• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1993년도 춘계학술대회
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• pp.21-24
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• 1993

The experimental results of visual stimulation with the tailored RF pulse are reported. Tailored RF pulse is used for the susceptibility effect imaging. Around 25% signal change of visual cortex area is detected during photic stimulation. Interestingly, with the tailored RF pulse, the signal intensity of visual cortex is deceased during photic stimulation. It is, however, increased with normal $T_2$ weighted imaging. The comparison between normal $T_2$ weighted imaging and the tailored RF pulse imaging are performed with 4T NMR system and the results with human volunteer are also presented.

• 대한약리학회지
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• 제11권2호
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• pp.55-59
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• 1975

Safety study of the continuous releasing dichlorvos-resin insecticide $(Mopari^{\circledR})$ was conducted in human volunteers and domestic fowls. For the purpose, the potential hazards in using the insecticide were observed in terms of the inhibition of plasma cholinesterase activity and the changes in the liver function (GOT, GPT, Alkaline phosphatase, Bilirubin, Thymol turbidity), the blood picture (RBC, WBC with differential count, Hemoglobin, Hematocrit and ESR) and the urine picture (sugar, albumin, pH and microscopic findings) in 40 healthy adult volunteers and 60 leghorn domestic fowls. In case of the human study the observation was continued for 2 months during the application of the insectiside ($1{\sim}3$ solid formulations/$30m^3$) in the living rooms of ordinary Korean dwelling houses or in the office. In the animal test, however, 1 to 5 solid formulations of the insecticide were applied in the fowl cage of $9.2m^3$ for 5 weeks. Any significant inhibition of the plasma cholinesterase activity was not observed in both the human volunteer and the fowl throughout the experimental period. And the liver function as well as the blood and urine pictures were also not changed after exposure to the vaporizing insecticide. It is considered from the result that the amount of dichlorvos released into the air by the continuous vaporizing dichlorvos-resin insecticide presents no significant hazardous effect on humans or animals in the present experimental condition.

• Bulletin of the Korean Chemical Society
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• 제30권7호
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• pp.1489-1496
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• 2009

This study was done for the determination and excretion profile of adrenosterone and its metabolites in human urine using both liquid chromatography with atmospheric pressure chemical ionization mass spectrometry and gas chromatography with mass spectrometry. Adrenosterone and its two metabolites were detected in human urine after administration a healthy volunteer with 75 mg of adrenosterone. We found that adrenosterone-M1 ($C_{19}H_{26}O_3$) was a reduction and adrenosterone-M2 ($C_{19}H_{26}O_4$) was a hydroxylation at C-ring, which did not know the exact position of the C-ring. The adrenosterone parent was detected by GC/TOF-MS, but not detected by LC/APCI/MS because of low intensity. Adrenosterone and its two metabolites were excreted as their glucuronided fractions. The recovery of this method ranged from 100.7 to 118.4% and the reproducibility and accuracy test were 85.5 to 112.0% and 1.1 to 8.4%, respectively. The excretion studies showed that adrenosterone and its metabolites were detectable in human urine during a 48 h period after oral administration, with maximum level of excretion at 4.1 h. The glucuro-/sulfaconjugated ratio of adrenosterone, M1 and M2 was 0.73 ${\pm}$ 0.03, 0.96 ${\pm}$ 0.06 and 0.89 ${\pm}$ 0.03 (n = 6), respectively. The amounts of adrenosterone excreted in urine were 14.75 ng for 48 h. Also, the maximum level of androsterone and 11$\beta$-hydroxy androsterone, which were endogenous steroids, were reached 4.1 h after the oral administration of adrenosterone.

