• Biomolecules & Therapeutics
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• 제4권4호
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• pp.323-329
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• 1996

A recombinant human erythropoietin (rHu-EPO), was administered intravenously to beagle dogs at doses of 100, 500 and 2, 500IU/kg/day for 30 days. There were no significant clinical signs such as body weight, food intake, physical and opthalmic examination, urine analysis, etc. Any toxic response was not observed except for enlarged spleen and extramedullary hematopoiesis. No observed adverse effect level (NOAEL) of rHu-EPO for 30 days was considered to be 100IU/kg/day in beagle dogs.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2000년도 가을 학술발표회논문집
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• pp.273-280
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• 2000

Building structures which are in need of large open space make the damping effect of the structures decrease greatly. Assembly and office buildings with a lower natural frequency have a higher possibility of experiencing excessive vibration induced by human activities. These excessive vibration make the residents uncomfortable and the serviceability deterioration. The loads induced by human activities were classified into two types. First type is in place loads as like jumping, foot stamping and body bouncing. The other type is moving loads as like walking, running and dancing. A series of laboratories experiments had been conducted to study the dynamic loads induced by human activities, The earlier works were mainly concerned to parameters study of dynamic loads as like activity type, weight, sex, surface condition of structure and etc. In this paper, we have measured directly the walking loads by using the platform. And we have evaluated and analyzed load-time history of walking loads. One of the most important parameter is pacing rate (walking speed) in the walking loads. The difference between the maximum value and minimum value of walking loads depends on the walking speed.

• Toxicological Research
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• 제9권1호
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• pp.99-105
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• 1993

LBD-007, a newly developed recombinant human interferon alphaA, was at dose levels of 0.3 $\times$$10^6$ , 6 $\times$ $10^6$ and 12 $\times$ $10^6$ IU/kg/day administered subcutaneously to pregnant New Zealand White rabbits during the organogenetic period. Cyclophosphamide was used as a positive control. All pregnant females were subjected to the caesarean section on day 28 of pregnancy. Effect of test substance on dams and embryonal development of fetuses were examined. 1. No treatment-related changes in clinical signs, food consuption, body weight and necropsy findings of dams were observed.

• 한국염색가공학회지
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• 제21권2호
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• pp.22-28
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• 2009

Human hair is a kind of fibrous keratin which has much cystine residues like wool fiber. It protects human head from the dangerous shock and is an organ to release heavy metals in human body. Recently, in many dyeing field there is a trend to utilize the natural dyes. Cochineal is a reddish natural mordant dye. When the cochineal is applied in human hair dyeing, it is expected that dyeing rate will be slow and wash fastness will be poor on account of large molecular weight relative to oxidative dyes. In this work, we investigated the effects of tributyl phosphate in hair dyeing with natural dye cochineal. Dyeability of hair increased significantly by adding tributyl phosphate in cochineal dyeing. Nevertheless the hair was slightly damaged during dyeing, the dyed hair showed a good wash fastness.

• Journal of Ginseng Research
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• 제20권4호
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• pp.520-539
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• 1996

Based upon Shennong's Ancient Chinese Medical Textbook and Tsorngji Mingyi Byelu. Ginseng has been widely used for over 2,000 years in oriental countries. Scientific basic medical study or clinical study on ginseng was seal·toed 1910's in Eastern countries and from the 1950's in Western countries To obtain kotvledge of clinical studies on Korean ginseng. I investigated the following items 1) Oriental pharmacological documents. 2) the start and corrent state of ginseng research. 3) Clinical studies, 4) epidemiological studies. 5) non-medical human studies. 6) Foreign evaluation in published papers, and 7) future perspectives of clinical study. Although wide and profound research has been carried on the effect of ginseng (diabetes cardiovascular diseases, hypertension, liver diseases. gastrointestinal disorders soress, bram function. aging, antiradiation effect. anemia. hemopoiesis. immuomodulating effect. and tonic effect). Systemic clinical study to determine the therapeutic effects of speciblc disease have hardly been done even in other countries Clinical study or researches with human as the target. on ginseng has been performed in the field of body tenperazure. Pulse, clinical symptoms and hematological findings . fatigue, porformances. anemia. essential hypertension. blood sugar. serum cholesterol. lipid and prolactin. adrenocortical function. impotence. hypospermia. male sterility, climacteric disorder. anticancer effects. cancer preventive effects. and viral hepatitis. adverse effects. and prefered type of ginseng. At the same time as trying preventives or therapeutics from dietary oi natural products scientific research to support that ginseng is not a mystery. should be porformad to prove the effectiveness of Korean ginseng in the treatment of certain diseases using scientific methods or epidemiological approach.

