• Title/Summary/Keyword: Hot Water Flow

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Anti-Proliferative Effect of Polysaccharides from Salicornia herbacea on Induction of G2/M Arrest and Apoptosis in Human Colon Cancer Cells

  • Ryu, Deok-Seon;Kim, Seon-Hee;Lee, Dong-Seok
    • Journal of Microbiology and Biotechnology
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    • v.19 no.11
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    • pp.1482-1489
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    • 2009
  • In this study, we investigated the anti-proliferative effect of polysaccharides from Salicornia herbacea on HT-29 human colon cancer cells. Crude polysaccharides from S. herbacea (CS) were prepared by extraction with hot steam water, and fine polysaccharides from S. herbacea (PS) were obtained through further size exclusion chromatography. The anti-proliferative effect of CS and PS were measured using the MTS assay, apoptosis analysis, cell cycle analysis, and RT-PCR. HT-29 cells were treated with CS or PS at different dosages (0.5, 1, 2, 4 mg $ml^{-1}$) for 24 or 48 h. CS and PS inhibited proliferation and stimulated apoptosis of cells in a dose-dependent manner. Flow cytometric analysis after Annexin V-FITC and PI staining revealed that treatment with CS or PS increased total apoptotic death of cells to 24.99% or 91.59%, respectively, in comparison with the control (13.51 %). PS increased early apoptotic death substantially - up to 12 times more than the control. Treatment with CS or PS resulted in a concentration-dependent increase of the G2/M cell population of the cell cycle as determined by flow cytometry. G2/M arrest was induced significantly with the highest concentration (4 mg $ml^{-1}$) of PS. RT-PCR was performed to study the correlation between G2/M arrest and transcription of cell cycle control genes. The anti-proliferative activity of CS and PS was accompanied by inhibition of cyclin B1, and Cdc 2 mRNA. Moreover, both CS and PS induced expression of the p53 tumor suppressor gene and the Cdk inhibitor p21. These results suggest that polysaccharides from S. herbacea have anti-cancer activity in human colon cancer cells.

Geochemical and Stable Isotopic Studies of the Matrix of Pebble Bearing Phyllitic Rocks and Carbonate Rocks from the Suanbo and Susanri District in the Okchon Geosynclinal Zone (옥천지향사대 내 수안보-수산 지역에 분포하는 함력천매암질암 기질의 화학 조성과 탄산염암의 안정동위원소 연구)

  • Kim, Kyu Han;Min, Kyung Duck
    • Economic and Environmental Geology
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    • v.29 no.1
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    • pp.25-33
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    • 1996
  • Stable isotopic ratios of the carbonate rocks and chemical compositions of the matrix of pebble bearing phyllitic rocks known as the Hwanggangri Formation, which are in hot debate on their origin such as tillite, debris flow and turbidite, were determined to interpret their depositional environment. Argillaceous matrix of the pebble bearing phyllitic rocks has a high content of CaO (av. 19.5%) and MgO (av. 8.3%), corresponding to calcareous sandy shale. No difference of chemical compositions including trace elements and REE is in the matrices between the Hwanggangri and the Kunjasan Formations. Carbonate rocks from the Okchon zone and outside of the zone range $-2.5{\sim}+6.1$‰ in ${\delta}^{13}C$ and $+5.8{\sim}+25.9$‰ in ${\delta}^{18}O$, indicating normal marine limestone. However, unusally $^{13}C$ enriched carbonate rocks might be deposited in the highly evaporated sedimentary basin. A wide variation of ${\delta}^{18}O$ values is responsible for metamorphism with a $^{18}O$ depleted meteoric water. Isotopic equilibrium temperatures by graphite-calcite geothermometer show a higher metamorphic temperature ($547{\sim}589^{\circ}C$) in the Okchon zone than those ($265{\sim}292^{\circ}C$) in the Samtaesan Formation of the Chosun group. Rhythmic alternation of relatively thin shale with thin limestone in the Kounri Formation is not cherty layer but thin limesilicate bed by metasomatic replacement. Judging from the isotopic and chemical compositions of the carbonate rocks and calcareous matrix of the pebble bearing phyllitic rocks, the Hwangganari Formation was deposited in the shallow marine environment favorable to debris flow.

