• 한국발생생물학회지:발생과생식
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• 제23권2호
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• pp.93-99
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• 2019

Nonylphenols (NPs) are widely used industrial materials, and are considered as potent endocrine disrupting chemical. Present study was undertaken to clarify the effect of subchronic low-dose NP exposure to F1 generation male mice. Mice were divided into 2 groups; (1) CON, control animals and (2) NP-50 ($50{\mu}g/L$), animals were treated with NP via drinking water. NP exposures were continuously conducted from parental pre-mating period until the postnatal day (PND) 55 of F1 offsprings. Mice were sacrificed on PND 55 and the tissue weights were measured. The initial body weights (at PND 21) and terminal body weights (PND 55) of the NP-50 animals were significantly lower than those of control animals (p<0.05). NP exposure induced a significant increase in the absolute weight of the testes (p<0.05). Conversely, the NP exposure caused significant decrease in the absolute weights of the epididymis (p<0.01), prostate (p<0.05) and seminal vesicle (p<0.05). Histopathological studies revealed that NP-treated animals exerted decreased seminiferous tubule diameters, reduced luminal area, and lower number of germ cells. Also some sloughing morphologies in the tubules were observed. In the caudal epididymis, fewer mature sperms and swollen epithelial cells were found in the NP-treated group. Our results confirmed that the subchronic low-dose NP exposure altered some male parameters and induced histopathological abnormalities in testis and epididymis of F1 mice. Since the NP dose used in this study is close to the average human daily NP exposure, our results could provide practically meaningful understanding of adverse effect of EDC in human.

• 한국방사선학회논문지
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• 제12권4호
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• pp.481-489
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• 2018

Brain MRI 검사에서는 영상을 얻기 위해 RF Pulse를 인체에 조사하게 되는데 이때 조사된 RF Pulse 에너지의 상당부분은 우리 몸에 그대로 흡수되게 되고 이로 인해 인체의 온도가 상승하게 되는데 노출정도에 따라 인체에 영향을 주게 된다. 그리고 같은 RF Pulse 에너지를 주었더라도 인체에 금속이 삽입되었다면 금속으로 인한 전자파 전도도가 증가하기 때문에 SAR가 증가하고 체온도 변화하게 된다. 이에 Brain MRI검사 시 치아 임플란트의 재료에 따라 발생되는 두부 전체의 SAR와 온도의 변화를 비교 분석하고자 한다. 실험은 인체 두부모델에 1.5Tesla MRI장비에서 발생되는 64MHz RF Pulse 주파수, 3.0Tesla MRI장비에서 발생되는 128MHz RF Pulse 주파수를 조사한 뒤 치아 임플란트 재료를 Titanium과 $Al_2O_3$로 변화시킨 경우 두부 전체의 SAR와 온도 변화를 알아본다. 치아 임플란트 재료의 변화에서 Titanium을 사용하였을 때, 두부 전체의 SAR와 온도는 높게 나타났다. 하지만 $Al_2O_3$을 사용하였을 때, Titanium보다 두부 전체의 SAR와 온도는 낮게 나타났다. 치아 임플란트의 재료는 금속의 비중이 작은 경금속이면서 전기적 도체인 Titanium과 비교했을 때 전기전도도가 낮은 전기적 부도체인 $Al_2O_3$에서 두부 전체의 SAR와 온도는 낮게 나타났다. 치아 임플란트 재료가 Titanium 일 경우 SAR의 최대값은 제한치보다 월등히 높기 때문에 향후 Titanium의 치아 임플란트 재료를 삽입한 환자가 Brain MRI 검사를 할 경우 환자의 생물학적 영향과 관련된 연구가 필요할 것이다. 또한, 치아 임플란트 시술 시 Titanium보다는 $Al_2O_3$ 재질의 치아 임플란트를 사용하는 것이 Brain MRI 검사에서 인체 두부 전체의 SAR와 온도를 감소시키는 방안이라는 점을 발견할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8155-8159
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• 2014

