• 제목/요약/키워드: Hs-CRP

검색결과 92건 처리시간 0.024초

60세 이상 노인에서 혈중 지단백(a)와 이상지질혈증의 관련성 (Relationship between Lipoprotein(a) and Dyslipidemia in the Elderly over 60 Years)

  • 서요한;신희영
    • 대한임상검사과학회지
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    • 제54권2호
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    • pp.95-102
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    • 2022
  • Lp(a)와 이상지질혈증의 관계가 명확하지 않아, 본 연구는 60세 이상 노인 환자를 대상으로 Lp(a)와 이상지질혈증의 관계를 조사하고자 하였다. 2014년 1월 1일부터 2020년 12월 31일까지 7년간 한 종합병원을 내원한 60세 이상 노인 중 나이, 성별, BMI, Lp(a), LDL-C, TG, HDL-C, hs-CRP, HbA1c, 지질강하제 복용 여부, 이상지질혈증 의사진단여부 등의 기록이 있는 2,580명을 최종 분석대상자로 선정하였다. Lp(a)와의 상관성은 hs-CRP (r=0.138), LDL-C (r=0.097), HDL-C (r=-0.089), TG (r=-0.073), 나이(r=0.072) 등이 유의하였으며, BMI, HbA1c는 유의하지 않았다. 변수들을 보정한 Lp(a)와 LDL-C의 편상관관계는 남성그룹에서만 유의하였다(r=0.158, P<0.001). 본 연구에서 이상지질혈증에 대한 Lp(a)의 4사분위의 교차비(교차비=1.376, 95% 신뢰구간=1.038~1.822)가 유의하게 나타남으로써 지질강하제 복용으로도 1차 표적인 LDL-C 수준을 낮추지 못했을 때, 2차적으로 고려해봐야 할 여러 요소 중 Lp(a)도 포함되어야 한다고 판단된다. 성별, 연령, 지질강하제 복용 여부 등에 따른 다양한 지질인자들에 대한 연구들이 필요하다고 사료된다.

Association between hearing loss and high-sensitivity C-reactive protein: the Kangbuk Samsung Cohort Study

  • Jihoon Kim;Yesung Lee;Eunhye Seo;Daehoon Kim;Jaehong Lee;Youshik Jeong;Seonghyun Kwon;Jinsook Jeong;Woncheol Lee
    • Annals of Occupational and Environmental Medicine
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    • 제35권
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    • pp.38.1-38.10
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    • 2023
  • Background: Hearing loss (HL) is linked to an elevated risk of cardiovascular diseases (CVDs). The pathogeneses of HL and CVD commonly involve inflammatory responses. Previous studies investigated elevated levels of inflammatory biomarkers in subjects with HL, however, their findings did not demonstrate statistical significance. In our cross-sectional and longitudinal study, we investigated the correlation between HL and increased high-sensitivity C-reactive protein (hsCRP) levels to determine how HL is associated with CVDs. Methods: We conducted a cross-sectional study with workers aged over 18 years who underwent health check-ups at our institution between 2012 and 2018 (n = 566,507), followed by conducting a longitudinal study of workers aged > 18 who underwent health checkups at least twice at our institution between 2012 and 2018 (n = 173,794). The definition of HL was as an average threshold of ≥ 20 dB in pure-tone air conduction at 0.5, 1.0, and 2.0 kHz in both ears. The incidence of increased hsCRP levels throughout the follow-up period was defined as a level exceeding 3 mg/L. Logistic regression and generalized estimating equations were performed to estimate the risk of increased hsCRP levels according to the occurrence of HL in groups stratified by age. Results: In the cross-sectional study, the multivariate-adjusted odds ratio (OR) was 1.17 (95% confidence interval [CI]: 1.02-1.34); the OR was 0.99 (95% CI: 0.80-1.22) in those under 40 and 1.28 (1.08-1.53) in those over 40. In the longitudinal study, the multivariable-adjusted OR was 1.05 (95% CI: 0.92-1.19); the OR was 1.10 (95% CI: 0.90-1.35) in those under 40 and 1.20 (1.01-1.43) in those over 40. Conclusions: This cross-sectional and longitudinal study identified an association between HL and increased hsCRP levels in workers aged over 40 years.