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A study of geothermal heat dump for solar collectors overheat protection (태양열 집열관 과열방지를 위한 지중열교환기 연구)

  • Hwang, Hyun-Chang;Chi, Ri-Guang;Lee, Kye-Bock;Rhi, Seok-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.7
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    • pp.616-622
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    • 2016
  • The heating load using solar hot water is lower in summer than in the other seasons. This decreased heating load leads to the overheating solar collectors and related components. To prevent overheating of the solar collectors, air cooling and shading shields were used. On the other hand, it requires additional mechanical components, and reduces the system reliability. The geothermal heat dump system to release the high temperature heat (over $150^{\circ}C$) transferred from the heat pipe solar collectors was investigated in the present study. Research on the heat dump to cool the solar collector is rare. Therefore, the present study was carried out to collect possible data of a geothermal heat dump to cool the solar collector. A helical type geothermal heat exchanger was buried at a 1.2m depth. Experimentally and numerically, the geothermal heat dump was investigated in terms of the effects of parameters, such as the quantity of solar radiation, aperture area of the collector and the mass flow rate. A pipe length of 50m on the geothermal heat exchanger was suitable with a 0.33 kg/s flow rate. The water reservoir was a possible co-operation solution linked to the geothermal heat exchanger.

Analysis of Long-term Thermal Performance of Solar Thermal System Connected to District Heating System (지역난방 적용 태양열시스템의 장기 열성능 분석)

  • Baek, Nam-Choon;Shin, U-Cheul
    • Journal of the Korean Solar Energy Society
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    • v.27 no.4
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    • pp.167-173
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    • 2007
  • This study analyzed by simulation using TRNSYS as well as by experiment on the solar district heating system installed for the first time for the district heating system in Bundang. Simulation analysis using TRNSYS focused on the thermal behavior and long-term thermal efficiency of solar system. Experiment carried out for the reliability of simulation system. This solar system where the circuits of two different collectors, flat plate and vacuum tube collector, are connected in series by a collector heat exchanger, and the collection characteristics of each circuit varies. Therefore, these differences must be considered for the system's control. This system uses variable flow rate control in order to obtain always setting temperature of hot water by solar system. Specifically, this is a system that heats returning district heating water (DHW) at approximately $60^{\circ}C$ using a solar collector without a storage tank, up to the setting temperature of approximately $85{\sim}95^{\circ}C$ To realize this, a flat plate collector and a vacuum tube collector are used as separate collector loops. The first heating is performed by a flat plate collector loop and the second by a vacuum tube collector loop. In a gross collector area basis, the mean system efficiency, for 4 years, of a flat plate collector is 33.4% and a vacuum tube collector is 41.2%. The yearly total collection energy is 2,342GJ and really collection energy per unit area ($m^2$) is 1.92GJ and 2.37GJ respectively for the flat plate vacuum tube collector. This result is very important on the share of each collector area in this type of solar district heating system.

Construction of the Heat Pump System Using Thermal Effluents for Greenhouse Facilities in Jeju and Evaluation of Cooling Performance (제주 시설온실 냉난방을 위한 발전소 온배수 활용 열펌프 시스템 구축 및 냉방성능 평가)

  • Lee, Yeon-Gun;Heo, Jaehyeok;Lee, Dong-Won;Hyun, Myung-Taek
    • Journal of Energy Engineering
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    • v.27 no.4
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    • pp.70-79
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    • 2018
  • A heat pump system using the thermal effluent from the Jeju thermal power plant of KOMIPO was constructed with the capacity of 300 RT to supply cool or hot water to greenhouse facilities located 3 km from the power station. The way of transporting heat from the thermal effluent to greenhouses at a long distance was optimized, and a monitoring system to measure the water temperature and detect a leakage in a pipe conduit was also installed. This paper presents the system configuration of the constructed heat pump system for air conditioning and heating of greenhouse facilities in Jeju, and the characteristics of major components deployed in the system. The preoperational tests of the heat pump system were conducted during the summer season in 2018 for evaluation of its cooling performance. The operational stability and cooling performance of the heat pump system were confirmed by investigating the measured fluid temperature and flow rate, and COP of the heat pump in a cooling mode.