• 가족자원경영과 정책
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• 제20권2호
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• pp.19-41
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• 2016

This study examines the human capital, economic capital, and psychological factors that influence social participation among the elderly in the future. The data, 'Survey on the Elderly in 2014', were collected from 'The Ministry of Health & Welfare' and the 'Korea Institute for Health and Social Affairs'. The samples included 10,279 elderly people who were over 65 years of age. Multiple regression analysis was used to analyze the research model. The findings are as follows. First, the highest participation awareness level of all was for the hobbies and leisure activities, and the lowest participation awareness level was for volunteer activities. Second, human capital factors such as age, education level, and health status, and economic capital factors such as household consumption expenditure and standard of living signigicant affected social participation awareness among the elderly. Psychological factors such as self-esteem, depression, and the subjective age of becoming elderly, also affected the social participation awareness. Third, awareness differed by sex. In particular, age and depression were restrictions of social participation awareness that were more common among elderly women than among elderly men, although single women were more likely to participate in religious, learning, and hobby and leisure activities. In contrast, chronic diseases and household consumption expenditures were more restrictive of social participation awareness among elderly men compared to elderly women. These results show that human capital, economic capital, and psychological factors heavily influence the social participation awareness of the elderly, although the degree of influence of these factors differs by sex.

• 한국엔터테인먼트산업학회논문지
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• 제14권8호
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• pp.427-436
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• 2020

이 연구는 대학운동부를 대상으로 인권감수성 수준을 알아보고 변인 간 인권감수성의 차이를 비교·분석하는 데 목적이 있다. 이러한 연구의 목적을 달성하기 위해 한국대학스포츠협의회에 등록된 대학을 중심으로 10개 대학교의 운동선수 188명을 유층집락무선표집으로 설문조사하였다. 수집된 자료는 IBM SPSS 24.0 프로그램을 사용하여 빈도분석을 실시하였고, 신뢰도를 구하기 위하여 cronbach's α를 산출하였다. 대학운동부의 다양한 특성에 따라 인권감수성 수준의 차이를 검증하기 위해서 기술통계분석, one-way ANOVA, 사후검증 방법으로 Scheffe를 사용하였으며, 다음과 같은 결론을 도출하였다. 첫째, 에피소드 중 대학운동부의 인권감수성 점수가 가장 높게 나타난 에피소드는 이주노동자의 노동권과 노인의 행복권이며, 인권감수성 점수가 가장 낮게 나타난 에피소드는 구금으로부터의 자유권, 사생활권이다. 또한, 인권감수성의 하위요인 중 책임지각과 상황지각이 결과지각보다 높다. 둘째, 대학운동부 특성에 따른 대학운동부의 인권감수성은 학교운동부규모, 수상실적에 따라 유의한 차이가 있다. 셋째, 대학운동부의 교육특성에 따른 대학운동부의 인권감수성 수준은 유의한 차이가 있다.

• 분석과학
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• 제33권2호
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• pp.59-67
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• 2020

Nadolol is a β-blocker drug, which effectively manages hypertension and angina pectoris. Its chemical structure allows the formation of four possible stereoisomers. A coupled column high-performance liquid chromatographic (HPLC) system with UV and fluorescence detection was investigated for simultaneously determining four nadolol enantiomers in human plasma. The plasma samples were prepared using a convenient liquid-liquid extraction process and passed through HPLC. Nadolol was initially separated from the endogenous compounds or other impurities in human plasma on a Phenomenex silica column, and its enantiomers were resolved and determined on a Chirapak AD-H column. The developed HPLC method achieved an effective chiral separation and significantly eliminated endogenous compound interference. This optimal HPLC method was validated following FDA guidelines. The results showed good selectivity, linearity, accuracy (90.50 % - 105.27 %), and precision (RSDs < 9.52 %) for each enantiomer. This method was also successfully applied to determine nadolol enantiomers in the plasma samples of a healthy male volunteer (after orally administering 80 mg racemic nadolol), proving its suitability for nadolol stereoselective pharmacokinetic studies.