Comparison of the Muscle Damage and Liver Function in Ultra-Marathon Race (100 km) by Sections

  • Shin, Kyung-A;Kim, Young-Joo
    • 대한의생명과학회지
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    • 제18권3호
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    • pp.276-282
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    • 2012
  • High-intensive endurance exercises induce cell changes in body, changes in structures and functions of the heart, the muscles, the cartilages, and the liver, as well as increase of inflammatory cytokine. The purpose of this study was to estimate the biochemical changes in the liver and muscles during ultra-marathon race (100 km) by sections. The blood of the subjects was collected before the marathon as a control in order to analyze serum creatine kinase (CK), lactic dehydrogenase (LDH), asprtate aminotransferase (AST), alanine aminotransferase (ALT), total(T)-bilirubin, direct(D)-bilirubin, total protein, albumin, uric acid, gamma-glutamyltranspeptidase (${\gamma}$-GTP), alkaline phosphatase (ALP), creatinine, blood urea nitrogen (BUN), and high sensitive C-reactive protein (hs-CRP) concentrations. The CK, LDH, D-bilirubin, AST and ALT concentrations at 50 km and 100 km were significantly increased compared to the control (P<0.05). The markers at 100 km were higher than those at 50 km (P<0.05). The T-bilirubin and hs-CRP concentrations showed no difference among the groups, whereas the markers at 100 km were higher than those of the control and at 50 km (P<0.05). In conclusion, this study shows that the ultra-marathon race (100 km) may induce the damage of the skeletal muscle, liver and kidney, intravascular hemolysis and inflammatory responses.

맥파전도속도(PWV)를 이용한 체질별 죽상동맥경화 위험인자에 대한 상관관계 연구 (A Study on the Correlation of Atherosclerosis Risk Factor and Pulse Wave Velocity(PWV) of Carotid-Femoral Artery With Sasang Constitution)

  • 임은영;이제원;장우석;백경민;전우현;정인권
    • 대한한방내과학회지
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    • 제31권3호
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    • pp.467-476
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    • 2010
  • Object : The purpose of this study was to investigate the correlation of atherosclerosis risk factors and pulse wave velocity (PWV) of carotid-femoral artery with Sasang constitution. This study also aimed to investigate the relationship between PWV and risk factors of atherosclerosis, including serum cholesterol and homosisteine, hs-CRP. Methods : We enrolled 160 patients without experience strokes who visited our hospital for a medical examination from January 1, 2008 to April 30, 2010 except patients whose body constitutions were undetermined according to QSCCII. We investigated the correlation between serum cholesterol values, blood pressure, body mass index(BMI), homosistein, hs-CRP and PWV. Pearson's correlation and partial correlation analysis were applied to examine the relationship between PWV and risk factors of atherosclerosis. Result : Among the 160 subjects, 54 were Taeumin, 54 were Soyangin, and 52 were Soeumin. The prevalences of high BMI (P-value <0.01), high hs-CRP(P-value <0.05), and high PWV(P-value <0.05) of Taeumin were higher than those of the other constitutions. PWV of carotid-femoral artery was significantly different among the three constitutional groups(Taeumin: $8.12{\pm}1.64m/sec$, Soyangin: $7.48{\pm}1.16m/sec$, Soeumin: $7.49{\pm}1.12m/sec$)(P-value <0.05). This research has show a statistical significance between the average amount of carotid-femoral artery PWV that is higher in Taeumin. Age factor of Taeumin was the effective determinant of the increase of mean PWV of carotid-femoral arteries. Conclusions : There were significant differences in the prevalence of atherosclerosis according to Sasang constitution. This study showed that atherosclerosis was more prevalent in Taeumin. Therefore, according to our results, risk of atherosclerosis was higher in Taeumin than among other constitutions.

과체중과 비만 여성의 HbA1c 지표에 따른 당뇨병 예방을 위한 영양상담의 효과 (Benefits of Nutrition Consultation for Preventing Diabetes According to HbA1c Levels in Overweight and Obese Women)

