• Molecules and Cells
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• 제38권12호
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• pp.1037-1043
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• 2015

The TAZ activator 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine] (TM-25659) inhibits adipocyte differentiation by interacting with peroxisome proliferator-activated receptor gamma. 1 TM-25659 was previously shown to decrease weight gain in a high fat (HF) diet-induced obesity (DIO) mouse model. However, the fundamental mechanisms underlying the effects of TM-25659 remain unknown. Therefore, we investigated the effects of TM-25659 on skeletal muscle functions in C2 myotubes and C57BL/6J mice. We studied the molecular mechanisms underlying the contribution of TM-25659 to palmitate (PA)-induced insulin resistance in C2 myotubes. TM-25659 improved PA-induced insulin resistance and inflammation in C2 myotubes. In addition, TM-25659 increased FGF21 mRNA expression, protein levels, and FGF21 secretion in C2 myotubes via activation of GCN2 pathways (GCN2-$phosphoelF2{\alpha}$-ATF4 and FGF21). This beneficial effect of TM-25659 was diminished by FGF21 siRNA. C57BL/6J mice were fed a HF diet for 30 weeks. The HF-diet group was randomly divided into two groups for the next 14 days: the HF-diet and HF-diet + TM-25659 groups. The HF diet + TM-25659-treated mice showed improvements in their fasting blood glucose levels, insulin sensitivity, insulin-stimulated Akt phosphorylation, and inflammation, but neither body weight nor food intake was affected. The HF diet + TM-25659-treated mice also exhibited increased expression of both FGF21 mRNA and protein. These data indicate that TM-25659 may be beneficial for treating insulin resistance by inducing FGF21 in models of PA-induced insulin resistance and HF diet-induced insulin resistance.

• 한국가스학회지
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• 제20권6호
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• pp.1-8
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• 2016

2012년 구미 불화수소 누출사고 이후 화학 물질 사고에 대한 사회적 불안감이 증폭되었고, 이러한 불안감 해소를 위해 2015년부터 장외영향평가제도가 도입되었다. 장외영향평가제도는 대부분의 화학물질을 대상으로 하며, 반도체, 디스플레이, 태양광 산업 등 첨단산업 분야에서 주로 사용되는 대부분의 고압 독성가스가 이에 포함된다. 우리나라 기업들이 첨단산업 분야에서 높은 경쟁력을 보유한 만큼, 국내에서 고압 독성가스 사용량은 지속적으로 증가하고 있으며 이에 따라 사고발생 가능성도 높아질 것으로 예상된다. 이러한 상황에 따라 본 연구에서는 국내에서 사용되는 고압 독성가스 중 제조량 및 사용량이 높은 물질을 대상으로 미국 환경보호청과 미국 해양대기국이 공동 개발한 ALOHA 프로그램을 활용하여 사고영향범위를 평가하였으며, 알진의 사고영향범위가 4,700 m로 가장 넓은 것으로 나타났다. 사고영향범위 결과는 고압 독성가스 누출 시 효과적인 안전거리 결정에 활용할 수 있을 것으로 기대한다.

• 한국치위생학회지
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• 제17권5호
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• pp.921-930
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• 2017

Objectives: The purposes of this study were to analyze the trade newspapers related to 'recognition of the dental hygienist as the healthcare professional' using R program and to identify opinions of groups concerned with dental hygienists. Methods: This study was designed with contents analysis and cross-sectional. The subjects of the study were the articles for the last three years in medical and dental newspapers about the recognition of the dental hygienist as the healthcare professional. The collected articles were categorized and classified for each group's opinions about the issue. The key words were extracted according to the priorities of the opinions of agreement and disagreement. They were visualized after frequency analysis using R, a big data analysis program. Results: A total of 237 newspaper articles were extracted among 270 ones containing opinions. 245 were positive opinions and 25 were negatives. The main key words of the agreement were 'Amendment of Medical Law', 'Medical Practice', and 'Legal Guarantee of the Practice'. Advocates addressed that the issues should be resolved with the amendment of the law, as dental hygienists are not guaranteed to work based on the current law although they are actually doing the medical practices. Main key words of disagreement were 'Legal Guarantee of the Practice', 'Revision of Medical Technician Law', and 'Review of Job Type'. They described that the problem can be resolved by revising medical technicians act, and it needs to consider as job types of all healthcare professional. Conclusions: In the group who showed the positive opinions, it is possible to utilize measures such as promoting the cooperation of dental hygienists and developing public consensus through publicity.

