• Biomolecules & Therapeutics
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• v.1 no.2
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• pp.266-269
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• 1993

The acute toxicity of a recombinant human interferon $\alpha$A (code name: LBD-007) was evaluated in both sexes of ICR mice, 5 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results, LBD-007 was not considered to induce any toxic effect on the mice in mortalities, clinical findigs, body weights and gross findings. It is suggested that LD$_{50}$ values in mice would be $>48{\times}10^8$ IU/kg in the oral, subcutaneous or intravenous routes.s.

• Biomolecules & Therapeutics
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• v.4 no.4
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• pp.323-329
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• 1996

A recombinant human erythropoietin (rHu-EPO), was administered intravenously to beagle dogs at doses of 100, 500 and 2, 500IU/kg/day for 30 days. There were no significant clinical signs such as body weight, food intake, physical and opthalmic examination, urine analysis, etc. Any toxic response was not observed except for enlarged spleen and extramedullary hematopoiesis. No observed adverse effect level (NOAEL) of rHu-EPO for 30 days was considered to be 100IU/kg/day in beagle dogs.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2000.10a
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• pp.273-280
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• 2000

Building structures which are in need of large open space make the damping effect of the structures decrease greatly. Assembly and office buildings with a lower natural frequency have a higher possibility of experiencing excessive vibration induced by human activities. These excessive vibration make the residents uncomfortable and the serviceability deterioration. The loads induced by human activities were classified into two types. First type is in place loads as like jumping, foot stamping and body bouncing. The other type is moving loads as like walking, running and dancing. A series of laboratories experiments had been conducted to study the dynamic loads induced by human activities, The earlier works were mainly concerned to parameters study of dynamic loads as like activity type, weight, sex, surface condition of structure and etc. In this paper, we have measured directly the walking loads by using the platform. And we have evaluated and analyzed load-time history of walking loads. One of the most important parameter is pacing rate (walking speed) in the walking loads. The difference between the maximum value and minimum value of walking loads depends on the walking speed.

• Toxicological Research
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• v.9 no.1
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• pp.99-105
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• 1993

LBD-007, a newly developed recombinant human interferon alphaA, was at dose levels of 0.3 $\times$$10^6$ , 6 $\times$ $10^6$ and 12 $\times$ $10^6$ IU/kg/day administered subcutaneously to pregnant New Zealand White rabbits during the organogenetic period. Cyclophosphamide was used as a positive control. All pregnant females were subjected to the caesarean section on day 28 of pregnancy. Effect of test substance on dams and embryonal development of fetuses were examined. 1. No treatment-related changes in clinical signs, food consuption, body weight and necropsy findings of dams were observed.

• Textile Coloration and Finishing
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• v.21 no.2
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• pp.22-28
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• 2009

Human hair is a kind of fibrous keratin which has much cystine residues like wool fiber. It protects human head from the dangerous shock and is an organ to release heavy metals in human body. Recently, in many dyeing field there is a trend to utilize the natural dyes. Cochineal is a reddish natural mordant dye. When the cochineal is applied in human hair dyeing, it is expected that dyeing rate will be slow and wash fastness will be poor on account of large molecular weight relative to oxidative dyes. In this work, we investigated the effects of tributyl phosphate in hair dyeing with natural dye cochineal. Dyeability of hair increased significantly by adding tributyl phosphate in cochineal dyeing. Nevertheless the hair was slightly damaged during dyeing, the dyed hair showed a good wash fastness.

• Journal of Ginseng Research
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• v.20 no.4
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• pp.520-539
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• 1996

Based upon Shennong's Ancient Chinese Medical Textbook and Tsorngji Mingyi Byelu. Ginseng has been widely used for over 2,000 years in oriental countries. Scientific basic medical study or clinical study on ginseng was seal·toed 1910's in Eastern countries and from the 1950's in Western countries To obtain kotvledge of clinical studies on Korean ginseng. I investigated the following items 1) Oriental pharmacological documents. 2) the start and corrent state of ginseng research. 3) Clinical studies, 4) epidemiological studies. 5) non-medical human studies. 6) Foreign evaluation in published papers, and 7) future perspectives of clinical study. Although wide and profound research has been carried on the effect of ginseng (diabetes cardiovascular diseases, hypertension, liver diseases. gastrointestinal disorders soress, bram function. aging, antiradiation effect. anemia. hemopoiesis. immuomodulating effect. and tonic effect). Systemic clinical study to determine the therapeutic effects of speciblc disease have hardly been done even in other countries Clinical study or researches with human as the target. on ginseng has been performed in the field of body tenperazure. Pulse, clinical symptoms and hematological findings . fatigue, porformances. anemia. essential hypertension. blood sugar. serum cholesterol. lipid and prolactin. adrenocortical function. impotence. hypospermia. male sterility, climacteric disorder. anticancer effects. cancer preventive effects. and viral hepatitis. adverse effects. and prefered type of ginseng. At the same time as trying preventives or therapeutics from dietary oi natural products scientific research to support that ginseng is not a mystery. should be porformad to prove the effectiveness of Korean ginseng in the treatment of certain diseases using scientific methods or epidemiological approach.

