• Journal of Microbiology and Biotechnology
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• v.32 no.7
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• pp.869-876
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• 2022

The skin, which is the largest organ of the human body, is in direct contact with pollutants in the surrounding atmosphere. Meanwhile, 1-nitropyrene (1-NP), the most abundant nitro-polycyclic aromatic hydrocarbon found in particulate matter, is known to have carcinogenic effects; however, studies on its toxicity in human and canine skin are still needed. In this study, we investigated 1-NP-induced apoptosis and inflammatory pathways in HaCaT cells. In addition, we also measured the cytoprotective effect of methyl gallate (MG), which is widely distributed in medicinal and edible plants and is well known for its anti-inflammatory and antioxidant properties. MG inhibited 1-NP-induced cell death and apoptosis pathways, including the cleavage of PARP and activation of caspase-3, -7, and -9. MG also suppressed 1-NP-induced COX-2 expression and phosphorylation of mitogen-activated protein kinases (MAPKs) and MAPK kinases (MAPKKs). Our findings suggest that 1-NP induces skin toxicity in human and canine through apoptosis and inflammatory responses, and moreover, that this can be prevented by treatment with MG.

• The Journal of the Korea Contents Association
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• v.19 no.3
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• pp.500-509
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• 2019

The study looked at the effect of body food on stress reduction and NK cell activity in improving natural healing for nurses, and examined whether it is effective in preventing and curing human health. The study was conducted for 30 days on 22 nurses who currently worked for more than a year at a general hospital in Gyeonggi Province. Stress measurements were conducted through pulse wave measuring instrument, and blood tests were conducted on the activity of NK cells. Treatment of collected data was performed by Paired t-testing through the Stat program SPSS 21 and providing body food suitable for the physical quality of participants after the classification of the body based on the internal diameter of the emperor and scholarship. Studies have shown that the effect on reducing the stress of body food has significant positive effects and that body food is effective for the activity of NK cells. This study has the following significance: First, the main health threat factor for modern people is the increased resistance of natural healing through body food to stress, which has the potential to prevent disease. Second, immunodeficiency in disease prevention and treatment is very important, which can increase the natural healing power of the human body by increasing the activity of NK cells through body food.

• Sleep Medicine and Psychophysiology
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• v.19 no.1
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• pp.5-10
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• 2012

The release of hormones and the metabolism of human body are controlled by the circadian rhythm related to sleep-wake cycle. Growth hormone, prolactin, thyroid stimulating hormone, cortisol, glucose, and insulin-secretion rates fluctuate according to the sleep-wake cycle. In addition, sleep is related to the appetite regulation and carbohydrate and other energy metabolism. Hypocretin (orexin), an excitatory neuropeptide, regulates waking and diet intake, and the poor sleep increases diet intake. The short sleep duration increases one's body mass index and impairs the function of the endocrine and metabolism, causing increases in the risk of glucose intolerance and diabetes. The poor sleep quality and sleep disorders have similar impact on the metabolic function. In short, the sleep loss and the poor quality of sleep have a detrimental effect on the endocrine and energy metabolism. The improvement of sleep quality by the future research and appropriate clinical treatment would contribute to the decrease of the metabolic diseases such as diabetes.

• Korean Journal of Veterinary Service
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• v.25 no.3
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• pp.309-314
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• 2002

Recombinant interleukin-2(IL-2) has demonstrated as an antineoplastic agent in mice and human, but the relatively low response rates observed in clinical trials. Therefore, the present study was undertaken in order to evaluate therapeutic activities of IL-2 for the establishment of therapeutic applications. At the onset of the experiment, normal C3H/HeN mice were injected with 5$\times$10$\^$6/ RD-995 tumor cells, murine ultraviolet radiation-induced fibrosarcoma, intraperitoneally. Beginning on day 6, experimental groups were treated with a 5-day course of IL-2(subcutaneous injection of 30,000 IU every 12 hours for 5 days). The result of this experiment revealed that body weight gradually decreased from 20th day in control mice. Subcutaneous IL-2 therapy prevented partially decrease body weight, and prolonged survival of mice compared with control group.

