• Nutrition Research and Practice
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• 제8권5호
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• pp.501-508
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• 2014

BACKGROUND/OBJECTIVES: Rubus Coreanus Miquel (RCM), used as a traditional Korean medicine, reduces chronic inflammatory diseases such as cancer and rheumatoid arthritis. However, its mechanism has not been elucidated. In this study, we examine the anti-inflammatory effects of RCM and their possible mechanisms using RAW 264.7 cells. MATERIALS/METHODS: Unripe RCM ethanol extract (UE), unripe RCM water extract (UH), ripe RCM ethanol extract (RE), and ripe RCM water extract (RH) were prepared. Inflammatory response was induced with LPS treatment, and expression of pro-inflammatory mediators (iNOS, COX-2, TNF-${\alpha}$, IL-$1{\beta}$, and IL-6) and NO and $PGE_2$ productions were assessed. To determine the anti-inflammatory mechanism of RCM, we measured NF-${\kappa}B$ and MAPK activities. RESULTS: UE and UH treatment significantly reduced NF-${\kappa}B$ activation and JNK and p38 phosphorylation and reduced transcriptional activities decreased iNOS, COX-2, and pro-inflammatory cytokines expressions, and NO and $PGE_2$ productions. RE and RH treatments reduced IL-$1{\beta}$ and IL-6 expressions through suppressions of JNK and p38 phosphorylation. CONCLUSIONS: In this study, we showed that RCM had anti-inflammatory effects by suppression of pro-inflammatory mediator expressions. Especially, unripe RCM showed strong anti-inflammatory effects through suppression of NF-${\kappa}B$ and MAPK activation. These findings suggest that unripe RCM might be used as a potential functional material to reduce chronic inflammatory responses.

• 한국산학기술학회논문지
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• 제19권8호
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• pp.78-85
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• 2018

본 연구에서는 2017년 20건의 화재가 발생한 냉동창고 화재사례중 발화원인의 판정에 다수의 의견이 존재하였던 사례에 대해 연구하였다. 연구 방법론은 NFPA 921 CODE에서 규정하고 있는 과학적 화재조사 방법이다. 과학적 화재조사 방법은 가설설정을 통한 논리적 추론에 의한 화재조사 방법으로 발화원인 판단에 오류를 최소화 시킨다. 반면에 비과학적 화재조사 방법은 발화원인의 판단에 주관적 추측, 추론적 판단 등의 비합리적 요소의 개입으로 많은 오류를 발생시킨다. 이는 결국 인적, 물적 책임의 문제 및 학문적 퇴보를 가져온다. 특히 목격된 화재(Sighted fire)에 비해 목격되지 않는 화재(Fire not seen)의 경우 원인조사에 있어서 더 많은 발화원인 의 오류를 만든다. 본 연구에서는 2017년 **시 **마트에서 발생한 냉동창고 정온전선의 화재사례에 대해 화재조사 보고서의 검토, 현장조사를 바탕으로한 가설A 와 가설B의 설정하였다. 설정된 가설은 NFPA 921 code 규정하고 있는 연역적 검정 방법중 실험으로 검정하였다. 이러한 분석방법은 향후 목격되지 않는 화재(Fire not seen) 및 원인 불명 화재의 발화원인 판단에 NEW Paradigm의 구축 할 것이다. 또한 본 연구의 실험 자료는 냉동창고 제조사 및 운영사에 통보, 화재 예방을 위한 기초 자료로 활용 될 것이다.

• 한국환경교육학회지:환경교육
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• 제9권1호
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• pp.39-57
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• 1996