• 한국병원경영학회지
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• 제24권4호
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• pp.70-84
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• 2019

Purposes: Despite a lot of prior studies on psychological empowerment on positive outcomes, the objectives of this paper were to examine the role of psychological empowerment on informal learning and the mediation role of informal learning between psychological empowerment and outcome variables focused upon physical therapists working in hospital industry. Methodology: Using survey methods, the data were collected from 198 physical therapists who have worked in Ulsan city and attended in annual meeting. Findings: Results showed that psychological empowerment predicted informal learning positively but differences in mediational mechanism. Specifically, the path between psychological empowerment and proactive behavior partially mediated but no mediating effect between psychological empowerment and helping behavior. This study identified the main role of psychological empowerment on informal learning, and it expands on positive functions of the concept to learning area in organizations. The other results help advanced understanding of differential mechanism through informal learning in the process between psychological empowerment and both outcomes. Practical Implications: The current study contributes to expend the area of prior findings on psychological empowerment to learning activities implemented by individual volunteer effort. For hospitals operating the teams of physical therapy, the significance for considering psychological empowerment is highlighted as for individual growth related to job and for change behavior in the individual level.

• The Korean Journal of Pain
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• 제14권1호
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• pp.19-25
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• 2001

Background: Transcutaneous electrical nerve stimulation (TENS) has been used widely, but its effects are controversial. This is probably due to the varying intensity and type of pain. We designed a study to assess the effects of the TENS on the RIII nociceptive flexion reflex as the resting pain level and the temporal summation as a repeated, movement related pain in 7 normal volunteer subjects. Methods: High frequency (80 Hz), non-noxious TENS was applied over the left popliteal fossa for 20 minutes. Ipsilateral RIII reflexes induced by single electrical stimulus and temporal summation of pain responses to repeated stimuli (five stimuli at 2 Hz) were recorded before, during (just before stopping), and subsequently at 20 minutes after TENS. Results: R (III) nociceptive flexion reflex activity during and after TENS was more significantly decreased than before treatment. However, the temporal summation threshold was not changed. Conclusions: We conclude that high frequency, non-noxious TENS could be effective on resting pain relief in the same segment but not on the movement related pain.

• 한국간호교육학회지
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• 제26권2호
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• pp.146-156
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• 2020

Purpose: The purpose of this study was to investigate the experience of nursing students who volunteered as dementia partners for elderly persons with dementia. Methods: This qualitative study utilized focus group interviews to investigate the experiences of 20 nursing students who performed dementia partner activities for more than one year. Data were analysed using an inductive content analysis approach based on Elo & Kyngäs. Results: The analysis yielded the following four major themes: "becoming a dementia expert," "becoming an evangelist for prevention of dementia," "overcoming prejudices against aged with dementia," and "acquiring motivation and skills of geriatric nursing" That means the experience as a dementia partner serves as an opportunity to broaden human understanding and shows its potential as a means to complement the effectiveness of practical nursing education. Conclusion: Dementia partner experiences have changed the perception, attitude and behavior of nursing students about the aged with dementia, so there is a need to extend this kind of experience to other students in nursing. Moreover, educational policy support should be continuously provided for this purpose.

• 가족자원경영과 정책
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• 제16권3호
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• pp.109-132
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• 2012

This study explores how unmarried workers use their leisure time according to the 2009 Korean Time Use Survey. The purposes of this study are: 1) to investigate leisure time as it relates to leisure participation rates and leisure participation time and 2) to analyze the effect of socio-demographic variables on leisure time and leisure participation by unmarried workers. The following is a summary of the major findings. First, leisure participation differed with variations in leisure activities. Unmarried workers participated in media contact, human relations activities, and hobby activities more than other activities. Participation in learning activities was higher on weekdays than on Sunday. Men participated in sports and outdoor activities more than women on Sundays. The participation rate of media contact was the highest, while the participation rate of volunteer activities was the lowest. Second, influencing factors on leisure time included gender, age, monthly income, and gender role attitudes when work time was controlled. For example, unmarried workers with egalitarian attitudes spent less leisure time. Third, gender was the strongest determinant of leisure participation. The probability of women's leisure participation was higher than men except in regards to sports and outdoor activities, and hobby activities.