• 한국식품영양학회지
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• 제30권4호
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• pp.703-709
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• 2017

This study analyzed the effect on weight and average daily gain, carcass grade, and blood characteristics and immunity in case of dietary addition of pegmatite to Hanwoo steers. Relative to Hanwoo steers, initial body weight was $257.3{\pm}11.74kg$ (8-months old after birth). Forty-eight Hanwoo steers were fed for 24 months using random arrangement (4 treatment plots${\times}$4 heads${\times}$3 repeat). The treatment plot (498.75~500.82 kg) had higher weight during the early fattening stage compared with that of the control plot (474.37 kg) (p<0.05). Regarding total cholesterol of the blood, the value was similar to one during initiation of testing, but the value increased gradually based on the progress of fattening. In addition, the triglyceride was considerably low in T2~T3 plots with high addition of pegmatite during the late fattening stage compared with other treatment plots (p<0.05). This study revealed a tendency in the IgG content that represented immunity as the addition of pegmatite became higher (p>0.05). This study found that the treatment plot (441.55~452.10 kg) had higher carcass weight compared with the control plot (436.30 kg). However, this study revealed that the treatment plot (2.30~2.55 points) had higher carcass quantity grade compared with the control plot (2.11 points). This study found that the control plot (3.55 points) had higher carcass quality grade compared with the treatment plot (2.67~3.09 points) (p>0.05). With studies combined, it was determined that dietary addition of pegmatite to the feed as clay minerals in fattening Hanwoo steers would improve feed intake, body weight gain and carcass quantity grade.

• 한국방재학회 논문집
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• 제11권2호
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• pp.147-156
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• 2011

홍수기 다목적댐 운영의 목적은 홍수조절용량을 최대한 이용하여 하류 주요 지점의 첨두홍수량을 저감시키거나, 계획홍수량을 초과하지 않도록 방류량과 방류시점을 조절함으로써 홍수피해규모를 최소화하는 것이다. 따라서 홍수기 다목적댐 운영에 있어 가장 중요한 것은 최적의 방류시점과 방류량의 결정이며 이를 통해 홍수기말 이수용량을 최대로 확보 하는 점이다. 본 연구에서는 다목적 최적화기법의 하나인 goal programming을 이용하여 홍수기 저수지 최적운영을 실시하였다. goal programming은 선형계획법 또는 비선형계획법을 이용하여 두 개 이상의 목적을 가진 문제의 최적 대안을 구하기 위해, 목표값으로부터의 편차의 합을 최소화하여 최적화하는 기법이다. 홍수기 다목적댐 운영에서 goal programming의 적용성을 검토하기 위해 실제 홍수 사상을 이용하여, 단일저수지 운영과 저수지 연계운영을 실시하였다. 단일저수지 운영을 적용하기 위한 시험유역으로는 충주댐 유역을 선정하였고 저수지 연계운영을 적용하기 위한 시험유역으로는 안동댐과 임하댐 유역을 선정하였다. goal programming의 결과 분석을 위해 저수지 모의운영 모형인 HEC-5 모형의 결과와 비교, 분석하였다. 검토 결과 goal programming을 이용할 경우 홍수기 말에 저수지 수위를 홍수기제한수위로 유지할 수 있었으며 주요 지점의 홍수량을 매 시간 적절히 계획홍수량 아래로 유지할 수 있었다. goal programming을 이용한 최적 운영의 경우 전 구간의 유입량을 알고 있다고 가정한 점에서 실제 저수지 운영과는 차이가 있으나, 적절한 제약조건을 적용하고 홍수예경보를 이용하여 예보된 유입량을 활용하면 최적의 방류량 시점과 방류량을 산정하여 홍수기 다목적댐을 효율적으로 운영할 수 있으며 주요 지점의 홍수량도 저감할 수 있을 것으로 판단된다.

• Investigative Magnetic Resonance Imaging
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• 제25권3호
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• pp.164-171
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• 2021

Purpose: Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Brain atrophy in this disease spectrum begins in the medial temporal lobe structure, which can be recognized by magnetic resonance imaging. To overcome the unsatisfactory inter-observer reliability of visual evaluation, quantitative brain volumetry has been developed and widely investigated for the diagnosis of MCI and AD. The aim of this study was to assess the prediction accuracy of quantitative brain volumetry using a fully automated segmentation software package, NeuroQuant^®, for the diagnosis of MCI. Materials and Methods: A total of 418 subjects from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease cohort were included in our study. Each participant was allocated to either a cognitively normal old group (n = 285) or an MCI group (n = 133). Brain volumetric data were obtained from T1-weighted images using the NeuroQuant software package. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to investigate relevant brain regions and their prediction accuracies. Results: Multivariate logistic regression analysis revealed that normative percentiles of the hippocampus (P < 0.001), amygdala (P = 0.003), frontal lobe (P = 0.049), medial parietal lobe (P = 0.023), and third ventricle (P = 0.012) were independent predictive factors for MCI. In ROC analysis, normative percentiles of the hippocampus and amygdala showed fair accuracies in the diagnosis of MCI (area under the curve: 0.739 and 0.727, respectively). Conclusion: Normative percentiles of the hippocampus and amygdala provided by the fully automated segmentation software could be used for screening MCI with a reasonable post-processing time. This information might help us interpret structural MRI in patients with cognitive impairment.