• Fashion & Textile Research Journal
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• v.7 no.3
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• pp.315-320
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• 2005

With regard to the fact that temperature of human body remains almost constant at $37^{\circ}C$, changes by circadian variation, this study intended to investigate the effect of circadian rhythm on physiological responses of human body according to body fat rate. Fifteen healthy adult women were recruited for this study and were measured body fat as a method of bio impedance. We organized subjects into three groups ; low body fat group(group L-less than 20% of body fat), medium body fat group(group M-20%~30% of body fat) and high body fat group(group H-more than 30% of body fat). The experiment was carried out in a climate chamber of $32^{\circ}C$, 60% RH with the repeat of 'Exercise' and 'Rest' period. Subjects participated in two experiments, one is morning experiment(called 'AM'), the other is afternoon experiment (called 'PM'). The results of this study are as follows ; As to the variation of rectal temperature, group L and M had a significant difference in the time of the day between AM and PM, but group H had almost the same rectal temperature in the two kinds of experimental time. The reason why group H had a smaller difference in the circadian rhythm of rectal temperature in this study is estimated at the Budd et al.(1991)'s results that body fat had effects on reduction in thermogenesis, radiation, mean skin temperature, and increase in insulation of the tissues. Group M had the highest mean skin temperature in the 'PM'. All the 3 groups didn't have stable values in 'AM'. But it showed more stable in 'PM' than 'AM'. Sweat rate was the highest in group H in both 'AM' and 'PM'. Group M had larger sweat rate in 'PM' than 'AM'. but in group L and H, sweat rate was almost the same in two kinds of time of the day. This result suggests that who have more or less body fat have larger difference in sweat rate between morning and afternoon than who have normal body fat.

• PNF and Movement
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• v.16 no.2
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• pp.179-185
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• 2018

Purpose: This study aimed to analyze the visual and spatial elements of the gait of a stroke patient who had diverse ankle weight loads applied, according to weight changes. Methods: The subject was a 57-year-old stroke patient diagnosed and hospitalized with a left intracerebral hemorrhage. A weight equivalent to 0%, 1%, and 2% of his body weight was applied to the area 5cm upward from the ankle using a Velcro strap. He was then trained on a treadmill, receiving a six-minute walk test to evaluate his gait ability. A gait analyzer was used to collect visual and spatial elements, such as gait distance, gait velocity, cadence, step length, stride length, and swing phase, according to a weight load equivalent to 0%, 1%, and 2% of his body weight. Results: According to the results of applying 0%, 1%, and 2% of his body weight on the ankle, except for gait velocity, his gait distance, cadence, step length, stride length, and swing phase were higher when 1% of his body weight was applied compared to 0% or 2% of his body weight. Conclusion: Applying a weight equivalent to 1% of the body weight to the ankle positively affected the visual and spatial element of the gait and heightened the efficiency of exercise during treadmill training, a gait-training tool generally used for stroke patients. However, the result is difficult to generalize because the number of subjects was small with only one subject.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1338-1339
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• 2008

In this paper, charging part by basic from Andrew's body model research to second a danger have affect on remaining and rehabilitation humans in space under water. The construction of a circuit make to Andrew's body model. It compare that voltages measure a hand, a breast, a groin and electric currents measure an arm, a breast, a leg with safety a limit of body through an electric current. Out of result, it research that magnitude and wave of body passing an electric current give the effect to the heart control a signal and it have affect on direct the ventricle of the heart in detail motion. A thing of this sort get through to the simulation by the ATP-Draw program. The results from above, it is publish one's research work with safety a limit electric angle take measurement of resistance a body in under water and to the voltage and electric current passing each parts.

