• Journal of the Korean Institute of Landscape Architecture
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• v.17 no.1
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• pp.55-68
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• 1989

^x This paper focuses on clarifying the diverse conceptions of landscape, of which ambiguity gives rise to confusion to the theory and practice of landscape architecture. Landscape in the form of landscipe has once indicated land, a defined space or a humanized environment, cultivated and inhabited for the purpose of biological sustenance of ordinary people. With the advent of landschap(landscape) painting, its concept moved from the real world to the scenery, a prospect, 'a portion of earth's surface that can be seen at once by a man who is himself upon the surface. 'Once appeared, it remained as a central concept until the 19th century when the modern land-scape architecture, which claims to stand for the democratic planning and environmental design, emerged. However, it still survives as the most popular concept :a landscape is a man-made, beautiful scene. To the contrary, the geographers hold that a landscape is not an actual scene viewed by a particular observer, but is a generalization induced from the observation of many individual scene. Since it is not only very attractive to the general public, but also very important to the designers, scholars and artists, operational definitions of landscape are urgently needed.

• Korean Institute of Interior Design Journal
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• v.15 no.2 s.55
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• pp.56-64
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• 2006

From ancient times to today the formation of centrality in architecture has taken very important role as an organizing device. However after 19th century modem architecture focused on the universal aspect and homogeneity of space, and developed its own vocabulary through de-centralization. Since 1960's the reflections on de-humanized space of modem space have been evloved. As those movement has been understood seriously, the centrality can be changed to phenomenological one. And The phenomenological centrality maintains organic balance with its surroundings not trying to form a hierarchic system. So it shows human-oriented tendency and facilitates experiential movements of human body. And it also gives a sense of being. The phenomenological centrality is comprised of center, boundary, and two types of axis. The characteristics of phenomenological centrality can be analyzed as practical and meaningful center, visible boundary, experiential movement, and unexpectable encounters with spaces and nature.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2004.11a
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• pp.140-143
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• 2004

The move from steel tubes to bent wood and the 'laboratory experiments' with wood which Aalto carried out in order to create furniture gave him vital impulses as he sought and found his own architecture style in the 1930s. Like his architecture Aalto's chair designs represent a 'humanized' interpretation of the severe aesthetic and radical technological experimentation of the Modern Movement. The purpose of this study is to find what is the result of the form of his works on the basis of main idea and tend of his works, to search the element and principle of formal composition, to establish the relation-ship between the architect's philosophy and the form of his works. Aalto's furniture, constructed of laminate bent wood or moulded plywood, is not only functionalistic, but also ideal for the psychological need of the people, which is the special quality that complements the Factionalism that features mostly on the metal tube furniture. It shows that Aalto is a humanist dealing with mechanized age.

• Biomedical Science Letters
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• v.25 no.4
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• pp.372-380
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• 2019

Mice with specific modified genes are useful means of studying development and disease. The CRISPR/Cas9 system is a very powerful and effective tool for generating genetically modified mice in a simple and fast manner. To generate human IgG light kappa constant knock-in mice, we tested by microinjection of a mixture of Cas9 protein, single-guide RNA and target homologous recombinant donor DNA into zygotes. We found that the injection of 10 ng/μL of Cas9 protein and crRNA/tracrRNA, rather than single guide RNA, induced the production of knock-in mice more effectively. Thus, our study provides valuable information that will help to improve the production of knock-in mice and contribute the successful generation of humanized Ab-producing mice in Korea.

• Journal of the Korean Institute of Landscape Architecture International Edition
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• no.2
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• pp.45-50
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• 2004

Confronting with series of environmental problems. caused by urbanization and the constantly improving consciousness of the entire society towards environmental protection, it has become an inevitable trend to develop parks and green space planning that guided by the principle of 'respecting nature, preferring ecology' and integrate function, arts and culture of landscape design. Aiming at specific project, humanized design should be laid stress on. With fundamental functional construction serving as the base, the reflection of cultural content and regional landscape as the characters, using various landscape gardening elements reasonably to enrich space design as well as highlighting leisure and sport function and following the concept 'human-centered', parks and green space filled with natural vitality and cultural spirit can be constructed, people, city and the nature could develop together in harmony.

• Childhood Kidney Diseases
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• v.24 no.2
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• pp.138-142
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• 2020

Atypical hemolytic uremic syndrome (aHUS) is an extremely rare and life-threatening disorder. Typical HUS is often caused by Shiga toxin-positive Escherichia coli, while aHUS is caused by dysregulation of the alternative pathway of the complement system in association with genetic abnormalities or development of autoantibodies. Eculizumab, a humanized anti-complement 5 monoclonal antibody, is recommended for the treatment of aHUS, but its long-term safety and efficacy in pediatric patients remain under review. In this paper, we report a pediatric case of aHUS with anti-complement factor H autoantibodies, who was treated successfully with eculizumab.