Antitumor and immunomodulatory effects of a hot water extract of Phellinus baumii using Sarcoma-180 in the mouse (Pheflinus baumii 자실체 추출물의 Sarcoma-180 에 대한 항암 및 면역효과)

  • Ha, Hyo-Cheol;Kim, Hyun-Pyo;Sim, Ji Young;Chang, Yun-Hee;Kim, Hyun Su
    • Journal of Mushroom
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    • v.2 no.4
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    • pp.169-174
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    • 2004
  • A hot water extract(HWE-P4) was separated from the fruit bodies of PMO-P4, and its antitumor and immunomodulatory activities against sarcoma-180 in ICR mice were investigated. The internal transcribed spacer(ITS) regions from PMO-P4 were amplified using polymerase chain reaction(PCR) and sequenced. The results revealed that PMO-P4 was belong to the Phellinus baumii. When oral administration at the dose of 160mg/kg/day in the mice until the end of the experiment with 2 week's pre-feeding of the HWE-P4, the survival rate of the mice was 152% for 50days after the inoculation of sarcoma-180 and the suppression rate of the tumor growth was 35.3%(p<0.05) for 28 days after inoculation of sarcoma-180. The HWE-P4 increased 71.4% of the CD4/CD8 ratio and 5-fold of the expression of CD25(IL-2 receptor chain) compared with the control. From these results, the antitumor activity of HWE-P4 is exerted through its immunomodulating activity on the host's immune system.

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A Numerical Study on the Performance Analysis of a Solar Air Heating System with Forced Circulation Method (강제순환 방식의 공기가열식 태양열 집열기의 성능분석에 관한 수치해석 연구)

  • Park, Hyeong-Su;Kim, Chul-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.3
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    • pp.122-126
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    • 2017
  • The aim of this study was to develop a device for solving the heating problem of living space using heated air, utilizing a simple air heater type collector for solar energy. At the present time, this study assessed the possibility of a development system through theoretical calculations for the amount of available energy according to the size change of the air-heated solar energy collector. To produce and supply hot water using the heat energy of the sun, hot water at $100^{\circ}C$ or less was produced using a flat or vacuum tube type collector. The purpose of this study was to research the air heating type solar collector that utilizes heating energy with heating air above $75^{\circ}C$, by designing and manufacturing an air piping type solar collector that is a simpler type than a conventional solar collector system. The analysis results were obtained for the generated air temperature ($^{\circ}C$) and the production of air (kg/h) to determine the performance of air heating by an air-heated solar collector according to the heat transfer characteristics in the collector of the model when a specified amount of heat flux was dropped into a solar collector of a certain size using PHOENICS, which is a heat flow analysis program applying the Finite Volume Method. From the analysis result, the temperature of the air obtained was approximately $40.5^{\circ}C$, which could be heated using an air heating tube with an inner diameter of 0.1m made of aluminum in a collector with a size of $1.2m{\times}1.1m{\times}0.19m$. The production of air was approximately 161 m3/h. This device can be applied to maintain a suitable environment for human activity using the heat energy of the sun.

A by-pass rainwater penetration sewer system for urban flooding mitigation (도시침수 저감을 위한 by-pass 빗물침투성 우수관거)

  • Lee, Bum-Sub;Ko, Keon-Ho;Kang, Ho-Yeong;Moon, Young-Il
    • Journal of Korea Water Resources Association
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    • v.49 no.9
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    • pp.799-807
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    • 2016
  • The aim of this study is to determine and propose the by-pass rainwater sewer system in order to reduce the urban floodplain from the locality heavy rain every year during the dry season and the sinkholes in the city as well as the shortage of groundwaters due to extreme hot weather condition and urban heat island phenomenon. Heavy rain occurs more than the years of heavy rainfall probability, comparison between the place where uses the existing pipes and connect the sewer system with by-pass rain permeability and without expanding sewer pipe replacement at intersection of Gangnam station 3.07 ha at Gangnam-gu, Seoul Metropolitan area, it indicates that average of 27 million KRW (44%) maintenance cost savings and maintain existing sewer system without any other countermeasures. For the city flooded reduction, by-pass rainwater permeable rainwater pipe multiplying the probability the number of years during summer season and increase the water flow capacity during spring and fall when a small amount of rain that, it also contribute to the total amount of underground water secured through the by-pass penetration.

