• 제목/요약/키워드: Human health risk

검색결과 1,030건 처리시간 0.026초

Odor Thresholds and Breathing Changes of Human Volunteers as Consequences of Sulphur Dioxide Exposure Considering Individual Factors

  • Kleinbeck, Stefan;Schaper, Michael;Juran, Stephanie A.;Kiesswetter, Ernst;Blaszkewicz, Meinolf;Golka, Klaus;Zimmermann, Anna;Bruning, Thomas;Van Thriel, Christoph
    • Safety and Health at Work
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    • 제2권4호
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    • pp.355-364
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    • 2011
  • Objectives: Though sulfur dioxide (SO2) is used widely at workplaces, itseffects on humans are not known. Thresholds are reportedwithout reference to gender or age and occupational exposure limits are basedon effects on lung functioning, although localized effects in the upper airways can be expected. This study's aim is to determine thresholds with respect to age and gender and suggests a new approach to risk assessment using breathing reflexes presumably triggered by trigeminal receptors in the upper airways. Methods: Odor thresholds were determined by the ascending method of limits in groups stratified by age and gender. Subjects rated intensities of different olfactory and trigeminal perceptions at different concentrations of $SO_2$. During the presentation of the concentrations, breathing movements were measured by respiratory inductive plethysmography. Results: Neither age nor gender effects were observed for odor threshold. Only ratings of nasal irritation were influenced bygender. A benchmark dose analysis on relative respiratory depth revealed a 10%-deviation from baseline at about 25.27 mg/$m^3$. Conclusion: The proposed new approach to risk assessment appearsto be sustainable. We discuss whether a 10%-deviation of breathingdepth is relevant.

Induced Abortion and Breast Cancer: Results from a Population-Based Case Control Study in China

  • Wu, Jun-Qing;Li, Yu-Yan;Ren, Jing-Chao;Zhao, Rui;Zhou, Ying;Gao, Er-Sheng
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권8호
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    • pp.3635-3640
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    • 2014
  • Aim: To determine whether induced abortion (IA) increases breast cancer (BC) risk. Materials and Methods: A population-based case-control study was performed from Dec, 2000 to November, 2004 in Shanghai, China, where IA could be verified through the family planning network and client medical records. Structured questionnaires were completed by 1,517 cases with primary invasive epithelial breast cancer and 1,573 controls frequency-matched to cases for age group. The information was supplemented and verified by the family planning records. Statistical analysis was conducted with SAS 9.0. Results: After adjusting for potential confounders, induced abortions were not found to be associated with breast cancer with OR=0.94 (95%CI= 0.79-1.11). Compared to parous women without induced abortion, parous women with 3 or more times induced abortion (OR=0.66, 95%CI=0.46 to 0.95) and women with 3 or more times induced abortion after the first live birth (OR=0.66, 95%CI =0.45 to 0.97) showed a lower risk of breast cancer, after adjustment for age, level of education, annual income per capita, age at menarche, menopause, parity times, spontaneous abortion, age at first live birth, breast-feeding, oral contraceptives, hormones drug, breast disease, BMI, drinking alcohol, drinking tea, taking vitamin/calcium tablet, physical activity, vocation, history of breast cancer, eating the bean. Conclusions: The results suggest that a history of induced abortions may not increase the risk of breast cancer.

Wet-work Exposure: A Main Risk Factor for Occupational Hand Dermatitis

  • Behroozy, Ali;Keegel, Tessa G.
    • Safety and Health at Work
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    • 제5권4호
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    • pp.175-180
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    • 2014
  • Wet-work can be defined as activities where workers have to immerse their hands in liquids for >2 hours per shift, or wear waterproof (occlusive) gloves for a corresponding amount of time, or wash their hands >20 times per shift. This review considers the recent literature on wet-work exposure, and examines wet-work as a main risk factor for developing irritant contact dermatitis of the hands. The aim of this paper is to provide a detailed description of wet-work exposure among specific occupational groups who extensively deal with water and other liquids in their occupations. Furthermore, it highlights the extent and importance of the subsequent adverse health effects caused by exposure to wet-work.

