• Proceedings of the Membrane Society of Korea Conference
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• 2005.05a
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• pp.83-84
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• 2005

• Polymer Science and Technology
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• v.21 no.5
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• pp.459-465
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• 2010

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.42-43
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• 2006

We have prepared random, block and graft copolymers with single or dual sensitivities to various stimuli. We have conjugated these polymers to proteins at random lysine sites or at specific sites designed into the protein by genetic engineering. We are also grafting the smart polymers to the surfaces of nanobeads. We are applying these smart conjugates and smart nanobeads in microfluidic devices for various applications, including diagnostics, affinity separations and enzyme bioprocesses. In this talk I will update our work with these interesting hybrid systems.

• Korean Journal of Soil Science and Fertilizer
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• v.46 no.6
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• pp.458-462
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• 2013

A drainage ditch is normally a component of drainage networks in farming systems to remove surplus water, but at the same time, it may act as a major conduit of agricultural nonpoint source pollutions such as sediment, nitrogen, phosphorus, and so on. The hybrid turbidity reduction system using biodegradable check dam and synthetic polymer was developed in this study to manage pollutant discharge from agricultural farmlands during rainfall events and/or irrigation periods. The performance of this hybrid system was assessed using a laboratory open channel sized in 10m-length and 0.2m-width. Various check dams using agricultural byproducts (e.g., rice straw, rice husks, coconut fiber and a mixture of rice husks and coconut fiber) were tested and additional physical factors (e.g., channel slope, flowrate, PAM dosage, turbidity level, etc.) affecting on turbidity reduction were applied to assess their performance. A series of lab experiments clearly showed that the hybrid turbidity reduction system could play a significant role as a supplementary of Best Management Practice (BMP). Moreover, the findings of this study could facilitate to develop an advanced BMP for minimizing nonpoint source pollution from agricultural farmlands and ultimately to achieve the sustainable agriculture.

• Proceedings of the Materials Research Society of Korea Conference
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• 2009.11a
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• pp.12.1-12.1
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• 2009

Nano-hydroxyapatite (N-HAp)has shown the pivotal role in producing bone-regenerative materials since it has similarity to natural bone minerals in terms of size, morphology, and the composition. Currently, the combination of biopolymers and N-HAp is recognizedas an attractive approach in generating hybrid scaffolds for bone tissueengineering. Surface engineering is an important issue since it determines whether cells can effectively adhere and proliferate on porous scaffolds. We aim to develop a synthetic approach to porous 3D scaffolds by immobilizing N-HAp on pore surfaces. The discrete nano-level anchoring of N-HAp on the scaffold pore surface is achieved using surface-repellent stable colloidal N-HAp with surface phosphate functionality. This rational surface engineering enables surface-anchored N-HAp to express its overall intrinsic bioactivity,since N-HAp is not phase-mixed with the polymers. The porous polymer scaffolds with surface-immobilized N-HAp provide more favorable environments thanconventional bulk phase-mixed polymer/N-HAp scaffolds in terms of cellular interaction and growth. In vitro biological evaluation using alkalinephosphatase activity assay supports that immobilized N-HAp on pore surfaces of polymer scaffolds contributed to the more enhanced in vitro osteogenicpotential. Besides, the scaffolds with surface-exposed N-HAp provide favorable environments for enhanced in vivo bone tissue growth, estimated by characteristic biomarkers of bone formation such as collagen. The results suggest that newly developed hybrid scaffolds with surface-immobilized N-HApmay serve as a useful 3D substrate with pore surfaces featuring excellent bonetissue-regenerative properties. Acknowledgement. This research was supported by a grant (code #: 2009K000430) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of the Ministry of Education, Science and Technology, Korea.

• Polymer(Korea)
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• v.37 no.5
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• pp.587-591
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• 2013

Poly(3,4-ethylenedioxythiophene) (PEDOT) has good properties such as high conductivity, optical transmittance, and chemical stability, while offering relatively weak physicochemical properties. The main purpose of this paper is the improvement of physicochemical properties such as solvent resistance and pencil hardness of PEDOT. Carboxyl groups in the anionic type waterborne polyurethane (WPU) chains can effectively crosslink each other in the presence of aziridine, resulting in physicochemically robust PEDOT/WPU organic-organic hybrid conductive thin films. The electrical conductivity, optical properties, and physicochemical properties of the hybrid conductive film were compared by varying the solid content and WPU portion in the coating precursor solution. From the results, the transparency and surface resistance of the hybrid film show a decreasing tendency with increasing solid content in the coating precursor. Moreover, solvent resistance and hardness were dramatically enhanced by hybridization of PEDOT and crosslinked WPU due to curing reactions between carboxyl groups.

