• Journal of Photoscience
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• 제9권2호
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• pp.150-153
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• 2002

Solar UV light is a well-known carcinogen. UVA radiation is probably carcinogenic to humans. In addition, recent investigations point to the importance of UVA irradiation in the photoaging. We investigated the mechanism of sequence- specific DNA damage using $\^$32/P-Iabeled DNA fragments in relation to carcinogenesis and aging. Furthermore, we investigated whether UVA accelerates the telomere shortening in human WI-38 fibroblasts. The exposure of double- stranded DNA fragments to 365 nm light in the presence of endogenous sensitizers produced sequence-specific cleavage at the 5' site of 5'-GG-3' and 5'-GGG-3' sequences. In addition, HPLC analysis revealed that sensitizers plus 365 nm light increased the 8-oxodG content of double-stranded DNA. We discuss the mechanisms of guanine-specific DNA damagecaused by excited photosensitizers in relation to carcinogenesis and aging.

• Journal of Gastric Cancer
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• 제14권2호
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• pp.67-86
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• 2014

Gastric cancer is one of the most common cancers in the world. Animal models have been used to elucidate the details of the molecular mechanisms of various cancers. However, most inbred strains of mice have resistance to gastric carcinogenesis. Helicobacter infection and carcinogen treatment have been used to establish mouse models that exhibit phenotypes similar to those of human gastric cancer. A large number of transgenic and knockout mouse models of gastric cancer have been developed using genetic engineering. A combination of carcinogens and gene manipulation has been applied to facilitate development of advanced gastric cancer; however, it is rare for mouse models of gastric cancer to show aggressive, metastatic phenotypes required for preclinical studies. Here, we review current mouse models of gastric carcinogenesis and provide our perspectives on future developments in this field.

• 한국대기환경학회지
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• 제15권4호
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• pp.371-383
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• 1999

This paper discusses the importance of indoor air quality based on literaure review of domestic and foreign studies. A number of international efforts to propose standards and guidelines for indoor environmental quality are also reviewed. The pattern of major studies on indoor air quality focussed on characterizaton of gaseous pollutants, particulates, and other specific pollutants during the past decades, whereas VOCs, specific carcinogen, and microbiological agents might be good target pollutants to investigate the effects of human health in recent years. Management of indoor air quality requires a different approach than that adopted for outdoor air. Adequate ventilation of the indoor environment is essential, and a balance between energy conservation and the need for good air quality is required. The ways for managing indoor air quality that will be of great importance are discussed a role of control policy for guidance on how to achieve good indoor air quality.

• 한국임상수의학회지
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• 제13권2호
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• pp.204-207
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• 1996

Fiberglass may be a pulmonary toxin and carcinogen because it imitates asbestos, as do other man-made mineral fibers. A 5-months-old Jind dog was accidentally exposed to fiberglass extensively for 3 months in a site of apartment construction. Canine acute clinical pneumoconiosis caused by fiberglass was diagnosed by history, ezamination of environment, physical examination, and chest x-ray check of patient. The main signs were anorexia, dyspnea, increased irregular opacities and air trapping in lung field of chest x-ray films. Because the fiverglass which is used for several purpose are dangerous for health of animal and human. fiberglass dust must be controlled to minimize the adverse effects of fiberglass in the environment.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.129-129
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• 2002

2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) a prototype of many halogenated aromatic hydrocarbons, is a ubiquitous, persistent environmental contaminant and the most powerful carcinogen categorized by IARC. Despite extensive research, the mechanisms of TCDD-induced carcinogenesis are poorly understood.(omitted)

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2018년도 춘계 학술논문 발표대회
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• pp.226-227
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• 2018