성별에 따른 초등학생 학교사고의 위험행동특성 (Characteristics of Risk Behavior Related to the School Accident between Male and Female Elementary School Students)

  • 이명선;이혜진
    • 한국학교ㆍ지역보건교육학회지
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    • 제12권1호
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    • pp.71-89
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    • 2011
  • Objectives: The purpose of this study is to identify risk behavior related to the school accident between male and female elementary school students. Methods: 838 School accident data provided by Seoul School Safety Council were analyzed by gender. Based on the results above, survey questionnaires on characteristics of school accident were developed. Self-reported data were collected from a sample population of 433 students in grade 5 to 6 students attending 4 elementary schools in Seoul. Results: The students who answered they experienced the accident in school for the past 1 year, accounts 60.5% of male and 39.5% of females students, which has statistically significant difference. The male's cases happened most around corridor/door, while female's cases happened most in the playground/gymnasium. As for the accident risk behavior, male students had the risk behavior by using the personal belongings/toys, while the female students had much risk behavior related to physical facility/playground. When classifying the characteristics of risk behaviors according to the accident causes, male students showed higher score in the accident risk behaviors related to play/fight than in those of the female students(p<0.05). Conclusions: Health care providers should develop school safety programs by characteristics of risk behavior between male and female elementary school students.

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노동조합 유무에 따른 위험정보 제공수준 차이 분석 (The comparison of provision of risk information between employees with labour union and non labour union)

  • 조흠학;이경용;김영선
    • 대한안전경영과학회지
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    • 제16권4호
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    • pp.257-262
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    • 2014
  • Risk information may be one of the most important factor for worker's safe behavior because that safe behavior can be oriented by attitude based on risk information. Traditionally KAP(knowledge, attitude and practice) model was useful frame for the change of human behavior. Knowledge is formed by information through experience and education. Worker's health may be prevented by his or her own active safe behavior based on risk information. This paper is to investigate the effect of labor union on the provirion of risk information by labor union. Data for analysis is the third Korean Working Conditions Survey done by Occupational Safety and Health Research Institute in 2011. The sample size is 50,032 economic active person surveyed by household interview survey with structure questionnaire by trained interviewer. The difference of risk information provision among employees was tested by mean difference test. The level of risk information of employees of companies with labor union is higher than that with non labour union. This paper has some implication for the promotion of safe behavior of employees through risk information provision mediated by labor union. Some limitation of this study may be considered because of using the cross sectional survey data.

환경 오염물질 비소의 체내 대사 및 인체 위해성 (Potential Risk to Human Health by Arsenic and Its Metabolite)

  • 배옥남;이무열;정승민;하지혜;정진호
    • Environmental Analysis Health and Toxicology
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    • 제21권1호
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    • pp.1-11
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    • 2006
  • Arsenic is a ubiquitous element found in several forms in environment. Although certain foods, such as marine fish, contain substantial levels of organic arsenic forms, they are relatively low in toxicity compared to inorganic forms. In contrast, arsenic in drinking water is predominantly inorganic and very toxic. Chronic ingestion of arsenic-contaminated drinking water is therefore the major pathway posing potential risk to human health. World populations are exposed to low to moderate levels of arsenic of parts per billion (ppb) to thousands of ppb. When exposed to human, it could metabolize into monomethylarsonous acid ($MMA^{III}$) and dimethylarsinous acid ($DMA^{III}$) which are highly toxic. Lots of stuides have been recently focused how $MMA^{III}\;and\;DMA^{III}$ induce toxic insults in various target tissues. Epidemiological studies revealed that chronic arsenic exposure caused cancer, cardiovascular diseases, and diabetes etc. In this review, the current understanding of arsenic on health effects will be discussed.

