• The Journal of the Acoustical Society of Korea
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• v.27 no.2E
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• pp.45-50
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• 2008

In recent years, quantitative ultrasound (QUS) technologies have played a growing role in the diagnosis of osteoporosis. Most of the commercial bone somometers measure speed of sound (SOS) and/or broadband ultrasonic attenuation (EUA) at peripheral skeletal sites. However, the QUS parameters are purely empirical measures that have not yet been firmly linked to physical parameters such as bone strength or porosity. In the present study, the theoretical models for wave propagation in cancellous bone, such as the Biot model, the stratified model, and the modified Biot-Attenborough (MBA) model, were applied to predict the dependence of phase velocity on porosity in cancellous bone. The optimum values for the input parameters of the three models in cancellous bone were determined by comparing the predictions with the previously published measurements in human cancellous bone in vitro. This modeling effort is relevant to the use of QUS in the diagnosis of osteoporosis because SOS is negatively correlated to the fracture risk of bone, and also advances our understanding of the relationship between phase velocity and porosity in cancellous bone.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.3 no.1
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• pp.31-47
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• 2005

Fatigue is a common experience in our daily life and in therapeutic exercises. Human muscle fatigue has been studied using a wide variety of exercise models, protocols and assessment methods. This study conducts quantitative evaluation of fatigue of knee extensor with surface electromyography and dynamometer and is to provide basic materials in physical therapy diagnosis and assessment of skeletal muscle. Measurement of two stages was conducted with 88 normal adults between their twenties and seventies, correlations and differences using collected data according to age was compared and correlations among measured items were analyzed and then the following conclusions were obtained. Analysis of sEMG and dynamometry of knee extensor showed that MDF, FI, MVIC, ET had the closest relations with age and MDF, FI, MVIC were significantly increase with aging. In addition, it was found that there were high correlation among items of analysis.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.3
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• pp.284-287
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• 1999

The nose, a striking features of the human face, is regarded by many clinicians as the keystone of facial esthetics. Clinically, as the treatment of a dentofacial deformity, the soft tissue changes that occurred normally with movement of the skeletal bases. Changes of the soft tissue in the maxillary orthognathic surgery are widening of alar base, elevated nasal tip and flattening of upper lip. In addition, soft tissue change is difficult to predict, it has considerable variability in the response of soft tissue. We reviewed patients who received Le Fort I advancement osteotomy in our department and analysed preoperative and postoperative alar base width, nasal height in clinical measurement and cephalometry and patient's satisfaction of postoperative nasal appearance.

• Culinary science and hospitality research
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• v.20 no.5
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• pp.84-92
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• 2014

Present study classified body composition to 4 groups categorized as sarcopenic obesity (SO), sarcopenic nonobesity (SNO), nonsarcopenic obesity (NSO), and nonsarcopenic nonobesity (NSNO) and then was performed to investigate that body composition associated with food consumption frequency as well as MS in individual aged 60 years or older. Body mass index and an appendicular skeletal muscle mass (ASM) divided by weight (Wt) of < 1 standard deviation (SD) below the sex-specific mean for young adults were used to define obesity and sarcopenia. A total of 1,433 subjects (658 male and 775 females) 60 years or older from the fifth Korea National Health and Nutritional Examination Survey 2010 participated in this study. One of the interesting findings was that the association of the prevalence of MS with body composition was higher in women than man. Other finding was that there were different food frequency and food preference according to 4 different groups between men and women. In addition, men are much more influenced by food than women. In conclusion, body composition changes were more related with food frequency in elderly men (60 years or older) than women. Women had a higher prevalence of MS than men, suggesting early nutritional intervention in elderly women may help them prevent body composition changes.

• Journal of Korean Institute of Industrial Engineers
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• v.23 no.4
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• pp.779-791
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• 1997

The purpose of this study is to measure a perceived joint discomfort in the seated and standing position, and to provide ranking systems of perceived joint discomfort. Nineteen mole subjects with no history of musculo-skeletal disorders participated in the experiment. Their physical characteristics were: age $-25.4{\pm}2.7$years, stature $-171.9{\pm}6.0cm$, and body weight $-67.1{\pm}7.0kg$. The results showed that the perceived joint discomforts were different depending upon the joints involved in motion and their movement directions (degree of freedom of motions), which implied that the human body motions and their degrees of freedom should be classified into several distinct classes that need to be assigned different weights of postural stress. Therefore, three ranking systems based on the perceived joint discomforts were suggested, which were classified by the degree of freedom of motions and joints, by only degree of freedom motions, and by joints involved in motion, respectively. In the seated position, the hip movement was the most stressful, the bock was the second, and the shoulder was the third. Likewise, in the standing postures, the hip was the most, the bock was the second, and the ankle was the third. It was expected that these joint motion ranking systems could be used by practitioners of health and safety to improve the comfort of working postures in industry.

