• 제목/요약/키워드: Hydroxyflavones

검색결과 3건 처리시간 0.021초

Synthesis and Inhibitory Activity against COX-2 Catalyzed Prostaglandin Production of Flavone Analogs

  • Tran, Thanh-Dao;Chi, Yeon-Sook;Kim, Jeong-Soo;Kim, Hyun-Pyo;Kim, Sang-Hee;Park, Hae-Il
    • 대한약학회:학술대회논문집
    • /
    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
    • /
    • pp.235.2-235.2
    • /
    • 2003
  • To decipher the structure-activity relationships of flavones for the inhibition of cyclooxygenase-2 catalyzed prostaglandin production, we synthesized 7-methxoyflavones, 7-hydroxyflavones, 5-methxoyflavones, 5-hydroxyflavones and flavones without any phenol group on A ring. Methoxyflavones were prepared from 2.6- and 2,4-dihydroxyacetophenones in 3 steps. Most of the methxoyflavones were converted to the corresponding hydroxyflavones by the reaction with BBr3 in good yields. (omitted)

  • PDF