위해성 평가 기법에 따른 토양 불소 기준안 연구 (Derivation of Soil Fluorine Standards Based on a Human Health Risk Assessment Method)

  • 정승우
    • 한국지하수토양환경학회지:지하수토양환경
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    • 제29권3호
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    • pp.14-22
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    • 2024
  • This study established risk-based fluoride soil contamination standards according to the Korean Soil Contaminant Risk Assessment Guidelines (SRAG). Ten exposure scenarios were evaluated, broadly categorized into Scenario 1, which used the default parameters from the current SRAG, and Scenario 2, which used the latest exposure factors and bio-concentration factors. Fluoride soil standards corresponding to a total hazard index (HI) of 1.0 were determined for each scenario. For children in agricultural areas, the derived risk-based soil fluoride standard was 70 mg/kg for Scenario 1 and 27 mg/kg for Scenario 2. In industrial areas, the risk-based fluoride soil standard was 2200 mg/kg in Scenario 1 and 2300 mg/kg in Scenario 2. This study clearly demonstrated that the crop ingestion exposure pathway exerted predominent influence on the estimated human health risk standards. Additionally, using the Added Risk Approach and considering soil background concentrations, the total fluoride soil standards for residential areas ranged from 232 mg/kg to 444 mg/kg, while the standards for industrial areas ranged from 2405 mg/kg to 2674 mg/kg.

서울 대기 중 미세 먼지 노출로 인한 위해도에 근거한 우선 관리 지역 선정 -이론적 사망 위해도 및 손실비용을 근거로- (Selection of Priority Areas Based on Human and Economic Risk from Exposure to Fine Particles in Seoul)

  • 김예신;이용진;신동천
    • Environmental Analysis Health and Toxicology
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    • 제19권1호
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    • pp.49-58
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    • 2004
  • It is important to select a risk based priority area for environmental policy formation and decision-making. We estimated the health risks and associated damage costs from exposure to fine particles and assigned priority areas for twenty -five districts in Seoul. In order to estimate the theoretical mortality incidence of the health risk, baseline risks were estimated from mortality rates in two low level areas of fine particles, Seocho Gu and Cheju city To estimate the damage cost from the risk estimates, we investigated and estimated the willingness to pay (WTP) for specific risk reduction. We assumed two different locations as the reference area, Cheju city as Scenario I and Seocho gu as Scenario II. From the results, the five districts, Kwangjin, Chungnang, Kangbuk, Nowon, and Kangnam, ranked high in the categories of both health risk and economic risk. Damage costs were over twenty billion won in each of these districts. As there are uncertainties in these results, the parameter values such as PM$_{2.5}$ level, dose -response slope factor, baseline risk, exposure population and WTP should be continuously validated and refined.d.

국내 도로 노면 퇴적입자 내 PAHs의 인체 위해성 평가 (Human Health Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) from Road Dust Sediments in Korea)

  • 이가인;김홍경;지승민;장용철
    • 환경영향평가
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    • 제29권4호
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    • pp.286-297
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    • 2020
  • 본 연구에서는 국내 4개 도시(6개 지점)로부터 도로 노면 퇴적입자 내 PAHs의 농도 및 분포특성을 비교, 분석하고 오염 수준에 대한 초과 발암 위해도를 산정하여 인체 위해성 평가를 수행하였다. 지역별 오염농도를 바탕으로 흡입, 섭취, 피부 노출에 대한 노출경로를 설정하여 결정론적 위해성평가를 수행한 결과, 울산 지역의 경우 위해도 발암 기준 1×10-6을 상회하는 결과가 나타났다. 또한 발암위해도가 있다고 판단되는 해당 지역에 대한 확률론적 위해성평가 결과, 확률적 평균값이 단일값을 활용한 결정론적 위해도 산정에서 도출되었던 발암위해도와 중앙값에 근접한 수준을 나타내었다. 민감도 분석 결과, 노출시간에 따른 기여도가 가장 크게 나타났다. 향후 기준치를 초과하는 발암 위해도를 나타내는 지역에 대한 위해도 관리는 물론 상세한 모니터링을 통한 추가 위해성 평가가 이루어져야 할 것으로 판단되며, 지역적 특성을 반영한 노출계수의 산정을 통해 인체 위해도 평가 결과 신뢰도를 높여야 할 것으로 사료된다.