  • 권용진;선우섭;문황운;박유경
    • 대한영양사협회학술지
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    • 제19권2호
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    • pp.112-123
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    • 2013
  • HbA1c was recently adopted as a reliable indicator for screening diabetes. This study investigated the ability of nutrition consultation to prevent diabetes in overweight women (BMI 23 $kg/m^2$ or more) using HbA1c as an indicator. Twenty overweight and obese women (with $HbA1c{\geq}5.7$%) completed the 12-week nutritional study, with individual and personalized nutrition counseling performed every 2 weeks. The main study guidelines involved the following: 1) reducing the intake of high fat foods and alcohol, 2) consuming a large amount of vegetables, 3) reducing the intake of simple sugars and empty-calorie foods, and 4) increasing physical activity to ${\geq}30$ min/day. Anthropometric (height, weight, BMI, body muscle (kg), body fat (%), waist and hip circumference, blood pressure) and biochemical parameters (fasting blood sugar (FBS), HbA1c, lipid profiles, hs-CRP) were measured before and after the nutrition consultation. After 12 weeks, the HbA1c<5.7% group had significant decreases in BMI, WC, HC, WHR, HbA1c, hs-CRP and also dietary intake of energy (P<0.01), carbohydrates, lipids (P<0.01), proteins (P<0.01) and cholesterol was significantly decreased (P<0.05). In the HbA1c ${\geq}5.7$% group, HbA1c, TC, LDL, NON-HDL, hs-CRP and dietary intake of energy, carbohydrate, lipid, protein, and cholesterol significantly decreased (P<0.05). These results suggest that nutrition consultation effectively helps to prevent diabetes in overweight and obese women after applying HbA1c standards. Overall, the improvement in all markers measured suggest that HbA1c is a good indicator for blood glucose regulation, helping to prevent diabetes.

Association between periodontal bacteria and degenerative aortic stenosis: a pilot study

  • Kataoka, Akihisa;Katagiri, Sayaka;Kawashima, Hideyuki;Nagura, Fukuko;Nara, Yugo;Hioki, Hirofumi;Nakashima, Makoto;Sasaki, Naoki;Hatasa, Masahiro;Maekawa, Shogo;Ohsugi, Yujin;Shiba, Takahiko;Watanabe, Yusuke;Shimokawa, Tomoki;Iwata, Takanori;Kozuma, Ken
    • Journal of Periodontal and Implant Science
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    • 제51권4호
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    • pp.226-238
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    • 2021
  • Purpose: Although several reports have described the relationship between periodontal disease and cardiovascular disease, information about the association between periodontal disease and the progression of degenerative aortic stenosis (AS) is lacking. Therefore, we performed a retrospective, single-center, pilot study to provide insight into this potential association. Methods: Data from 45 consecutive patients (19 men; median age, 83 years) with mild or moderate degenerative aortic stenosis were analyzed for a mean observation period of 3.3±1.9 years. The total amount of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis and titers of serum immunoglobulin G (IgG) against periodontal bacteria and high-sensitivity C-reactive protein (hs-CRP) were evaluated. Aortic valve area (AVA), maximal velocity (Vmax), mean pressure gradient (mean PG), and the Doppler velocity index (DVI) were evaluated. The change in each parameter per year ([ParameterLATEST-ParameterBASELINE]/Follow-up Years) was calculated from the retrospective follow-up echocardiographic data (baseline vs. the most recently collected data [latest]). Results: No correlation was found between the concentration of periodontopathic bacteria in the saliva and AS status/progression. The anti-P. gingivalis antibody titer in the serum showed a significant positive correlation with AVA and DVI. Additionally, there was a negative correlation between the anti-P. gingivalis IgG antibody titer and mean PG. The hs-CRP concentration showed positive correlations with Vmax and mean PG. Meanwhile, a negative correlation was observed between the anti-P. gingivalis IgG antibody titer and ΔAVA/year and Δmean PG/year. The hs-CRP concentration showed positive correlations with Vmax and mean PG, and it was significantly higher in patients with rapid aortic stenosis progression (ΔAVA/year <-0.1) than in their counterparts. Conclusions: Our results suggest that periodontopathic bacteria such as A. actinomycetemcomitans and P. gingivalis are not directly related to the status/progression of degenerative AS. However, inflammation and a lower immune response may be associated with disease progression.

광산 이직근로자의 만성폐쇄성폐질환 기류제한 중증도와 염증 및 산화스트레스 (Inflammation and Oxidative Stress as related to Airflow Limitation Severity in Retired Miners with Chronic Obstructive Pulmonary Disease)