• Proceedings of the Korean Society of Toxicology Conference
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• 2000.11a
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• pp.31-41
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• 2000

The major issue in the post genome sequencing era is determination of gene expression patterns in variety of biological systems. A microarray system is a powerful technology for analyzing the expression profile of thousands of genes at one experiment. In this study, we constructed cDNA microarray which carries 2,304 cDNAS derived from oligo-capped mouse cDNA library. Using this hand-made microarray we determined gene expression in various biological systems. To determine tissue specific genes, we compared Nine genes were highly-expressed in adult mouse brain compared to kidney, liver, and skeletal muscle. Tissue distribution analysis using DNA microarray extracted 9 genes that were predominantly expressed in the brain. A database search showed that five of the 9 genes, MBP, SC1, HiAT3, S100 protein-beta, and SNAP25, were previously known to be expressed at high level in the brain and in the nervous system. One gene was highly sequence similar to rat S-Rex-s/human NSP-C, suggesting that the gene is a mouse homologue. The remaining three genes did not match to known genes in the GenBank/EMBL database, indicating that these are novel genes highly-expressed in the brain. Our DNA microarray was also used to detect differentiation specific genes, hormone dependent genes, and transcription-factor-induced genes. We conclude that DNA microarray is an excellent tool for identifying differentially expressed genes.

• Toxicological Research
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• v.3 no.1
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• pp.33-44
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• 1987

A fertility study was carried out in Sprague Daxley rats which have been given the intravenous or intraperitoneal injections of rHuIFN-${\alpha}$A, a commecially available therapeutic agent, at dose levels of $1{\times}10^5$, $4{\times}10^5$ and $1.2{\times}10^6$ I.U/kg/day. Male rats were treated with rHuIFN-${\alpha}$A from 60 days before pairing and until the completion of mating. Femal rats received rHuIFN-${\alpha}$A for 22days prior to mating and up to day of gestation. All pregnant females were sacrificed on day 20 of gestation and all fetuses were examined for abnormalities. Both the male and female animals treated with rHuIFN-${\alpha}$A did not show any abnormal responses. No abnormal signs were seen in reproducibility for the rats treated with rHuIFN-${\alpha}$A. No External, internal and skeletal anomalies attributable to rHuIFN-${\alpha}$A were observed in the fetuses. It was concluded that rHuIFN-${\alpha}A$ had no harmful effect on mating, fertilization, implantation, or embryonic development.

• Toxicological Research
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• v.3 no.1
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• pp.45-53
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• 1987

A teratogenicity study was carried out on Sprague-Dawley rats which have been given the intravenously or intraperitonealy injections of rHuIFN-${\alpha}$A, an available therapeutic agent, at dose levels of $1{\times}10^5$, $4{\times}10^5$ and $1.2{\times}10^6$ I.U/kg/day for a period of 11 days from day 7 to day 17 of gestation. Two-thirds of the pregnant females in each group were sacrificed on day 20 of gestation and their fetuses were examined. The remaining dams were allowed to litter naturally, and the postnatal development of the off springs was observed. No changes were observed in all aspects of parameters between the treated and the control dams. The incidence of external, internal, and skeletal anomalies were not significantly increased in the fetuses of any treated groups. The rHuIFN-${\alpha}A$ caused no effects on parturition, lactation, and postnatal growth.

• Biomedical Science Letters
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• v.7 no.2
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• pp.59-64
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• 2001

Nebulin is an unusually large actin-binding protein specific to the skeletal muscle of vertebrates. The correlation of nebulin size with thin filament length have led to the suggestion that nebulin acts as a molecular ruler for the length of thin filaments. An SH3 domain occupies the C terminus of nebulin, in the sarcomeric Z-disk and is preceded by a 120-residue stretch containing multiple putative phosphorylation sites. SH3 domain mediates protein-protein interaction involved in the subcellular localization of proteins, cytoskeletal organization and signal transduction. However the binding partner and physiological role of nebulin SH3 domains remains unknown. Using the yeast two-hybrid system, we identified supervillin, an actin-binding protein, as a nebulin SH3 domain-interacting protein. The SH3 domain of nebulin binds to the sequence encoding amino acids 977 to 1335 of supervillin. But the sequence encoding amino acids 977 to 1335 displays weaker binding than the sequence encoding amino acids 977 to 1788.

• BMB Reports
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• v.45 no.11
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• pp.612-622
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• 2012

Olfactory receptors (ORs) detect volatile chemicals that lead to the initial perception of smell in the brain. The olfactory receptor (OR) is the first protein that recognizes odorants in the olfactory signal pathway and it is present in over 1,000 genes in mice. It is also the largest member of the G protein-coupled receptors (GPCRs). Most ORs are extensively expressed in the nasal olfactory epithelium where they perform the appropriate physiological functions that fit their location. However, recent whole-genome sequencing shows that ORs have been found outside of the olfactory system, suggesting that ORs may play an important role in the ectopic expression of non-chemosensory tissues. The ectopic expressions of ORs and their physiological functions have attracted more attention recently since MOR23 and testicular hOR17-4 have been found to be involved in skeletal muscle development, regeneration, and human sperm chemotaxis, respectively. When identifying additional expression profiles and functions of ORs in non-olfactory tissues, there are limitations posed by the small number of antibodies available for similar OR genes. This review presents the results of a research series that identifies ectopic expressions and functions of ORs in non-chemosensory tissues to provide insight into future research directions.