• 복식
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• 제57권4호
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• pp.9-17
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• 2007

Somatotype is human body shape and physique type which can be classified not only by the size, but also by the shape or posture of the body. Postural variations in the alignment of the back, shoulder, and neck can have an adverse effect on the fit of garments designed to hang from the shoulders. There have been some previous studies about the lateral upper torso by analyzing photographic measurements. In this study, 3D body scan images were used to classify the side somatotype of upper lateral method even though they are major data in the classification of upper torso. This study focused on following objective.; 1) To apply new and developing technology into the apparel industry analyzing 3D body scan images. 2) To classify upper laterla torso using the data through the new improver technology, 3D body scanner. 3) To propose basic materials for well fitted garments for each type of figure. The test subjects for this study were two hundreds nine female aged 19 years and up who were recruited in Cornell university body scan research team. Seventeen Variables(12 angles, 5 lengths) out of 3D body scan data were measured based on these landmarks and applied to analyze. The result of factor analysis indicated that 6 factors were extracted through factor analysis and orthogonal rotation by the method of Varimax and those factors comprise 62.5% of total variance. And the somatotype of upper body is classified into 3 types of figures according to cluster analysis; Bent forward posture, Straight posture, Swayback posture. Future study could be addressed about the somatotype of body by the age group based on the large database with wide variety of age.

• Nuclear Engineering and Technology
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• 제40권7호
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• pp.551-560
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• 2008

Radiation has stochastic aspects in its generation, its choice of interaction mode during traveling in media, and its impact on living bodies. In certain circumstances, like in high dose environments resulting from low-LET radiation, the variance in its impact on a target volume is negligible. On the contrary, in low dose environments, especially when they are attributed to high-LET radiation, the impact on the target carries with it a large variance. This variation is more significant for smaller target volumes. Microdosimetric techniques, which have been developed to estimate the distribution of radiation energy deposited to cellular and subcellular-sized targets, contrast with macrodosimetric techniques which count only the average value. Since cells and DNA compounds are the critical targets in human bodies, microdosimetry, or dose estimation by microscopic approach, helps one better analyze the biological effects of radiation on the human body. By utilizing microbeam systems designed for individual cell irradiation, scientists have discovered that human cells exhibit radiosensitive reactions without being hit themselves (bystander effect). During the past 10 or more years, a new therapeutic protocol using discontinuous multiple micro-slit beams has been investigated for its clinical application. It has been suggested that the beneficial bystander effect is the essence of this protocol.

• Korean Journal of Acupuncture
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• 제33권3호
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• pp.139-147
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• 2016

