• 한국세라믹학회지
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• 제42권10호
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• pp.660-664
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• 2005

Hydroxyapatite powder was injected into the tooth after decayed tooth clinic. The microstructure of tooth was observed after a tooth extraction in the body. The hydroxyapatite powder was stiffened and the junction of hydroxyapatite powder and tooth was observed. The Ca/P atomic ratio of hydroxyapatite-tooth boundary was higher than hydroxyapatite matrix. And microhardness of hydroxyapatite matrix was 92.4 Hv. The junction of hydroxyapatite powder and tooth was due to the $Ca^{2+}$ ion shift of hydroxyapatite or the firm waxy body was due to setting of hydroxyapatite powder.

• 한국세라믹학회지
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• 제31권11호
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• pp.1265-1270
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• 1994

Ultra-fine hydroxyapatite powder were synthesized by the hydrothermal reaction at 10 atm, 3 hrs of Ca(OH)2 suspension with (NH4)2HPO4 solution, and were characterized sintering behavior. Sintered bodies of hydroxyapatite powders which synthesized by hydrothermal reaction method has less weight loss, less sintering shrinkage and superior mechanical property, and was more dense than sintered bodies of hydroxyapatite powder which synthesized by wet method. Sintered bodies were hydroxyapatite single phase. When soack in Ringer's solution for 2 weeks, hydroxyapatite powders preserved hydroxyapatite and sintered body absorbed trace of Ca2+ ion with soaked time.

• 한국세라믹학회지
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• 제27권6호
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• pp.721-728
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• 1990

Hydroxyapatite powders were synthesized with Ca/P=1.67 and pH=11 by precipitaton method, after characterization of these specimen, behavior in Ringer's solution and biocompatibility of hydroxyapatite, such as cytotoxity test and implantation test, were investigated. The hydroxyapatite ceramics had structural stability in Ringer's solution, and hydroxyapatite ceramics did not prevent cell growing and exhibit any cytotoxic effects. In implantation of hydroxyapatite ceramics into muscle under abdome of guinea pig, hydroxyapatite ceramics did not show any symptom of rejection for cellular texture.

• 한국세라믹학회지
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• 제27권3호
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• pp.311-320
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• 1990

Hydroxyapatite powders were synthesized with Ca/P=1.67, 1.70 and pH=7, 11 by precipitation method and fluorine substituted hydroxyapatite ceramics were prepared using these powders. After characterization of these hydorxyapatite bioceramics, chemical bonding between these sepcimens in simulated body fluid was investigated. Bysubstitution of 7.5% of fluorine, hydroxyapatite was prevented to decompose into β-tricalcium phosphate and its sintered density and mechanical strength were increased. The bending strength of these hydroxyapatite ceramics was 137MPa. The hydroxyapatite ceramics chemically bonded each other in Ringer's solution and the component of bonded layer was also hydroxyapatite.

• 한국세라믹학회지
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• 제27권7호
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• pp.907-915
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• 1990

The hydroxyapatite powder was prepared by the precipitation method. The obtained powder was heat-treated and its products were investigated in order to characterize its decomposition process. The powder was Ca-deficient hydroxyapatite with no relation to the Ca/P mole ratio in the initial solution. The obtained hydroxyapatite was thermally decomposed into tricalcium phosphate [Ca3(PO4)2, TCP] after heat-treatment above 80$0^{\circ}C$ and the extent of the decomposition was dependent on the nonstoichiometry of obtained hydroxyapatite, and the resultant hydroxyapatite and tricalcium phosphate maintained stable forms up to 120$0^{\circ}C$. The hydroxyapatite powder had the better stability with the samller the nonstoichinometry of hydroxyapatite. And the quantities of tricalcium phosphate obtained after decomposition were decreased, and also the corresponding decomposition temperatures were increased with decreasing extent of nonstoichiometry in precipitated hydroxyapatite.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.432.1-432.1
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• 2014

Hydroxyapatite (Ca10(PO4)6(OH)2) is known as the main inorganic component of mature mammalian bones and teeth. Because of its biocompatibility, hydroxyapatite has attracted much attention due to its potential applications in many biomedical researches. Here, we tested a therapeutic potential for the use of hydroxyapatite as an anticancer drug delivery vector. We prepared various types of hydroxyapatite having different chemical contents and morphologies using hydrothermal synthesis. The capability of hydroxyapatite as drug delivery materials was examined by adsorption kinetics of 5-fluorouracil molecules, a common anticancer drug, in phosphate buffered saline. We find that hydroxyapatite with smaller crystal size and higher phosphate contents shows improved adsorption property. Given that hydroxyapatite provides a scaffold for bone regeneration, these results highlight a potential use of hydroxyapatite in therapies aimed at osteosarcoma.