• Childhood Kidney Diseases
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• v.26 no.1
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• pp.58-62
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• 2022

Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury without any association with preceding diarrhea. Dysregulation of the complement system is the most common cause of aHUS, and monoclonal humanized anti-C5 antibodies are now recommended as the first-line treatment for aHUS. However, if the complement pathway is not the cause of aHUS, C5 inhibitors are ineffective. In this study, we report the second reported case of aHUS caused by DGKE mutations in Republic of Korea. The patient was an 11-month-old infant who presented with prodromal diarrhea similar to typical HUS, self-remitted with conservative management unlike complement-mediated aHUS but recurred with fever. While infantile aHUS often implies genetic dysregulation of the complement system, other rare genetic causes, such as DGKE mutation, need to be considered before deciding long-term treatment with C5 inhibitors.

• The Journal of the Korea Contents Association
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• v.13 no.10
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• pp.256-265
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• 2013

With economic development and ever-changing technology, human has entered the era of "Product-as-a-Service". At the same time, the update of the product gradually accelerated. The demand of consumers for products are slowly changed, they pay more attention to convenience, comfort and reliable quality and safety of the product. That is the humanized design problem that often mentioned in the product design. This also put forward new requirements for the design and development of product modeling. So how to reflect the humanized ideas in the product design has also become common focus of attention of product designers, users and producers of a new era. The paper is based on the principles of ergonomics to investigate and improve the daily life utensil - flashlight. Firstly, make a sample survey of the flashlight in Beijing market and analyze the characteristics and problems of flashlight products. Secondly, explore the use of the flashlight and proposed Flashlight curved grip design to reduce the occurrence of wrist discomfort and damage to the body caused by poor posture of the operation of users. Finally, determine the range of the length and width of the body of the flashlight according to the length and width measurement data of the Chinese palm. Wishing that the improvements of flashlight products in ergonomics can improve use of feelings of these products and give a theoretical guidance for solving similar problems.

• The Korean Society of Law and Medicine
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• v.7 no.2
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• pp.75-96
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• 2006

Having gone through socioeconomic changes from an agricultural to a post-industrial society, mental health system accordingly has been changed. In Korea where the socioeconomic change has been so rapid, the mental health system and law have been behind the socioeconomic system. Post-industrial society needs more humanized and advanced mental health system, however, Korean mental health law reflects ideology of Korean society in industrial age. This paper attempts to assess the significance Korea's Mental Health Law against the backdrop of socioeconomic changes. A substantial part of the report is devoted to identifying discrepancies between Korea's Mental Health Law and the perspectives of post-industrial ideology and areas for improvement. Improvement in mental health law should take place in line with the changes occurring in socioeconomic environments, the social concept of family, and the public awareness of human rights. Korea's mental health law should be changed in a way to improve hospitalization procedure for people with mental illness, promote the opening of mental health facilities and improve the quality of the lives of the mentally ill. Further changes are deemed necessary in the public and media view of mental illness. Also, the national budget will have to be increased with a view to raise the social rights of those with mental illness to receive quality rehabilitation services.

• Clinical and Experimental Pediatrics
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• v.54 no.5
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• pp.192-196
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• 2011

Respiratory syncytial virus (RSV) is a main cause of hospitalization for bronchiolitis and pneumonia in infants worldwide. Children with hemodynamically significant congenital heart disease (HS-CHD), as well as premature infants are at high risk for severe RSV diseases. Mortality rates for CHD patients hospitalized with RSV have been reported as about 24 times higher compared with those without RSV infection. Recently with advances in intensive care, mortality rates in CHD patients combined with RSV have decreased below 2%. The requirements of intensive care and mechanical ventilation for CHD patients with RSV infection were still higher than those without RSV infection or with non-CHD children. RSV infection has frequently threatened CHD infants with congestive heart failure, cyanosis, or with pulmonary hypertension. As a progressive RSV pneumonitis in those infants develops, the impairment of oxygen uptake, the breathing workload gradually increases and eventually causes to significant pulmonary hypertension, even after the operation. Preventing RSV infection as much as possible is very important, especially in infants with HS-CHD. A humanized monoclonal antibody, palivizumab, has effective in preventing severe RSV disease in high-risk infants, and progressive advances in supportive care including pulmonary vasodilator have dramatically decreased the mortality (<1%). Depending on the global trend, Korean Health Insurance guidelines have approved the use of palivizumab in children <1 year of age with HS-CHD since 2009. Korean data are collected for RSV prophylaxis in infants with CHD.