• 동양고전연구
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• 제55호
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• pp.35-58
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• 2014

이 논문은 회재(晦齋) 이언적(李彦迪, 1491~1553)의 "중용구경연의"를 고찰한 것이다. 주지하다시피 회재는 16세기를 대표하는 사상가 가운데 한 사람으로, 일찍이 조한보(曺漢輔, ?~?) 사이에 벌어졌던 태극논쟁(太極論爭)은 주자성리학(朱子性理學)을 조선에 정착시키는데 큰 역할을 하였으며, 아울러 지치주의(至治主義)의 이론적 체계를 확립한 학자이기도하다. "대학"과 "중용"에 담긴 지치주의 이념을 군주(君主)에게 진헌하고자 저술된 책이 바로 회재의 "대학장구보유"와 "중용구경연의"이다. 회재는 수기(修己)의 도(道)에 속하는 조목에 있어서 "대학"이 "중용"보다 더 체계적이고 자세한 반면에 치인(治人)의 도(道)에 해당하는 조목은 "중용"이 "대학" 보다 더 구체적이라고 하여 '표리(表裏)의 관계'로 파악하고, 이 둘을 함께 보아야만 제왕위치(帝王爲治)의 규모가 갖추어 진다고 하였다. 특히 "중용구경연의"는 송나라 진덕수(眞德秀)의 "대학연의(大學衍義)"와 명나라 구준(丘濬)의 "대학연의보(大學衍義補)"를 모방하여 당시의 군주였던 명종(明宗)으로 하여금 이제 삼왕(二帝三王)의 지치(至治)를 실현시킬 목적으로 저술된 책으로, 이는 퇴계의 "성학십도"와 율곡의 "성학집요"에 많은 영향을 끼쳤다.

• 한국빅데이터학회지
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• 제5권2호
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• pp.187-199
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• 2020

WHO는 3월 11일을 기준으로 COVID-19를 유행병으로 선포하였다. 국내에서는 27,000명의 확진자가 발생하였으며, 전세계적으로는 5,000만명이 넘는 확진자가 발생하였다. 이처럼 COVID-19으로 인한 감염이 확산되면서 역학조사의 중요성이 다시 한 번 대두되고 있는 상황이다. 하지만 지난 대구 경북 사례를 시작으로 다수의 확진자가 발생하였고, 현재 역학조사 방식에 한계가 있음을 인지하였다. 이에 질병관리본부는 스마트시티 데이터허브 기술을 활용한 역학조사 지원시스템을 개발하여 역학조사에 활용하였다. 본 논문에서 제안하는 시스템은 역학조사 지원시스템의 일부로 대용량의 이동통신사 데이터를 처리하기 위한 빅데이터 기반 역학조사 지원 시스템이다. 본 시스템을 통해 기존에는 어려웠던 이동통신사 데이터의 이상치 처리나 2명 이상의 접촉자가 발생한 핫스팟 지역 생성 등의 처리가 가능해졌다. 그 결과, 이상치 처리는 요청건당 30초, 핫스팟의 경우 평균 10분 이내에 처리할 수 있게 되었다. 본 연구는 빅데이터 시스템을 역학조사에 접목하고 역학조사를 지원한 첫 사례로써, 빅데이터 시스템의 역학조사에 대한 실용적 활용 가능성을 제시하고 있다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 춘계학술대회
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• pp.33-33
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• 2020

Watermelon (Citrullus lanatus) is a non-seasonal, economically important, cucurbit cultivated throughout the world with Asia as a continent contributing the most. As part of the effort in diversifying watermelon genetic resources in the already cultivated group, this study was devoted to providing baseline data on morphological quality traits and health-beneficial phytonutrients of watermelon germplasm collections, thereby promoting watermelon research and cultivation programs. To this end, we reported morphological traits, citrulline, and arginine levels of watermelon genetic resources obtained from the gene bank of Agrobiodiversity Center, Republic of Korea, and discussed the relationship between each other. Diverse characteristics were observed among many of the traits. But, most of the genetic resources (>90%) were either red or pink-fleshed. Korean origin fruits contained intermediate levels of soluble solid content (SSC) while The USA, Russian, Tajikistan, Turkmenistan, Taiwan, and Uruguay originated had generally the highest levels of soluble solids. The citrulline and arginine contents using HPLC method were ranged from 6.9 to 52.1 mg/g (average, 27.3 mg/g) and 1.8 to 21.3 mg/g (average, 9.8 mg/g), respectively. The citrulline content determined using Citrulline Assay Kit was ranged from 6.5 to 42.8 mg/g (average, 27.0 mg/g). Resources with high citrulline and arginine levels contained low SSC. Whereas, red- and pink-colored flesh samples had less citrulline compared to yellow and orange. In addition to the profiling of morphological characters and phytonutrients, molecular marker characterization and identification of sources of resistance to diseases and pests are recommended for a more complete diversity analysis of watermelon genetic resources.

• 대한의용생체공학회:의공학회지
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• 제31권4호
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• pp.280-284
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• 2010

Approvals of medical device increase every year as industry of medical device grows. Therefore KFDA keeps trying to improve approval systems. However, the firms of medical device are in trouble due to regulation amendment, a firm of small size, exchange of the person in charge. The staffs of KFDA increase their work load because applicants of approval of medical device aren't used to writing of document. Therefore the firm of medical device in business have a long term. KFDA develops eight guidance document item by item for one-step evaluation and approval for Medical Devices because applicants of approval of medical device write documents easily. KFDA reviewer can carry on quick reviewing in use of this eight guidances. This guidance are improved on satisfaction of applicants of approval of medical device.