Background: Breast cancer is the serious health concern in India causing the highest mortality rate in females, which occurs due to uncontrolled cell division and can be metastasize to other parts of the human body. Interactions with estrogen receptor (ER) alpha are mainly responsible for the malignant tumors with regulation of the transcription of various genes as a transcription factor. Most of the drugs currently used for the breast cancer treatment produce various side effects and hence we focused on natural compounds which do not exhibit any toxic effect against normal human cells. Materials and Methods: Structure of human ER was retrieved from the Protein Data Bank and the structures of flavonoid compounds have been collected from PubChem database. Molecular docking and drug likeness studies were performed for those natural compounds to evaluate and analyze the anti-breast cancer activity. Results: Finally two compounds satisfying the Lipinski's rule of five were reported. The two compounds also exhibited highest binding affinity with human ER greater than 10.5 Kcal/mol. Conclusions: The results of this study can be implemented in the drug designing pipeline.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2607-2610
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• 2013

Malignant glioma, also known as brain cancer, is the most common intracranial tumor, having an extremely high mortality and recurrence rate. The survival rate of the affected patients is very low and treatment is difficult. Hence, growth inhibition of glioma has become a hot topic in the study of brain cancer treatment. Among the various isothiocyanate compounds, it has been confirmed that benzyl isothiocyanate (BITC) can inhibit the growth of a variety of tumors, including leukemia, glioma and lung cancer, both inside and outside the body. This study explored inhibitory effects of BITC on human glioma U87MG cells, as well as potential mechanisms. It was found that BITC could inhibit proliferation, induce apoptosis and arrest cell cycling of U87MG cells. In addition, it inhibited the expression of SOD and GSH, and caused oxidative stress to tumor cells. Therefore, it is believed that BITC can inhibit the growth of U87MG cells outside the body. Its mechanism may be related to the fact that BITC can cause oxidative stress to tumor cells.

• 국제물리치료학회지
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• 제1권1호
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• pp.19-25
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• 2010

The purpose of this study was to determine the effects of heat application on the immune activities of the human body. To exam, furthermore, the immune effect from the healthy volunteer(male:15, female:15) by monitoring changes of immune substances such as various leukocytes[total white blood cell(WBC), eosinophil, neutrophil, basophil, monocyte, and lymphocyte], a comparative study with warm water immersion($40.8{\pm}0.3^{\circ}C$) and infrared(250W) was carried out. The plasma analysis showed that the count of white blood cell, eosinophil, and neutrophil were elevated in warm water immersion- or infrared. stimulated group compared with control group. However, the count of basophil was decreased in both warm water immersion- and infrared-stimulated group than control group. Therefore, these results suggest that the thermostimulation improved immune activity.

• 한국의학물리학회지:의학물리
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• 제31권2호
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• pp.29-34
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• 2020

Purpose: The interaction of various substances inserted into the human body and radiation can confirm the radiation enhancement effect. A Leksell frame inserted into the human body for gamma knife treatment will cause not only pain and inconvenience to the patient, but also additional exposure to the patient's normal tissues. In this study, we attempt to confirm the additional exposure caused by the interaction of the Leksell frame and thermoplastic mask, and ⁶⁰Co used for gamma knife treatment. Methods: A ⁶⁰Co energy of 1.17, 1.33 MeV is applied using Monte Carlo simulation, and fixation screws and thermoplastic mask are fabricated using aluminum and titanium alloy, and Carbon compounds. Results: Results show a dose enhancement of up to 396.27% higher compared with that without a Leksell frame and up to 391.25% in thermoplastic mask. Conclusions: Hence, appropriate treatment methods and materials must be used to reduce additional exposure to normal tissues.