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.673-697
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• 2018

BACKGROUND: Cartilage tissue engineering (CTE) aims to obtain a structure mimicking native cartilage tissue through the combination of relevant cells, three-dimensional scaffolds, and extraneous signals. Implantation of 'matured' constructs is thus expected to provide solution for treating large injury of articular cartilage. Type I collagen is widely used as scaffolds for CTE products undergoing clinical trial, owing to its ubiquitous biocompatibility and vast clinical approval. However, the long-term performance of pure type I collagen scaffolds would suffer from its limited chondrogenic capacity and inferior mechanical properties. This paper aims to provide insights necessary for advancing type I collagen scaffolds in the CTE applications. METHODS: Initially, the interactions of type I/II collagen with CTE-relevant cells [i.e., articular chondrocytes (ACs) and mesenchymal stem cells (MSCs)] are discussed. Next, the physical features and chemical composition of the scaffolds crucial to support chondrogenic activities of AC and MSC are highlighted. Attempts to optimize the collagen scaffolds by blending with natural/synthetic polymers are described. Hybrid strategy in which collagen and structural polymers are combined in non-blending manner is detailed. RESULTS: Type I collagen is sufficient to support cellular activities of ACs and MSCs; however it shows limited chondrogenic performance than type II collagen. Nonetheless, type I collagen is the clinically feasible option since type II collagen shows arthritogenic potency. Physical features of scaffolds such as internal structure, pore size, stiffness, etc. are shown to be crucial in influencing the differentiation fate and secreting extracellular matrixes from ACs and MSCs. Collagen can be blended with native or synthetic polymer to improve the mechanical and bioactivities of final composites. However, the versatility of blending strategy is limited due to denaturation of type I collagen at harsh processing condition. Hybrid strategy is successful in maximizing bioactivity of collagen scaffolds and mechanical robustness of structural polymer. CONCLUSION: Considering the previous improvements of physical and compositional properties of collagen scaffolds and recent manufacturing developments of structural polymer, it is concluded that hybrid strategy is a promising approach to advance further collagen-based scaffolds in CTE.

• Polymer(Korea)
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• v.31 no.1
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• pp.86-91
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• 2007

Polydimethylsiloxane branched HEMA (SH) was Prepared by reacting polydimethylsilorane prepolymer and 2-hydroxyethyl methacrylate (HEMA). Polyacrylate modified Polyorganosiloxane (SMPA) was prepared by polymerization of methacrylic acid(MA), allyl glycidyl ether(AGE), aminopro- pyltrimethoxysilane (APTS), and SH. Their structures were confirmed by the measurement of FTIR and $^1H-NMR$ and thermal properties of SMPA were studied from TGA. Residual weight of SMPA at $400^{\circ}C$ increased according to increasing content of the APTS to 63 from 55%. SMPA sealant was prepared by adding additives, such as viscosity increasing agent, crosslinking agent, and fillers. Adhesion characteristics of SMPA-3 sealant was determined to be maximum load elongation, 2.01 %, and break load elongation, 2.28%. Adhesion characteristics for SMPA sealant prepared from SMPA-3 were better than those for SMPA sealant prepared from SMPA-1 and SMPA-2.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.2
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• pp.137-142
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• 2017

Recently, the reduction of vehicle weight has been increasingly studied, in order to enhance the fuel efficiency of passenger cars. In particular, the seat frame is being studied actively, owing to considerations of driver safety from external impact damage. Therefore, this study focuses on high strength steel sheet (SPFC980)/polymer heterojunction hybrid materials, and their performance in regards to impact energy absorption. The ratio of impact energy absorption was observed to be relatively higher in the SPFC980/polymer hybrid materials under the impact load. This was found by calculating the equivalent flexural rigidity, which is the bending effect, according to the Castigliano theorem. An efficient wire-web structure was investigated through the simulation of different wire-web designs such as triangular, rectangular, octagonal, and hexagonal structures. The hexagonal wire-web structure was shown to have the least impact damage, according to the simulations. This study can be utilized for seat frame design for passengers' safety, owing to efficient impact absorption.

• Applied Chemistry for Engineering
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• v.25 no.6
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• pp.581-585
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• 2014

We conducted investigation on the hybridization of poly(3,4-ethylenedioxythiophene)/poly(styrene sulfonate) (PEDOT : PSS) with graphene derivative (G-PSS), which has been prepared by wrapping reduced graphene oxide (RGO) with PSS. In situ polymerization of PEDOT/PSS in the presence of G-PSS afforded the PEDOT/PSS and graphene hybrid (GP). The analysis of XPS, IR and Raman spectroscopies for GP showed that PEDOT/PSS was successfully synthesized and hybridized with graphene. Compared to the G-PSS, GP showed an enhanced electrical conductivity of $4.46{\times}10^2S/m$ with a good wter-dispersity.