  • 이종성;신재훈;백진이;정지영;최병순
    • 한국산업보건학회지
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    • 제29권2호
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    • pp.251-258
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    • 2019
  • Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Inflammation and oxidative stress are associated with COPD. The aim of this study was to evaluate the relationship among inflammation, oxidative stress, and airflow limitation severity in retired miners with COPD. Methods: The levels of serum high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation, degree of reactive oxygen metabolites(dROMs) and biological antioxidants potential(BAP) in plasma as biomarkers for oxidative stress were measured in 211 male subjects with COPD. Degree of airflow limitation severity as determined by spirometry was divided into three grades grouped according to the classification of the Global Initiatives for Obstructive Lung Disease(GOLD)(1, mild; 2, moderate; $3{\leq}$, severe or more) using a fixed ratio, post- bronchodilator $FEV_1/FVC$ < 0.7. Results: Mean levels of dROMs significantly increased in relation to airflow limitation severity(GOLD 1, 317.8 U.CARR vs. GOLD 2, 320.3 U.CARR vs. GOLD $3{\leq}$, 350.9 U.CARR, p=0.047) and dROMs levels were correlated with serum hsCRP levels(r=0.514, p<0.001). Mean levels of hsCRP were higher in current smokers(non-smoker, 1.47 mg/L vs. smoker, 2.34 mg/L, p=0.006), and tended to increase with degree of airflow limitation severity(p=0.071). Mean levels of BAP were lower in current smokers(non-smoker, $1873{\mu}mol/L$ vs. smoker, $1754{\mu}mol/L$, p=0.006). Conclusions: These results suggest that inflammation and oxidative stress are related to airflow limitation severity in retired miners with COPD, and there was a correlation between inflammation and oxidative stress.

Cardiovascular risk factors of early atherosclerosis in school-aged children after Kawasaki disease

  • Cho, Hyun Jeong;Yang, Soo In;Kim, Kyung Hee;Kim, Jee Na;Kil, Hong Ryang
    • Clinical and Experimental Pediatrics
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    • 제57권5호
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    • pp.217-221
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    • 2014
  • Purpose: The aim of this study was to determine whether school-aged children with Kawasaki disease (KD) have an increased risk for early atherosclerosis. Methods: The study included 98 children. The children were divided into the following groups: group A (n=19), KD with coronary arterial lesions that persisted or regressed; group B (n=49), KD without coronary arterial lesions; and group C (n=30), healthy children. Anthropometric variables and the levels of biochemical markers, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A, apolipoprotein B, homocysteine, highsensitivity C-reactive protein (hs-CRP), and brachial artery stiffness using pulse wave velocity were compared among the three groups. Results: There were no significant differences in blood pressure and body index among the three groups. Additionally, there was no sex-specific difference. Moreover, the levels of triglyceride, HDL-C, apolipoprotein A, and hs-CRP did not differ among the three groups. However, the levels of total cholesterol (P =0.018), LDL-C (P =0.0003), and apolipoprotein B (P =0.029) were significantly higher in group A than in group C. Further, the level of homocysteine and the aortic pulse wave velocity were significantly higher in groups A and B than in group C (P=0.0001). Conclusion: School-aged children after KD have high lipid profiles and arterial stiffness indicating an increased risk for early atherosclerosis.

가미방기황기탕(加味防己黃芪湯) 주정 추출물이 류마티스 관절염 동물병태모델에 미치는 영향 (Effects of GamiBangkeehwangkee-tang (fángjǐhuángqí-tāng) ethanol extract on Collagen-induced Rheumatoid Arthritis model of DBA/1 mice)

  • 심부용;최학주;박지원;김동희
    • 대한본초학회지
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    • 제29권6호
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    • pp.95-102
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    • 2014
  • Objectives : The purpose of this study is to prove the effect of GamiBangkeehwangkee-tang (f$\acute{a}$ngj$\check{i}$hu$\acute{a}$ngq$\acute{i}$-t$\bar{a}$ng, BHT) ethanol extract on the immunity and rheumatoid arthritis related inflammatory cytokines. Methods : We checked viability in RAW 264.7 cell after treat by BHT. Then we measured inflammatory and immunity factors of DBA/1 mice with rheumatoid arthritis induced by collagen after BHT oral administration. Also, we checked micro-CT image, bone volume and bone inflammation ratio in micro-CT and structural parameter test. Results : BHT showed cell viability of 95% or higher in all concentration in RAW 264.7 cells. BHT treated group decreased level in serum of IgM and IgG test by 36% and 25% respectively. And BHT treated group showed significant decrease in WBC, neutrophil, lymphocyte and monocytes immune cell ratio in blood by 47%, 22%, 56% and 85% respectively. Also, BHT treated group decreased level in serum of $IL-1{\beta}$, IL-6, IL-17, $TNF-{\alpha}$ and hs-CRP tests by 29%, 33%, 32%, 24% and 56% respectively. Finally, BHT treated group showed increase ratio of bone volume that decrease ratio of bone inflammation. Conclusions : In this study, the results were observed rheumatoid arthritis factors cytokine decrease in serum. And BHT showed immunoglobulin and immune cells ratio decrease in serum and blood. Also, BHT depending on effects of inflammatory and immunity in hs-CRP test, micro-CT, structural parameter test. Thus, these results can used as a effective drug of BHT for inflammation and immunity.