• International Journal of Automotive Technology
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• 제6권4호
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• pp.383-390
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• 2005

This study proposes an innovative design guideline to assist the evaluation and improvement of the dynamic comfort of vehicle seating. The existing evaluation method for the comfort of vehicle seating was investigated to broach problems in evaluation. It was found that the currently existing evaluation method employs the resonance frequency of the vibration system composed of the seat and the human body and the maximum vibration transmissibility. This study proposes a design guideline aimed at the enhancement of vibration transmission characteristics above the resonance range, particularly within the range of 10-18 Hz. In order to meet this guideline, a seat was constructed out of foam having a low damping coefficient. It was then installed in a vehicle for a driving test. The driving test confirmed the improvement of the dynamic comfort of the seat. The result of evaluation of the improved seat using the SEAT index, an industry standard widely used to evaluate the dynamic comfort of a seat considering the perceptivity characteristics of the human body, showed that the perceptive vibration transmission had reduced by more than $11\%$. The effect of the modification of seat foam was also verified through a subjective assessment of dynamic comfort of the seats.

• 한국의류학회지
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• 제19권1호
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• pp.142-148
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• 1995

In this study, FVM (Finite Volume Method) which is one of the 2-dimensional numerical approach has been conducted to anticipate the temperature distribution between skin and clothes by the change of air temperature and fabric characteristics including fabric thickness. Several experimental works have been done to understand the thermal insulation effect (If fabrics on a human body by measuring the averaged temperature in the air layer between skin and clothes or by measuring the thermal resistance of fabrics. However, the formal method is inconvenient to measure the temperature distribution in the air layer to evaluate the insulation rate of the clothes on the skin because the real size of the clearance between skin and the clothes is too small to place the temperature sensor, and in the Tatter method the relationship between human body and the fabrics are ignored. However, the numerical method will be very effective and economical way to evaluate the insulation efficiency of clothes when the computational result is in the reliable range. As the result of this study, the temperature change in the sir layer between skin and clothes was linear to the fabric thickness and this result coincides with many previous experimental results. Moreover, it is possible to predict the optimum fabric thickness for the best thermal insulation in the air layer between skin and clothes.

• 복식문화연구
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• 제21권4호
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• pp.521-534
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• 2013

This study aims to identify the formative features of inflatable fashion that has changed its form or fulfilled specific functions by inserting air between fabrics or between clothes and the human body. Images of inflatable fashion images after the 1990s were collected from the literature and internet data and were analyzed based on the formative features of inflatable design. Through this analysis, it was determined that there were four formative features of inflatable fashion: First, inflatable fashion has functionality. General fashion also has functionality, but inflatable fashion has expanded functionalities such as an air bag effect or insulation due to injected air. Second, the formative potential. Inflatable fashion can be changed into different forms depending on the amount of air injected. Light-weighted air holds up the material of the clothes. So new forms that are different from conventional fashion, which gives inflatable fashion its formative potential, can be suggested. Third, aesthetic expansion. Inflatable fashion when its volume is expanded expresses the beauty of scale, or expresses a voluptuous beauty when part of human body is exaggerated. Fourth, it has an unconstructive characteristic. Space that is visible due to the transparent material of inflatable fashion expresses the intention of the designer to fulfill an unconstructive concept. In conclusion, the formative features of inflatable design have formative significances : practicality, aesthetic significance, semantics and technical significance.

• Journal of Biosystems Engineering
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• 제25권2호
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• pp.131-140
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• 2000

Spraying operation is one of the most essential in an orchard management and it is also hazardous to human body. for automatic and unmanned spraying , an autonomous travelling vehicle is demanded. In this study, a telemeter was developed using infrared beam which could detect trunks and obstacles measure distance and direction from the vehicle travelling in the orchard. The telemeter system was composed of two infrared LED transmitters and receivers, a beam scanning device for continuous object detection , two rotary encoders for angle detector, and a beam level controller for uneven soil surface. The detected distance and direction signal s were sent to personal computer which made for the system display the angular and distance measurements through I/O board. According to a field test in an apple farm, the system detected up to 10m distance under 12 V of transmitted beam intensity, however, it was recommended that the proper beam transmit intensity be 7 v at the 10 m distance, because of the negative effect to human body at 12 V. The error rate of this system was 0.92 % when the actual distance was compared to measured one. The system was feasible at the small error rate. The developed telemeter system was an important part for autonomous travelling vehicle provided the real time object recognition . A direction control system could be constructed suing the system. It is expected that the system could greatly contribute to the development of autonomous farm vehicle.