• Journal of the Korean Society of Costume
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• v.57 no.4 s.113
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• pp.9-17
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• 2007

Somatotype is human body shape and physique type which can be classified not only by the size, but also by the shape or posture of the body. Postural variations in the alignment of the back, shoulder, and neck can have an adverse effect on the fit of garments designed to hang from the shoulders. There have been some previous studies about the lateral upper torso by analyzing photographic measurements. In this study, 3D body scan images were used to classify the side somatotype of upper lateral method even though they are major data in the classification of upper torso. This study focused on following objective.; 1) To apply new and developing technology into the apparel industry analyzing 3D body scan images. 2) To classify upper laterla torso using the data through the new improver technology, 3D body scanner. 3) To propose basic materials for well fitted garments for each type of figure. The test subjects for this study were two hundreds nine female aged 19 years and up who were recruited in Cornell university body scan research team. Seventeen Variables(12 angles, 5 lengths) out of 3D body scan data were measured based on these landmarks and applied to analyze. The result of factor analysis indicated that 6 factors were extracted through factor analysis and orthogonal rotation by the method of Varimax and those factors comprise 62.5% of total variance. And the somatotype of upper body is classified into 3 types of figures according to cluster analysis; Bent forward posture, Straight posture, Swayback posture. Future study could be addressed about the somatotype of body by the age group based on the large database with wide variety of age.

• Nuclear Engineering and Technology
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• v.40 no.7
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• pp.551-560
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• 2008

Radiation has stochastic aspects in its generation, its choice of interaction mode during traveling in media, and its impact on living bodies. In certain circumstances, like in high dose environments resulting from low-LET radiation, the variance in its impact on a target volume is negligible. On the contrary, in low dose environments, especially when they are attributed to high-LET radiation, the impact on the target carries with it a large variance. This variation is more significant for smaller target volumes. Microdosimetric techniques, which have been developed to estimate the distribution of radiation energy deposited to cellular and subcellular-sized targets, contrast with macrodosimetric techniques which count only the average value. Since cells and DNA compounds are the critical targets in human bodies, microdosimetry, or dose estimation by microscopic approach, helps one better analyze the biological effects of radiation on the human body. By utilizing microbeam systems designed for individual cell irradiation, scientists have discovered that human cells exhibit radiosensitive reactions without being hit themselves (bystander effect). During the past 10 or more years, a new therapeutic protocol using discontinuous multiple micro-slit beams has been investigated for its clinical application. It has been suggested that the beneficial bystander effect is the essence of this protocol.

• Korean Journal of Acupuncture
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• v.33 no.3
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• pp.139-147
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• 2016

Purpose : The acupuncture existed more than 2000 years and has flourished not only in Asia but also in medical field of modern world. In addition, empirical evidences from biomedicine have been expended in many ways in order to objectify the field of acupuncture. Thus, the effect and mechanism of the acupuncture has been revealed in human and other animals. In this article, I attempt to explain what doctors and patients subjectively experience through acupuncture treatment and its clinical significance based on mind-body medicine. Methods : The experience and clinical significance of the acupuncture was examined in the view of mind-body medicine, also reviewed research trends related to meditation understanding the clinical effectiveness of acupuncture. Results and Conclusions : Traditional Korean medical doctor perceive generally "jogi " and "chishin " meaning the regulation of the balance of the various functions in the human body and patient's consciousness and psychology state as mightily important concept concerning the therapeutic effect of acupuncture. Despite scientific approach to objective understanding of the acupuncture was performed in the meantime, practitioners put emphasis on experience based on sensate and interaction between doctor-patient. As it reflects the recent understanding of the psychological effects associated with the clinical efficacy of acupuncture, it has been presented one by one through neuroscience and cognitive science. Therefore it is important that interpreting the clinical effectiveness of acupuncture into Mind-body medicine can form a new awareness and attitudes toward traditional medicine.

• Korean Journal of Human Ecology
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• v.9 no.4
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• pp.471-482
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• 2000

The purpose of this study is to produce slacks pattern for pregnant women in the mid or second half period of their pregnancy according to the development figure of the body shell from a follow-up measurement. We here would like to produce slacks pattern for pregnant women constructed to fit better with their individual property in their figure and to help maintain the shape and beauty of the lower half of body and would compare it with two manufactured slacks pattern. The results of the study were as follows; 1. As the pregnancy proceeds, the height of natural-waist line went up spontaneously due to the projection of abdominal region, therefore, it was given darts at the front zipper part so that they could maintain a nice figure and to avoid possibility of feeling oppressed. To acquire a slimmer outfit, we made of the slacks-bottom narrower than the width at the knee line, and it worked out. 2. Sensory evaluation for appearance: According to the statistical of the result of 19items on the questionaire, all items showed significant difference(a$\leq$0.01) between the new and A(bunka) B(Kim's pattern) method slacks pattern, with the new pattern having higher scores. The new drafting method proved to be better fitted, to fit the shape of bodies properly and to get a visual effect to look slim.