Analysis on Pool Temperature Variation along Pool Water Management System Operation in Research Reactor (연구용원자로에서 수조수관리계통 운전에 따른 수조수 온도 해석)

  • Choi, Jungwoon;Lee, Sunil;Park, Ki-Jung;Seo, KyoungWoo
    • Transactions of the KSME C: Technology and Education
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    • v.5 no.2
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    • pp.135-143
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    • 2017
  • The domestic unique research reactor, HANARO (Hi-flux Advanced Neutron Application ReactOr), has been constructed with the open-pool, the core is submerged in, for the multi-purpose neutron application. The reactor has a primary cooling system to remove the fission heat from the core and its connected fluidic systems. Since the works are required at the reactor pool top as a characteristic of the research reactor, the radiation shall be minimized with the operation of the hot water layer system to avoid unnecessary radiation exposure on the workers during work at the pool top. Moreover, the pool water management system is connected to the reactor pool to maintain the pool temperature below $50^{\circ}C$ to minimize the uprising radioactive gas or impurity from the colder pool bottom. For the efficient flow rate of the PWMS, the thermal capacity of heat exchanger is selected with 260 kW in the normal operation condition. In this paper, the modeling is formulated to figure out whether or not each pool temperature maintains below the temperature limit and the calculation results show that the designed PWMS heat exchanger has enough capacity with the design margin regardless of the reactor operation mode.

Recent Progress in Air-Conditioning and Refrigeration Research : A Review of Papers Published in the Korean Journal of Air-Conditioning and Refrigeration Engineering in 2016 (설비공학 분야의 최근 연구 동향 : 2016년 학회지 논문에 대한 종합적 고찰)

  • Lee, Dae-Young;Kim, Sa Ryang;Kim, Hyun-Jung;Kim, Dong-Seon;Park, Jun-Seok;Ihm, Pyeong Chan
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.29 no.6
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    • pp.327-340
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    • 2017
  • This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2016. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. Conclusions are as follows. (1) The research works on the thermal and fluid engineering have been reviewed as groups of flow, heat and mass transfer, the reduction of pollutant exhaust gas, cooling and heating, the renewable energy system and the flow around buildings. CFD schemes were used more for all research areas. (2) Research works on heat transfer area have been reviewed in the categories of heat transfer characteristics, pool boiling and condensing heat transfer and industrial heat exchangers. Researches on heat transfer characteristics included the results of the long-term performance variation of the plate-type enthalpy exchange element made of paper, design optimization of an extruded-type cooling structure for reducing the weight of LED street lights, and hot plate welding of thermoplastic elastomer packing. In the area of pool boiling and condensing, the heat transfer characteristics of a finned-tube heat exchanger in a PCM (phase change material) thermal energy storage system, influence of flow boiling heat transfer on fouling phenomenon in nanofluids, and PCM at the simultaneous charging and discharging condition were studied. In the area of industrial heat exchangers, one-dimensional flow network model and porous-media model, and R245fa in a plate-shell heat exchanger were studied. (3) Various studies were published in the categories of refrigeration cycle, alternative refrigeration/energy system, system control. In the refrigeration cycle category, subjects include mobile cold storage heat exchanger, compressor reliability, indirect refrigeration system with $CO_2$ as secondary fluid, heat pump for fuel-cell vehicle, heat recovery from hybrid drier and heat exchangers with two-port and flat tubes. In the alternative refrigeration/energy system category, subjects include membrane module for dehumidification refrigeration, desiccant-assisted low-temperature drying, regenerative evaporative cooler and ejector-assisted multi-stage evaporation. In the system control category, subjects include multi-refrigeration system control, emergency cooling of data center and variable-speed compressor control. (4) In building mechanical system research fields, fifteenth studies were reported for achieving effective design of the mechanical systems, and also for maximizing the energy efficiency of buildings. The topics of the studies included energy performance, HVAC system, ventilation, renewable energies, etc. Proposed designs, performance tests using numerical methods and experiments provide useful information and key data which could be help for improving the energy efficiency of the buildings. (5) The field of architectural environment was mostly focused on indoor environment and building energy. The main researches of indoor environment were related to the analyses of indoor thermal environments controlled by portable cooler, the effects of outdoor wind pressure in airflow at high-rise buildings, window air tightness related to the filling piece shapes, stack effect in core type's office building and the development of a movable drawer-type light shelf with adjustable depth of the reflector. The subjects of building energy were worked on the energy consumption analysis in office building, the prediction of exit air temperature of horizontal geothermal heat exchanger, LS-SVM based modeling of hot water supply load for district heating system, the energy saving effect of ERV system using night purge control method and the effect of strengthened insulation level to the building heating and cooling load.