolo-[2,3a]benzimidazole-2-thione intermediate was reacted with one equivalent of alkyl halides to give the corresponding 2-alkylthio derivatives, which were further alkylated through the reaction with another one equivalent of different alkyl halides to afford the target compounds; 1-alkyl-2alkylthio-1,2,4-traizolo[2,3-a]benzimidazoles. On the other hand, the 1,2-disubstituted derivatives with two identical alkyl substituents were prepared by the reaction of 1,2,4-triazolo[2,3-a]benzimidazole-2-thione with two equivalents of the alkyl halides. The structures of the new compounds were assigned by spectral and elemental methods of analyses. The synthesized compounds were tested for their antibacterial and antifungal activities. Most of the tested compounds proved comparable results with those of ampicillin and fluconazole reference drugs. The study indicated that, the antibacterial as well as the antifungal activities of the test compounds were improved with increase in the bulkiness of the introduced alkyl groups. Also, some active antibacterial compounds were tested for their antimycobacterial activity. All the test compounds showed equipotent antitubercular activity as that of INH as a reference drug.