• Proceedings of the PSK Conference
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• 2003.04a
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• pp.235.2-235.2
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• 2003

To decipher the structure-activity relationships of flavones for the inhibition of cyclooxygenase-2 catalyzed prostaglandin production, we synthesized 7-methxoyflavones, 7-hydroxyflavones, 5-methxoyflavones, 5-hydroxyflavones and flavones without any phenol group on A ring. Methoxyflavones were prepared from 2.6- and 2,4-dihydroxyacetophenones in 3 steps. Most of the methxoyflavones were converted to the corresponding hydroxyflavones by the reaction with BBr3 in good yields. (omitted)

• Bulletin of the Korean Chemical Society
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• v.30 no.6
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• pp.1397-1400
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• 2009

• Journal of the Korean Chemical Society
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• v.53 no.3
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• pp.382-386
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• 2009