• 한국세라믹학회지
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• 제26권2호
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• pp.171-178
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• 1989

In order to develope hydroxyapatite ceramics which has mechanical strength as bio-implant materials and get the basic data for the study and application of biocompatibility, hydroxyapatite was synthesized at Ca/P=1.67~1.75, pH 7~11 by precipitation method. Using prepared powders, the sintered body, fluorine substituted body and the porous body was formed and their properties were investigated. The sample obtained in condition of Ca/P=1.67, pH 7 and sintering at 1,15$0^{\circ}C$ was decomposed to $\beta$-tricalcium phosphate, and co-existed with hydroxyapatite. Hydroxyapatite synthesized at pH 11 was not easily decomposed to $\beta$-tricalcium phosphate at sintering process. The substitution of a small amount of fluorine for hydroxyapatite prevented hydroxyapatite from being decompsed to $\beta$-tricalcium phosphate. Hydroxyapatite ceramics which substited of 10% fluorine was prepared at 1,15$0^{\circ}C$, and the valueof bending strength for this body were found to be 112MPa.

• 공업화학
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• 제8권6호
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• pp.994-999
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• 1997

참치 뼈로부터 추출한 hydroxyapatite [$Ca_{10}(PO_4)_6(OH)_2$] 와 여기에 소결성 증진을 위해 wollastonite($CaSiO_3$)를 첨가하여 고상반응시킨 세라믹 소결체의 결정상, 미세구조와 꺽임강도(bending strength) 등의 특성을 고찰하였다. 참치 뼈에서 추출한 hydroxyapatite자체의 소결성은 매우 취약하였는데, 이는 건식법의 입자분쇄 한계 때문으로 보인다. Hydroxyapatite에 wollastonite가 첨가된 경우 소결온도가 $1250^{\circ}C$이하에서는 hydroxyapatite와 pseudowollastonite(${\alpha}-CaSiO_3$)가 혼재된 결정상을 보였으나, 온도가 증가할수록 hydroxyapatite의 분해에 따른 whitlockite [$Ca_3(PO_4)_2$] 상이 관찰되었다. 소결온도가 $1250^{\circ}C$이하에서는 미세한 입자들과 많은 기공들이 분포하였으며, 소결온도가 증가할수록 입자의 크기는 증가하여 소결이 상당히 진행된 미세구조를 나타내었다. Wollastonite가 첨가된 소결시편의 평균 꺽임강도는 18MPa로서 해면골(cancellous bone)의 최대 꺽임강도인 20MPs에 근접한 것으로 나타났다.

• 한국세라믹학회지
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• 제40권11호
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• pp.1096-1101
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• 2003

생체친화성이 증진된 생체재료를 얻기 위하여 실리콘 원료로 tetraethyl orthosilicate를 사용하여 실리콘이 치환된 hydroxyapatite를 합성하였으며 FT-IR, XRD, 그리고 ICP 분석결과로부터 실리콘이 hydroxyapatite 구조내에 치환되어 있음을 확인하였다. 성분분석 결과 2 wt%까지의 실리콘을 함유하는 hydroxyapatite인 경우는 120$0^{\circ}C$에서 소결 후에도 원래의 hydroxyapatite 구조를 잘 유지하고 있는 것이 XRD와 HRTEM으로 확인되었으나 그 이상의 실리콘을 함유하는 hydroxyapatite인 경우는 110$0^{\circ}C$에서 부터 상분리가 일어나 XRD에서 tricalcium phosphate와 calcium phosphate silicate상이 검출되기 시작하였다.

• 열처리공학회지
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• 제28권1호
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• pp.17-23
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• 2015

Hydroxyapatite coatings were fabricated by a room temperature spray method on zirconia substrates and the influence of heat-treatment on their microstructure was also investigated. Phase composition of coated hydroxyapatite films was similar to the starting powder, but the grain size of hydroxyapatite particles was reduced to the size of nano-scale about 100 nm. Grain size, particle compactness, and adhesiveness to zirconia of hydroxyapatite coatings were increased with heat-treatment temperature, but some of cracks by heat-treatment above $1100^{\circ}C$ were initiated between hydroxyapatite coatings and zirconia substrate. Heat-treated hydroxyapatite layers show the dissolution in SBF solution for 5 days. Hydroxyapatite-coated specimen heat-treated at $1100^{\circ}C$ for 1 h has a good biocompatibility, which specimen induced the nanocrystalline hydroxyapatite precipitates on the coating surface by the immersion in SBF solution for 5 days.