• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 1996년도 춘계학술발표회 초록집
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• pp.73-87
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• 1996

The outer-most electrons of metal atoms and the remining valence electrons of any molecular atoms make three dimensional crystallizing $\pi$-bondings. The electrons on the $\pi$-bonding orbital rotate clockwise or counter-clockwise and they then make electro-magnetic waves between atoms on the orbital because electron move between plus charged ions. The three dimensional crystallizing $\pi$-bonding orbitals are quantum-mechanically modeled by a cyclic Kronig-Penny Model and energy band structures are analyzed with their potential barrier thickness. The waves generated between plus charged ions are the particular $\pi$-far infrared rays, which have dual properties between material and electro-magnetic waves and can be measured not by modern electro-magnetic tester but biosensor such as finger's force tester. Because the $\pi$-rays can be modulated with electro-magnetic waves it can be applied for harmful electro-magnetic wave killers. Because the $\pi$-rays make new three dimensional crystallizing $\pi$-bonding orbitals in the material the food and drink can be transformed into a helpful physical constitutional property for human health. Distinction between crystalline and amorphous metals is possible because very strong crystalline $\pi$-bonding orbitals can not easily be transformed into another. The $\pi$-rays can also be applied for biofunctional diagnostics and therapy. Gravitational field is one of the electro-magnetic fields. And also magnetic field and gravitational force field make charge's movement. ($\times$ = q, : magnetic field, : force field, q: plus charge, : velocity field)

• 한국정보과학회논문지:소프트웨어및응용
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• 제37권1호
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• pp.80-84
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• 2010

손 추적 기술은 인간과 기계와의 효율적인 의사소통을 위한 손동작 인식 기술의 핵심 기반 기술이다. 최근의 손 추적 연구는 3차원 손 모델을 이용한 연구 방향에 초점을 맞추고 있고, 기존의 2차원 손 모델을 이용한 방법보다 강인한 추적 성능을 보이고 있다. 본 논문에서는 결합된 파티클 필터에 기반한 새로운 3차원 손 추적 방법을 제안한다. 이는 전역적 손 형상과 지역적 손가락 움직임을 분리하여 추정하고, 각각의 추정 결과를 서로의 사전 정보로 이용하여 기존의 방법보다 빠르고 강인한 추적을 가능하게 한다. 또한, 추적 성능 향상을 위해 색상과 에지를 함께 고려한 다중 증거 결합 방법을 적용한다. 실험결과, 제안하는 방법은 복잡한 배경이나 동작에서도 강인한 추적 결과를 보였다.

• Nutrition Research and Practice
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• 제18권4호
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• pp.451-463
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• 2024

BACKGROUND/OBJECTIVES: The umami taste receptor (TAS1R1/TAS1R3) is endogenously expressed in skeletal muscle and is involved in myogenesis; however, there is a lack of evidence about whether the expression of the umami taste receptor is involved in muscular diseases. This study aimed to elucidate the effects of the umami taste receptor and its mechanism on muscle wasting in cancer cachexia using in vivo and in vitro models. MATERIALS/METHODS: The Lewis lung carcinoma-induced cancer cachexia model was used in vivo and in vitro, and the expressions of umami taste receptor and muscle atrophy-related markers, muscle atrophy F-box protein, and muscle RING-finger protein-1 were analyzed. RESULTS: Results showed that TAS1R1 was significantly downregulated in vivo and in vitro under the muscle wasting condition. Moreover, overexpression of TAS1R1 in vitro in the human primary cell model protected the cells from muscle atrophy, and knockdown of TAS1R1 using siRNA exacerbated muscle atrophy. CONCLUSION: Taken together, the umami taste receptor exerts protective effects on muscle-wasting conditions by restoring dysregulated muscle atrophy in cancer cachexia. In conclusion, this result provided evidence that the umami taste receptor exerts a therapeutic anti-cancer cachexia effect by restoring muscle atrophy.