All kinds of environmental problems are related to each local and geographical environment. For this reason, it is necessary for schools in each region to provide environmental education which suits the geographical character of their particular region. In order to provide solutions to the environmental problems of each school's geographic region, the goal of this research is as follows: 1. We can make students realize the relationship between the human race and the environment by teaching according to the environmental conditions in each local area. 2. By teaching students about the problems in their own local environment, we can increase their concern about the state of their local surroundings. 3. When teaching about the environment, it is useful to use educational material which suits the character of each local region. 4. Students' interest in environmental preservation can be aroused through extracurricular environmental activities. The ares concerned are Chonnam and Kwangju City, which are divided into urban, industrial, rural, coastal, and mountainous areas. The conclusion about considering environmental education in environmental school social studies is as follows: 1. Kwangju and Chonnam should be divided into five sections, each with similar geographical environments. This will be an improvement over the old uniform approach to environmental studies in which all regions were treated as being the same each region will now receive special attention. 2. It is necessary to maximize the efficient use of the Environmental Education Building. When Media, environmental data and special materials for environmental education are used effectively, teachers can lead class effectively and students will be more interested in the class. 3. We can detect the cause of pollution, increase interest in the environment and easily solve environmental problems by collecting and displaying environmental educational materials. 4. An environmental education corner could boost students' interest in environmental problems and could act as a kind of bridge between theoretical and practical education. 5. Media and environmental data must be specialized according to the geographic character of each region. In this way, we can expect to improve the quality of environmental education over the simplistic environmental education of previous years. 6. Students will become interested in the problems of the region in which they live through social studies, and primarily through the environmental curriculum. 7. We can prevent learning deficiencies by making a consistent teaching plan. The teaching and learning methods will be improved and the teachers will be proud of what they teach. 8. The purpose of the Education Procedure Content Analysis is to make teaching and learning concise and easy by systematizing environmental and related subjects. This can be done by adding an environmental unit to the geographic section of social studies. 9. Citizens' interest in their own residential environment can be increased through action by sustaining environmental preservation movements to local region people.

• 간호행정학회지
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• 제4권1호
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• pp.73-88
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• 1998

The management of nursing resource is very important. that is because nursing staff accounts for 30-40% of total staff in a hospital and nurses provide patoents with attentive service for hours daily. The continuous turnover of nursing staff. however, impedes the quality-oriented nursing care, which will consequently leads to the loss of human and material resource in competitive society. This study aimed to calculate nurse's activity and compare the activity amount based on career experience. Futhermore it aimed to find factors which would influence 'quality weighed direct nursing activity amount'. Questionnaires and check lists for this study were distributed to nurses in a suburban hospital outside of Seoul from October 20 to November 14. 1997. The nursing activities were calculated according to professionality. independency and working hour. And then it were accumulated by quality score. The collected data was analyzed by statistical methods as t-test, ANOVA, correlation, multiple regression. The results of this study were as follows ; Firstly, carrel' experience had no influence on the quality weighed nursing activity amount. But the quality level of service of skilled nurses was higher than that of new nurses. Secondly, career was a variable affecting the quality in nursing service. So career was positively related to the quality of nursing care. Patient's disease severity and number of patient were positively correlated with weighed nursing activity amount. But job satisfaction was negatively correlated v:ith the amount. Thirdly, the independent variables which had significant influence on the weighed nursing activity amount were disease severity and the number of patients, The severity score and number of patient were directly proportional to the weighed nursing activity amount. This results indicated· that weighed nursing activity amount was influenced by the number of patient and patient's disease severity. The quality score of nursing services for experienced members is higher than that of new staff. But both new and skilled staff showed no difference in the quality weighed nursing activity amount. Internal and. external environment influences nursing activities. The quality of nursing services is very important factor in nursing activity. Therefore nursing managers should make an effort to improve nursing care quality through continuous research. Also they should try to maintain experience nurses and assign nursing staff appropriately with patient's severity and other relevant factors being considered. The quality-improved nursing care in the hospital will strengthen hospital's competitiveness.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.121-126
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• 2013