Recently, as the interest of the government and the public on energy saving has increased, the airtightness of buildings has been improved to improve the insulation performance of buildings. However, indoor air pollution due to increase of pollution source in indoor space and lack of ventilation is increasing and interest in indoor air quality is increasing. In 2003, the Ministry of Environment enacted and promulgated the Act on Indoor Air Quality Control in Multi-use Facilities. Radon is a naturally occurring radioactive inert gas with colorless, tasteless and odorless nature. The concentration is high in a room where radon can not escape. Although lononggas is naturally occurring, it is not interested in living environment, but it is easily inhaled through human body through respiration and causes lung cancer in long-term exposure. Therefore, this study intends to carry out an experiment for the reduction of radon gas, which is the first carcinogen in indoor air pollution sources.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2019년도 춘계 학술논문 발표대회
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• pp.40-41
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• 2019

Fine dust, which is emerging as a global problem, attracted much attention recently in Korea. One of the reasons is that recent factory relocation and expansion in China affected the increase of domestic fine dust concentration due to the influence of the Yangtze river battalion and westerlies. Fine dust is a big problem not only in outdoor but also indoors. The room requires periodic ventilation and is also essential for improving indoor air quality. The fine dusts are designated as Group 1 carcinogens in WHO and the risk of fine dusts on the human body due to respiratory diseases is also increasing. In this study, the characteristics of the fine dust adsorption matrix are examined and the actual application direction is derived.

• 월간산업보건
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• 통권63호
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• pp.27-32
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• 1993

직업과 질병간의 관련성이 역학적인 방법에 의하여 밝혀진 대표적인 예로 직업성 암을 들수 있다. 실제로 이러한 노력에 의하여 현재에 이르러는 작업장에서 사용되는 몇가지 물질들이 발암성물질로 분류(Recogniz Human Carcinogen)되어 있다. 이 글은 Monson이 저술한 'Occupational Epidemiology'중에서 'Occupation and cancer'의 첫 부분과, 암발생과의 관련성이 확립된 직업성 폭로물질들을 열거한 표를 번역한 것이다. 내용중에서도 언급하고 있듯이 화학군(group of chemicals)이 제시된 경우에는 그 군에 속한 모든 화학물질들이 발암원성 물질이라는 것은 아니고, 작업공정이 열거된 예에서도 그 공정에서 어떠한 물질이 과연 발암성인지를 밝혀내기에 충분한 정보가 아직 없다. 그러나 직업과 암에 관한 역학적 연구의 역사적인 배경, 현 상태 등을 파악하는데에 좋은 자료일 것으로 생각되어 게재하고자 한다. - 저자 주 -

• 실내환경 및 냄새 학회지
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• 제16권4호
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• pp.297-307
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• 2017

As radon is a naturally occurring radioactive gas that can cause lung cancer and is classified as a Group 1 carcinogen, it is essential for the public to be aware of what radon is, and how to manage radon. Therefore, general information on radon, as well as its health risks, measurement methods, mitigation methods and suggestions for its management are addressed in this article. Over the last one to two decades, a number of wide-ranging studies on radon measurement and mitigation have been conducted in Korea, and the results of each study are comparable to the research achievements of other developed countries. For this reason, it is time to systematically establish a well-made Korean radon management organization.

• Mycobiology
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• 제50권1호
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• pp.96-98
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• 2022

The Aspergilli of the section Nidulantes series Versicolores are among the most recurrent molds in indoor environments. These species cause damage to the quality of air. Indeed, they are responsible for allergies, aggravation of asthma and can even cause infections in immunocompromised patients. Molds belonging to the Versicolores series also produce sterigmatocystin, a mycotoxin classified as potential human carcinogen by the International Agency for Research on Cancer (group 2B). Here, we provide for the first time the genome of three species of the series Versicolores: Aspergillus creber, Aspergillus jensenii and Aspergillus protuberus which are the most abundant species of this series in bioaerosols. The genomes of these three species could be assembled with a percentage of completeness of 97.02%, 96.21% and 95.35% for Aspergillus creber, A. jensenii and A. protuberus respectively. These data will allow to study the genes and gene clusters responsible for the expression of virulence factors, the biosynthesis of mycotoxins and the proliferation of these ubiquitous and recurrent molds.