• Molecules and Cells
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• 제37권3호
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• pp.226-233
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• 2014

Excessive reactive oxygen species (ROS) generated from abnormal cellular process lead to various human diseases such as inflammation, ischemia, and Parkinson's disease (PD). Sensitive to apoptosis gene (SAG), a RING-FINGER protein, has anti-apoptotic activity and anti-oxidant activity. In this study, we investigate whether Tat-SAG, fused with a Tat domain, could protect SH-SY5Y neuroblastoma cells against 1-methyl-4-phenylpyridinium ($MPP^+$) and dopaminergic (DA) neurons in the substantia nigra (SN) against 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) toxicity. Western blot and immunohistochemical analysis showed that, unlike SAG, Tat-SAG transduced efficiently into SH-SY5Y cells and into the brain, respectively. Tat-SAG remarkably suppressed ROS generation, DNA damage, and the progression of apoptosis, caused by $MPP^+$ in SH-SY5Y cells. Also, immunohistochemical data using a tyrosine hydroxylase antibody and cresyl violet staining demonstrated that Tat-SAG obviously protected DA neurons in the SN against MPTP toxicity in a PD mouse model. Tat-SAG-treated mice showed significant enhanced motor activities, compared to SAG- or Tat-treated mice. Therefore, our results suggest that Tat-SAG has potential as a therapeutic agent against ROS-related diseases such as PD.

• Journal of Gastric Cancer
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• 제20권2호
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• pp.212-224
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• 2020

Purpose: miR-205 is a tumor suppressor and plays an important role in tumor invasiveness. However, the role of miR-205 in human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. The aim of this study was to investigate the molecular mechanism of miR-205 in the regulation of EMT in GC invasion. Materials and Methods: Quantitative polymerase chain reaction (qPCR) was used to detect the expression of miR-205 in GC. Further, the correlation between the pathological parameters and prognosis of GC was statistically analyzed. A transwell model was used to evaluate the effect of miR-205-3p on the invasion and migration of GC cells. qPCR, western blotting, and luciferase assay were performed to analyze the relationship and target effects between miR-205-3p and the expression of zinc finger electron box binding homologous box 1 (ZEB1) and 2 (ZEB2). Results: We found that the levels of miR-205-3p were significantly lower (P<0.05) in GC tissues than in matched normal tissues. Additionally, the expression of miR-205-3p was related to the tumor invasion depth, lymph node metastasis, lymph node invasion, and tumor, node, metastasis stage. Patients with lower miR-205-3p expression levels in the tumors had a poorer prognosis. The in vitro assays indicated that miR-205-3p could affect the invasion ability and EMT of GC cells by targeting the expression of both ZEB1 and ZEB2. Conclusions: miR-205-3p promotes GC progression and affects the prognosis of patients by targeting both ZEB1 and ZEB2 to directly influence EMT.

• 인터넷정보학회논문지
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• 제21권4호
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• pp.17-23
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• 2020

인간의 특성과 관련된 측정 항목을 나타내는 생체정보는 도난이나 분실의 염려가 없으므로 높은 신뢰성을 가진 보안 기술로서 큰 주목을 받고 있다. 이러한 생체정보 중 지문은 본인 인증, 신원 파악 등의 분야에 주로 사용된다. 신원을 파악할 때 지문 이미지에 인증을 수행하기 어려운 상처, 주름, 습기 등의 문제가 있을 경우, 지문 전문가가 전처리단계를 통해 직접 지문에 어떠한 문제가 있는지 파악하고 문제에 맞는 영상처리 알고리즘을 적용해 문제를 해결한다. 이때 지문에 상처와 주름이 있는 지문 영상을 판별해주는 인공지능 소프트웨어를 구현하면 손쉽게 상처나 주름의 여부를 확인할 수 있고, 알맞은 알고리즘을 선정해 쉽게 지문 이미지를 개선할 수 있다. 본 연구에서는 이러한 인공지능 소프트웨어의 개발을 위해 캄보디아 왕립대학교의 학생 1,010명, Sokoto 오픈 데이터셋 600명, 국내 학생 98명의 모든 손가락 지문을 취득해 총 17,080개의 지문 데이터베이스를 구축했다. 구축한 데이터베이스에서 상처나 주름이 있는 경우를 판별하기 위해 기준을 확립하고 전문가의 검증을 거쳐 데이터 어노테이션을 진행했다. 트레이닝 데이터셋과 테스트 데이터셋은 캄보디아의 데이터, Sokoto 데이터로 구성하였으며 비율을 8:2로 설정했다. 그리고 국내 학생 98명의 데이터를 검증 데이터 셋으로 설정했다, 구성된 데이터셋을 사용해 Classic CNN, AlexNet, VGG-16, Resnet50, Yolo v3 등의 다섯 가지 CNN 기반 아키텍처를 구현해 학습을 진행했으며 지문의 상처와 주름 판독에서 가장 좋은 성능을 보이는 모델을 찾는 연구를 수행했다. 다섯가지 아키텍처 중 지문 영상에서 상처와 주름 여부를 가장 잘 판별할 수 있는 아키텍처는 ResNet50으로 검증 결과 81.51%로 가장 좋은 성능을 보였다.