Background: Significance of HPV infection and genic mutation of APC and K-ras in rectal cancer has been investigated but not clarified. The objective of our study was to investigate these parameters in patients with rectal cancer to analyze correlations with biological behaviour, to determine relationships among the three, and also to demonstrate survival prognosis effects. Methods: From December 2007 to September 2008, 75 rectal cancer cases confirmed by histopathology in the Tumor Hospital of Xinjiang Medical University were enrolled. The control group consisted of normal rectal mucous membrane taken simultaneously, a least 10 cm distant from the carcinoma fringe. HPV DNA, the MCR of APC and exon-1 of K-ras were detected by PCR and PCR-SSCP. All results were analyzed in relation to clinical pathological material, using chi-square and correlation analysis via SPSS.13 and Fisher's Exact Probability via STATA. 9.0. All 75 patients were followed up for survival analysis using Kaplan-Meier and Log-rank tests. Results: 55 out of 75 cases demonstrated gene HPV L1 while it was notdetected in normal rectal mucosa tissue. HPV infection was correlated with age and lymphatic metastasis (P<0.05) but not other characteristics, such as ethnicity, tumor size, histological type, tumor type, Duke's stage and infiltration depth. Some 43 cases exhibited APC genic mutation (57.3%) and 34 K-ras genic mutation (45.3%). APC genic mutation was correlated with gender(P<0.05), but not age, histological type, infiltration depth, lymphatic metastasis and Duke's stage. In 55 cases of rectal cancer with HPV infection, there were 31 cases with genic mutation of APC (56.4%) and 24 with genic mutation of K-ras (43.6%). For the 20 cases of rectal cancer with non-HPV infection, the figures were 12 cases (60%) and 10 (50.0%), respectively, with no significant relation. Survival analysis showed no statistical significance for K-ras genic mutation, APC genic mutation or HPV infection (P>0.05). However, the survival time of the patients with HPV infection was a little shorter than in cases without HPV infection. Conclusions: Our results suggest that HPV infection might be an important factor to bring about malignant phenotype of rectal cancer and influence prognosis. Genic mutation of APC and K-ras might be common early molecular events of rectal cancer, but without prognostic effects on medium-term or early stage patients with rectal cancer.

• 대한지리학회지
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• 제39권4호
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• pp.495-513
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• 2004

효율적인 국토환경관리와 지속 가능한 생태자원의 보존을 위해서는 지형 및 토양의 공간적인 분포특성과 그것이 각종 자연 및 인문현상들과 가지는 상관성에 대한 이해가 선행되어야 한다. 기존의 지형분류법은 대부분 지형형성과정 혹은 지형의 단순한 형태분류에 치중하여, 분류 결과와 지표면에서 나타나는 다양한 생태학적 현상들과의 관련성을 파악하기 어려운 단점이 있었다. 이 연구는 지표면에서 나타나는 물과 에너지, 그리고 물질의 흐름을 생태적 환경특성을 반영하는 주원인으로 규정하고, 이에 근거하여 전산화된 지형분류법을 개발하는 것을 목적으로 한다. 지표면을 에너지와 물질의 흐름을 반영하는 8개의 토양지형단위(sod landscape units)로 구분하였으며, 이것을 수치고도모델(DEM)로부터 추출하는 방법을 개발하였다. 경기도 양평군의 약 12$extrm{km}^2$ 크기의 지역에 개발된 기법을 적용하여 토양지형단위들을 분류한 뒤, 각 단위들의 공간적인 분포특성을 살펴보았다. 개발된 방법은 일반적으로 구할 수 있는 수치고도모델에 적용할 수 있어, 넓은 지역의 지형특성들을 쉽게 파악할 수 있는 장점을 가지고 있다. 또한 분류된 토양지형단위들은 자연환경조사와 제반 수문 및 토양환경 특성 파악에 중요한 기본자료를 제공할 수 있을 것으로 기대된다. 하지만 제시된 방법이 보다 널리 쓰이기 위해서는 기존 수치지도의 정확성의 문제, 사용된 수치고도모델의 격자크기에 따라 분류기준의 변화를 야기 시키는 스케일의 문제, 그리고 다양한 지형형성작용과의 상관성에 관한 보다 체계적인 연구가 요구된다.

• 대한치과보철학회지
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• 제45권4호
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• pp.492-505
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• 2007