목적 : 침술은 동북아시아 지역의 중심에서 시작하여 2천년 이상의 역사와 함께 아시아뿐만 아니라 근-현대 전 세계의 임상의료 현장에서 크게 번창하고 있다. 이와 함께 침술의 객관화를 위하여 의생명과학 여러 방면에서 검증하는 노력이 진행되어 오고 있다. 그 과정을 통해 각종 동물을 비롯해 사람에서 침술의 다양한 효과와 기전이 점차 밝혀지고 있다. 필자는 침술 치료에서 의사와 환자가 주관적으로 경험하는 것을 설명하고, 그것의 임상적 유의성을 심신의학적 측면에서 이해하고자 하였다. 방법 : 침술과 명상에서 각각 진행되었던 뇌신경과학 분야의 여러 실험 결과들을 비교함으로써 심신 상관성이란 의미를 찾고자 하였다. 그밖에 한의학 임상영역에 시도되는 한의학과 심리학이 접목된 새로운 치료법을 정리하였다. 결과 및 결론: 침술의 치료효과와 관련해 "조기치신(調氣治神)"을 매우 중요한 개념으로 표현하고 있다. 이는 인체에 다양한 기능의 균형을 조절하고, 환자의 의식과 심리상태를 조절한다고 설명한다. 전통의학과 현대의학의 큰 차이는 현대의학은 환자와 질병을 대상화시켜 객관화 하는 노력을 추구하였고, 전통의학은 환자와 의사가 경험하는 대상을 자신과 분리하지 않는 주관적 체험을 추구하고 있다는 것이다. 그리고 전통의학은 주관적 체험을 배제하지 않고 진료에서 활용한다는 것이다. 그래서 전통의학의 역할과 의미를 이해하고자 한다면, 객관적 효과와 수량적 결과뿐만 아니라 환자와 의사의 주관적 체험과 이야기도 중요하게 다뤄져야 한다. 침술의 역할과 의미는 의사와 환자 사이에서 나타나는 행위의 모든 과정을 고려해 설명해야 할 것이다. 아마도 그 과정에서 침술이 찾는 해결의 길은 명상이 찾는 해결의 길과 만날 것이라 믿는다.

• 한국생활과학회지
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• 제9권4호
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• pp.471-482
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• 2000

The purpose of this study is to produce slacks pattern for pregnant women in the mid or second half period of their pregnancy according to the development figure of the body shell from a follow-up measurement. We here would like to produce slacks pattern for pregnant women constructed to fit better with their individual property in their figure and to help maintain the shape and beauty of the lower half of body and would compare it with two manufactured slacks pattern. The results of the study were as follows; 1. As the pregnancy proceeds, the height of natural-waist line went up spontaneously due to the projection of abdominal region, therefore, it was given darts at the front zipper part so that they could maintain a nice figure and to avoid possibility of feeling oppressed. To acquire a slimmer outfit, we made of the slacks-bottom narrower than the width at the knee line, and it worked out. 2. Sensory evaluation for appearance: According to the statistical of the result of 19items on the questionaire, all items showed significant difference(a$\leq$0.01) between the new and A(bunka) B(Kim's pattern) method slacks pattern, with the new pattern having higher scores. The new drafting method proved to be better fitted, to fit the shape of bodies properly and to get a visual effect to look slim.

• Asian-Australasian Journal of Animal Sciences
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• 제20권6호
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• pp.850-855
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• 2007

Leptin is the adipocyte-specific product of the obese gene and plays a major role in food intake and energy metabolism. Leptin research was mainly focused on mammalian species, but understanding of leptin and its function in poultry is very poor. In this study, the duck leptin gene was amplified using the reverse transcription-polymerase chain reaction (RT-PCR) from duck liver RNA. The cDNA fragment was inserted into the pET-28a expression vector, and the resulting plasmid was expressed in Escherichia coli BL21 (DE3). Experimental mice were given an intraperitoneal injection of 10 mg/kg leptin dissolved in phosphate buffered saline (PBS), while the control mice were injected with PBS. The effect of leptin on food intake, body weight and fatty deposition in mice was detected. Sequence analysis revealed that duck leptin had a length of 438 nucleotides which encoded a peptide with 146 amino acid residues. The sequence shares highly homology to other animals. The coding sequence of duck leptin was 84 and 86% identical to human and pig leptin nucleotides sequence. Highest identity was with the rat coding sequence (95%). The identity of the amino acid sequence was 84, 82 and 96% respectively compared to that of the human, pig and rat. Results of SDS-PAGE analysis indicated that a fusion protein was specifically expressed in E. coli BL21 (DE3). The purified product was found to be biologically active during tests. Continuous administration of recombinant duck leptin inhibited food intake. Despite the decrease of food intake, leptin significantly induced body weight and fatty deposition. These changes were accompanied by a significant down-secretion of plasma glucose, cholesterol, triglyceride and insulin levels in mice. The observations provide evidence for an inhibitory effect of leptin in the regulation of food intake and for a potential role of duck leptin in the regulation of lipogenesis.