• Archives of Plastic Surgery
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• v.48 no.6
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• pp.583-589
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• 2021

Background In prosthesis-based breast reconstruction patients, the drain tends to be kept in place longer than in patients who undergo only mastectomy. Postoperative arm exercise also increases the drainage volume. However, to preserve shoulder function, early exercise is recommended. In this study, we investigated the effect of early exercise on the total drainage volume and drain duration in these patients. Methods We designed a prospective randomized trial involving 56 patients who underwent immediate breast reconstruction following mastectomy using tissue expanders. In each group, the patients were randomized either to perform early arm exercises using specific shoulder movement guidelines 2 days after surgery or to restrict arm movement above the shoulder height until drain removal. The drain duration and the total amount of drainage were the primary endpoints. Results There were no significant differences in age, height, weight, body mass index, or mastectomy specimen weight between the two groups. The total amount of drainage was 1,497 mL in the early exercise group and 1,336 mL in the exercise restriction group. The duration until complete removal of the drains was 19.71 days in the early exercise group and 17.11 days in the exercise restriction group. Conclusions Exercise restriction after breast reconstruction did not lead to a significant difference in the drainage volume or the average time until drain removal. Thus, early exercise is recommended for improved shoulder mobility postoperatively. More long-term studies are needed to determine the effect of early exercise on shoulder mobility in prosthesis-based breast reconstruction patients.

• Science of Emotion and Sensibility
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• v.20 no.3
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• pp.141-150
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• 2017

The purpose of this study was to analyze the effect of the shape and attached position of E-textile-based stretchable sensors on motion-sensing performance and to investigate the requirements for the optimal structure of clothes for sensing limb motions. An experimental garment was prepared with different sensor shapes, and attachment positions. A child subject, wearing the experimental garment, performed arm and leg bending and extension motions at $60^{\circ}$, $90^{\circ}$ and $120^{\circ}$ motion angles, at a rate of 60 deg/sec. The changes in voltage triggered by the stretching and contracting of the fabric-sensor were measured, and an acceleration sensor was utilized to verify that the experimental motions were correctly performed. Dummy arms and legs of a child were manufactured to perform an identical test, in order to compare the dummy results with the actual human body experiment results. The analysis showed that the reproducibility and reliability of the rectangular sensor, showing uniform and stable were higher than those of the boat-shaped sensor, in both the dummy and the human body experiments. The attachment position of the sensor was more reproducible and reliable when placed on 4 cm below the elbow and knee joints in the dummy test, when placed in the joints of the elbow and knee, in children experiment. The appropriate shapes and attached positions of the sensor for sensing the motions were analyzed, and the results proved that motion-sensing of the human body is possible by utilizing flexible fabric-sensors integrated into clothes.

• Journal of Nutrition and Health
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• v.50 no.6
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• pp.578-584
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• 2017

Purpose: Excess intake of sodium is a major diet-related risk factor for human diseases including hypertension and cancer as well as obesity and inflammation. However, findings are still controversial, and evidence is lacking in Koreans. Therefore, for better understanding of the role of dietary sodium intake in disease etiology, this study investigated the effects of dietary sodium intake on adiposity, inflammation, and hormones in Koreans. Methods: A total of 80 males and females joined the study. The general characteristics and dietary intake data were investigated by trained interviewers using a questionnaire and 24-h dietary recall, respectively. For the markers of adiposity, body weight, body mass index, percent of body fat, visceral fat area, and waist and hip circumference were measured. For the inflammation and hormone markers, leptin, adiponectin, insulin, tumor necrosis $factor-{\alpha}$, and interleukin-6 were also analyzed. Results: Multivariate linear regression analyses suggested that dietary sodium intake was not associated with adiposity. However, dietary sodium showed a significant association with insulin level: Plasma insulin concentration increased with sodium intake independent of other dietary intake or percent of body fat (${\beta}=0.296$, adjusted $r^2=0.276$, p < 0.01). Other markers for inflammation and hormonal responses were not associated with dietary sodium intake. Conclusion: Findings suggested that dietary sodium intake may be a critical modifying factor in the level of plasma insulin. However, it showed a limited effect on obesity and other inflammation markers and hormone levels. These findings should be confirmed in larger, well-designed investigations.