Statement of problem: An orthodontic miniscrew implant has been used as a skeletal anchorage for orthodontic treatment. However, any relation among the influence of the cortical bone, morphologic differences of orthodontic miniscrew implants and new bone formation hasn't been made clear yet. Purpose: The purpose of this study was to evaluate whether the orthodontic miniscrew implant could work as an intraoral skeletal anchorage immediately and stably for orthodontic treatment after insertion of it. Material and methods: Two types of orthodontic miniscrew implants were used in this experiment; tapered type and straight type. One hundred and sixty eight orthodontic miniscrew implants were inserted into the tibiae of 21 rabbits and sacrificed on 3, 7, 11, 14, 21 and 28days later after insertion of them to study removal torque values and histologic and histomorphometric analyses. Results: The results were as follows. 1. The removal torque values of the tapered type were higher than those of the straight type in all groups(p<0.05). 2. There wasn't any distinguishing differences between the tapered type and the straight type about the new bone formation percentage. 3. The removal torque values for both the tapered type and the straight type were gradually decreased at early stages of the test but started to increase at the 7 days group of the straight type and the 11 days group of the tapered type. 4. New bone formation percentage was increased gradually for both the tapered and the straight types as time passed(p<0.05). 5. It was found that the tapered type showed lower values in the cortical bone about both the maximum equilibratory stress distribution and the maximum principal stress distribution than the straight type in linear finite elements analysis. Conclusion: According to the research, the removal torque values were decreased at 7 days group of the tapered type and 11 days group of the straight type after the insertion of the orthodontic miniscrew implants in tibiae of rabbits. Considering the human bone activity, it is better to apply the orthodontic force $3{\sim}4$ weeks later than to apply it immediately after the insertion of orthodontic miniscrew implants. Considering that general orthodontic force is about $250{\sim}500$ grams, the tapered type can be worked as a stable skeletal anchor age in an orthodontic treatment even if the orthodontic force is applied on it immediately after the insertion of it.

• Spatial Information Research
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• 제16권3호
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• pp.279-290
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• 2008

자연재해로 인한 수많은 피해 중 특히 산사태 등 사면붕괴로 인한 피해는 인간에게 많은 인적/물적 자원의 손실을 가져왔다. 이런 사면붕괴로 인한 피해를 줄이고자 사면붕괴 예방을 위해 다양한 계측장비를 이용하여 사면붕괴 예 경보 시스템을 구축하였다. 하지만 대상사면에 접근성 문제를 해결하고 위험 사면 전체에 대한 안전성 평가를 실시할 수 있는 효율적인 계측장비는 많지 않은 실정이다. 이에 사면붕괴예방을 위한 효율적인 계측장비로서 측량학적인 접근 방법으로 사면거동의 정확한 계측을 위해 지상라이다시스템을 이용하여 사면붕괴 예방을 위한 시스템의 활용가능성 판단을 위한 실험을 실시하였다. 본 연구에서는 인공으로 조성되어 사면안정화 공법이 적용된 토사사면에 사면상부에서 단계별로 실물 하중을 가하여 하중에 따른 사면의 거동을 Total Station과 지상라이다시스템을 이용하여 계측하였다. 두 시스템을 이용하여 계측한 성과의 정확한 비교 분석을 위해 두 시스템의 계측 결과를 동일한 좌표계로 일치시키는 3D Similarity Transformation을 통해 서로 다른 좌표계를 가지고 있는 두 좌표계를 하나의 좌표계로 통일시켜 사면이 실물하중에 어떤 거동이 일어나는지를 분석하였다. 타켓중심의 사면거동 분석결과, 지상라이다 시스템은 Total Station과 비교해 X축으로는 1cm이내의 차이가, Y축으로는 규칙적이지 않는 거동의 경향이 발생하고, Z축으로는 서로 유사한 경향을 보였다. 연속된 점에 대한 사면지동 분석결과, Y축의 위치에 따라 사면 하부에서 상부의 방향으로 사면거동의 경향이 다르게 나타나 Total Station에서 분석하기 어려웠던 사면의 연속적인 변화를 관찰할 수 있었다. 따라서 지상라이다 시스템은 Total Station에 버금가는 측량성과를 획득하여 효율적인 사면모니터링을 위한 계측장비로 판단되었으며 기존의 사면모니터링기법의 한계를 대체 할 수 있는 측량학적 분석방법으로 많은 활용이 기대된다.

• 지질공학
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• 제17권2호
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• pp.163-176
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• 2007

사면붕괴는 사면에서 풍화물질, 암석, 토석류 등이 중력 방향으로 이동하는 일련의 거동으로 정의되며 여러 요인의 복합적인 작용으로 발생한다. 사면붕괴는 주요한 자연 재해 중의 하나로 매년 직접, 혹은 간접적으로 사회적 경제적으로 많은 인명, 재산 피해를 유발시킨다. 따라서 이러한 사면재해의 위험을 효과적으로 감소시키기 위해서는 사면의 상태를 평가할 수 있는 적절한 평가 기준이 필요하며, 이를 기반으로 피해 사례를 통한 피해 금액 산출과 투자 우선순위를 결정하여 종합적인 사면에 대한 평가법과 관리체계 개발이 절실히 요구되고 있다. 본 연구에서는 사면 안정성 평가를 위하여 적절한 기준을 제시하고자 위험도 분석 방법을 개발하여 새로운 사면 안정성 평가 기법을 제안하고자 한다. 본 연구에서 시행된 위험도 분석에는 비교적 안전한 사면 10개, 위험한 사면 10개, 붕괴된 사면 10개 등 총 30개의 국도변 도로 절취사면조사 자료가 사용되었다. 위험도 분석은 사면파괴위험성 분석과 피해도 분석으로 이루어져 있으며 위험도 분석결과 위험도 점수는 안정한 사면, 위험한 사면, 붕괴사면 순으로 점수가 높았으며, 각 그룹별로 서로 점수 분포가 구별되었다. 이러한 결과를 통해 볼 때 본 연구에서 제안된 위험도 분석기법은 기존의 분석기법에 비해 사면의 상태와 안정성을 종합적으로 평가할 수 있고 사면의 위험도를 보다 정확하게 파악할 수 있을 것으로 판단된다.

• 유통과학연구
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• 제13권4호
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• pp.45-53
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• 2015

Purpose - Online shopping enables consumers to conveniently purchase products irrespective of the time and place. As a result, several online shopping companies have emerged to cater to this growing market and, therefore, the competition among them has become increasingly intense. This paper evaluates the comparative efficiency of online shopping companies for a multi-year period (2009-2013), in order to help online shopping managers identify major drivers for enhancing management efficiency and the subsequent competitiveness. Research design, data, and methodology - The researchers collected the data from 2009 to 2013 from the distribution yearbook. This paper analyzes the marketability (sales figures), profitability (business profits), and management conditions (net profits) of domestic online shopping enterprises by incorporating information on human resources (number of employees) and material resources (total assets and capital). Therefore, the number of employees, total assets, and capital are selected as input variables, and sales figures, business profits, and net profits as the output variables. In this study, Data Envelopment Analysis (DEA) was used to measure the comparative efficiency of domestic online shopping companies. In addition, the Malmquist Productivity Index was used to evaluate the trend of change of Decision Making Units' (DMUs') efficiency for a multi-year period. Results - First, as of 2013, Interpark (2.415) was found to be the most efficient online shopping enterprise, followed by Aladdin Communications (2.117), Hyundai Home shopping (1.867), Home&Shopping (1.176), NS Home shopping (1.170), Commerce Planet (1.126), CJ O Shopping (1.105), Ebay Korea (1.088), and GS Home Shopping (1.051). Second, this study recognizes how the management efficiency has changed for the period 2009-2013. Third, the lesser the capital and employees, the more are the net profits, and the better is the management efficiency of domestic online shopping companies. Lastly, the productivity of such companies is influenced by endogenous factors rather than exogenous factors such as shifts in business environment and technological advances. Conclusions - DHC Korea influenced various distribution channels to reach customers through the Internet. Consequently, this helped in increasing the awareness about its products, in addition to an increase in sales. These achievements can be attributed to the characteristics of online shopping companies. Although it is easy for these companies to suggest goods for one-off purchases, they however have difficulties in retaining customers. Overcoming this challenge can be one of the ways to benchmark a successful case of an efficient company. For example, an online shopping company can attract customers by developing a corresponding mobile application as a convenient way to shop online. Additionally, they can satisfy customers by quick delivery of purchased products, which is possible by building an effective logistics network. Our study indicates that the productivity of an online shopping company was influenced by endogenous factors driven by improvements in managerial practices rather than exogenous factors. Accordingly, online shopping companies should adopt strategies to improve their operational efficiency rather than sales volume-oriented management.